en-usOptimal salt and water balance after dialysis is a primary goal of renal replacement therapy (RRT). Inadequate fluid management leads to significant morbidity and mortality from complications of hypervolemia and hypovolemia. Fluid management is an area ripe for innovation that has a significant impact on the quality of life of people with kidney failure. It is a critical part of renal replacement therapy, and too much or too little volume can result in severe complications. Despite the unmet patient need, there are no approved devices to objectively measure volume status. There are many techniques available, yet clinicians lack technologies to accurately assess volume status. Therefore, the clinical approach to volume assessment is subjective and involves trial and error. <p></p><p> </p><p> This collection of articles from JASN and CJASN has been curated to represent the top articles published in the last two years on fluid management including blood volume measuring and monitoring, biomarkers and more.</p>Sun, 03 Jul 2022 08:49:37 GMThttp://cct.highwire.org/feeds/asn/fluid-management.rsshttp://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06480619?cct=218810.2215/CJN.06480619Wed, 29 Apr 2020 08:37:30 GMT-07:00Bioimpedance Guided Fluid Management in Peritoneal DialysisTian, NaYang, XiaoGuo, QunyingZhou, QianYi, ChunyanLin, JianxiongCao, PeiyiYe, HongjianChen, MenghuaYu, Xueqing2020-04-29T08:37:30-07:00doi:10.2215/CJN.06480619hwp:resource-id:clinjasn;15/5/685American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyfluid overload, bioelectrical impedance analysis, fluid control, short-term outcome, Control Groups, Cardiovascular Diseases, Electric Impedance, Body Water, Survival Rate, peritoneal dialysis, dialysis, Water-Electrolyte Imbalance, Maintenance, diabetes mellitusOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-05-07May 07, 202010.2215/CJN.064806191555-90411555-905X2020-04-29T08:37:30-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles1555685597694599http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12281019?cct=218810.2215/CJN.12281019Wed, 25 Mar 2020 06:32:37 GMT-07:00Trajectories of Serum Sodium on In-Hospital and 1-Year Survival among Hospitalized PatientsChewcharat, ApiThongprayoon, CharatCheungpasitporn, WisitMao, Michael A.Thirunavukkarasu, SorkkoKashani, Kianoush B.2020-03-25T06:32:37-07:00doi:10.2215/CJN.12281019hwp:resource-id:clinjasn;15/5/600American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologysodium, survival, hospitalized patients, hyponatremia, hypernatremia, hospital mortality, cohort studies, hospitalization, hospitalsOriginal ArticlesAcid/Base and Electrolyte DisordersOriginal ArticlesAcid/Base and Electrolyte Disordersresearch-article20202020-05-07May 07, 202010.2215/CJN.122810191555-90411555-905X2020-03-25T06:32:37-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles155600607http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12481019?cct=218810.2215/CJN.12481019Thu, 16 Apr 2020 02:04:02 GMT-07:00Pilot Study of Return of Genetic Results to Patients in Adult NephrologyNestor, Jordan G.Marasa, MaddalenaMilo-Rasouly, HilaGroopman, Emily E.Husain, S. AliMohan, SumitFernandez, HildaAggarwal, Vimla S.Ahram, Dina F.Vena, NatalieBogyo, KelsieBomback, Andrew S.Radhakrishnan, JaiAppel, Gerald B.Ahn, WooinCohen, David J.Canetta, Pietro A.Dube, Geoffrey K.Rao, Maya K.Morris, Heather K.Crew, Russell J.Sanna-Cherchi, SimoneKiryluk, KrzysztofGharavi, Ali G.2020-04-16T14:04:02-07:00doi:10.2215/CJN.12481019hwp:resource-id:clinjasn;15/5/651American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologygenetic renal disease, human genetics, chronic kidney disease, familial nephropathy, adult, humans, nephrology, retrospective studies, pilot projects, workflow, medical genetics, exome, biological specimen banks, whole exome sequencing, kidney diseases, genetic testing, genomics, referral and consultation, patient care, cohort studiesOriginal ArticlesGeneticsOriginal ArticlesGeneticsresearch-article20202020-05-07May 07, 202010.2215/CJN.124810191555-90411555-905X2020-04-16T14:04:02-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles155651664http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08170719?cct=218810.2215/CJN.08170719Thu, 02 Apr 2020 01:32:20 GMT-07:00A Post Hoc Analysis of Statin Use in Tolvaptan Autosomal Dominant Polycystic Kidney Disease Pivotal TrialsShoaf, Susan E.Ouyang, JohnSergeyeva, OlgaEstilo, AlvinLi, HuiLeung, Deborah2020-04-02T13:32:20-07:00doi:10.2215/CJN.08170719hwp:resource-id:clinjasn;15/5/643American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyADPKD, chronic renal disease, polycystic kidney disease, statins, pharmacokinetics, Alanine Transaminase, Polycystic Kidney, Autosomal Dominant, Aspartate Aminotransferases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Tolvaptan, Allopurinol, Confidence Intervals, Incidence, Abdominal Pain, Research Design, Organic Anion Transporters, Antidiuretic Hormone Receptor Antagonists, chronic kidney diseaseOriginal ArticlesCystic Kidney DiseaseOriginal ArticlesCystic Kidney Diseaseresearch-article20202020-05-07May 07, 202010.2215/CJN.081707191555-90411555-905X2020-04-02T13:32:20-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles155643650http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12371019?cct=218810.2215/CJN.12371019Wed, 15 Jul 2020 12:02:46 GMT-07:00Effects of Intensive Blood Pressure Control in Patients with and without AlbuminuriaChang, Alex R.Kramer, HollyWei, GuoBoucher, RobertGrams, Morgan E.Berlowitz, DanBhatt, UdayanCohen, Debbie L.Drawz, PaulPunzi, HenryFreedman, Barry I.Haley, WilliamHawfield, AmretHorwitz, EdwardMcLouth, ChristopherMorisky, DonPapademetriou, VasiliosRocco, Michael V.Wall, BarryWeiner, Daniel E.Zias, AthenaBeddhu, Srinivasan,2020-07-15T12:02:46-07:00doi:10.2215/CJN.12371019hwp:resource-id:clinjasn;15/8/1121American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyblood pressure, hypertension, albuminuria, chronic kidney disease, cardiovascular disease, mortality, systolic blood pressure, clinical trialOriginal ArticlesHypertensionOriginal ArticlesHypertensionresearch-article20202020-08-07August 07, 202010.2215/CJN.123710191555-90411555-905X2020-07-15T12:02:46-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15881121108111281083http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.16011219?cct=218810.2215/CJN.16011219Tue, 28 Jul 2020 10:43:58 GMT-07:00Efficacy and Safety of Daprodustat Compared with Darbepoetin Alfa in Japanese Hemodialysis Patients with AnemiaAkizawa, TadaoNangaku, MasaomiYonekawa, TaekoOkuda, NobuhikoKawamatsu, ShinyaOnoue, TomohiroEndo, YukihiroHara, KatsutoshiCobitz, Alexander R.2020-07-28T10:43:58-07:00doi:10.2215/CJN.16011219hwp:resource-id:clinjasn;15/8/1155American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, anemia, hemodialysis, Erythropoiesis, hypoxia-inducible factor prolyl hydroxylase inhibitor, daprodustat, HIF, clinical trial, double-blind, hemoglobin, hepcidinOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-08-07August 07, 202010.2215/CJN.160112191555-90411555-905X2020-07-28T10:43:58-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15811551165http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09410620?cct=218810.2215/CJN.09410620Wed, 15 Jul 2020 12:02:46 GMT-07:00Intensive Blood Pressure Lowering Should Be the Goal for Most Individuals at High Risk of Cardiovascular Disease Irrespective of AlbuminuriaAscher, Simon B.Ix, Joachim H.2020-07-15T12:02:46-07:00doi:10.2215/CJN.09410620hwp:resource-id:clinjasn;15/8/1081American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyblood pressure, proteinuria, albuminuria, chronic kidney disease, cardiovascular disease, randomized controlled trials, hypertensionEditorialsEditorialseditorial20202020-08-07August 07, 202010.2215/CJN.094106201555-90411555-905X2020-07-15T12:02:46-07:002020-08-07Clinical Journal of the American Society of NephrologyEditorials15881081112110831128http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04160320?cct=218810.2215/CJN.04160320Fri, 22 May 2020 05:48:43 GMT-07:00Clinical Features of Maintenance Hemodialysis Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, ChinaWu, JunLi, JushuangZhu, GeliZhang, YanxiaBi, ZhiminYu, YeanHuang, BoFu, ShouzhiTan, YiqingSun, JianbinLi, Xiangyou2020-05-22T05:48:43-07:00doi:10.2215/CJN.04160320hwp:resource-id:clinjasn;15/8/1139American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologysevere acute respiratory syndrome coronavirus 2, OVID-19, kidney failure, maintenance hemodialysis, CoronavirusOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-08-07August 07, 202010.2215/CJN.041603201555-90411555-905X2020-05-22T05:48:43-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15888113910731087114510741089http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14561119?cct=218810.2215/CJN.14561119Tue, 28 Jul 2020 10:43:59 GMT-07:00Developments in the Histopathological Classification of ANCA-Associated Glomerulonephritisvan Daalen, Emma E.Wester Trejo, Maria A.C.Göçeroğlu, ArdaFerrario, FrancoJoh, KensukeNoël, Laure-HélèneOgawa, YayoiWilhelmus, SuzanneBall, Miriam J.Honsova, EvaHruskova, ZdenkaKain, RenateKimura, TomoyoshiKollar, MarekKronbichler, AndreasLindhard, KristinePuéchal, XavierSalvatore, StevenSzpirt, WladimirTakizawa, HidekiTesar, VladimirBerden, Annelies E.Dekkers, Olaf M.Hagen, E. ChristiaanOosting, JanRahmattulla, ChinarWolterbeek, RonBos, Willem JanBruijn, Jan A.Bajema, Ingeborg M.2020-07-28T10:43:59-07:00doi:10.2215/CJN.14561119hwp:resource-id:clinjasn;15/8/1103American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyANCA, kidney biopsy, Antibodies, Antineutrophil Cytoplasmic, Confidence Intervals, Observer Variation, glomerulonephritis, Renal Insufficiency, Cohort Studies, Prognosis, BiopsyOriginal ArticlesGlomerular and Tubulointerstitial DiseasesOriginal ArticlesGlomerular and Tubulointerstitial Diseasesresearch-article20202020-08-07August 07, 202010.2215/CJN.145611191555-90411555-905X2020-07-28T10:43:59-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15881103107811111080http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09910620?cct=218810.2215/CJN.09910620Thu, 16 Jul 2020 07:30:40 GMT-07:00Drug Selection for Treating Hypertension in Dialysis PatientsShafi, TariqMiskulin, Dana C.2020-07-16T07:30:40-07:00doi:10.2215/CJN.09910620hwp:resource-id:clinjasn;15/8/1084American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhypertension, antihypertensive drug class, dialysisEditorialsEditorialseditorial20202020-08-07August 07, 202010.2215/CJN.099106201555-90411555-905X2020-07-16T07:30:40-07:002020-08-07Clinical Journal of the American Society of NephrologyEditorials15881084112910861138http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.16021219?cct=218810.2215/CJN.16021219Thu, 02 Jul 2020 07:49:00 GMT-07:00External Validation of the International IgA Nephropathy Prediction ToolZhang, JunjunHuang, BoLiu, ZhangsuoWang, XutongXie, MinhuaGuo, RuxueWang, YongliYu, DanWang, PanfeiZhu, YuzeRen, Jingjing2020-07-02T07:49:00-07:00doi:10.2215/CJN.16021219hwp:resource-id:clinjasn;15/8/1112American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyIgA nephropathy, external validation, international prediction tool, glomerular filtration rate, Glomerulonephritis, IGA, Calibration, Kidney Failure, Chronic, Cohort Studies, BiopsyOriginal ArticlesGlomerular and Tubulointerstitial DiseasesOriginal ArticlesGlomerular and Tubulointerstitial Diseasesresearch-article20202020-08-07August 07, 202010.2215/CJN.160212191555-90411555-905X2020-07-02T07:49:00-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15811121120http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12201019?cct=218810.2215/CJN.12201019Thu, 16 Jul 2020 07:30:40 GMT-07:00Comparative Efficacy and Safety of BP-Lowering Pharmacotherapy in Patients Undergoing Maintenance DialysisShaman, Ahmed M.Smyth, BrendanArnott, ClarePalmer, Suetonia C.Mihailidou, Anastasia S.Jardine, Meg J.Gallagher, Martin P.Perkovic, VladoJun, Min2020-07-16T07:30:40-07:00doi:10.2215/CJN.12201019hwp:resource-id:clinjasn;15/8/1129American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhypertension, systolic blood pressure, chronic kidney disease, renal dialysis, Antihypertensive agents, Adverse events, Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Antagonists, Renin, Calcium Channel Blockers, blood pressure, Mineralocorticoid Receptor Antagonists, Peptidyl-Dipeptidase A, Cardiovascular Diseases, hypotension, risk factorsOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-08-07August 07, 202010.2215/CJN.122010191555-90411555-905X2020-07-16T07:30:40-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15881129108411381086http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09600620?cct=218810.2215/CJN.09600620Tue, 28 Jul 2020 10:43:59 GMT-07:00Keeping Up with the TimesBrix, Silke R.Geetha, Duvuru2020-07-28T10:43:59-07:00doi:10.2215/CJN.09600620hwp:resource-id:clinjasn;15/8/1078American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyANCA, vasculitis, glomerulonephritis, outcomesEditorialsEditorialseditorial20202020-08-07August 07, 202010.2215/CJN.096006201555-90411555-905X2020-07-28T10:43:59-07:002020-08-07Clinical Journal of the American Society of NephrologyEditorials15881078110310801111http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11650919?cct=218810.2215/CJN.11650919Fri, 22 May 2020 05:48:45 GMT-07:00Apixaban versus No Anticoagulation in Patients Undergoing Long-Term Dialysis with Incident Atrial FibrillationMavrakanas, Thomas A.Garlo, KatherineCharytan, David M.2020-05-22T05:48:45-07:00doi:10.2215/CJN.11650919hwp:resource-id:clinjasn;15/8/1146American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyapixaban, atrial fibrillation, dialysis, mortality, ischemic stroke, hemorrhagic stroke, Ischemic Attack, Transient, Stroke, Propensity Score, Incidence, Retrospective Studies, Brain Ischemia, Pyridones, Pyrazoles, Anticoagulants, Thromboembolism, Myocardial InfarctionOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-08-07August 07, 202010.2215/CJN.116509191555-90411555-905X2020-05-22T05:48:45-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15811461154http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12671019?cct=218810.2215/CJN.12671019Fri, 19 Jun 2020 10:04:56 GMT-07:00Racial Differences in Risk Factors for Kidney Stone FormationZisman, Anna L.Coe, Fredric L.Cohen, Andrew J.Riedinger, Christopher B.Worcester, Elaine M.2020-06-19T10:04:56-07:00doi:10.2215/CJN.12671019hwp:resource-id:clinjasn;15/8/1166American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney stones, ethnicity, Calcium Oxalate, Uric Acid, African Americans, Kidney Calculi, risk factors, calcium phosphateOriginal ArticlesNephrolithiasisOriginal ArticlesNephrolithiasisresearch-article20202020-08-07August 07, 202010.2215/CJN.126710191555-90411555-905X2020-06-19T10:04:56-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15811661173http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08890620?cct=218810.2215/CJN.08890620Wed, 01 Jul 2020 08:26:23 GMT-07:00Adverse Drug Effects in Patients with CKDPerazella, Mark A.Nolin, Thomas D.2020-07-01T08:26:23-07:00doi:10.2215/CJN.08890620hwp:resource-id:clinjasn;15/8/1075American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, acute kidney injury, drug toxicity, pharmacology, renin-angiotensin system blockers, hemorrhage, drug-related side effects and adverse reactions, renal insufficiency, chronic, glomerular filtration rateEditorialsEditorialseditorial20202020-08-07August 07, 202010.2215/CJN.088906201555-90411555-905X2020-07-01T08:26:23-07:002020-08-07Clinical Journal of the American Society of NephrologyEditorials15881075109010771102http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12791019?cct=2188Assessment of GFR is central to clinical practice, research, and public health. Current Kidney Disease Improving Global Outcomes guidelines recommend measurement of serum creatinine to estimate GFR as the initial step in GFR evaluation. Serum creatinine is influenced by creatinine metabolism as well as GFR; hence, all equations to estimate GFR from serum creatinine include surrogates for muscle mass, such as age, sex, race, height, or weight. The guideline-recommended equation in adults (the 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine equation) includes a term for race (specified as black versus nonblack), which improves the accuracy of GFR estimation by accounting for differences in non-GFR determinants of serum creatinine by race in the study populations used to develop the equation. In that study, blacks had a 16% higher average measured GFR compared with nonblacks with the same age, sex, and serum creatinine. The reasons for this difference are only partly understood, and the use of race in GFR estimation has limitations. Some have proposed eliminating the race coefficient, but this would induce a systematic underestimation of measured GFR in blacks, with potential unintended consequences at the individual and population levels. We propose a more cautious approach that maintains and improves accuracy of GFR estimates and avoids disadvantaging any racial group. We suggest full disclosure of use of race in GFR estimation, accommodation of those who decline to identify their race, and shared decision making between health care providers and patients. We also suggest mindful use of cystatin C as a confirmatory test as well as clearance measurements. It would be preferable to avoid specification of race in GFR estimation if there was a superior, evidence-based substitute. The goal of future research should be to develop more accurate methods for GFR estimation that do not require use of race or other demographic characteristics.10.2215/CJN.12791019Mon, 11 May 2020 08:13:20 GMT-07:00Kidney Disease, Race, and GFR EstimationAssessment of GFR is central to clinical practice, research, and public health. Current Kidney Disease Improving Global Outcomes guidelines recommend measurement of serum creatinine to estimate GFR as the initial step in GFR evaluation. Serum creatinine is influenced by creatinine metabolism as well as GFR; hence, all equations to estimate GFR from serum creatinine include surrogates for muscle mass, such as age, sex, race, height, or weight. The guideline-recommended equation in adults (the 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine equation) includes a term for race (specified as black versus nonblack), which improves the accuracy of GFR estimation by accounting for differences in non-GFR determinants of serum creatinine by race in the study populations used to develop the equation. In that study, blacks had a 16% higher average measured GFR compared with nonblacks with the same age, sex, and serum creatinine. The reasons for this difference are only partly understood, and the use of race in GFR estimation has limitations. Some have proposed eliminating the race coefficient, but this would induce a systematic underestimation of measured GFR in blacks, with potential unintended consequences at the individual and population levels. We propose a more cautious approach that maintains and improves accuracy of GFR estimates and avoids disadvantaging any racial group. We suggest full disclosure of use of race in GFR estimation, accommodation of those who decline to identify their race, and shared decision making between health care providers and patients. We also suggest mindful use of cystatin C as a confirmatory test as well as clearance measurements. It would be preferable to avoid specification of race in GFR estimation if there was a superior, evidence-based substitute. The goal of future research should be to develop more accurate methods for GFR estimation that do not require use of race or other demographic characteristics.Levey, Andrew S.Titan, Silvia M.Powe, Neil R.Coresh, JosefInker, Lesley A.2020-05-11T08:13:20-07:00doi:10.2215/CJN.12791019hwp:resource-id:clinjasn;15/8/1203American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhuman, Cystatin C, creatinine, glomerular filtration rate, African Americans, Public Health, Decision Making, Shared, Body Weights and Measures, Renal Insufficiency, Chronic, Health Personnel, Demography, Kidney Function TestsFeaturesFeaturesresearch-article20202020-08-07August 07, 202010.2215/CJN.127910191555-90411555-905X2020-05-11T08:13:20-07:002020-08-07Clinical Journal of the American Society of NephrologyFeatures15881203120112121202http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01030120?cct=218810.2215/CJN.01030120Wed, 01 Jul 2020 08:26:24 GMT-07:00Adverse Drug Reactions in Patients with CKDLaville, Solène M.Gras-Champel, ValérieMoragny, JulienMetzger, MarieJacquelinet, ChristianCombe, ChristianFouque, DenisLaville, MauriceFrimat, LucRobinson, Bruce M.Stengel, BénédicteMassy, Ziad A.Liabeuf, Sophie,2020-07-01T08:26:24-07:00doi:10.2215/CJN.01030120hwp:resource-id:clinjasn;15/8/1090American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, pharmacoepidemiology, antithrombotic agents, adverse drug reactions, risk factors, diuretics, Renin-Angiotensin System, glomerular filtration rate, Cohort Studies, Renal Insufficiency, Chronic, Drug-Related Side Effects and Adverse Reactions, hospitalization, Medical RecordsOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-08-07August 07, 202010.2215/CJN.010301201555-90411555-905X2020-07-01T08:26:24-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15881090107511021077http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09730620?cct=218810.2215/CJN.09730620Tue, 07 Jul 2020 07:17:46 GMT-07:00COVID-19 in Patients with Kidney DiseaseAjaimy, MariaMelamed, Michal L.2020-07-07T07:17:46-07:00doi:10.2215/CJN.09730620hwp:resource-id:clinjasn;15/8/1087American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologydialysis, transplantation, COVID-19EditorialsEditorialseditorial20202020-08-07August 07, 202010.2215/CJN.097306201555-90411555-905X2020-07-07T07:17:46-07:002020-08-07Clinical Journal of the American Society of NephrologyEditorials15888108711391174108911451178http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09100620?cct=218810.2215/CJN.09100620Thu, 02 Jul 2020 07:49:00 GMT-07:00Long-Term Hemodialysis during the COVID-19 PandemicGedney, Nieltje2020-07-02T07:49:00-07:00doi:10.2215/CJN.09100620hwp:resource-id:clinjasn;15/8/1073American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyacute renal failure, chronic dialysis, chronic kidney disease, chronic kidney failure, chronic renal failure, COVID-19, dialysis, end stage kidney disease, end-stage renal disease, kidney disease, kidney failurePatient VoicePatient Voiceresearch-article20202020-08-07August 07, 202010.2215/CJN.091006201555-90411555-905X2020-07-02T07:49:00-07:002020-08-07Clinical Journal of the American Society of NephrologyPatient Voice15881073113910741145http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00690120?cct=218810.2215/CJN.00690120Mon, 11 May 2020 08:13:20 GMT-07:00Precision in GFR ReportingGrubbs, Vanessa2020-05-11T08:13:20-07:00doi:10.2215/CJN.00690120hwp:resource-id:clinjasn;15/8/1201American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyrace-based medicine, GFR reporting, precision, glomerular filtration rate, Cystatin CPerspectivesPerspectivesresearch-article20202020-08-07August 07, 202010.2215/CJN.006901201555-90411555-905X2020-05-11T08:13:20-07:002020-08-07Clinical Journal of the American Society of NephrologyPerspectives15881201120312021212http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01490220?cct=218810.2215/CJN.01490220Tue, 12 May 2020 07:02:16 GMT-07:00I Love Nephrology, but Should I Be a Nephrologist?Arora, Tanima2020-05-12T07:02:16-07:00doi:10.2215/CJN.01490220hwp:resource-id:clinjasn;15/8/1193American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologynephrology, Education, Career Trainee, Initiatives, nephrologistsPerspectivesPerspectivesresearch-article20202020-08-07August 07, 202010.2215/CJN.014902201555-90411555-905X2020-05-12T07:02:16-07:002020-08-07Clinical Journal of the American Society of NephrologyPerspectives15811931194http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10500919?cct=218810.2215/CJN.10500919Thu, 09 Jul 2020 07:55:51 GMT-07:00Careers in Critical Care NephrologySanghavi, Sarah F.Campbell, Kirk N.2020-07-09T07:55:51-07:00doi:10.2215/CJN.10500919hwp:resource-id:clinjasn;15/8/1198American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycritical care, workforce, recruitment, training, intensivist, intensive care, Career Choice, Fellowships and ScholarshipsPerspectivesPerspectivesresearch-article20202020-08-07August 07, 202010.2215/CJN.105009191555-90411555-905X2020-07-09T07:55:51-07:002020-08-07Clinical Journal of the American Society of NephrologyPerspectives15811981200http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14471119?cct=218810.2215/CJN.14471119Thu, 05 Mar 2020 06:30:38 GMT-08:00Ensuring Gender-Affirming Care in NephrologyMohottige, DinushikaLunn, Mitchell R.2020-03-05T06:30:38-08:00doi:10.2215/CJN.14471119hwp:resource-id:clinjasn;15/8/1195American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyTransgender Persons, Transsexualism, nephrology, Gender Identity, Improving Care, Gender ExpansivePerspectivesPerspectivesresearch-article20202020-08-07August 07, 202010.2215/CJN.144711191555-90411555-905X2020-03-05T06:30:38-08:002020-08-07Clinical Journal of the American Society of NephrologyPerspectives15811951197http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09670819?cct=2188Whether individual results of genetic research studies ought to be disclosed to study participants has been debated in recent decades. Previously, the prevailing expert view discouraged the return of individual research results to participants because of the potential lack of analytic validity, questionable clinical validity and medical actionability, and questions about whether it is the role of research to provide participants with their data. With additional knowledge of participant perspectives and shifting views about the benefits of research and respect for participants, current expert consensus is moving toward support of returning such results. Significant ethical controversies remain, and there are many practical questions left to address, including appropriate procedures for returning results and the potential burden to clinicians when patients seek guidance about the clinical implications of research results. In this review, we describe current views regarding the return of genetic research results, including controversies and practical challenges, and consider the application of these issues to research on apolipoprotein L1 (APOL1), a gene recently associated with health disparities in kidney disease. Although this case is unique, it illustrates the complexities involved in returning results and highlights remaining questions.10.2215/CJN.09670819Mon, 10 Feb 2020 08:18:15 GMT-08:00At the Research-Clinical InterfaceWhether individual results of genetic research studies ought to be disclosed to study participants has been debated in recent decades. Previously, the prevailing expert view discouraged the return of individual research results to participants because of the potential lack of analytic validity, questionable clinical validity and medical actionability, and questions about whether it is the role of research to provide participants with their data. With additional knowledge of participant perspectives and shifting views about the benefits of research and respect for participants, current expert consensus is moving toward support of returning such results. Significant ethical controversies remain, and there are many practical questions left to address, including appropriate procedures for returning results and the potential burden to clinicians when patients seek guidance about the clinical implications of research results. In this review, we describe current views regarding the return of genetic research results, including controversies and practical challenges, and consider the application of these issues to research on apolipoprotein L1 (APOL1), a gene recently associated with health disparities in kidney disease. Although this case is unique, it illustrates the complexities involved in returning results and highlights remaining questions.West, Kathleen M.Blacksher, ErikaCavanaugh, Kerri L.Fullerton, Stephanie M.Umeukeje, Ebele M.Young, Bessie A.Burke, Wylie2020-02-10T08:18:15-08:00doi:10.2215/CJN.09670819hwp:resource-id:clinjasn;15/8/1181American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologygenetic renal disease, research results, ethics, humans, consensus, apolipoprotein L1, genetic research, disclosure, knowledge, kidney, diseases, Kidney Genomics SeriesGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-08-07August 07, 202010.2215/CJN.096708191555-90411555-905X2020-02-10T08:18:15-08:002020-08-07Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease15811811189http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.15011219?cct=2188The American Society of Nephrology Presidential Address was delivered by Mark Rosenberg at Kidney Week 2019 on November 7, 2019 in Washington, DC. The Address describes a remarkable alignment—a syzygy of policy, science, innovation accelerators, clinical trials, clinical care delivery, and activated patients—that exists today in the kidney space. As a community, we must ensure that the strategies developed to take advantage of this alignment, such as Advancing American Kidney Health, succeed. We must overcome our current challenges to thrive as a meaningful specialty. We have an incredible opportunity to come together as a kidney community to ensure success that realigns the priorities and incentives in kidney medicine to better achieve kidney health for all people throughout the world. The time is now to act.10.2215/CJN.15011219Tue, 24 Mar 2020 07:47:32 GMT-07:00Presidential Address Kidney Week 2019The American Society of Nephrology Presidential Address was delivered by Mark Rosenberg at Kidney Week 2019 on November 7, 2019 in Washington, DC. The Address describes a remarkable alignment—a syzygy of policy, science, innovation accelerators, clinical trials, clinical care delivery, and activated patients—that exists today in the kidney space. As a community, we must ensure that the strategies developed to take advantage of this alignment, such as Advancing American Kidney Health, succeed. We must overcome our current challenges to thrive as a meaningful specialty. We have an incredible opportunity to come together as a kidney community to ensure success that realigns the priorities and incentives in kidney medicine to better achieve kidney health for all people throughout the world. The time is now to act.Rosenberg, Mark E.2020-03-24T07:47:32-07:00doi:10.2215/CJN.15011219hwp:resource-id:clinjasn;15/8/1213American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologydialysis, kidney, kidney failure, nephrology, transplantation, policy, kidney diseases, patientparticipationFeaturesFeaturesresearch-article20202020-08-07August 07, 202010.2215/CJN.150112191555-90411555-905X2020-03-24T07:47:32-07:002020-08-07Clinical Journal of the American Society of NephrologyFeatures15812131219http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01200120?cct=218810.2215/CJN.01200120Thu, 30 Apr 2020 07:33:45 GMT-07:00Association of Race and Risk of Graft Loss among Kidney Transplant Recipients in the US Military Health SystemForman, Crystal J.Yuan, Christina M.Jindal, Rahul M.Agodoa, Lawrence Y.Abbott, Kevin C.Nee, Robert2020-04-30T07:33:45-07:00doi:10.2215/CJN.01200120hwp:resource-id:clinjasn;15/8/1179American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, transplant outcomes, United States Renal Data System, end stage kidney disease, Military Health System, Medical Assistance, Graft Survival, Graft RejectionResearch LettersResearch Lettersresearch-article20202020-08-07August 07, 202010.2215/CJN.012001201555-90411555-905X2020-04-30T07:33:45-07:002020-08-07Clinical Journal of the American Society of NephrologyResearch Letters15811791180http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05170420?cct=218810.2215/CJN.05170420Mon, 18 May 2020 12:58:57 GMT-07:00Early Outcomes of Outpatient Management of Kidney Transplant Recipients with Coronavirus Disease 2019Husain, S. AliDube, GeoffreyMorris, HeatherFernandez, HildaChang, Jae-HyungPaget, KathrynSritharan, SharlineePatel, ShefaliPawliczak, OlgaBoehler, MiaTsapepas, DemetraCrew, R. JohnCohen, David J.Mohan, Sumit2020-05-18T12:58:57-07:00doi:10.2215/CJN.05170420hwp:resource-id:clinjasn;15/8/1174American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, COVID-19, SARS-CoV2, coronavirus, Outpatients, Statistics, Nonparametric, creatinine, severe acute respiratory syndrome coronavirus 2, Cohort Studies, hospitalization, DyspneaOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-08-07August 07, 202010.2215/CJN.051704201555-90411555-905X2020-05-18T12:58:57-07:002020-08-07Clinical Journal of the American Society of NephrologyOriginal Articles15881174108711781089http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.15941219?cct=218810.2215/CJN.15941219Mon, 23 Mar 2020 05:27:10 GMT-07:00Use of Checkpoint Inhibitors in a Kidney Transplant Recipient with Metastatic CancerOng, Song ChingMannon, Roslyn B.2020-03-23T05:27:10-07:00doi:10.2215/CJN.15941219hwp:resource-id:clinjasn;15/8/1190American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycancer, renal transplantation, rejection, kidney transplantation, Neoplasms, Neoplasms, Second PrimaryKidney Case Conference: Nephrology Quiz and QuestionnaireKidney Case Conference: Nephrology Quiz and Questionnaireresearch-article20202020-08-07August 07, 202010.2215/CJN.159412191555-90411555-905X2020-03-23T05:27:10-07:002020-08-07Clinical Journal of the American Society of NephrologyKidney Case Conference: Nephrology Quiz and Questionnaire15811901192http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0003172020?cct=218810.34067/KID.0003172020Wed, 17 Jun 2020 01:34:06 GMT-07:00Is an Environmental Nephrotoxin the Primary Cause of CKDu (Mesoamerican Nephropathy)? PRODe Broe, Marc E.Vervaet, Bejamin A.2020-06-17T13:34:06-07:00doi:10.34067/KID.0003172020hwp:resource-id:kidney360;1/7/591American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, agriculture, agrochemicals, atrophy, calcineurin inhibition, Central America, CKDu, lysosome, Mesoamerican nephropathy, nephritis, interstitial, nephrotoxicity, pesticide, proximal tubule, renal insufficiency, chronic, Sri Lanka, toxinDebates in NephrologyDebates in Nephrologyresearch-article20202020-07-3010.34067/KID.00031720202641-76502020-06-17T13:34:06-07:002020-07-30Kidney360Debates in Nephrology17591595http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001182020?cct=218810.34067/KID.0001182020Thu, 30 Jul 2020 05:30:20 GMT-07:00AKI in a Patient Engaged in Vegetable JuicingObadan, Odianosen I.Yudd, Michael2020-07-30T05:30:20-07:00doi:10.34067/KID.0001182020hwp:resource-id:kidney360;1/7/716American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acute Kidney Injury, Biopsy, Casts, Creatinine, Hyperoxaluria, Juicing, Kidney, Nephropathy, PolarizedClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-07-3010.34067/KID.00011820202641-76502020-07-30T05:30:20-07:002020-07-30Kidney360Clinical Images in Nephrology and Dialysis17716717http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0003682020?cct=218810.34067/KID.0003682020Thu, 30 Jul 2020 05:30:20 GMT-07:00Renal Safety of Nonsteroidal Anti-Inflammatory Drugs and Opioids in Hospitalized Patients on Renin-Angiotensin System InhibitorsHung, Adriana M.Chung, Cecilia P.2020-07-30T05:30:20-07:00doi:10.34067/KID.0003682020hwp:resource-id:kidney360;1/7/586American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, acute kidney injury, analgesics, opioid, angiotensins, anti-inflammatory agents, non-steroidal, drug interactions, hospitalization, pain management, renin, vascular resistanceEditorialsEditorialseditorial20202020-07-3010.34067/KID.00036820202641-76502020-07-30T05:30:20-07:002020-07-30Kidney360Editorials17586587http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001692020?cct=218810.34067/KID.0001692020Tue, 12 May 2020 01:40:04 GMT-07:00Interactions between FGF23 and Genotype in Autosomal Dominant Polycystic Kidney DiseaseGrau, LauraGitomer, BereniceMcNair, BryanWolf, MylesHarris, PeterBrosnahan, GodelaTorres, VicenteSteinman, TheodoreYu, AlanChapman, ArleneChonchol, MichelNowak, Kristen L.2020-05-12T13:40:04-07:00doi:10.34067/KID.0001692020hwp:resource-id:kidney360;1/7/648American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360cystic kidney disease, FGF23, fibroblast growth factors, genotype, kidney failure, chronic, mineral metabolism, mutation, polycystic kidney disease, polycystic kidney, autosomal dominant, vitamin DOriginal InvestigationsCystic Kidney DiseaseOriginal InvestigationsCystic Kidney Diseaseresearch-article20202020-07-3010.34067/KID.00016920202641-76502020-05-12T13:40:04-07:002020-07-30Kidney360Original Investigations17648656http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001572020?cct=218810.34067/KID.0001572020Fri, 08 May 2020 01:27:20 GMT-07:00A Night Float System in Nephrology Fellowship: A Mixed Methods EvaluationPlotkin, Jennifer B.Xu, Eric J.Fine, Derek M.Knicely, Daphne H.Sperati, C. JohnSozio, Stephen M.2020-05-08T13:27:20-07:00doi:10.34067/KID.0001572020hwp:resource-id:kidney360;1/7/631American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, analysis of variance, assessment, continuity of patient care, education, faculty, fellowship, focus groups, mixed methods, nephrology, night float, surveys and questionnaires, work-life balanceOriginal InvestigationsClinical NephrologyOriginal InvestigationsClinical Nephrologyresearch-article20202020-07-3010.34067/KID.00015720202641-76502020-05-08T13:27:20-07:002020-07-30Kidney360Original Investigations17631639http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001972020?cct=2188Renal fibrosis is a major hallmark of CKD, regardless of the underlying etiology. In fibrosis development and progression, myofibroblasts play a pivotal role, producing extracellular matrix and interacting with various resident cells in the kidney. Over the past decade, the origin of myofibroblasts has been thoroughly investigated. Emerging evidence suggests that renal myofibroblasts originate from several cellular sources, including resident fibroblasts, pericytes, and bone marrow–derived cells. The contribution of resident fibroblasts is most crucial, and currently available data strongly suggest the importance of functional heterogeneity and plasticity of fibroblasts in kidney disease progression. Resident fibroblasts acquire distinct phenotypes based on their local microenvironment and exert multifactorial functions. For example, age-dependent alterations of renal fibroblasts make a significant contribution to the formation of tertiary lymphoid tissues, which promote local inflammation after injury in the aged kidney. In conjunction with fibrosis development, dysfunction of resident fibroblasts provokes unique pathologic conditions including renal anemia and peritubular capillary loss, both of which are major complications of CKD. Although renal fibrosis is considered detrimental in general, recent studies suggest it has beneficial roles, such as maintaining functional crosstalk with injured proximal tubular cells and supporting their regeneration. These findings provide novel insight into the mechanisms of renal fibrosis, which could be regarded as an adaptive process of kidney injury and repair. Precise understanding of the functional heterogeneity of resident fibroblasts and myofibroblasts has the potential to facilitate the development of novel therapeutics against kidney diseases. In this review, we describe the current perspective on the origin of myofibroblasts and fibroblast heterogeneity, with special emphasis on the dual aspects of renal fibrosis, both beneficial and detrimental, in CKD progression.10.34067/KID.0001972020Fri, 15 May 2020 09:56:42 GMT-07:00Janus-Faced: Molecular Mechanisms and Versatile Nature of Renal FibrosisRenal fibrosis is a major hallmark of CKD, regardless of the underlying etiology. In fibrosis development and progression, myofibroblasts play a pivotal role, producing extracellular matrix and interacting with various resident cells in the kidney. Over the past decade, the origin of myofibroblasts has been thoroughly investigated. Emerging evidence suggests that renal myofibroblasts originate from several cellular sources, including resident fibroblasts, pericytes, and bone marrow–derived cells. The contribution of resident fibroblasts is most crucial, and currently available data strongly suggest the importance of functional heterogeneity and plasticity of fibroblasts in kidney disease progression. Resident fibroblasts acquire distinct phenotypes based on their local microenvironment and exert multifactorial functions. For example, age-dependent alterations of renal fibroblasts make a significant contribution to the formation of tertiary lymphoid tissues, which promote local inflammation after injury in the aged kidney. In conjunction with fibrosis development, dysfunction of resident fibroblasts provokes unique pathologic conditions including renal anemia and peritubular capillary loss, both of which are major complications of CKD. Although renal fibrosis is considered detrimental in general, recent studies suggest it has beneficial roles, such as maintaining functional crosstalk with injured proximal tubular cells and supporting their regeneration. These findings provide novel insight into the mechanisms of renal fibrosis, which could be regarded as an adaptive process of kidney injury and repair. Precise understanding of the functional heterogeneity of resident fibroblasts and myofibroblasts has the potential to facilitate the development of novel therapeutics against kidney diseases. In this review, we describe the current perspective on the origin of myofibroblasts and fibroblast heterogeneity, with special emphasis on the dual aspects of renal fibrosis, both beneficial and detrimental, in CKD progression.Arai, HiroyukiYanagita, Motoko2020-05-15T09:56:42-07:00doi:10.34067/KID.0001972020hwp:resource-id:kidney360;1/7/697American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, bone marrow, disease progression, extracellular matrix, fibrosis, kidney, myofibroblasts, pericytes, phenotype, renal insufficiency, chronic, Basic ScienceReview ArticlesReview Articlesreview-article20202020-07-3010.34067/KID.00019720202641-76502020-05-15T09:56:42-07:002020-07-30Kidney360Review Articles17697704http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000912019?cct=218810.34067/KID.0000912019Wed, 27 May 2020 01:36:08 GMT-07:00Incidence, Risk Factors, and Outcomes of Neonatal Renal Vein Thrombosis in Ontario: Population-Based Cohort StudyOuellette, Allison C.Darling, Elizabeth K.Sivapathasundaram, BranavanBabe, GlendaPerez, RichardChan, Anthony K.C.Chanchlani, Rahul2020-05-27T13:36:08-07:00doi:10.34067/KID.0000912019hwp:resource-id:kidney360;1/7/640American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, cohort studies, infant, newborn, neonatology, nephrology, Ontario, pediatrics, population, pre-eclampsia, renal veins, thrombosisOriginal InvestigationsClinical NephrologyOriginal InvestigationsClinical Nephrologyresearch-article20202020-07-3010.34067/KID.00009120192641-76502020-05-27T13:36:08-07:002020-07-30Kidney360Original Investigations17640647http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002922020?cct=218810.34067/KID.0002922020Wed, 17 Jun 2020 01:34:06 GMT-07:00Is an Environmental Nephrotoxin the Primary Cause of CKDu (Mesoamerican Nephropathy)? CONWesseling, Catharina2020-06-17T13:34:06-07:00doi:10.34067/KID.0002922020hwp:resource-id:kidney360;1/7/596American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, CKDnt, CKDu, etiology, heat stress, India, Mesoamerican nephropathy, metals, occupation, pesticides, Sri LankaDebates in NephrologyDebates in Nephrologyresearch-article20202020-07-3010.34067/KID.00029220202641-76502020-06-17T13:34:06-07:002020-07-30Kidney360Debates in Nephrology17596601http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001242020?cct=218810.34067/KID.0001242020Thu, 30 Jul 2020 05:30:20 GMT-07:00Right Arm Pain and Swelling in an End-Stage Kidney Disease PatientJdiaa, Sara S.Gebrael, Diala I.Koubar, Sahar H.2020-07-30T05:30:20-07:00doi:10.34067/KID.0001242020hwp:resource-id:kidney360;1/7/714American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360bone mineral disease, brown tumors, hyperparathyroidism, chronic kidney disease, ESKD, osteitis fibrosa cystica, renalosteodystrophyClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-07-3010.34067/KID.00012420202641-76502020-07-30T05:30:20-07:002020-07-30Kidney360Clinical Images in Nephrology and Dialysis17714715http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002082020?cct=218810.34067/KID.0002082020Wed, 27 May 2020 01:36:08 GMT-07:00Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and PatientsPadilla, Luz A.Hurst, DanielLopez, RaymondKumar, VineetaCooper, David K.C.Paris, Wayne2020-05-27T13:36:08-07:00doi:10.34067/KID.0002082020hwp:resource-id:kidney360;1/7/657American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, attitude, genetic engineering, heterografts, kidney, kidney transplantation, logistic models, patient, personality, provider, religion, surveys and questionnaires, transplantation, heterologous, xenotransplantationOriginal InvestigationsTransplantationOriginal InvestigationsTransplantationresearch-article20202020-07-3010.34067/KID.00020820202641-76502020-05-27T13:36:08-07:002020-07-30Kidney360Original Investigations17657662http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0003412020?cct=218810.34067/KID.0003412020Wed, 17 Jun 2020 01:34:06 GMT-07:00Is an Environmental Nephrotoxin the Primary Cause of CKDu (Mesoamerican Nephropathy)? CommentaryMadero, Magdalena2020-06-17T13:34:06-07:00doi:10.34067/KID.0003412020hwp:resource-id:kidney360;1/7/602American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, CKDu, environmental toxins, Mesoamerican NephropathyModerator CommentaryModerator Commentaryarticle-commentary20202020-07-3010.34067/KID.00034120202641-76502020-06-17T13:34:06-07:002020-07-30Kidney360Moderator Commentary17602603http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020060844?cct=218810.1681/ASN.2020060844Thu, 23 Jul 2020 12:29:42 GMT-07:00No Zoom Required: Meeting at the β-Intercalated CellsLin, Wie-YinMuallem, Shmuel2020-07-23T12:29:42-07:00doi:10.1681/ASN.2020060844hwp:resource-id:jnephrol;31/8/1655American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologypendrin, CFTR, bicarbonate, excretionUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-08-01August 202010.1681/ASN.20200608441046-66731533-34502020-07-23T12:29:42-07:002020-08Journal of the American Society of NephrologyUp Front Matters31881655171116571727http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101106?cct=218810.1681/ASN.2019101106Tue, 23 Jun 2020 08:10:25 GMT-07:00Fibroblast Growth Factor 23 and Risk of Hospitalization with Infection in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) StudyIshigami, JunichiTaliercio, Jonathan T.Feldman, Harold I.Srivastava, AnandTownsend, Raymond R.Cohen, Debbie L.Horwitz, Edward J.Rao, PandurangaCharleston, JeanneFink, Jeffrey C.Ricardo, Ana C.Sondheimer, JamesChen, Teresa K.Wolf, MylesIsakova, TamaraAppel, Lawrence J.Matsushita, Kunihiro,Go, Alan S.He, JiangLash, James P.Rahman, Mahboob2020-06-23T08:10:25-07:00doi:10.1681/ASN.2019101106hwp:resource-id:jnephrol;31/8/1836American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, Chronic inflammation, fibroblastClinical EpidemiologyClinical Epidemiologyresearch-article20202020-08-01August 202010.1681/ASN.20191011061046-66731533-34502020-06-23T08:10:25-07:002020-08Journal of the American Society of NephrologyClinical Epidemiology31818361846http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020060880?cct=218810.1681/ASN.2020060880Mon, 13 Jul 2020 11:02:23 GMT-07:00Improving Equity in Medication Use through Better Kidney Function MeasurementTuot, Delphine S.2020-07-13T11:02:23-07:00doi:10.1681/ASN.2020060880hwp:resource-id:jnephrol;31/8/1657American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydisparities, diabetes, eGFR, metforminUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-08-01August 202010.1681/ASN.20200608801046-66731533-34502020-07-13T11:02:23-07:002020-08Journal of the American Society of NephrologyUp Front Matters31881657184716581858http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020060907?cct=218810.1681/ASN.2020060907Fri, 31 Jul 2020 10:00:32 GMT-07:00This Month's HighlightsAmerican Society of Nephrology2020-07-31T10:00:32-07:00doi:10.1681/ASN.2020060907hwp:resource-id:jnephrol;31/8/iAmerican Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyThis Month's HighlightsThis Month's Highlightsin-brief20202020-08-01August 202010.1681/ASN.20200609071046-66731533-34502020-07-31T10:00:32-07:002020-08Journal of the American Society of NephrologyThis Month's Highlights318iihttp://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010053?cct=218810.1681/ASN.2020010053Thu, 23 Jul 2020 12:29:43 GMT-07:00Impaired Renal HCO3- Excretion in Cystic FibrosisBerg, PederSvendsen, Samuel L.Sorensen, Mads V.Larsen, Casper K.Andersen, Jesper FrankJensen-Fangel, SørenJeppesen, MajbrittSchreiber, RainerCabrita, InesKunzelmann, KarlLeipziger, Jens2020-07-23T12:29:43-07:00doi:10.1681/ASN.2020010053hwp:resource-id:jnephrol;31/8/1711American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycystic fibrosis, ion transport, kidney tubule, renal tubular acidosisBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20200100531046-66731533-34502020-07-23T12:29:43-07:002020-08Journal of the American Society of NephrologyBasic Research31881711165517271657http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101066?cct=218810.1681/ASN.2019101066Thu, 16 Jul 2020 09:45:48 GMT-07:00Mortality in US Hemodialysis Patients Following Exposure to Wildfire SmokeXi, YuzhiKshirsagar, Abhijit V.Wade, Timothy J.Richardson, David B.Brookhart, M. AlanWyatt, LaurenRappold, Ana G.2020-07-16T09:45:48-07:00doi:10.1681/ASN.2019101066hwp:resource-id:jnephrol;31/8/1824American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyenvironmental exposure, wildfire, hemodialysis patients, mortalityClinical EpidemiologyClinical Epidemiologyresearch-article20202020-08-01August 202010.1681/ASN.20191010661046-66731533-34502020-07-16T09:45:48-07:002020-08Journal of the American Society of NephrologyClinical Epidemiology31818241835http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020190?cct=218810.1681/ASN.2020020190Wed, 17 Jun 2020 06:33:10 GMT-07:00Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2–Dependent Mechanism in Polycystic Kidney DiseaseDwivedi, NidhiTao, ShixinJamadar, AbedaSinha, SonaliHoward, ChristiannaWallace, Darren P.Fields, Timothy A.Leask, AndrewCalvet, James P.Rao, Reena2020-06-17T06:33:10-07:00doi:10.1681/ASN.2020020190hwp:resource-id:jnephrol;31/8/1697American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologypolycystic kidney disease, renal fibrosis, vasopressin receptorBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20200201901046-66731533-34502020-06-17T06:33:10-07:002020-08Journal of the American Society of NephrologyBasic Research31816971710http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121272?cct=218810.1681/ASN.2019121272Tue, 16 Jun 2020 05:23:36 GMT-07:00Estimation of Intraglomerular Pressure Using Invasive Renal Arterial Pressure and Flow Velocity Measurements in HumansCollard, Didiervan Brussel, Peter M.van de Velde, LennartWijntjens, Gilbert W.M.Westerhof, Berend E.Karemaker, John M.Piek, Jan J.Reekers, Jim A.Vogt, Liffertde Winter, Robbert J.van den Born, Bert-Jan H.2020-06-16T05:23:36-07:00doi:10.1681/ASN.2019121272hwp:resource-id:jnephrol;31/8/1905American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyrenal hemodynamics, glomerular hyperfiltration, renal hypertensionClinical ResearchClinical Researchresearch-article20202020-08-01August 202010.1681/ASN.20191212721046-66731533-34502020-06-16T05:23:36-07:002020-08Journal of the American Society of NephrologyClinical Research3181119052562571914257258http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019111209?cct=218810.1681/ASN.2019111209Fri, 24 Jul 2020 07:43:52 GMT-07:00Long-Term Functional Patency and Cost-Effectiveness of Arteriovenous Fistula Creation under Regional Anesthesia: a Randomized Controlled TrialAitken, EmmaKearns, RachelGaianu, LucianJackson, AndrewSteven, MarkKinsella, JohnClancy, MarcMacfarlane, Alan2020-07-24T07:43:52-07:00doi:10.1681/ASN.2019111209hwp:resource-id:jnephrol;31/8/1871American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyarteriovenous access, arteriovenous fistula, chronic dialysis, chronic kidney diseaseClinical ResearchClinical Researchresearch-article20202020-08-01August 202010.1681/ASN.20191112091046-66731533-34502020-07-24T07:43:52-07:002020-08Journal of the American Society of NephrologyClinical Research31818711882http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090960?cct=218810.1681/ASN.2019090960Wed, 08 Jul 2020 09:11:03 GMT-07:00Distinct Modes of Balancing Glomerular Cell Proteostasis in Mucolipidosis Type II and III Prevent ProteinuriaSachs, WiebkeSachs, MarliesKrüger, ElkeZielinski, StephanieKretz, OliverHuber, Tobias B.Baranowsky, AnkeWestermann, Lena MarieVoltolini Velho, RenataLudwig, Nataniel FlorianoYorgan, Timur AlexanderDi Lorenzo, GiorgiaKollmann, KatrinBraulke, ThomasSchwartz, Ida VanessaSchinke, ThorstenDanyukova, TatyanaPohl, SandraMeyer-Schwesinger, Catherine2020-07-08T09:11:03-07:00doi:10.1681/ASN.2019090960hwp:resource-id:jnephrol;31/8/1796American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologymucolipidosis, osteopenia, proteotoxic stress, integrated stress response, glomerular disease, lysosomal storage disorderBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20190909601046-66731533-34502020-07-08T09:11:03-07:002020-08Journal of the American Society of NephrologyBasic Research31817961814http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101070?cct=218810.1681/ASN.2019101070Thu, 25 Jun 2020 08:23:13 GMT-07:00Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic CardiomyopathySodhi, KomalWang, XiaoliangChaudhry, Muhammad AslamLakhani, Hari VishalZehra, MishghanPratt, RebeccaNawab, AtharCottrill, Cameron L.Snoad, BrianBai, FangDenvir, JamesLiu, JiangSanabria, Juan R.Xie, ZijianAbraham, Nader G.Shapiro, Joseph I.2020-06-25T08:23:13-07:00doi:10.1681/ASN.2019101070hwp:resource-id:jnephrol;31/8/1746American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycardiovascular disease, chronic kidney disease, obesity, oxidative stress, uremia, adipocyteBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20191010701046-66731533-34502020-06-25T08:23:13-07:002020-08Journal of the American Society of NephrologyBasic Research31817461760http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010024?cct=218810.1681/ASN.2020010024Fri, 26 Jun 2020 07:17:32 GMT-07:00Obstructive Sleep Apnea, Other Sleep Characteristics, and Risk of CKD in the Atherosclerosis Risk in Communities Sleep Heart Health StudyFull, Kelsie M.Jackson, Chandra L.Rebholz, Casey M.Matsushita, KunihiroLutsey, Pamela L.2020-06-26T07:17:32-07:00doi:10.1681/ASN.2020010024hwp:resource-id:jnephrol;31/8/1859American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologysleep, aging, nocturnal hypoxemia, obstructive sleep apneaClinical EpidemiologyClinical Epidemiologyresearch-article20202020-08-01August 202010.1681/ASN.20200100241046-66731533-34502020-06-26T07:17:32-07:002020-08Journal of the American Society of NephrologyClinical Epidemiology31818591869http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101119?cct=218810.1681/ASN.2019101119Mon, 13 Jul 2020 11:02:22 GMT-07:00The FDA Metformin Label Change and Racial and Sex Disparities in Metformin Prescription among Patients with CKDShin, Jung-ImSang, YingyingChang, Alex R.Dunning, Stephan C.Coresh, JosefInker, Lesley A.Selvin, ElizabethBallew, Shoshana H.Grams, Morgan E.2020-07-13T11:02:22-07:00doi:10.1681/ASN.2019101119hwp:resource-id:jnephrol;31/8/1847American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydisparities, metformin, chronic kidney disease, FDA drug label, creatinine, estimated glomerular filtration rate, chronic kidney disease, clinical epidemiology, creatinine, glomerular filtration rateClinical EpidemiologyClinical Epidemiologyresearch-article20202020-08-01August 202010.1681/ASN.20191011191046-66731533-34502020-07-13T11:02:22-07:002020-08Journal of the American Society of NephrologyClinical Epidemiology31881847165718581658http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050707?cct=218810.1681/ASN.2020050707Wed, 08 Jul 2020 09:11:02 GMT-07:00Authors’ ReplyWeaver, Robert G.Tonelli, MarcelloLamb, Edmund J.Hemmelgarn, Brenda R.2020-07-08T09:11:02-07:00doi:10.1681/ASN.2020050707hwp:resource-id:jnephrol;31/8/1916American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologykidney transplantation, albuminuria, proteinuriaLetters to the EditorLetters to the Editorletter20202020-08-01August 202010.1681/ASN.20200507071046-66731533-34502020-07-08T09:11:02-07:002020-08Journal of the American Society of NephrologyLetters to the Editor31881916191519171916http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010028?cct=2188Although high-protein diets continue to be popular for weight loss and type 2 diabetes, evidence suggests that worsening renal function may occur in individuals with—and perhaps without—impaired kidney function. High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. It is possible that long-term high protein intake may lead to de novo CKD. The quality of dietary protein may also play a role in kidney health. Compared with protein from plant sources, animal protein has been associated with an increased risk of ESKD in several observational studies, including the Singapore Chinese Health Study. Potential mediators of kidney damage from animal protein include dietary acid load, phosphate content, gut microbiome dysbiosis, and resultant inflammation. In light of such findings, adopting current dietary approaches that include a high proportion of protein for weight reduction or glycemic control should be considered with care in those at high risk for kidney disease. Given the possibility of residual confounding within some observational studies and the conflicting evidence from previous trials, long-term studies including those with large sample sizes are warranted to better ascertain the effects of high protein intake on kidney health.10.1681/ASN.2020010028Wed, 15 Jul 2020 12:55:09 GMT-07:00The Effects of High-Protein Diets on Kidney Health and LongevityAlthough high-protein diets continue to be popular for weight loss and type 2 diabetes, evidence suggests that worsening renal function may occur in individuals with—and perhaps without—impaired kidney function. High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. It is possible that long-term high protein intake may lead to de novo CKD. The quality of dietary protein may also play a role in kidney health. Compared with protein from plant sources, animal protein has been associated with an increased risk of ESKD in several observational studies, including the Singapore Chinese Health Study. Potential mediators of kidney damage from animal protein include dietary acid load, phosphate content, gut microbiome dysbiosis, and resultant inflammation. In light of such findings, adopting current dietary approaches that include a high proportion of protein for weight reduction or glycemic control should be considered with care in those at high risk for kidney disease. Given the possibility of residual confounding within some observational studies and the conflicting evidence from previous trials, long-term studies including those with large sample sizes are warranted to better ascertain the effects of high protein intake on kidney health.Ko, Gang-JeeRhee, Connie M.Kalantar-Zadeh, KamyarJoshi, Shivam2020-07-15T12:55:09-07:00doi:10.1681/ASN.2020010028hwp:resource-id:jnephrol;31/8/1667American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologynutrition, chronic kidney disease, high protein diet, glomerular hyperfiltration, proteinuriaUp Front MattersReviewUp Front MattersReviewreview-article20202020-08-01August 202010.1681/ASN.20200100281046-66731533-34502020-07-15T12:55:09-07:002020-08Journal of the American Society of NephrologyUp Front Matters31816671679http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070696?cct=218810.1681/ASN.2019070696Fri, 19 Jun 2020 10:06:05 GMT-07:00Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental GlomerulosclerosisMerchant, Michael L.Barati, Michelle T.Caster, Dawn J.Hata, Jessica L.Hobeika, LilianeCoventry, SusanBrier, Michael E.Wilkey, Daniel W.Li, MingRood, Ilse M.Deegens, Jeroen K.Wetzels, Jack F.Larsen, Christopher P.Troost, Jonathan P.Hodgin, Jeffrey B.Mariani, Laura H.Kretzler, MatthiasKlein, Jon B.McLeish, Kenneth R.2020-06-19T10:06:05-07:00doi:10.1681/ASN.2019070696hwp:resource-id:jnephrol;31/8/1883American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyfocal segmental glomerulosclerosis, extracellular matrix, collapsing FSGS, glomerular epithelial cells, cathepsinClinical ResearchClinical Researchresearch-article20202020-08-01August 202010.1681/ASN.20190706961046-66731533-34502020-06-19T10:06:05-07:002020-08Journal of the American Society of NephrologyClinical Research31818831904http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020138?cct=218810.1681/ASN.2020020138Tue, 16 Jun 2020 05:23:36 GMT-07:00A Modest Proposal to Spur Innovation in Chronic Dialysis CareHostetter, Thomas H.2020-06-16T05:23:36-07:00doi:10.1681/ASN.2020020138hwp:resource-id:jnephrol;31/8/1664American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyESKD, Research Support, chronic dialysisUp Front MattersPerspectivesUp Front MattersPerspectivesresearch-article20202020-08-01August 202010.1681/ASN.20200201381046-66731533-34502020-06-16T05:23:36-07:002020-08Journal of the American Society of NephrologyUp Front Matters31816641666http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050545?cct=218810.1681/ASN.2020050545Wed, 08 Jul 2020 09:11:04 GMT-07:00The Estimation Formula for the Urinary Albumin-Creatinine Ratio Based on the Protein-Creatinine Ratio Are Not Valid for a Kidney Transplant and a Living Donor CohortJehn, UlrichGörlich, DennisReuter, Stefan2020-07-08T09:11:04-07:00doi:10.1681/ASN.2020050545hwp:resource-id:jnephrol;31/8/1915American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologykidney transplantation, kidney donation, albuminuriaLetters to the EditorLetters to the Editorletter20202020-08-01August 202010.1681/ASN.20200505451046-66731533-34502020-07-08T09:11:04-07:002020-08Journal of the American Society of NephrologyLetters to the Editor31881915191619161917http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101042?cct=218810.1681/ASN.2019101042Thu, 25 Jun 2020 08:23:13 GMT-07:00Therapeutic Effect of Adipose Derived Mesenchymal Stem Cell Transplantation in Reducing Restenosis in a Murine Angioplasty ModelCai, ChuanqiKilari, SreenivasuluZhao, ChengleiSimeon, Michael L.Misra, AvanishLi, Yiqingvan Wijnen, Andre J.Mukhopadhyay, DebabrataMisra, Sanjay2020-06-25T08:23:13-07:00doi:10.1681/ASN.2019101042hwp:resource-id:jnephrol;31/8/1781American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyarteriovenous fistula, stem cell, vascular accessBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20191010421046-66731533-34502020-06-25T08:23:13-07:002020-08Journal of the American Society of NephrologyBasic Research31817811795http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030336?cct=218810.1681/ASN.2020030336Thu, 04 Jun 2020 05:58:30 GMT-07:00Striking a Balance in Simultaneous Heart Kidney Transplant: Optimizing Outcomes for All Wait-Listed PatientsShaw, Brian I.Sudan, Debra L.Boulware, L. EbonyMcElroy, Lisa M.2020-06-04T05:58:30-07:00doi:10.1681/ASN.2020030336hwp:resource-id:jnephrol;31/8/1661American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologykidney transplantation, transplant outcomes, heart failureUp Front MattersPerspectivesUp Front MattersPerspectivesresearch-article20202020-08-01August 202010.1681/ASN.20200303361046-66731533-34502020-06-04T05:58:30-07:002020-08Journal of the American Society of NephrologyUp Front Matters31816611664http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040432?cct=218810.1681/ASN.2020040432Tue, 05 May 2020 05:45:03 GMT-07:00Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2Farkash, Evan A.Wilson, Allecia M.Jentzen, Jeffrey M.2020-05-05T05:45:03-07:00doi:10.1681/ASN.2020040432hwp:resource-id:jnephrol;31/8/1683American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCOVID-19, SARS-CoV-2, acute kidney failure, autopsy, renal pathology, electron microscopyRapid CommunicationRapid Communicationresearch-article20202020-08-01August 202010.1681/ASN.20200404321046-66731533-34502020-05-05T05:45:03-07:002020-08Journal of the American Society of NephrologyRapid Communication31318101683249416872494http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050558?cct=218810.1681/ASN.2020050558Fri, 19 Jun 2020 10:06:04 GMT-07:00AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL1 High-Risk GenotypeWu, HuijuanLarsen, Christopher P.Hernandez-Arroyo, Cesar F.Mohamed, Muner M.B.Caza, TiffanySharshir, Moh’dChughtai, AsimXie, LipingGimenez, Juan M.Sandow, Tyler A.Lusco, Mark A.Yang, HaichunAcheampong, EllenRosales, Ivy A.Colvin, Robert B.Fogo, Agnes B.Velez, Juan Carlos Q.2020-06-19T10:06:04-07:00doi:10.1681/ASN.2020050558hwp:resource-id:jnephrol;31/8/1688American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycollapsing glomerulopathy, APOL1, kidney biopsy, SARS-CoV-2, nephrotic, COVID-19Rapid CommunicationRapid Communicationresearch-article20202020-08-01August 202010.1681/ASN.20200505581046-66731533-34502020-06-19T10:06:04-07:002020-08Journal of the American Society of NephrologyRapid Communication31816881695http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050640?cct=218810.1681/ASN.2020050640Wed, 01 Jul 2020 08:29:06 GMT-07:00Possible Protective Effect of Renin-Angiotensin System Inhibitors in COVID-19 Induced Acute Kidney InjuryKow, Chia SiangHasan, Syed Shahzad2020-07-01T08:29:06-07:00doi:10.1681/ASN.2020050640hwp:resource-id:jnephrol;31/8/1917American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyacute kidney injury, COVID-19, renin-angiotensin system inhibitorLetters to the EditorLetters to the Editorletter20202020-08-01August 202010.1681/ASN.20200506401046-66731533-34502020-07-01T08:29:06-07:002020-08Journal of the American Society of NephrologyLetters to the Editor31881917191819181919http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050599?cct=218810.1681/ASN.2020050599Tue, 16 Jun 2020 07:39:41 GMT-07:00Acute Start Peritoneal Dialysis during the COVID-19 Pandemic: Outcomes and ExperiencesEl Shamy, OsamaPatel, NiraleeAbdelbaset, Mohamed HalimChenet, LindaTokita, JojiLookstein, RobertLee, David S.Cohen, Noah A.Sharma, ShuchitaUribarri, Jaime2020-06-16T07:39:41-07:00doi:10.1681/ASN.2020050599hwp:resource-id:jnephrol;31/8/1680American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydialysis, peritoneal dialysis, acute renal failure, COVID-19Research LetterResearch Letterresearch-article20202020-08-01August 202010.1681/ASN.20200505991046-66731533-34502020-06-16T07:39:41-07:002020-08Journal of the American Society of NephrologyResearch Letter31816801682http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040534?cct=218810.1681/ASN.2020040534Fri, 19 Jun 2020 10:06:04 GMT-07:00Epidemiology of COVID-19 in an Urban Dialysis CenterCorbett, Richard W.Blakey, SarahNitsch, DorotheaLoucaidou, MarinaMcLean, AdamDuncan, NeillAshby, Damien R.,2020-06-19T10:06:04-07:00doi:10.1681/ASN.2020040534hwp:resource-id:jnephrol;31/8/1815American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyclinical epidemiology, haemodialysis, COVID-19Clinical EpidemiologyClinical Epidemiologyresearch-article20202020-08-01August 202010.1681/ASN.20200405341046-66731533-34502020-06-19T10:06:04-07:002020-08Journal of the American Society of NephrologyClinical Epidemiology31818151823http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020060809?cct=2188This article contains a podcast athttps://www.asn-online.org/media/podcast/JASN/2020_07_21_JASN2020060809.mp310.1681/ASN.2020060809Mon, 13 Jul 2020 11:02:22 GMT-07:00COVID-19, Racism, and Racial Disparities in Kidney Disease: Galvanizing the Kidney Community ResponseThis article contains a podcast athttps://www.asn-online.org/media/podcast/JASN/2020_07_21_JASN2020060809.mp3Crews, Deidra C.Purnell, Tanjala S.2020-07-13T11:02:22-07:00doi:10.1681/ASN.2020060809hwp:resource-id:jnephrol;31/8/1American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyEthnic minority, health disparity, COVID-19, chronic kidney disease, structural racismUp Front MattersPerspectivesUp Front MattersPerspectivesresearch-article20202020-08-01August 202010.1681/ASN.20200608091046-66731533-34502020-07-13T11:02:22-07:002020-08Journal of the American Society of NephrologyUp Front Matters31813http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020060799?cct=218810.1681/ASN.2020060799Wed, 01 Jul 2020 08:29:06 GMT-07:00Authors’ ReplyBatlle, DanielSoler, Maria JoseWelling, Paul A.Swaminathan, Sundararaman,2020-07-01T08:29:06-07:00doi:10.1681/ASN.2020060799hwp:resource-id:jnephrol;31/8/1918American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycovid-19, acute renal failure, ace2, soluble ACE2, AKI, ACE inhibitors, Angiotensin II receptor blockersLetters to the EditorLetters to the Editorletter20202020-08-01August 202010.1681/ASN.20200607991046-66731533-34502020-07-01T08:29:06-07:002020-08Journal of the American Society of NephrologyLetters to the Editor31881918191719191918http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019111163?cct=218810.1681/ASN.2019111163Fri, 24 Jul 2020 07:43:53 GMT-07:00Podocyte Integrin-β3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic NephropathyMadhusudhan, ThatiGhosh, SanchitaWang, HongjieDong, WeiGupta, DheerendraElwakiel, AhmedStoyanov, StoyanAl-Dabet, Moh’d MohanadKrishnan, ShruthiBiemann, RonaldNazir, SumraZimmermann, SilkeMathew, AkashGadi, IhsanRana, RajivZeng-Brouwers, JinyangMoeller, Marcus J.Schaefer, LilianaEsmon, Charles T.Kohli, ShreyReiser, JochenRezaie, Alireza R.Ruf, WolframIsermann, Berend2020-07-24T07:43:53-07:00doi:10.1681/ASN.2019111163hwp:resource-id:jnephrol;31/8/1762American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydiabetic nephropathy, integrin αvβ3, RhoA signaling, activated protein C, coagulation proteasesBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20191111631046-66731533-34502020-07-24T07:43:53-07:002020-08Journal of the American Society of NephrologyBasic Research31817621780http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070703?cct=218810.1681/ASN.2019070703Tue, 23 Jun 2020 08:10:24 GMT-07:00Drug Testing for Residual Progression of Diabetic Kidney Disease in Mice Beyond Therapy with Metformin, Ramipril, and EmpagliflozinMotrapu, MangaŚwiderska, Monika KatarzynaMesas, IreneMarschner, Julian AurelioLei, YutianMartinez Valenzuela, LauraFu, JiaLee, KyungAngelotti, Maria LuciaAntonelli, GiuliaRomagnani, PaolaAnders, Hans-JoachimAnguiano, Lidia2020-06-23T08:10:24-07:00doi:10.1681/ASN.2019070703hwp:resource-id:jnephrol;31/8/1729American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyglomerulosclerosis, diabetic nephropathy, translational research, diabetic kidney disease, regenerationBasic ResearchBasic Researchresearch-article20202020-08-01August 202010.1681/ASN.20190707031046-66731533-34502020-06-23T08:10:24-07:002020-08Journal of the American Society of NephrologyBasic Research31817291745http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000852020?cct=218810.34067/KID.0000852020Wed, 20 May 2020 09:38:56 GMT-07:00Anemia and Incident End-Stage Kidney DiseaseSaraf, Santosh L.Hsu, Jesse Y.Ricardo, Ana C.Mehta, RupalChen, JingChen, Teresa K.Fischer, Michael J.Hamm, LeeSondheimer, JamesWeir, Matthew R.Zhang, XiaomingWolf, MylesLash, James P.2020-05-20T09:38:56-07:00doi:10.34067/KID.0000852020hwp:resource-id:kidney360;1/7/623American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, anemia, CKD progression, cohort studies, ESKD, ethnic groups, follow-up studies, hemoglobin, kidney failure, chronic, renal insufficiency, chronicOriginal InvestigationsChronic Kidney DiseaseOriginal InvestigationsChronic Kidney Diseaseresearch-article20202020-07-3010.34067/KID.00008520202641-76502020-05-20T09:38:56-07:002020-07-30Kidney360Original Investigations17623630http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001222019?cct=218810.34067/KID.0001222019Tue, 28 Apr 2020 09:39:51 GMT-07:00Global Dialysis Perspective: ArgentinaOrias, MarceloRosa Diez, Guillermo Javier2020-04-28T09:39:51-07:00doi:10.34067/KID.0001222019hwp:resource-id:kidney360;1/7/676American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, Argentina, cardiovascular diseases, delivery of health care, gross domestic product, hospitals, public, insurance, health, kidney failure, chronic life expectancy, local government, peritoneal dialysis, renal dialysis, renal insufficiency, chronicGlobal PerspectivesGlobal Perspectivesresearch-article20202020-07-3010.34067/KID.00012220192641-76502020-04-28T09:39:51-07:002020-07-30Kidney360Global Perspectives17676679http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000762020?cct=218810.34067/KID.0000762020Fri, 24 Apr 2020 07:54:10 GMT-07:00Global Dialysis Perspective: ThailandKanjanabuch, TalerngsakTakkavatakarn, Kullaya2020-04-24T07:54:10-07:00doi:10.34067/KID.0000762020hwp:resource-id:kidney360;1/7/671American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, government, gross domestic product, health expenditures, insurance, health, kidney failure, chronic, peritoneal dialysis, renal dialysis, renal insufficiency, chronic, renal replacement therapy, social security, Thailand, universal health insuranceGlobal PerspectivesGlobal Perspectivesresearch-article20202020-07-3010.34067/KID.00007620202641-76502020-04-24T07:54:10-07:002020-07-30Kidney360Global Perspectives17671675http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001432020?cct=218810.34067/KID.0001432020Mon, 27 Apr 2020 01:35:29 GMT-07:00Effect of Renin-Angiotensin System Inhibitors on the Comparative Nephrotoxicity of NSAIDs and Opioids during HospitalizationMiano, Todd A.Shashaty, Michael G. S.Yang, WeiBrown, Jeremiah R.Zuppa, AthenaHennessy, Sean2020-04-27T13:35:29-07:00doi:10.34067/KID.0001432020hwp:resource-id:kidney360;1/7/604American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, ACE inhibitors, acute renal failure, angiotensin, chronic kidney disease, diuretics, drug interactions, drug nephrotoxicity, glomerular filtration rate, hospitalization, nephrotoxicityOriginal InvestigationsAcute Kidney Injury and ICU NephrologyOriginal InvestigationsAcute Kidney Injury and ICU Nephrologyresearch-article20202020-07-3010.34067/KID.00014320202641-76502020-04-27T13:35:29-07:002020-07-30Kidney360Original Investigations17604613http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000182019?cct=218810.34067/KID.0000182019Mon, 27 Apr 2020 09:33:02 GMT-07:00Lack of Histological and Molecular Signature Response to Tocilizumab in Kidney Transplants with Chronic Active Antibody Mediated Rejection: A Case SeriesKumar, DhirenYakubu, IdrisSafavi, FroughLevy, MarlonMoinuddin, IrfanKimball, PamelaKamal, LaylaKing, AnneMassey, DavisHalloran, PhilipGupta, Gaurav2020-04-27T09:33:02-07:00doi:10.34067/KID.0000182019hwp:resource-id:kidney360;1/7/663American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, antibody mediated rejection, chronic rejection, IL6 inhibition, immunosuppression, kidney transplant, rejection, tocilizumabOriginal InvestigationsTransplantationOriginal InvestigationsTransplantationresearch-article20202020-07-3010.34067/KID.00001820192641-76502020-04-27T09:33:02-07:002020-07-30Kidney360Original Investigations17663670http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001772020?cct=218810.34067/KID.0001772020Fri, 15 May 2020 01:36:40 GMT-07:00Strategies to Expand the Deceased Donor Pool for Pediatric Kidney Transplant RecipientsKizilbash, Sarah J.Chavers, Blanche M.2020-05-15T13:36:40-07:00doi:10.34067/KID.0001772020hwp:resource-id:kidney360;1/7/691American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, child, death, growth and development, kidney failure, chronic, kidney transplantation, registries, tissue donors, transplant recipients, waiting listsPerspectivesPerspectivesresearch-article20202020-07-3010.34067/KID.00017720202641-76502020-05-15T13:36:40-07:002020-07-30Kidney360Perspectives17691693http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000732020?cct=218810.34067/KID.0000732020Thu, 30 Jul 2020 05:30:20 GMT-07:00Fever and Gross Hematuria in a Kidney Transplant RecipientThorne, PeterArroyo, Juan PabloConcepcion, Beatrice P.2020-07-30T05:30:20-07:00doi:10.34067/KID.0000732020hwp:resource-id:kidney360;1/7/712American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, adenovirus, fever, hematuria, transplantClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-07-3010.34067/KID.00007320202641-76502020-07-30T05:30:20-07:002020-07-30Kidney360Clinical Images in Nephrology and Dialysis17712713http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001822020?cct=218810.34067/KID.0001822020Fri, 22 May 2020 09:26:36 GMT-07:00Frailty and the Potential Kidney Transplant Recipient: Time for a More Holistic Assessment?Wu, Henry H.L.Woywodt, AlexanderNixon, Andrew C.2020-05-22T09:26:36-07:00doi:10.34067/KID.0001822020hwp:resource-id:kidney360;1/7/685American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360geriatric nephrology, assessment, decision making, shared, frailty, quality of life, renal insufficiency, chronic, renal replacement therapy, renal transplantationPerspectivesPerspectivesresearch-article20202020-07-3010.34067/KID.00018220202641-76502020-05-22T09:26:36-07:002020-07-30Kidney360Perspectives17685690http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002112020?cct=2188Individuals with HIV are at increased risk for ESKD. Kidney transplantation is the best treatment for ESKD in the HIV+ population. Despite reduced access to transplantation, patients who are HIV+ have excellent outcomes and clearly benefit from receiving one. Common post-transplant complications and management concerns, including the optimal antiretroviral regimen, immunosuppression protocols, infectious prophylaxis, hepatitis C coinfection, metabolic complications, and malignancy are all discussed.10.34067/KID.0002112020Wed, 06 May 2020 01:43:10 GMT-07:00Kidney Transplantation in Patients with HIVIndividuals with HIV are at increased risk for ESKD. Kidney transplantation is the best treatment for ESKD in the HIV+ population. Despite reduced access to transplantation, patients who are HIV+ have excellent outcomes and clearly benefit from receiving one. Common post-transplant complications and management concerns, including the optimal antiretroviral regimen, immunosuppression protocols, infectious prophylaxis, hepatitis C coinfection, metabolic complications, and malignancy are all discussed.Sawinski, Deirdre2020-05-06T13:43:10-07:00doi:10.34067/KID.0002112020hwp:resource-id:kidney360;1/7/705American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, anti-retroviral agents, coinfection, hepatitis C, HIV infections, immunosuppression, kidney failure, chronic, kidney transplantationReview ArticlesReview Articlesreview-article20202020-07-3010.34067/KID.00021120202641-76502020-05-06T13:43:10-07:002020-07-30Kidney360Review Articles17705711http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000712019?cct=218810.34067/KID.0000712019Wed, 13 May 2020 01:27:03 GMT-07:00Foreign Perspective on Achieving a Successful Peritoneal Dialysis-First ProgramLi, Philip Kam-TaoRosenberg, Mark E.2020-05-13T13:27:03-07:00doi:10.34067/KID.0000712019hwp:resource-id:kidney360;1/7/680American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, cost-benefit analysis, hemodialysis, home, Hong Kong, kidney failure, chronic, PD-first policy, peritoneal dialysis, peritoneal dialysis, continuous ambulatory, renal insufficiency, chronic, renal replacement therapy, United StatesGlobal PerspectivesGlobal Perspectivesresearch-article20202020-07-3010.34067/KID.00007120192641-76502020-05-13T13:27:03-07:002020-07-30Kidney360Global Perspectives17680684http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0003112020?cct=218810.34067/KID.0003112020Thu, 30 Jul 2020 05:30:20 GMT-07:00CKRT Clotting and Cerebrovascular Accident in a Critically Ill PatientCervantes, Carmen ElenaMenez, StevenHanouneh, Mohamad2020-07-30T05:30:20-07:00doi:10.34067/KID.0003112020hwp:resource-id:kidney360;1/7/718American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, blood coagulation, citrates, continuous kidney replacement therapy, COVID-19, heparin, hypercoagulability, thromboembolism, thrombophiliaClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-07-3010.34067/KID.00031120202641-76502020-07-30T05:30:20-07:002020-07-30Kidney360Clinical Images in Nephrology and Dialysis17718719http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002672020?cct=218810.34067/KID.0002672020Thu, 04 Jun 2020 01:34:49 GMT-07:00COVID-19: A Home Dialysis Nurse PerspectiveBushey, MargaretSpaeth, DonaLaCroix, Cynthia2020-06-04T13:34:49-07:00doi:10.34067/KID.0002672020hwp:resource-id:kidney360;1/7/694American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, ambulatory care facilities, COVID-19, emergency planning, hemodialysis, home, pandemic, renal dialysis, severe acute respiratory syndrome coronavirus 2, workflowPerspectivesPerspectivesresearch-article20202020-07-3010.34067/KID.00026720202641-76502020-06-04T13:34:49-07:002020-07-30Kidney360Perspectives17694696http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0003722020?cct=218810.34067/KID.0003722020Thu, 11 Jun 2020 09:42:44 GMT-07:00Acute Kidney Injury in the Time of COVID-19Chan, LiliCoca, Steven G.2020-06-11T09:42:44-07:00doi:10.34067/KID.0003722020hwp:resource-id:kidney360;1/7/588American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, acute kidney failure, chronic kidney disease, coronavirus, COVID-19, dialysis, SARS-CoV-2EditorialsEditorialseditorial20202020-07-3010.34067/KID.00037220202641-76502020-06-11T09:42:44-07:002020-07-30Kidney360Editorials17588590http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002652020?cct=218810.34067/KID.0002652020Wed, 13 May 2020 10:16:30 GMT-07:00Acute Kidney Injury Associated with Coronavirus Disease 2019 in Urban New OrleansMohamed, Muner M.B.Lukitsch, IvoTorres-Ortiz, Aldo E.Walker, Joseph B.Varghese, VipinHernandez-Arroyo, Cesar F.Alqudsi, MuhannadLeDoux, Jason R.Velez, Juan Carlos Q.2020-05-13T10:16:30-07:00doi:10.34067/KID.0002652020hwp:resource-id:kidney360;1/7/614American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, acute kidney injury, black, COVID-19, dialysis, hospital mortality, ICU, New Orleans, obesity, phenotype, proteinuria, renal replacement therapy, SARS, SARS-CoV-2, United StatesOriginal InvestigationsAcute Kidney Injury and ICU NephrologyOriginal InvestigationsAcute Kidney Injury and ICU Nephrologyresearch-article20202020-07-3010.34067/KID.00026520202641-76502020-05-13T10:16:30-07:002020-07-30Kidney360Original Investigations17614622http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13821119?cct=2188Patients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy. Progression to kidney failure often develops over a number of years, and is associated with systemic oxalosis, intensive dialysis, and often combined kidney and liver transplantation. There are no therapies approved by the Food and Drug Association. Thus, the Kidney Health Initiative, in partnership with the Oxalosis and Hyperoxaluria Foundation, initiated a project to identify end points for clinical trials. A workgroup of physicians, scientists, patients with primary hyperoxaluria, industry, and United States regulators critically examined the published literature for clinical outcomes and potential surrogate end points that could be used to evaluate new treatments. Kidney stones, change in eGFR, urine oxalate, and plasma oxalate were the strongest candidate end points. Kidney stones affect how patients with primary hyperoxaluria feel and function, but standards for measurement and monitoring are lacking. Primary hyperoxaluria registry data suggest that eGFR decline in most patients is gradual, but can be unpredictable. Epidemiologic data show a strong relationship between urine oxalate and long-term kidney function loss. Urine oxalate is reasonably likely to predict clinical benefit, due to its causal role in stone formation and kidney damage in CKD stages 1–3a, and plasma oxalate is likely associated with risk of systemic oxalosis in CKD 3b–5. Change in slope of eGFR could be considered the equivalent of a clinically meaningful end point in support of traditional approval. A substantial change in urine oxalate as a surrogate end point could support traditional approval in patients with primary hyperoxaluria type 1 and CKD stages 1–3a. A substantial change in markedly elevated plasma oxalate could support accelerated approval in patients with primary hyperoxaluria and CKD stages 3b–5. Primary hyperoxaluria type 1 accounts for the preponderance of available data, thus heavily influences the conclusions. Addressing gaps in data will further facilitate testing of promising new treatments, accelerating improved outcomes for patients with primary hyperoxaluria.10.2215/CJN.13821119Thu, 12 Mar 2020 07:57:36 GMT-07:00End Points for Clinical Trials in Primary HyperoxaluriaPatients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy. Progression to kidney failure often develops over a number of years, and is associated with systemic oxalosis, intensive dialysis, and often combined kidney and liver transplantation. There are no therapies approved by the Food and Drug Association. Thus, the Kidney Health Initiative, in partnership with the Oxalosis and Hyperoxaluria Foundation, initiated a project to identify end points for clinical trials. A workgroup of physicians, scientists, patients with primary hyperoxaluria, industry, and United States regulators critically examined the published literature for clinical outcomes and potential surrogate end points that could be used to evaluate new treatments. Kidney stones, change in eGFR, urine oxalate, and plasma oxalate were the strongest candidate end points. Kidney stones affect how patients with primary hyperoxaluria feel and function, but standards for measurement and monitoring are lacking. Primary hyperoxaluria registry data suggest that eGFR decline in most patients is gradual, but can be unpredictable. Epidemiologic data show a strong relationship between urine oxalate and long-term kidney function loss. Urine oxalate is reasonably likely to predict clinical benefit, due to its causal role in stone formation and kidney damage in CKD stages 1–3a, and plasma oxalate is likely associated with risk of systemic oxalosis in CKD 3b–5. Change in slope of eGFR could be considered the equivalent of a clinically meaningful end point in support of traditional approval. A substantial change in urine oxalate as a surrogate end point could support traditional approval in patients with primary hyperoxaluria type 1 and CKD stages 1–3a. A substantial change in markedly elevated plasma oxalate could support accelerated approval in patients with primary hyperoxaluria and CKD stages 3b–5. Primary hyperoxaluria type 1 accounts for the preponderance of available data, thus heavily influences the conclusions. Addressing gaps in data will further facilitate testing of promising new treatments, accelerating improved outcomes for patients with primary hyperoxaluria.Milliner, Dawn S.McGregor, Tracy L.Thompson, AlizaDehmel, BastianKnight, JohnRosskamp, RalfBlank, MelanieYang, SixunFargue, SoniaRumsby, GillGroothoff, JaapAllain, MeaghanWest, MelissaHollander, KimLowther, W. ToddLieske, John C.2020-03-12T07:57:36-07:00doi:10.2215/CJN.13821119hwp:resource-id:clinjasn;15/7/1056American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyoxalate, kidney stones, clinical trial end points, rare kidney disease, primary hyperoxaluria type 1, hyperoxaluria, primary, liver transplantation, renal dialysis, hyperoxaluria, kidney calculi, kidney, renal insufficiency, registries, biomarkers, renal insufficiency, chronicFeatureFeatureresearch-article20202020-07-01July 01, 202010.2215/CJN.138211191555-90411555-905X2020-03-12T07:57:36-07:002020-07-01Clinical Journal of the American Society of NephrologyFeature15710561065http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13411119?cct=218810.2215/CJN.13411119Wed, 27 May 2020 07:35:57 GMT-07:00Secondary Hyperparathyroidism in a Patient with CKDHyder, RyyanSprague, Stuart M.2020-05-27T07:35:57-07:00doi:10.2215/CJN.13411119hwp:resource-id:clinjasn;15/7/1041American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyCKD, Hyperparathyroidism, Secondary, Renal Insufficiency, Chronic, parathyroid hormoneKidney Case Conference: How I TreatKidney Case Conference: How I Treatresearch-article20202020-07-01July 01, 202010.2215/CJN.134111191555-90411555-905X2020-05-27T07:35:57-07:002020-07-01Clinical Journal of the American Society of NephrologyKidney Case Conference: How I Treat15710411043http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00590120?cct=218810.2215/CJN.00590120Fri, 22 May 2020 05:48:44 GMT-07:00Malaria, Collapsing Glomerulopathy, and Focal and Segmental GlomerulosclerosisAmoura, ArianeMoktefi, AnissaHalfon, MatthieuKarras, AlexandreRafat, CédricGibier, Jean-BaptisteGleeson, Patrick J.Servais, AudeArgy, NicolasMaillé, PascaleBelenfant, XavierGueutin, VictorDelpierre, AlexiaTricot, LeilaEl Karoui, KhalilJourde-Chiche, NoémieHouze, SandrineSahali, DilAudard, Vincent2020-05-22T05:48:44-07:00doi:10.2215/CJN.00590120hwp:resource-id:clinjasn;15/7/964American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyFSGS, collapsing glomerulopathy, minimal change nephrotic syndrome, kidney biopsy, malaria infection, APOL1 protein, human, HIV-Associated Nephropathy, nephrotic syndrome, HIV Infections, immunohistochemistry, Follow-Up StudiesOriginal ArticlesGlomerular and Tubulointerstitial DiseasesOriginal ArticlesGlomerular and Tubulointerstitial Diseasesresearch-article20202020-07-01July 01, 202010.2215/CJN.005901201555-90411555-905X2020-05-22T05:48:44-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles157964972http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13611119?cct=218810.2215/CJN.13611119Mon, 29 Jun 2020 04:21:53 GMT-07:00The Importance of Kidney Medullary Tissue for the Accurate Diagnosis of BK Virus Allograft NephropathyNankivell, Brian J.Renthawa, JasveenShingde, MeenaKhan, Asrar2020-06-29T04:21:53-07:00doi:10.2215/CJN.13611119hwp:resource-id:clinjasn;15/7/1015American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyBK Virus, kidney transplantation, Polyomavirus, immunohistochemistry, Polyomavirus Infections, kidney disease, Transplantation, Biopsy, Virus Replication, Banff schemaOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-07-01July 01, 202010.2215/CJN.136111191555-90411555-905X2020-06-29T04:21:53-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles15710151023http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13861119?cct=218810.2215/CJN.13861119Thu, 11 Jun 2020 07:10:24 GMT-07:00Urinary Lithogenic Risk Profile in ADPKD Patients Treated with TolvaptanBargagli, MatteoDhayat, Nasser A.Anderegg, ManuelSemmo, MariamHuynh-Do, UyenVogt, BrunoFerraro, Pietro ManuelFuster, Daniel G.2020-06-11T07:10:24-07:00doi:10.2215/CJN.13861119hwp:resource-id:clinjasn;15/7/1007American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyADPKD, kidney stones, tolvaptan, calcium oxalate, polycystic kidney, autosomal dominant, creatinine, glomerular filtration rate, uric acid, calcium phosphate, dibasic, dihydrate, linear models, citric acid, body mass index, alkalies, prospective studies, cohort studies, follow-up studies, kidney calculiOriginal ArticlesNephrolithiasisOriginal ArticlesNephrolithiasisresearch-article20202020-07-01July 01, 202010.2215/CJN.138611191555-90411555-905X2020-06-11T07:10:24-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles157710079231014925http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13781119?cct=218810.2215/CJN.13781119Thu, 04 Jun 2020 05:59:34 GMT-07:00Dialysis RegretSaeed, FahadLadwig, Susan A.Epstein, Ronald M.Monk, Rebeca D.Duberstein, Paul R.2020-06-04T05:59:34-07:00doi:10.2215/CJN.13781119hwp:resource-id:clinjasn;15/7/957American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyregret, shared dialysis decision-making, decisional regret, aged, living wills, logistic models, life expectancy, renal dialysis, prognosis, terminal care, odds ratio, surveys and questionnaires, decision making, renal insufficiency, chronic, emotions, marital status, attitudeOriginal ArticlesGeriatric and Palliative NephrologyOriginal ArticlesGeriatric and Palliative Nephrologyresearch-article20202020-07-01July 01, 202010.2215/CJN.137811191555-90411555-905X2020-06-04T05:59:34-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles157957963http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14191119?cct=218810.2215/CJN.14191119Tue, 23 Jun 2020 08:08:43 GMT-07:00The Electronic Medical Record and Nephrology Fellowship Education in the United StatesYuan, Christina M.Little, Dustin J.Marks, Eric S.Watson, Maura A.Raghavan, RajeevNee, Robert,2020-06-23T08:08:43-07:00doi:10.2215/CJN.14191119hwp:resource-id:clinjasn;15/7/949American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyMedical Record, Nephrology Fellowship, Clinical Education, Burnout, Work Hours, Work Compression, Electronic Health Records, Fellowships and Scholarships, Reading, Social Desirability, Records, Physicians, Radiology, Surveys and Questionnaires, Documentation, FacultyOriginal ArticlesClinical NephrologyOriginal ArticlesClinical Nephrologyresearch-article20202020-07-01July 01, 202010.2215/CJN.141911191555-90411555-905X2020-06-23T08:08:43-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles1577949917956919http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07610520?cct=218810.2215/CJN.07610520Thu, 11 Jun 2020 07:10:25 GMT-07:00ADPKD, Tolvaptan, and Nephrolithiasis RiskHoorn, Ewout J.Zietse, Robert2020-06-11T07:10:25-07:00doi:10.2215/CJN.07610520hwp:resource-id:clinjasn;15/7/923American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycalcium, cyclic AMP, cystic kidney, hypercalciuria, kidney stones, kidney tubule, polycystic kidney disease, risk factors, Polycystic Kidney, Autosomal Dominant, Tolvaptan, Kidney CalculiEditorialsEditorialseditorial20202020-07-01July 01, 202010.2215/CJN.076105201555-90411555-905X2020-06-11T07:10:25-07:002020-07-01Clinical Journal of the American Society of NephrologyEditorials157792310079251014http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08050520?cct=218810.2215/CJN.08050520Fri, 26 Jun 2020 07:25:19 GMT-07:00Role of Skeletal Muscle Mitochondrial Dysfunction in CKDRyan, Alice S.2020-06-26T07:25:19-07:00doi:10.2215/CJN.08050520hwp:resource-id:clinjasn;15/7/912American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyRenal Insufficiency, Chronic, Muscle, Skeletal, mitochondria, chronic kidney diseaseEditorialsEditorialseditorial20202020-07-01July 01, 202010.2215/CJN.080505201555-90411555-905X2020-06-26T07:25:19-07:002020-07-01Clinical Journal of the American Society of NephrologyEditorials1577912926913936http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11010919?cct=218810.2215/CJN.11010919Thu, 30 Apr 2020 07:33:44 GMT-07:00JAK-STAT Activity in Peripheral Blood Cells and Kidney Tissue in IgA NephropathyTao, JianlingMariani, LauraEddy, SeanMaecker, HoldenKambham, NeerajaMehta, KshamaHartman, JohnWang, WeiqiKretzler, MatthiasLafayette, Richard A.2020-04-30T07:33:44-07:00doi:10.2215/CJN.11010919hwp:resource-id:clinjasn;15/7/973American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyIgA nephropathy, Cell Signaling, gene transcription, pathology, Glomerulonephritis, IGA, Glomerular Mesangium, Diabetic, Nephropathies, Glomerulosclerosis, Focal Segmental, Phosphorylation, Monocytes, Leukocytes, Mononuclear, Transcriptome, Kidney, Glomerulus, JAK2 protein, human, Janus Kinase 2, kidney, proteinuria, BiopsyOriginal ArticlesGlomerular and Tubulointerstitial DiseasesOriginal ArticlesGlomerular and Tubulointerstitial Diseasesresearch-article20202020-07-01July 01, 202010.2215/CJN.110109191555-90411555-905X2020-04-30T07:33:44-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles157973982http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13371019?cct=218810.2215/CJN.13371019Tue, 21 Apr 2020 04:51:20 GMT-07:00Response to First Course of Intensified Immunosuppression in Genetically Stratified Steroid Resistant Nephrotic SyndromeMason, Anna E.Sen, Ethan S.Bierzynska, AgnieszkaColby, ElizabethAfzal, MaryamDorval, GuillaumeKoziell, Ania B.Williams, MaggieBoyer, OliviaWelsh, Gavin I.Saleem, Moin A.,2020-04-21T04:51:20-07:00doi:10.2215/CJN.13371019hwp:resource-id:clinjasn;15/7/983American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologynephrotic syndrome, pediatric nephrology, progression of renal failure, transplant outcomes, Rituximab, Exome, Radar, immunosuppression, Base Sequence, Genetic Testing, Renal Insufficiency, Biopsy, Disease Progression, Registries, Cohort StudiesOriginal ArticlesGlomerular and Tubulointerstitial DiseasesOriginal ArticlesGlomerular and Tubulointerstitial Diseasesresearch-article20202020-07-01July 01, 202010.2215/CJN.133710191555-90411555-905X2020-04-21T04:51:20-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles1577983920994922http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11200919?cct=218810.2215/CJN.11200919Wed, 17 Jun 2020 06:44:42 GMT-07:00Mortality and Recovery Associated with Kidney Failure due to Acute Kidney InjuryShah, SilviLeonard, Anthony C.Harrison, KathleenMeganathan, KarthikeyanChristianson, Annette L.Thakar, Charuhas V.2020-06-17T06:44:42-07:00doi:10.2215/CJN.11200919hwp:resource-id:clinjasn;15/7/995American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyacute renal failure, renal recovery, ESKD, mortality, race, sex, dialysis, Acute Kidney Injury, kidney, Hispanic Americans, Asian Continental Ancestry Group, diabetes mellitusOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-07-01July 01, 202010.2215/CJN.112009191555-90411555-905X2020-06-17T06:44:42-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles1579951006http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13831119?cct=218810.2215/CJN.13831119Thu, 12 Mar 2020 07:57:36 GMT-07:00Primary HyperoxaluriaLawrence, Jennifer E.Wattenberg, Debra J.2020-03-12T07:57:36-07:00doi:10.2215/CJN.13831119hwp:resource-id:clinjasn;15/7/909American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyprimary hyperoxaluria, patient perspective, hyperoxaluria, kidney stones, genetic disease, child, adult, humans, preschool child, adolescent, primary hyperoxaluria type 1, caregivers, gastrostomy, water, renal dialysis, oxalates, kidney calculi, kidney, parents, surveys and questionnaires, internet, type 2 diabetes mellitusPatient VoicePatient Voiceeditorial20202020-07-01July 01, 202010.2215/CJN.138311191555-90411555-905X2020-03-12T07:57:36-07:002020-07-01Clinical Journal of the American Society of NephrologyPatient Voice157909911http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08080520?cct=218810.2215/CJN.08080520Mon, 29 Jun 2020 04:21:53 GMT-07:00Individualizing Treatment of Steroid-Resistant Nephrotic SyndromeBagga, ArvindSinha, Aditi2020-06-29T04:21:53-07:00doi:10.2215/CJN.08080520hwp:resource-id:clinjasn;15/7/920American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychildren, focal segmental glomerulosclerosis, idiopathic nephrotic syndrome, proteinuria, nephrotic syndromeEditorialsEditorialseditorial20202020-07-01July 01, 202010.2215/CJN.080805201555-90411555-905X2020-06-29T04:21:53-07:002020-07-01Clinical Journal of the American Society of NephrologyEditorials1577920983922994http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07260520?cct=218810.2215/CJN.07260520Tue, 23 Jun 2020 08:08:42 GMT-07:00From Nihilism to OpportunityOlson, Andrew P.J.Rosenberg, Mark E.2020-06-23T08:08:42-07:00doi:10.2215/CJN.07260520hwp:resource-id:clinjasn;15/7/917American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologynephrology, outcomes, electronic health record, educationEditorialsEditorialseditorial20202020-07-01July 01, 202010.2215/CJN.072605201555-90411555-905X2020-06-23T08:08:42-07:002020-07-01Clinical Journal of the American Society of NephrologyEditorials1577917949919956http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07960520?cct=218810.2215/CJN.07960520Thu, 25 Jun 2020 10:36:32 GMT-07:00Considering Our Patients and Tempering TerminologyIngelfinger, Julie R.2020-06-25T10:36:32-07:00doi:10.2215/CJN.07960520hwp:resource-id:clinjasn;15/7/914American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologynomenclature, patient, language, terminologyEditorialsEditorialseditorial20202020-07-01July 01, 202010.2215/CJN.079605201555-90411555-905X2020-06-25T10:36:32-07:002020-07-01Clinical Journal of the American Society of NephrologyEditorials1577914937916948http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06290420?cct=218810.2215/CJN.06290420Tue, 09 Jun 2020 06:29:26 GMT-07:00CorrectionAmerican Society of Nephrology2020-06-09T06:29:26-07:00doi:10.2215/CJN.06290420hwp:resource-id:clinjasn;15/7/1027American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyErratumErratumcorrection20202020-07-01July 01, 202010.2215/CJN.062904201555-90411555-905X2020-06-09T06:29:26-07:002020-07-01Clinical Journal of the American Society of NephrologyErratum15157210272091027218http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001082019?cct=218810.34067/KID.0001082019Thu, 19 Mar 2020 09:36:56 GMT-07:00Short-Term Immunopathological Changes Associated with Pulse Steroids/IVIG/Rituximab Therapy in Late Kidney Allograft Antibody Mediated RejectionDegner, Kenna R.Wilson, Nancy A.Reese, Shannon R.Parajuli, SandeshAziz, FahadGarg, NeetikaMohamed, MahaSingh, TriptiMandelbrot, Didier A.Panzer, Sarah E.Redfield, Robert R.Van Hyfte, KristinZhong, WeixiongHidalgo, Luis G.Djamali, Arjang2020-03-19T09:36:56-07:00doi:10.34067/KID.0001082019hwp:resource-id:kidney360;1/5/389American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, antibody mediated rejection, B-lymphocytes, regulatory BAFF, CD8-positive T-lymphocytes, DSA, immunoglobulins, intravenous, kidney transplantation, prospective studies, rituximab, T-lymphocytes, regulatory, Basic Science, Basic ScienceOriginal InvestigationsTransplantationOriginal InvestigationsTransplantationresearch-article20202020-05-2810.34067/KID.00010820192641-76502020-03-19T09:36:56-07:002020-05-28Kidney360Original Investigations15389398http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000242020?cct=218810.34067/KID.0000242020Thu, 28 May 2020 10:00:25 GMT-07:00Green Effluent in a Patient on Continuous Veno-venous HemodiafiltrationDias Gonçalves, PriscilaRamos de Freitas, Geraldo RubensReis, Thiago de Azevedo2020-05-28T10:00:25-07:00doi:10.34067/KID.0000242020hwp:resource-id:kidney360;1/5/428American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acute Kidney Injury and ICU Nephrology, Akute Kidney Injure, effluent, hemodiafiltration, methylene blueClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-05-2810.34067/KID.00002420202641-76502020-05-28T10:00:25-07:002020-05-28Kidney360Clinical Images in Nephrology and Dialysis15428429http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000352020?cct=218810.34067/KID.0000352020Thu, 28 May 2020 10:00:25 GMT-07:00Facial Deformity in a Patient with Chronic Secondary HyperparathyroidismDhont, SebastiaanViaene, LiesbethEvenepoel, Pieter2020-05-28T10:00:25-07:00doi:10.34067/KID.0000352020hwp:resource-id:kidney360;1/5/430American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Chronic Kidney Disease, dialysis, hyperparathyroidism, Leontiatis osseaClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-05-2810.34067/KID.00003520202641-76502020-05-28T10:00:25-07:002020-05-28Kidney360Clinical Images in Nephrology and Dialysis15430431http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000532019?cct=218810.34067/KID.0000532019Tue, 31 Mar 2020 01:29:42 GMT-07:00Influence of Medications Containing Acid Salts on Serum Bicarbonate in CKDGardner, JohnTuttle, KunaniRaphael, Kalani L.2020-03-31T13:29:42-07:00doi:10.34067/KID.0000532019hwp:resource-id:kidney360;1/5/330American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acid/base and electrolyte disorders, acid-base equilibrium, acidosis, anion gap, bicarbonate, carbon dioxide, cross-sectional studies, diabetes mellitus, gabapentin, hydrochloric acid, metformin, polypharmacy, renal insufficiency, chronicOriginal InvestigationsAcid/Base and Electrolyte DisordersOriginal InvestigationsAcid/Base and Electrolyte Disordersresearch-article20202020-05-2810.34067/KID.00005320192641-76502020-03-31T13:29:42-07:002020-05-28Kidney360Original Investigations15330336http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000302020?cct=218810.34067/KID.0000302020Tue, 24 Mar 2020 02:22:15 GMT-07:00Utility of Peritoneal Scintigraphy in Peritoneal Dialysis Patients: One Center ExperienceSosa Barrios, R. HaridianRioja Martín, María EugeniaBurguera Vion, VíctorSantos Carreño, Astrid LucíaFernández Lucas, MilagrosRivera Gorrín, Maite E.2020-03-24T14:22:15-07:00doi:10.34067/KID.0000302020hwp:resource-id:kidney360;1/5/354American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, dialysate leak, imaging test, peritoneal dialysis, renal replacement therapy, scintigraphyOriginal InvestigationsDialysisOriginal InvestigationsDialysisresearch-article20202020-05-2810.34067/KID.00003020202641-76502020-03-24T14:22:15-07:002020-05-28Kidney360Original Investigations15354358http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000072020?cct=218810.34067/KID.0000072020Thu, 02 Apr 2020 10:11:53 GMT-07:00Clinical Response and Pattern of B cell Suppression with Single Low Dose Rituximab in NephrologyGeorge, JacobAlex, SunuThomas, E.T. ArunGracious, NobleVineetha, Nalanda S.Kumar, Sajeev2020-04-02T10:11:53-07:00doi:10.34067/KID.0000072020hwp:resource-id:kidney360;1/5/359American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, antibody-mediated rejection, frequently relapsing nephrotic syndrome, idiopathic membranous nephropathy, immunosuppression, kidney transplantation, nephrotic syndrome, steroid-dependent nephrotic syndromeOriginal InvestigationsGlomerular and Tubulointerstitial DiseasesOriginal InvestigationsGlomerular and Tubulointerstitial Diseasesresearch-article20202020-05-2810.34067/KID.00000720202641-76502020-04-02T10:11:53-07:002020-05-28Kidney360Original Investigations15359367http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000422020?cct=218810.34067/KID.0000422020Wed, 18 Mar 2020 08:02:50 GMT-07:00Use of Immune Checkpoint Inhibitors in End Stage Kidney Disease Patients, Single Center Experience and Review of the LiteratureHirsch, Jamie S.Wanchoo, RimdaNg, Jia H.Khanin, YuriyJhaveri, Kenar D.2020-03-18T08:02:50-07:00doi:10.34067/KID.0000422020hwp:resource-id:kidney360;1/5/399American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, checkpoint inhibitors, dialysis, immunotherapy, nivolumab, onconephrology, pembrolizumabBrief CommunicationBrief Communicationbrief-report20202020-05-2810.34067/KID.00004220202641-76502020-03-18T08:02:50-07:002020-05-28Kidney360Brief Communication15399402http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000282019?cct=218810.34067/KID.0000282019Fri, 27 Mar 2020 02:22:52 GMT-07:00Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney CancerTrott, Josephine F.Abu Aboud, OmranMcLaughlin, BridgetAnderson, Katie L.Modiano, Jaime F.Kim, KyoungmiJen, Kuang-YuSenapedis, WilliamChang, HuaLandesman, YosefBaloglu, ErkanPili, RobertoWeiss, Robert H.2020-03-27T14:22:52-07:00doi:10.34067/KID.0000282019hwp:resource-id:kidney360;1/5/376American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360nephro-pharmacology, immunology, lymphocytes, metabolism, pathology, renal carcinoma, Basic ScienceOriginal InvestigationsNephropharmacologyOriginal InvestigationsNephropharmacologyresearch-article20202020-05-2810.34067/KID.00002820192641-76502020-03-27T14:22:52-07:002020-05-28Kidney360Original Investigations15376388http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000982019?cct=218810.34067/KID.0000982019Tue, 31 Mar 2020 06:00:11 GMT-07:00Baseline Diastolic Blood Pressure and Cardiovascular Outcomes in SPRINT Participants with Chronic Kidney DiseaseChang, Tara I.Wei, GuoBoucher, RobertKramer, HollyChertow, Glenn M.Cheung, Alfred K.Greene, TomWhelton, Paul K.Beddhu, Srinivasan2020-03-31T06:00:11-07:00doi:10.34067/KID.0000982019hwp:resource-id:kidney360;1/5/368American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Hypertension, Blood Pressure, Cause of Death, Hypertension, Randomized Controlled Trials, Renal Insufficiency, Chronic, SPRINTOriginal InvestigationsHypertensionOriginal InvestigationsHypertensionresearch-article20202020-05-2810.34067/KID.00009820192641-76502020-03-31T06:00:11-07:002020-05-28Kidney360Original Investigations15368375http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000272019?cct=2188Gadolinium-based contrast agents (GBCAs) have provided much needed image enhancement in magnetic resonance imaging (MRI) important in the advancement of disease diagnosis and treatment. The paramagnetic properties of ionized gadolinium have facilitated these advancements, but ionized gadolinium carries toxicity risk. GBCAs were formulated with organic chelates designed to reduce these toxicity risks from unbound gadolinium ions. They were preferred over iodinated contrast used in computed tomography and considered safe for use. As their use expanded, the development of new diseases associated with their use (including nephrogenic systemic fibrosis) has drawn more attention and ultimately caution with their clinical administration in those with impaired renal function. Use of GBCAs in those with preserved renal function was considered to be safe. However, in this new era with emerging clinical and experimental evidence of brain gadolinium deposition in those with repeated exposure, these safety assumptions are once again brought into question. This review article aims to add new perspectives in thinking about the role of GBCA in current clinical use. The new information begs for further discussion and consideration of the risk-benefit ratio of use of GBCAs.10.34067/KID.0000272019Wed, 15 Apr 2020 01:24:45 GMT-07:00Gadolinium-Based Contrast Agent Use, Their Safety, and Practice EvolutionGadolinium-based contrast agents (GBCAs) have provided much needed image enhancement in magnetic resonance imaging (MRI) important in the advancement of disease diagnosis and treatment. The paramagnetic properties of ionized gadolinium have facilitated these advancements, but ionized gadolinium carries toxicity risk. GBCAs were formulated with organic chelates designed to reduce these toxicity risks from unbound gadolinium ions. They were preferred over iodinated contrast used in computed tomography and considered safe for use. As their use expanded, the development of new diseases associated with their use (including nephrogenic systemic fibrosis) has drawn more attention and ultimately caution with their clinical administration in those with impaired renal function. Use of GBCAs in those with preserved renal function was considered to be safe. However, in this new era with emerging clinical and experimental evidence of brain gadolinium deposition in those with repeated exposure, these safety assumptions are once again brought into question. This review article aims to add new perspectives in thinking about the role of GBCA in current clinical use. The new information begs for further discussion and consideration of the risk-benefit ratio of use of GBCAs.Do, CatherineDeAguero, JoshuaBrearley, AdrianTrejo, XochitlHoward, TamaraEscobar, G. PatriciaWagner, Brent2020-04-15T13:24:45-07:00doi:10.34067/KID.0000272019hwp:resource-id:kidney360;1/6/561American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Chronic Kidney Disease, Contrast Media, Fibrosis, Gadolinium, Image Enhancement, Magnetic Resonance Imaging, Nephrogenic Fibrosing Dermopathy, Risk Assessment, Tomography, X-Ray Computed, Basic ScienceBasic Science for CliniciansBasic Science for Cliniciansresearch-article20202020-06-2510.34067/KID.00002720192641-76502020-04-15T13:24:45-07:002020-06-25Kidney360Basic Science for Clinicians16561568http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0003022020?cct=218810.34067/KID.0003022020Thu, 25 Jun 2020 05:30:20 GMT-07:00Use of Gadolinium-Based Contrast Agents in Patients with Severe Renal Impairment. Absence of Risk Versus Caution: A Nephrologist’s PerspectiveRudnick, Michael R.Wahba, Ihab M.Leonberg-Yoo, Amanda K.2020-06-25T05:30:20-07:00doi:10.34067/KID.0003022020hwp:resource-id:kidney360;1/6/433American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, chronic kidney disease, gadolinium-based contrast agents, magnetic resonance imaging, nephrogenic systemic fibrosisEditorialEditorialeditorial20202020-06-2510.34067/KID.00030220202641-76502020-06-25T05:30:20-07:002020-06-25Kidney360Editorial16433435http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001062020?cct=218810.34067/KID.0001062020Fri, 17 Apr 2020 08:35:12 GMT-07:00Sildenafil Citrate Does Not Reprogram Risk of Hypertension and Chronic Kidney Disease in Offspring of Preeclamptic Pregnancies in the Dahl SS/Jr RatTurbeville, Hannah R.Johnson, Ashley C.Garrett, Michael R.Sasser, Jennifer M.2020-04-17T08:35:12-07:00doi:10.34067/KID.0001062020hwp:resource-id:kidney360;1/6/510American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Hypertension, Angiotensin II, Developmental Programming, Diet, Hypertension, Kidney Diseases, Phosphodiesterase 5 Inhibitors, Pre-Eclampsia, Pregnancy, Rats, Inbred Dahl, Sildenafil Citrate, Sodium Chloride, Basic ScienceOriginal InvestigationsHypertensionOriginal InvestigationsHypertensionresearch-article20202020-06-2510.34067/KID.00010620202641-76502020-04-17T08:35:12-07:002020-06-25Kidney360Original Investigations16510520http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000212020?cct=218810.34067/KID.0000212020Thu, 16 Apr 2020 01:40:02 GMT-07:00Identification of Podocyte Cargo Proteins by Proteomic Analysis of Clathrin-Coated VesiclesGroener, MarwinWang, YingCross, ElizabethTian, XuefeiEbenezer, KarenBaik, EunicePedigo, ChristopherSchiffer, MarioInoue, KazunoriIshibe, Shuta2020-04-16T13:40:02-07:00doi:10.34067/KID.0000212020hwp:resource-id:kidney360;1/6/480American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360glomerular and tubulointerstitial diseases, clathrin-coated vesicles, clathrin-mediated endocytosis, glomerular diseases, immunoblotting, kidney glomerulus, mice, podocytes, proteomics, Basic ScienceOriginal InvestigationsGlomerular and Tubulointerstitial DiseasesOriginal InvestigationsGlomerular and Tubulointerstitial Diseasesresearch-article20202020-06-2510.34067/KID.00002120202641-76502020-04-16T13:40:02-07:002020-06-25Kidney360Original Investigations16480490http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000812019?cct=218810.34067/KID.0000812019Thu, 30 Apr 2020 06:13:33 GMT-07:00Dexamethasone for Preventing Major Adverse Kidney Events following Cardiac Surgery: Post-Hoc Analysis to Identify SubgroupsVenugopal, HemaJacob, Kirolos A.Dieleman, Jan M.Leaf, David E.2020-04-30T06:13:33-07:00doi:10.34067/KID.0000812019hwp:resource-id:kidney360;1/6/530American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, acute kidney injury, cardiac surgical procedures, cardiopulmonary bypass, dexamethasone, glucocorticoids, inflammation, steroidsBrief CommunicationsBrief Communicationsin-brief20202020-06-2510.34067/KID.00008120192641-76502020-04-30T06:13:33-07:002020-06-25Kidney360Brief Communications16530533http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000432020?cct=218810.34067/KID.0000432020Tue, 21 Apr 2020 01:45:16 GMT-07:00Renal Manifestations of Common Variable ImmunodeficiencyCaza, Tiffany N.Hassen, Samar I.Larsen, Christopher P.2020-04-21T13:45:16-07:00doi:10.34067/KID.0000432020hwp:resource-id:kidney360;1/6/491American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Glomerular and Tubulointerstitial Diseases, Glomerular disease, Immunodeficiency, Membranous nephropathy, Renal biopsy, Tubulointerstitial nephritisOriginal InvestigationsGlomerular and Tubulointerstitial DiseasesOriginal InvestigationsGlomerular and Tubulointerstitial Diseasesresearch-article20202020-06-2510.34067/KID.00004320202641-76502020-04-21T13:45:16-07:002020-06-25Kidney360Original Investigations16491500http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000652020?cct=218810.34067/KID.0000652020Thu, 25 Jun 2020 05:30:20 GMT-07:00Refractory Proteinuria in a Patient with Lupus NephritisOda, YasuhiroHoshino, JunichiUbara, Yoshifumi2020-06-25T05:30:20-07:00doi:10.34067/KID.0000652020hwp:resource-id:kidney360;1/6/580American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360diabetes and the kidney, diabetic nephropathy, glomerulonephritis, lupus erythematosus, systemic, lupus nephritisClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-06-2510.34067/KID.00006520202641-76502020-06-25T05:30:20-07:002020-06-25Kidney360Clinical Images in Nephrology and Dialysis16580581http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000662020?cct=218810.34067/KID.0000662020Thu, 25 Jun 2020 05:30:20 GMT-07:00CT Scan Surprise in a Potential Kidney DonorSingh, PrinceBentall, AndrewErickson, Stephen B.2020-06-25T05:30:20-07:00doi:10.34067/KID.0000662020hwp:resource-id:kidney360;1/6/582American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Transplantation, ectopia, evaluation, fused Kidney, Living DonorsClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-06-2510.34067/KID.00006620202641-76502020-06-25T05:30:20-07:002020-06-25Kidney360Clinical Images in Nephrology and Dialysis16582583http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001102019?cct=218810.34067/KID.0001102019Tue, 07 Apr 2020 01:33:52 GMT-07:00Association between NSAID Exposure and Kidney Function Decline in Primary Care PatientsPai, Amy BartonVassalotti, Joseph A.Fox, Chester H.Carroll, Jennifer K.Pulver, Gerald E.Dickinson, L. MiriamPace, Wilson D.2020-04-07T13:33:52-07:00doi:10.34067/KID.0001102019hwp:resource-id:kidney360;1/6/521American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360nephro-pharmacology, acute kidney injury, adverse effects, anti-inflammatory agents, non-steroidal, chronic kidney disease, nonprescription drugs, NSAID, primary health care, renal insufficiency, chronic, United States Food and Drug AdministrationBrief CommunicationsBrief Communicationsbrief-report20202020-06-2510.34067/KID.00011020192641-76502020-04-07T13:33:52-07:002020-06-25Kidney360Brief Communications16521523http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000962019?cct=218810.34067/KID.0000962019Tue, 28 Apr 2020 09:39:51 GMT-07:00Vascular Dysfunction, Oxidative Stress, and Inflammation in Chronic Kidney DiseaseNowak, Kristen L.Jovanovich, AnnaFarmer-Bailey, HeatherBispham, NinaStruemph, TaylorMalaczewski, MikaelaWang, WeiChonchol, Michel2020-04-28T09:39:51-07:00doi:10.34067/KID.0000962019hwp:resource-id:kidney360;1/6/501American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360hemodynamics and vascular regulation, brachial artery, cardiovascular diseases, dilatation, endothelium, human umbilical vein endothelial cells, inflammation, NADP, oxidative stress, pulse wave analysis, renal insufficiency, chronic, vascular, vascular stiffnessOriginal InvestigationsHemodynamics and Vascular RegulationOriginal InvestigationsHemodynamics and Vascular Regulationresearch-article20202020-06-2510.34067/KID.00009620192641-76502020-04-28T09:39:51-07:002020-06-25Kidney360Original Investigations16501509http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001962020?cct=218810.34067/KID.0001962020Mon, 27 Apr 2020 01:35:29 GMT-07:00Point-of-Care Ultrasound for Native Kidney BiopsiesPalacherla, JithendranathO’Neill, W. Charles2020-04-27T13:35:29-07:00doi:10.34067/KID.0001962020hwp:resource-id:kidney360;1/6/527American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Biopsy, Faculty, Internship and Residency, Kidney Diseases, Nephrology, Point-of-Care Systems, Radiation Exposure, Radiologists, Schools, Medical, Tomography, X-Ray Computed, Ultrasonography, WorkforceBrief CommunicationsBrief Communicationsin-brief20202020-06-2510.34067/KID.00019620202641-76502020-04-27T13:35:29-07:002020-06-25Kidney360Brief Communications16527529http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000382019?cct=2188Cerebral edema, in a variety of circumstances, may be accompanied by states of hyponatremia. The threat of brain injury from hypotonic stress-induced astrocyte demyelination is more common when vulnerable patients with hyponatremia who have end stage liver disease, traumatic brain injury, heart failure, or other conditions undergo overly rapid correction of hyponatremia. These scenarios, in the context of declining urinary output from CKD and/or AKI, may require controlled elevations of plasma tonicity vis-à-vis increases of the plasma sodium concentration. We offer a strategic solution to this problem via sodium-based osmotherapy applied through a conventional continuous RRT modality: predilution continuous venovenous hemofiltration.10.34067/KID.0000382019Wed, 26 Feb 2020 09:56:34 GMT-08:00Sodium-Based Osmotherapy in Continuous Renal Replacement Therapy: a Mathematical ApproachCerebral edema, in a variety of circumstances, may be accompanied by states of hyponatremia. The threat of brain injury from hypotonic stress-induced astrocyte demyelination is more common when vulnerable patients with hyponatremia who have end stage liver disease, traumatic brain injury, heart failure, or other conditions undergo overly rapid correction of hyponatremia. These scenarios, in the context of declining urinary output from CKD and/or AKI, may require controlled elevations of plasma tonicity vis-à-vis increases of the plasma sodium concentration. We offer a strategic solution to this problem via sodium-based osmotherapy applied through a conventional continuous RRT modality: predilution continuous venovenous hemofiltration.Yee, JerryMohiuddin, NaushabaGradinariu, TudorUduman, JuniorFrinak, Stanley2020-02-26T09:56:34-08:00doi:10.34067/KID.0000382019hwp:resource-id:kidney360;1/4/281American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acid/Base and Electrolyte Disorders, Advection, Dialysance of sodium, osmotherapy, Replacement fluid, sodium concentration adjustment ratio, Sodium-gradient, Urea reduction ratioReview ArticlesReview Articlesreview-article20202020-04-3010.34067/KID.00003820192641-76502020-02-26T09:56:34-08:002020-04-30Kidney360Review Articles14281291http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001062019?cct=218810.34067/KID.0001062019Fri, 13 Mar 2020 01:41:04 GMT-07:00The Effect of Risk of Maturation Failure and Access Type on Arteriovenous Access-Related Costs among Hemodialysis PatientsKosa, Sarah D.Gafni, AmiramThabane, LehanaLok, Charmaine E.2020-03-13T13:41:04-07:00doi:10.34067/KID.0001062019hwp:resource-id:kidney360;1/4/248American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, arteriovenous access, cost, fistula, graft, hemodialysis, maturation failure, vascular accessOriginal InvestigationsDialysisOriginal InvestigationsDialysisresearch-article20202020-04-3010.34067/KID.00010620192641-76502020-03-13T13:41:04-07:002020-04-30Kidney360Original Investigations14248257http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000752020?cct=218810.34067/KID.0000752020Fri, 13 Mar 2020 01:41:04 GMT-07:00Does Vascular Access Type Affect Access–Related Costs?Thamer, Mae2020-03-13T13:41:04-07:00doi:10.34067/KID.0000752020hwp:resource-id:kidney360;1/4/229American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Diabetes and the Kidney, Anti-Inflammatory Agents, Diabetic Nephropathies, Inflammation, Pentoxifylline, Sodium-Glucose Transporter 2 Inhibitors, Standard of CareEditorialEditorialeditorial20202020-04-3010.34067/KID.00007520202641-76502020-03-13T13:41:04-07:002020-04-30Kidney360Editorial14229231http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000572019?cct=218810.34067/KID.0000572019Tue, 03 Mar 2020 08:11:32 GMT-08:00Venous Thrombotic Events in ANCA-Associated Vasculitis: Incidence and Risk FactorsIsaacs, BradleyGapud, Eric J.Antiochos, BrendanSeo, PhilipGeetha, Duvuru2020-03-03T08:11:32-08:00doi:10.34067/KID.0000572019hwp:resource-id:kidney360;1/4/258American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Glomerular and Tubulointerstitial Diseases, ANCA, MPO ANCA, PR3 ANCA, RPGN, VASCULITIS, VENOUS THROMBOSISOriginal InvestigationsGlomerular and Tubulointerstitial DiseasesOriginal InvestigationsGlomerular and Tubulointerstitial Diseasesresearch-article20202020-04-3010.34067/KID.00005720192641-76502020-03-03T08:11:32-08:002020-04-30Kidney360Original Investigations14258262http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000452019?cct=218810.34067/KID.0000452019Thu, 30 Apr 2020 08:30:19 GMT-07:00Abdominal Pain in a Patient with AsymmetryWeisinger, Jose R.Freundlich, Michael2020-04-30T08:30:19-07:00doi:10.34067/KID.0000452019hwp:resource-id:kidney360;1/4/314American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Mineral Metabolism, Nephrolithiasis, Beckwith-Wiedemann Syndrome, Medullary sponge kidney, nephrocalcinosis, Nephrolithiasis, Unilateral nephrocalcinosis, sucroferric oxyhydroxideClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-04-3010.34067/KID.00004520192641-76502020-04-30T08:30:19-07:002020-04-30Kidney360Clinical Images in Nephrology and Dialysis14314315http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000592019?cct=218810.34067/KID.0000592019Thu, 30 Apr 2020 08:30:19 GMT-07:00AKI in a Patient with Cerebral ToxoplasmosisPatel, JayeshKuppachi, Sarat2020-04-30T08:30:19-07:00doi:10.34067/KID.0000592019hwp:resource-id:kidney360;1/4/316American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Nephrolithiasis, Acute Kidney Injury, Kidney Calculi, Morbidity, Sulfadiazine, Toxoplasmosis, CerebralClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-04-3010.34067/KID.00005920192641-76502020-04-30T08:30:19-07:002020-04-30Kidney360Clinical Images in Nephrology and Dialysis14316317http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000262019?cct=218810.34067/KID.0000262019Thu, 26 Mar 2020 08:30:18 GMT-07:00Abdominal Pain in a Patient with HypercalcemiaSingh, PrinceManohar, SandhyaErickson, Stephen2020-03-26T08:30:18-07:00doi:10.34067/KID.0000262019hwp:resource-id:kidney360;1/3/223American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acid/Base and Electrolyte Disorders, Mineral Metabolism, Nephrolithiasis, Abdominal Pain, Electrolytes, Hypercalcemia, Kidney Calculi, MineralsClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-03-2610.34067/KID.00002620192641-76502020-03-26T08:30:18-07:002020-03-26Kidney360Clinical Images in Nephrology and Dialysis13223224http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000092019?cct=218810.34067/KID.0000092019Thu, 26 Mar 2020 08:30:18 GMT-07:00Unusual Cause for Continuous Renal Replacement Therapy Filter ClottingWhitlow, MichaelRajasekaran, ArunRizk, Dana2020-03-26T08:30:18-07:00doi:10.34067/KID.0000092019hwp:resource-id:kidney360;1/3/225American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Dialysis, Acute Renal Failure, Dialysis, LipidsClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-03-2610.34067/KID.00000920192641-76502020-03-26T08:30:18-07:002020-03-26Kidney360Clinical Images in Nephrology and Dialysis13225226http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001052019?cct=218810.34067/KID.0001052019Mon, 02 Mar 2020 09:31:19 GMT-08:00Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney DiseaseZimmerman, Kurt A.Huang, JifengHe, LanRevell, Dustin Z.Li, ZhangHsu, Jung-ShanFitzgibbon, Wayne R.Hazard, E. StarrHardiman, GaryMrug, MichalBell, P. DarwinYoder, Bradley K.Saigusa, Takamitsu2020-03-02T09:31:19-08:00doi:10.34067/KID.0001052019hwp:resource-id:kidney360;1/3/179American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Cystic Kidney Disease, ADPKD, chemokine, cytokine, gene therapy, inflammation, Basic ScienceOriginal InvestigationsCystic Kidney DiseaseOriginal InvestigationsCystic Kidney Diseaseresearch-article20202020-03-2610.34067/KID.00010520192641-76502020-03-02T09:31:19-08:002020-03-26Kidney360Original Investigations13179190http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001192019?cct=218810.34067/KID.0001192019Tue, 11 Feb 2020 01:38:00 GMT-08:00Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: PROEijgelsheim, MarkSprangers, Ben2020-02-11T13:38:00-08:00doi:10.34067/KID.0001192019hwp:resource-id:kidney360;1/3/158American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Glomerular and Tubulointerstitial Diseases, checkpoint inhibitors, interstitial nephritis, kidney biopsy, onconephrologyDebates in NephrologyDebates in Nephrologyresearch-article20202020-03-2610.34067/KID.00011920192641-76502020-02-11T13:38:00-08:002020-03-26Kidney360Debates in Nephrology13158161http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000132020?cct=218810.34067/KID.0000132020Tue, 11 Feb 2020 01:38:00 GMT-08:00Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: CONGutgarts, VictoriaGlezerman, Ilya G.2020-02-11T13:38:00-08:00doi:10.34067/KID.0000132020hwp:resource-id:kidney360;1/3/162American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acute Kidney Injury and ICU Nephrology, Abatacept, Apoptosis Regulatory Proteins, Immune checkpoint inhibitors, Immune System, Neoplasms, Programmed Cell Death 1 ReceptorDebates in NephrologyDebates in Nephrologyresearch-article20202020-03-2610.34067/KID.00001320202641-76502020-02-11T13:38:00-08:002020-03-26Kidney360Debates in Nephrology13162165http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000422019?cct=218810.34067/KID.0000422019Tue, 18 Feb 2020 02:10:57 GMT-08:00Profiling APOL1 Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell TranscriptomicsLiu, EstherRadmanesh, BehramChung, Byungha H.Donnan, Michael D.Yi, DanDadi, AmalSmith, Kelly D.Himmelfarb, JonathanLi, MingyaoFreedman, Benjamin S.Lin, Jennie2020-02-18T14:10:57-08:00doi:10.34067/KID.0000422019hwp:resource-id:kidney360;1/3/203American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Genetics, APOL1, endoplasmic reticulum stress, focal and segmental glomerulosclerosis, functional genomics, genome editing, induced pluripotent stem cells, nephron progenitor cells, organoids, Basic ScienceOriginal InvestigationsGeneticsOriginal InvestigationsGeneticsresearch-article20202020-03-2610.34067/KID.00004220192641-76502020-02-18T14:10:57-08:002020-03-26Kidney360Original Investigations13203215http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001072019?cct=218810.34067/KID.0001072019Tue, 11 Feb 2020 01:38:00 GMT-08:00Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: CommentaryPerazella, Mark A.2020-02-11T13:38:00-08:00doi:10.34067/KID.0001072019hwp:resource-id:kidney360;1/3/166American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acute Kidney Injury and ICU Nephrology, Clinical Nephrology, acute kidney injury, acute tubular injuury, acute tubulinterstitial nephritis, cancer, eosinophilia, immune checkpoint inhibitor, kidney biopsy, pyuria, T-cells, urinalysisModerator CommentaryModerator Commentaryarticle-commentary20202020-03-2610.34067/KID.00010720192641-76502020-02-11T13:38:00-08:002020-03-26Kidney360Moderator Commentary13166168http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000302019?cct=218810.34067/KID.0000302019Mon, 17 Feb 2020 05:30:10 GMT-08:00Remote Treatment Monitoring on Hospitalization and Technique Failure Rates in Peritoneal Dialysis PatientsChaudhuri, SheetalHan, HaoMuchiutti, CarlosRyter, JessicaReviriego-Mendoza, MartaMaddux, DuganLarkin, John W.Usvyat, Len A.Chatoth, DineshKooman, Jeroen P.Maddux, Franklin W.2020-02-17T05:30:10-08:00doi:10.34067/KID.0000302019hwp:resource-id:kidney360;1/3/191American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Chronic Kidney Disease, Chronic Kidney Disease, End Stage Kidney Disease, Hospitalization, Peritoneal Dialysis, Remote Monitoring, Technique FailureOriginal InvestigationsDialysisOriginal InvestigationsDialysisresearch-article20202020-03-2610.34067/KID.00003020192641-76502020-02-17T05:30:10-08:002020-03-26Kidney360Original Investigations13191202http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000352019?cct=218810.34067/KID.0000352019Thu, 23 Jan 2020 10:23:26 GMT-08:00Seasonal and Secular Trends of Cardiovascular, Nutritional, and Inflammatory Markers in Patients on HemodialysisTerner, ZacharyLong, AndrewReviriego-Mendoza, MartaLarkin, John W.Usvyat, Len A.Kotanko, PeterMaddux, Franklin W.Wang, Yuedong2020-01-23T10:23:26-08:00doi:10.34067/KID.0000352019hwp:resource-id:kidney360;1/2/93American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Chronic Kidney Disease, Dialysis, Albumin, End Stage Kidney Disease, Hemodialysis, Hospitalization, Interdialytic Weight Gain, Seasons, Systolic Blood Pressure, UltrafiltrationOriginal InvestigationsDialysisOriginal InvestigationsDialysisresearch-article20202020-02-2710.34067/KID.00003520192641-76502020-01-23T10:23:26-08:002020-02-27Kidney360Original Investigations1293105http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000142019?cct=218810.34067/KID.0000142019Fri, 31 Jan 2020 05:30:08 GMT-08:00Association between Endothelial Dysfunction, Biomarkers of Renal Function, and Disease Severity in Sickle Cell DiseaseAyoola, Oluwagbemiga OluwoleBolarinwa, Rahman AyodeleOnwuka, Chidiogo ChukwunweikeIdowu, Bukunmi MichaelAderibigbe, Adeniyi Sunday2020-01-31T05:30:08-08:00doi:10.34067/KID.0000142019hwp:resource-id:kidney360;1/2/79American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Anemia, Sickle Cell, Biomarkers, Brachial artery, Creatinine, CST3 protein, human, Cystatin C, Endothelial dysfunction, Fetal Hemoglobin, Flow mediated dilatation, P-Selectin, Renal artery resistivity index, Renal function, Sickle Nephropathy, Tertiary Care CentersOriginal InvestigationsClinical NephrologyOriginal InvestigationsClinical Nephrologyresearch-article20202020-02-2710.34067/KID.00001420192641-76502020-01-31T05:30:08-08:002020-02-27Kidney360Original Investigations127985http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000952019?cct=2188Chemotherapeutic agents require precise dosing to ensure optimal efficacy and minimize complications. For those agents that are removed from the body by the kidney, accurate knowledge of GFR is critical. In addition, GFR needs to be determined rapidly, easily, and, if possible, with little additional cost. The ability to easily measure GFR also allows for rapid detection of nephrotoxicity. Current methodologies include direct clearance measurement of an indicator substance or estimation of creatinine clearance or GFR through regression equations that use a serum marker, such as creatinine or cystatin C. These methodologies all have shortfalls and limitations, some of which are specific to the patient with cancer. Newer methodologies that directly measure GFR are in clinical trials and offer the ability to rapidly and noninvasively provide accurate estimates of drug clearance as well as detection of nephrotoxicity. These methods offer the opportunity to refine drug dosing and improve outcomes.10.34067/KID.0000952019Mon, 13 Jan 2020 05:30:09 GMT-08:00GFR Measurement and Chemotherapy Dosing in Patients with Kidney Disease and CancerChemotherapeutic agents require precise dosing to ensure optimal efficacy and minimize complications. For those agents that are removed from the body by the kidney, accurate knowledge of GFR is critical. In addition, GFR needs to be determined rapidly, easily, and, if possible, with little additional cost. The ability to easily measure GFR also allows for rapid detection of nephrotoxicity. Current methodologies include direct clearance measurement of an indicator substance or estimation of creatinine clearance or GFR through regression equations that use a serum marker, such as creatinine or cystatin C. These methodologies all have shortfalls and limitations, some of which are specific to the patient with cancer. Newer methodologies that directly measure GFR are in clinical trials and offer the ability to rapidly and noninvasively provide accurate estimates of drug clearance as well as detection of nephrotoxicity. These methods offer the opportunity to refine drug dosing and improve outcomes.McMahon, Blaithin A.Rosner, Mitchell H.2020-01-13T05:30:09-08:00doi:10.34067/KID.0000952019hwp:resource-id:kidney360;1/2/141American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Nephro-Pharmacology, cancer, chemotherapy, creatinine, cystatin C, glomerular filtration rate, kidney functionReview ArticlesReview Articlesreview-article20202020-02-2710.34067/KID.00009520192641-76502020-01-13T05:30:09-08:002020-02-27Kidney360Review Articles12141150http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000252019?cct=218810.34067/KID.0000252019Thu, 27 Feb 2020 08:33:17 GMT-08:00Hypertension and Acute Kidney Injury following an Allograft BiopsyZafar, Zubair SaeedP. Marin, Ethan2020-02-27T08:33:17-08:00doi:10.34067/KID.0000252019hwp:resource-id:kidney360;1/2/152American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Hypertension, Transplantation, Acute Kidney Injury, Allografts, Aneurysm, False, Biopsy, Hypertension, Page kidney, renal biopsy, subcapsular hematoma, Transplantation, HomologousClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisother20202020-02-2710.34067/KID.00002520192641-76502020-02-27T08:33:17-08:002020-02-27Kidney360Clinical Images in Nephrology and Dialysis12152153http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000072019?cct=218810.34067/KID.0000072019Tue, 21 Jan 2020 07:11:18 GMT-08:00Prevalence and Persistence of Uremic Symptoms in Incident Dialysis PatientsRhee, Eugene P.Guallar, EliseoHwang, SeungyoungKim, NooriTonelli, MarcelloMoe, Sharon M.Himmelfarb, JonathanThadhani, Ravi I.Powe, Neil R.Shafi, Tariq2020-01-21T07:11:18-08:00doi:10.34067/KID.0000072019hwp:resource-id:kidney360;1/2/86American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Quality of Life, Renal Dialysis, Symptoms, UremiaOriginal InvestigationsDialysisOriginal InvestigationsDialysisresearch-article20202020-02-2710.34067/KID.00000720192641-76502020-01-21T07:11:18-08:002020-02-27Kidney360Original Investigations128692http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000852019?cct=2188Immune checkpoint inhibitors (ICPIs) have transformed the landscape of oncology, but are associated with a variety of autoimmune adverse events, including AKI. ICPI-associated AKI (ICPI-AKI) is emerging as an increasingly frequent cause of AKI in patients with cancer, and poses unique diagnostic and management challenges to clinicians who care for these patients. In this review, we describe the incidence and risk factors for ICPI-AKI, including proton pump inhibitor use, CKD, and combination immunotherapy. We discuss the limitations of the various definitions used for ICPI-AKI in prior studies, and propose a novel classification system (definite, probable, and possible ICPI-AKI) that recognizes the diagnostic uncertainty inherent in many cases. We discuss the key clinicopathologic features and treatment strategies for ICPI-AKI, including the role of kidney biopsy versus empirical treatment with steroids. We also explore the under-studied area of ICPI use in the setting of solid organ transplantation, where nephrologists and oncologists must balance the risk of rejection versus treating the underlying malignancy. Finally, we summarize existing data on the role of ICPI rechallenge after an episode of ICPI-AKI.10.34067/KID.0000852019Tue, 14 Jan 2020 05:30:09 GMT-08:00Immune Checkpoint Inhibitor Nephrotoxicity: Update 2020Immune checkpoint inhibitors (ICPIs) have transformed the landscape of oncology, but are associated with a variety of autoimmune adverse events, including AKI. ICPI-associated AKI (ICPI-AKI) is emerging as an increasingly frequent cause of AKI in patients with cancer, and poses unique diagnostic and management challenges to clinicians who care for these patients. In this review, we describe the incidence and risk factors for ICPI-AKI, including proton pump inhibitor use, CKD, and combination immunotherapy. We discuss the limitations of the various definitions used for ICPI-AKI in prior studies, and propose a novel classification system (definite, probable, and possible ICPI-AKI) that recognizes the diagnostic uncertainty inherent in many cases. We discuss the key clinicopathologic features and treatment strategies for ICPI-AKI, including the role of kidney biopsy versus empirical treatment with steroids. We also explore the under-studied area of ICPI use in the setting of solid organ transplantation, where nephrologists and oncologists must balance the risk of rejection versus treating the underlying malignancy. Finally, we summarize existing data on the role of ICPI rechallenge after an episode of ICPI-AKI.Gupta, ShrutiCortazar, Frank B.Riella, Leonardo V.Leaf, David E.2020-01-14T05:30:09-08:00doi:10.34067/KID.0000852019hwp:resource-id:kidney360;1/2/130American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Clinical Nephrology, Acute Kidney Injury and ICU Nephrology, Nephro-Pharmacology, acute interstitial nephritis, Acute kidney injury, acute tubulointerstitial nephritis, immune-related adverse event, immunotherapyReview ArticlesReview Articlesreview-article20202020-02-2710.34067/KID.00008520192641-76502020-01-14T05:30:09-08:002020-02-27Kidney360Review Articles12130140http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000692019?cct=218810.34067/KID.0000692019Mon, 03 Feb 2020 05:30:09 GMT-08:00Oxidized-ATP Attenuates Kidney Allograft Rejection By Inhibiting T-Cell, B-Cell, and Macrophage ActivityDing, XiangWilson, Nancy A.Redfield, Robert R.Panzer, Sarah E.Verhoven, BretReese, Shannon R.Zhong, WeixiongShi, LeiBurlingham, William J.Denlinger, Loren C.Djamali, Arjang2020-02-03T05:30:09-08:00doi:10.34067/KID.0000692019hwp:resource-id:kidney360;1/2/106American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Transplantation, allograft, Antibody mediated rejection, B cell, IL6, Kidney transplantation, Macrophages, oATP, P2X7R, purinergic receptor, Rejection, T cell, Basic ScienceOriginal InvestigationsTransplantationOriginal InvestigationsTransplantationresearch-article20202020-02-2710.34067/KID.00006920192641-76502020-02-03T05:30:09-08:002020-02-27Kidney360Original Investigations12106114http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000122019?cct=218810.34067/KID.0000122019Thu, 27 Feb 2020 08:33:17 GMT-08:00Acute Bilateral Knee Pain in a Dialysis Patient with Severe Secondary HyperparathyroidismAllon, Michael2020-02-27T08:33:17-08:00doi:10.34067/KID.0000122019hwp:resource-id:kidney360;1/2/151American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Hyperparathyroidism, Secondary, Magnetic Resonance Imaging, Parathyroidectomy, Patellar Ligament, Renal Dialysis, RuptureClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-02-2710.34067/KID.00001220192641-76502020-02-27T08:33:17-08:002020-02-27Kidney360Clinical Images in Nephrology and Dialysis12151151http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050521?cct=218810.1681/ASN.2019050521Fri, 29 May 2020 08:26:18 GMT-07:00Prevalence and Risk Factors for CKD in the General Population of Southwestern NicaraguaFerguson, RyanLeatherman, SarahFiore, MadelineMinnings, KaileyMosco, MarthaKaufman, JamesKerns, EricAmador, Juan JoseBrooks, Daniel R.Fiore, MelissaParekh, Rulan S.Fiore, Louis2020-05-29T08:26:18-07:00doi:10.1681/ASN.2019050521hwp:resource-id:jnephrol;31/7/1585American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyMesoamerican nephropathy, Nicaragua, chronic kidney disease, renal insufficiency, public health, epidemiologyClinical EpidemiologyClinical Epidemiologyresearch-article20202020-07-01July 202010.1681/ASN.20190505211046-66731533-34502020-05-29T08:26:18-07:002020-07Journal of the American Society of NephrologyClinical Epidemiology31715851593http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080852?cct=218810.1681/ASN.2019080852Mon, 01 Jun 2020 02:02:41 GMT-07:00Gut Microbial Metabolites Induce Donor-Specific Tolerance of Kidney Allografts through Induction of T Regulatory Cells by Short-Chain Fatty AcidsWu, HuilingSinger, JulianKwan, Tony K.Loh, Yik WenWang, ChuanminTan, JianLi, Yan J.Lai, Sum Wing ChristinaMacia, LaurenceAlexander, Stephen I.Chadban, Steven J.2020-06-01T14:02:41-07:00doi:10.1681/ASN.2019080852hwp:resource-id:jnephrol;31/7/1445American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologytransplantation, acute allograft rejection, tolerance, chronic allograft rejection, immunologyBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20190808521046-66731533-34502020-06-01T14:02:41-07:002020-07Journal of the American Society of NephrologyBasic Research31771445141714611418http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090956?cct=218810.1681/ASN.2019090956Fri, 05 Jun 2020 09:32:14 GMT-07:00Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic CystinosisDe Leo, EsterElmonem, Mohamed A.Berlingerio, Sante PrincieroBerquez, MarineFesta, Beatrice PaolaRaso, RobertoBellomo, FrancescoStarborg, TobiasJanssen, Manoe JacobaAbbaszadeh, ZeinabCairoli, SaraGoffredo, Bianca MariaMasereeuw, RosalindeDevuyst, OlivierLowe, MartinLevtchenko, ElenaLuciani, AlessandroEmma, FrancescoRega, Laura Rita2020-06-05T09:32:14-07:00doi:10.1681/ASN.2019090956hwp:resource-id:jnephrol;31/7/1522American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologylysosomal storage disease, autophagy, endocytosis, apoptosis, reactiveBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20190909561046-66731533-34502020-06-05T09:32:14-07:002020-07Journal of the American Society of NephrologyBasic Research31715221537http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050702?cct=218810.1681/ASN.2020050702Thu, 11 Jun 2020 07:13:30 GMT-07:00In Memorium: Burton Rose, 1942–2020Hoenig, Melanie P.Steinman, Theodore I.Pollak, Martin R.Zeidel, Mark L.2020-06-11T07:13:30-07:00doi:10.1681/ASN.2020050702hwp:resource-id:jnephrol;31/7/1421American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyObituary, JASN, RoseUp Front MattersObituariesUp Front MattersObituariesother20202020-07-01July 202010.1681/ASN.20200507021046-66731533-34502020-06-11T07:13:30-07:002020-07Journal of the American Society of NephrologyUp Front Matters31714211422http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080767?cct=218810.1681/ASN.2019080767Mon, 18 May 2020 01:11:01 GMT-07:00Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in MiceSilva Barbosa, Anne C.Zhou, DongXie, YangChoi, You-JinTung, Hung-ChunChen, XinyunXu, MeishuGibbs, Robert B.Poloyac, Samuel M.Liu, SilviaYu, YanpingLuo, JianhuaLiu, YouhuaXie, Wen2020-05-18T13:11:01-07:00doi:10.1681/ASN.2019080767hwp:resource-id:jnephrol;31/7/1496American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyacute kidney injury, renal ischemia-reperfusion, estrogen sulfotransferase, kidney-liver crosstalk, calcitriolBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20190807671046-66731533-34502020-05-18T13:11:01-07:002020-07Journal of the American Society of NephrologyBasic Research31714961508http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080848?cct=218810.1681/ASN.2019080848Mon, 18 May 2020 01:11:01 GMT-07:00Early Predictors of Arteriovenous Fistula Maturation: A Novel Perspective on an Enduring ProblemFarrington, Crystal A.Robbin, Michelle L.Lee, TimmyBarker-Finkel, JillAllon, Michael2020-05-18T13:11:01-07:00doi:10.1681/ASN.2019080848hwp:resource-id:jnephrol;31/7/1617American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyarteriovenous fistula, vascular mapping, ultrasound, maturation, arterial diameterClinical ResearchClinical Researchresearch-article20202020-07-01July 202010.1681/ASN.20190808481046-66731533-34502020-05-18T13:11:01-07:002020-07Journal of the American Society of NephrologyClinical Research31716171627http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060623?cct=218810.1681/ASN.2019060623Wed, 03 Jun 2020 06:22:57 GMT-07:00Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in JapanAkizawa, TadaoIwasaki, ManabuYamaguchi, YusukeMajikawa, YoshikatsuReusch, Michael2020-06-03T06:22:57-07:00doi:10.1681/ASN.2019060623hwp:resource-id:jnephrol;31/7/1628American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, roxadustat, anemia, darbepoetin alfa, hemodialysis, clinical trialClinical ResearchClinical Researchresearch-article20202020-07-01July 202010.1681/ASN.20190606231046-66731533-34502020-06-03T06:22:57-07:002020-07Journal of the American Society of NephrologyClinical Research31744162810051005163910051007http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090879?cct=218810.1681/ASN.2019090879Tue, 02 Jun 2020 09:18:14 GMT-07:00Neutrophil Gelatinase–Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting TH17 ImmunitySchreiber, AdrianRousselle, AnthonyKlocke, JanBachmann, SebastianPopovic, SuncicaBontscho, JuliaSchmidt-Ott, Kai M.Siffrin, VolkerJerke, UweAshraf, Muhammad ImtiazPanzer, UlfKettritz, Ralph2020-06-02T09:18:14-07:00doi:10.1681/ASN.2019090879hwp:resource-id:jnephrol;31/7/1569American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyANCA glomerulonephritis, ngal, TH17, neutrophilBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20190908791046-66731533-34502020-06-02T09:18:14-07:002020-07Journal of the American Society of NephrologyBasic Research31715691584http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050624?cct=218810.1681/ASN.2020050624Mon, 01 Jun 2020 02:02:41 GMT-07:00Authors' ReplyMacdougall, Iain C.Ford, Ian2020-06-01T14:02:41-07:00doi:10.1681/ASN.2020050624hwp:resource-id:jnephrol;31/7/1654American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyLetters to the EditorLetters to the Editorletter20202020-07-01July 202010.1681/ASN.20200506241046-66731533-34502020-06-01T14:02:41-07:002020-07Journal of the American Society of NephrologyLetters to the Editor31771654165316541654http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101121?cct=218810.1681/ASN.2019101121Tue, 02 Jun 2020 09:18:11 GMT-07:00Expanded Imaging Classification of Autosomal Dominant Polycystic Kidney DiseaseBae, Kyongtae T.Shi, TiangeTao, ChengYu, Alan S. L.Torres, Vicente E.Perrone, Ronald D.Chapman, Arlene B.Brosnahan, GodelaSteinman, Theodore I.Braun, William E.Srivastava, AvantikaIrazabal, Maria V.Abebe, Kaleab Z.Harris, Peter C.Landsittel, Douglas P.,2020-06-02T09:18:11-07:00doi:10.1681/ASN.2019101121hwp:resource-id:jnephrol;31/7/1640American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyADPKD, clinical trial, kidney volume, risk factorsClinical ResearchClinical Researchresearch-article20202020-07-01July 202010.1681/ASN.20191011211046-66731533-34502020-06-02T09:18:11-07:002020-07Journal of the American Society of NephrologyClinical Research31716401651http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050669?cct=218810.1681/ASN.2020050669Fri, 05 Jun 2020 09:32:14 GMT-07:00Gerhard Giebisch (1927–2020): A Leader in Kidney PhysiologyMurer, HeiniWagner, Carsten A.2020-06-05T09:32:14-07:00doi:10.1681/ASN.2020050669hwp:resource-id:jnephrol;31/7/1419American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyObituary, Giebisch, Cell & Transport PhysiologyUp Front MattersObituariesUp Front MattersObituariesother20202020-07-01July 202010.1681/ASN.20200506691046-66731533-34502020-06-05T09:32:14-07:002020-07Journal of the American Society of NephrologyUp Front Matters31714191420http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040540?cct=218810.1681/ASN.2020040540Mon, 01 Jun 2020 02:02:41 GMT-07:00At the Crossroads for Intravenous Iron DosingKshirsagar, Abhijit V.Li, XiaojuanRobinson, Bruce M.Brookhart, M. Alan2020-06-01T14:02:41-07:00doi:10.1681/ASN.2020040540hwp:resource-id:jnephrol;31/7/1653American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyclinical nephrology, dialysis, anemiaLetters to the EditorLetters to the Editorletter20202020-07-01July 202010.1681/ASN.20200405401046-66731533-34502020-06-01T14:02:41-07:002020-07Journal of the American Society of NephrologyLetters to the Editor31771653165416541654http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101032?cct=218810.1681/ASN.2019101032Mon, 15 Jun 2020 09:37:08 GMT-07:00Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric GlomerulosclerosisFeng, DiKumar, MukeshMuntel, JanGurley, Susan B.Birrane, GabrielStillman, Isaac E.Ding, LaiWang, MinxianAhmed, SaimaSchlondorff, JohannesAlper, Seth L.Ferrante, TomMarquez, Susan L.Ng, Carlos F.Novak, RichardIngber, Donald E.Steen, HannoPollak, Martin R.2020-06-15T09:37:08-07:00doi:10.1681/ASN.2019101032hwp:resource-id:jnephrol;31/7/1479American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, focal segmental glomerulosclerosis, glomerular disease, cytoskeleton, podocyte, proteinuriaBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20191010321046-66731533-34502020-06-15T09:37:08-07:002020-07Journal of the American Society of NephrologyBasic Research31714791495http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020151?cct=218810.1681/ASN.2020020151Thu, 04 Jun 2020 05:58:30 GMT-07:00GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based CohortsEriksen, Bjørn O.Palsson, RunolfurEbert, NatalieMelsom, Toralfvan der Giet, MarkusGudnason, VilmundurIndridason, Olafur S.Inker, Lesley A.Jenssen, Trond G.Levey, Andrew S.Solbu, Marit D.Tighiouart, HocineSchaeffner, Elke2020-06-04T05:58:30-07:00doi:10.1681/ASN.2020020151hwp:resource-id:jnephrol;31/7/1602American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyepidemiology and outcomes, geriatric nephrology, glomerular filtration rate, glomerular hyperfiltration, renal dysfunction, renal function declineClinical EpidemiologyClinical Epidemiologyresearch-article20202020-07-01July 202010.1681/ASN.20200201511046-66731533-34502020-06-04T05:58:30-07:002020-07Journal of the American Society of NephrologyClinical Epidemiology31716021615http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019111205?cct=218810.1681/ASN.2019111205Tue, 09 Jun 2020 06:33:09 GMT-07:00CKD Increases Carbonylation of HDL and Is Associated with Impaired Antiaggregant PropertiesFlorens, NansCalzada, CatherineLemoine, SandrineBoulet, Marie MichèleGuillot, NicolasBarba, ChristopheRoux, JulieDelolme, FrédericPage, AdelinePoux, Jean MichelLaville, MauriceMoulin, PhilippeSoulère, LaurentGuebre-Egziabher, FitsumJuillard, LaurentSoulage, Christophe O.2020-06-09T06:33:09-07:00doi:10.1681/ASN.2019111205hwp:resource-id:jnephrol;31/7/1462American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, platelets, cardiovascular disease, dyslipidemia, thrombosis, dialysisBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20191112051046-66731533-34502020-06-09T06:33:09-07:002020-07Journal of the American Society of NephrologyBasic Research31714621477http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070728?cct=218810.1681/ASN.2019070728Thu, 11 Jun 2020 07:13:30 GMT-07:00Uremic Toxic Blood-Brain Barrier Disruption Mediated by AhR Activation Leads to Cognitive Impairment during Experimental Renal DysfunctionBobot, MickaëlThomas, LaurentMoyon, AnaïsFernandez, SamanthaMcKay, NathalieBalasse, LaureGarrigue, PhilippeBrige, PaulineChopinet, SophiePoitevin, StéphaneCérini, ClaireBrunet, PhilippeDignat-George, FrançoiseBurtey, StéphaneGuillet, BenjaminHache, Guillaume2020-06-11T07:13:30-07:00doi:10.1681/ASN.2019070728hwp:resource-id:jnephrol;31/7/1509American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, uremia, dementiaBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20190707281046-66731533-34502020-06-11T07:13:30-07:002020-07Journal of the American Society of NephrologyBasic Research31715091521http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050733?cct=218810.1681/ASN.2020050733Tue, 30 Jun 2020 10:00:32 GMT-07:00This Month's HighlightsAmerican Society of Nephrology2020-06-30T10:00:32-07:00doi:10.1681/ASN.2020050733hwp:resource-id:jnephrol;31/7/iAmerican Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyThis Month’s HighlightsThis Month’s Highlightsin-brief20202020-07-01July 202010.1681/ASN.20200507331046-66731533-34502020-06-30T10:00:32-07:002020-07Journal of the American Society of NephrologyThis Month’s Highlights317iihttp://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020232?cct=218810.1681/ASN.2020020232Tue, 02 Jun 2020 09:18:13 GMT-07:00Renomedullary Interstitial Cell Endothelin A Receptors Regulate BP and Renal FunctionHu, ChunyanLakshmipathi, JayalakshmiStuart, DeborahPeti-Peterdi, JanosGyarmati, GeorginaHao, Chuan-MingHansell, PeterKohan, Donald E.2020-06-02T09:18:13-07:00doi:10.1681/ASN.2020020232hwp:resource-id:jnephrol;31/7/1555American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyrenomedullary, interstitial cell, blood pressure, endothelin receptorBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20200202321046-66731533-34502020-06-02T09:18:13-07:002020-07Journal of the American Society of NephrologyBasic Research31715551568http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10320819?cct=218810.2215/CJN.10320819Fri, 26 Jun 2020 07:25:19 GMT-07:00Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance HemodialysisGamboa, Jorge L.Roshanravan, BabackTowse, TheodoreKeller, Chad A.Falck, Aaron M.Yu, ChangFrontera, Walter R.Brown, Nancy J.Ikizler, T. Alp2020-06-26T07:25:19-07:00doi:10.2215/CJN.10320819hwp:resource-id:clinjasn;15/7/926American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologymitochondria, hemodialysis, Skeletal muscle, chronic kidney disease, Chronic inflammation, oxidative stress, Sarcopenia, Frailty, Mitochondrial Dynamics, Phosphocreatine, Phosphorus, Walk Test, Mitochondria, Muscle, DNM1L protein, human, Mitochondrial Proteins, Microtubule-Associated Proteins, Magnetic Resonance Spectroscopy, Muscle, Skeletal, Renal Insufficiency, Chronic, InflammationOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-07-01July 01, 202010.2215/CJN.103208191555-90411555-905X2020-06-26T07:25:19-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles1577926912936913http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00900120?cct=218810.2215/CJN.00900120Thu, 25 Jun 2020 10:36:31 GMT-07:00Patient and Caregiver Perspectives on Terms Used to Describe Kidney HealthTong, AllisonLevey, Andrew S.Eckardt, Kai-UweAnumudu, SamayaArce, Cristina M.Baumgart, AmandaDunn, LoueseGutman, TaliaHarris, TessLightstone, LizScholes-Robertson, NicoleShen, Jenny I.Wheeler, David C.White, David M.Wilkie, MartinCraig, Jonathan C.Jadoul, MichelWinkelmayer, Wolfgang C.2020-06-25T10:36:31-07:00doi:10.2215/CJN.00900120hwp:resource-id:clinjasn;15/7/937American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycommunication, education, nomenclature, patient-centered care, chronic kidney disease, caregivers, focus groups, judgment, self-management, ownership, language, prognosis, personal satisfaction, renal insufficiency, chronic, kidney failure, decision making, patient participation, fear, patient-centered care, AustraliaOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-07-01July 01, 202010.2215/CJN.009001201555-90411555-905X2020-06-25T10:36:31-07:002020-07-01Clinical Journal of the American Society of NephrologyOriginal Articles15777937907914948908916http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13761119?cct=2188The overall kidney survival among lupus nephritis patients has improved with currently used induction immunosuppression regimens of corticosteroids and either cyclophosphamide or mycophenolate mofetil; however, there still remains a significant number of lupus nephritis patients who do not achieve remission with these regimens. Investigators have looked at other immunosuppressive regimens for lupus nephritis, and there has been interest in the use of calcineurin inhibitors in this regard. Calcineurin inhibitors are potentially an attractive option because of their established ability to inhibit T cell function, attenuate proteinuria through non-immunologic means, and their safety in pregnancy and lactation. In this review, we discuss the findings and limitations of selected trials that evaluated the use of calcineurin inhibitors in the treatment of lupus nephritis, either with corticosteroids alone or as a component of multitarget therapy when combined with mycophenolate mofetil. There may be a role for calcineurin inhibitors among patients with heavy proteinuria, as well as younger patients with refractory lupus nephritis. The multitarget therapy trials reveal higher rates of remission compared with mycophenolate mofetil alone and cyclophosphamide; however, some trials highlight the possibility of more infectious adverse events. We discuss the need for further study of calcineurin inhibitors in more diverse patient populations and the need for trials with longer follow-up with “hard” endpoints beyond proteinuria reduction, such as worsening CKD or repeat protocol biopsies, given the calcineurin inhibitors ability to reduce proteinuria non-immunologically and thus increased rate of relapse when the drug is tapered. While there may indeed be a space for calcineurin inhibitors to help increase remission rates in lupus nephritis patients, more work is needed to help address the questions the studies available to date have yet to answer.10.2215/CJN.13761119Mon, 09 Mar 2020 06:34:41 GMT-07:00The Evolving Role of Calcineurin Inhibitors in Treating Lupus NephritisThe overall kidney survival among lupus nephritis patients has improved with currently used induction immunosuppression regimens of corticosteroids and either cyclophosphamide or mycophenolate mofetil; however, there still remains a significant number of lupus nephritis patients who do not achieve remission with these regimens. Investigators have looked at other immunosuppressive regimens for lupus nephritis, and there has been interest in the use of calcineurin inhibitors in this regard. Calcineurin inhibitors are potentially an attractive option because of their established ability to inhibit T cell function, attenuate proteinuria through non-immunologic means, and their safety in pregnancy and lactation. In this review, we discuss the findings and limitations of selected trials that evaluated the use of calcineurin inhibitors in the treatment of lupus nephritis, either with corticosteroids alone or as a component of multitarget therapy when combined with mycophenolate mofetil. There may be a role for calcineurin inhibitors among patients with heavy proteinuria, as well as younger patients with refractory lupus nephritis. The multitarget therapy trials reveal higher rates of remission compared with mycophenolate mofetil alone and cyclophosphamide; however, some trials highlight the possibility of more infectious adverse events. We discuss the need for further study of calcineurin inhibitors in more diverse patient populations and the need for trials with longer follow-up with “hard” endpoints beyond proteinuria reduction, such as worsening CKD or repeat protocol biopsies, given the calcineurin inhibitors ability to reduce proteinuria non-immunologically and thus increased rate of relapse when the drug is tapered. While there may indeed be a space for calcineurin inhibitors to help increase remission rates in lupus nephritis patients, more work is needed to help address the questions the studies available to date have yet to answer.Peleg, YonatanBomback, Andrew S.Radhakrishnan, Jai2020-03-09T06:34:41-07:00doi:10.2215/CJN.13761119hwp:resource-id:clinjasn;15/7/1066American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyPregnancy, lupus nephritis, Calcineurin Inhibitors, Mycophenolic Acid, Follow-Up Studies, T-Lymphocytes, Cyclophosphamide, Immunosuppressive Agents, immunosuppression, proteinuria, Lactation, Adrenal Cortex Hormones, Recurrence, Biopsy, Infections, Renal Insufficiency, ChronicReviewReviewreview-article20202020-07-01July 01, 202010.2215/CJN.137611191555-90411555-905X2020-03-09T06:34:41-07:002020-07-01Clinical Journal of the American Society of NephrologyReview15710661072http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13061019?cct=218810.2215/CJN.13061019Mon, 27 Apr 2020 08:36:27 GMT-07:00The Feasibility and Safety of Obtaining Research Kidney Biopsy Cores in Patients with DiabetesHogan, Jonathan J.Owen, Jonathan G.Blady, Shira J.Almaani, SalemAvasare, Rupali S.Bansal, ShwetaLenz, OliverLuciano, Randy L.Parikh, Samir V.Ross, Michael J.Sharma, DeepSzerlip, HaroldWadhwani, ShikhaTownsend, Raymond R.Palmer, Matthew B.Susztak, KatalinMottl, Amy K.,2020-04-27T08:36:27-07:00doi:10.2215/CJN.13061019hwp:resource-id:clinjasn;15/7/1024American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney biopsy, diabetic nephropathy, Feasibility Studies, Biopsy, diabetes mellitusResearch LetterResearch Letterresearch-article20202020-07-01July 01, 202010.2215/CJN.130610191555-90411555-905X2020-04-27T08:36:27-07:002020-07-01Clinical Journal of the American Society of NephrologyResearch Letter15710241026http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04370420?cct=218810.2215/CJN.04370420Thu, 23 Apr 2020 06:00:39 GMT-07:00Genetic Roadmap for Kidney Involvement of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) InfectionZhang, Yue-miaoZhang, Hong2020-04-23T06:00:39-07:00doi:10.2215/CJN.04370420hwp:resource-id:clinjasn;15/7/1044American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyCOVID-19, kidney involvement, severe acute respiratory syndrome coronavirus 2, human ACE2, genetic perspectivePerspectivesPerspectivesresearch-article20202020-07-01July 01, 202010.2215/CJN.043704201555-90411555-905X2020-04-23T06:00:39-07:002020-07-01Clinical Journal of the American Society of NephrologyPerspectives15710441046http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11860919?cct=218810.2215/CJN.11860919Mon, 24 Feb 2020 09:10:56 GMT-08:00EHR-Based Clinical TrialsAbdel-Kader, KhaledJhamb, Manisha2020-02-24T09:10:56-08:00doi:10.2215/CJN.11860919hwp:resource-id:clinjasn;15/7/1050American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyelectronic health record, pragmatic, chronic kidney disease, acute kidney injury, humans, creatinine, kidney transplantation, nephrology, albuminuria, electronic health records, explosions, prevalence, blood pressure, translational medical research, patient selection, risk factors, developed countries, renal dialysis, chronic renal insufficiency, kidney, registries, biomarkers, phenotype, randomized controlled trialsPerspectivesPerspectivesresearch-article20202020-07-01July 01, 202010.2215/CJN.118609191555-90411555-905X2020-02-24T09:10:56-08:002020-07-01Clinical Journal of the American Society of NephrologyPerspectives15710501052http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13221019?cct=218810.2215/CJN.13221019Wed, 08 Apr 2020 11:34:34 GMT-07:00Mineralocorticoid Receptor Antagonists in ESKDAgarwal, AdhishCheung, Alfred K.2020-04-08T11:34:34-07:00doi:10.2215/CJN.13221019hwp:resource-id:clinjasn;15/7/1047American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyHumans, mineralocorticoid receptor antagonists, renal dialysis, aldosterone, mineralocorticoids, cardiovascular diseases, risk factors, chronic kidney failure, chronic renal insufficiency, hyperaldosteronism, heart failure, diabetes mellitus, hospitalization, Kidney Failure, ChronicPerspectivesPerspectivesresearch-article20202020-07-01July 01, 202010.2215/CJN.132210191555-90411555-905X2020-04-08T11:34:34-07:002020-07-01Clinical Journal of the American Society of NephrologyPerspectives15710471049http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.15771219?cct=2188Genome-wide association studies (GWASs) have facilitated the unbiased discovery of hundreds of genomic loci associated with CKD and kidney function. The vast majority of disease-associated DNA variants are noncoding. Those that are causal in CKD pathogenesis likely modulate transcription of target genes in a cell type–specific manner. To gain novel biological insights into mechanisms driving the development of CKD, the causal variants (which are usually not the most significant variant reported in a GWAS), their target genes, and causal cell types need to be identified. This functional validation requires a large number of new data sets, complex bioinformatics analyses, and experimental cellular and in vivo studies. Here, we review the basic principles and some of the current approaches being leveraged to assign functional significance to a genotype–phenotype association.10.2215/CJN.15771219Mon, 08 Jun 2020 05:28:45 GMT-07:00Complexities of Understanding Function from CKD-Associated DNA VariantsGenome-wide association studies (GWASs) have facilitated the unbiased discovery of hundreds of genomic loci associated with CKD and kidney function. The vast majority of disease-associated DNA variants are noncoding. Those that are causal in CKD pathogenesis likely modulate transcription of target genes in a cell type–specific manner. To gain novel biological insights into mechanisms driving the development of CKD, the causal variants (which are usually not the most significant variant reported in a GWAS), their target genes, and causal cell types need to be identified. This functional validation requires a large number of new data sets, complex bioinformatics analyses, and experimental cellular and in vivo studies. Here, we review the basic principles and some of the current approaches being leveraged to assign functional significance to a genotype–phenotype association.Lin, JennieSusztak, Katalin2020-06-08T05:28:45-07:00doi:10.2215/CJN.15771219hwp:resource-id:clinjasn;15/7/1028American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyKidney Genomics Series, Genome-Wide Association Study, Computational Biology, Genomics, Genetic Association Studies, Renal Insufficiency, Chronic, DNAGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-07-01July 01, 202010.2215/CJN.157712191555-90411555-905X2020-06-08T05:28:45-07:002020-07-01Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease15710281040http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08730620?cct=218810.2215/CJN.08730620Thu, 25 Jun 2020 10:36:32 GMT-07:00Nephrology Nomenclature: How to Accelerate Patient Anxiety, Suppress Engagement, and Mire the Advance of Medical InnovationConway, Paul T.2020-06-25T10:36:32-07:00doi:10.2215/CJN.08730620hwp:resource-id:clinjasn;15/7/907American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyAnxiety, Kidney Precision Medicine Project, KidneyX, Kidney Health Initiative, Patient Engagement, Advancing American Kidney Health, Pre-Dialysis, CKD stages, End Stage Renal Disease, Communication, Education, Nomenclature, Patient-Centered Care, Chronic Kidney Disease, Caregivers, Focus Groups, Judgment, Self-Management, Ownership, Language, Prognosis, Personal Satisfaction, Renal Insufficiency, Chronic, Kidney Failure, Chronic, Decision Making, Patient Participation, Fear, Patient-Centered CarePatient VoicePatient Voiceeditorial20202020-07-01July 01, 202010.2215/CJN.087306201555-90411555-905X2020-06-25T10:36:32-07:002020-07-01Clinical Journal of the American Society of NephrologyPatient Voice1577907937908948http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12661019?cct=218810.2215/CJN.12661019Mon, 24 Feb 2020 09:10:56 GMT-08:00Understanding WorkRosner, Mitchell HowardFalk, Ronald J.2020-02-24T09:10:56-08:00doi:10.2215/CJN.12661019hwp:resource-id:clinjasn;15/7/1053American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyproductivity, relative value unit, benchmark, aged, humans, United States, relative value scales, current procedural terminology, U.S. Centers for Medicare and Medicaid Services, American Medical Association, nephrology, Medicaid, Medicare, efficiency, physicians, office visits, malpractice, renal dialysis, fibrinogenPerspectivesPerspectivesresearch-article20202020-07-01July 01, 202010.2215/CJN.126610191555-90411555-905X2020-02-24T09:10:56-08:002020-07-01Clinical Journal of the American Society of NephrologyPerspectives157121053183210551834http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121331?cct=2188Optimal care occurs when patients possess the skills, knowledge, and confidence needed to effectively manage their health. Promoting such patient activation in kidney disease care is increasingly being prioritized, and patient activation has recently emerged as central to kidney disease legislative policy in the United States. Two options of the Centers for Medicare and Medicaid Services Kidney Care Choices model—the Kidney Care First option and the Comprehensive Kidney Care Contracting option—now include patient activation as a quality metric; both models specifically name the patient activation measure (PAM) as the patient-reported outcome to use when assessing activation in kidney disease. Because nephrology practices participating in these models will receive capitated payments according to changes in patients’ PAM scores, it is time to more critically evaluate this measure as it applies to patients with kidney disease. In this review, we raise important issues related to the PAM’s applicability to kidney health, review and summarize existing literature that applies this measure to patients with kidney disease, and outline key elements to consider when implementing the PAM into practice and policy. Our aim is to spur further dialogue regarding how to assess and address patient activation in kidney disease to facilitate best practices for supporting patients in the successful management of their kidney health.10.1681/ASN.2019121331Thu, 11 Jun 2020 07:13:31 GMT-07:00Measuring Patient Activation as Part of Kidney Disease Policy: Are We There Yet?Optimal care occurs when patients possess the skills, knowledge, and confidence needed to effectively manage their health. Promoting such patient activation in kidney disease care is increasingly being prioritized, and patient activation has recently emerged as central to kidney disease legislative policy in the United States. Two options of the Centers for Medicare and Medicaid Services Kidney Care Choices model—the Kidney Care First option and the Comprehensive Kidney Care Contracting option—now include patient activation as a quality metric; both models specifically name the patient activation measure (PAM) as the patient-reported outcome to use when assessing activation in kidney disease. Because nephrology practices participating in these models will receive capitated payments according to changes in patients’ PAM scores, it is time to more critically evaluate this measure as it applies to patients with kidney disease. In this review, we raise important issues related to the PAM’s applicability to kidney health, review and summarize existing literature that applies this measure to patients with kidney disease, and outline key elements to consider when implementing the PAM into practice and policy. Our aim is to spur further dialogue regarding how to assess and address patient activation in kidney disease to facilitate best practices for supporting patients in the successful management of their kidney health.Nair, DevikaCavanaugh, Kerri L.2020-06-11T07:13:31-07:00doi:10.1681/ASN.2019121331hwp:resource-id:jnephrol;31/7/1435American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyPatient self-assessment, kidney disease, outcomesUp Front MattersReviewsUp Front MattersReviewsresearch-article20202020-07-01July 202010.1681/ASN.20191213311046-66731533-34502020-06-11T07:13:31-07:002020-07Journal of the American Society of NephrologyUp Front Matters31714351443http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010081?cct=2188Cardiac hypertrophy is a common feature in patients with CKD. Recent studies revealed that two phosphate regulators, fibroblast growth factor-23 and α-Klotho, are highly involved in the pathophysiologic process of CKD-induced cardiac hypertrophy. With decreasing renal function, elevated fibroblast growth factor-23 and decreased α-Klotho may contribute to cardiac hypertrophy by targeting the heart directly or by inducing systemic changes, such as vascular injury, hemodynamic disorders, and inflammation. However, several studies have demonstrated that disturbances in the fibroblast growth factor-23/α-Klotho axis do not lead to cardiac hypertrophy. In this review, we describe the cardiac effects of the fibroblast growth factor-23/α-Klotho axis and summarize recent progress in this field. In addition, we present not only the main controversies in this field but also provide possible directions to resolve these disputes.10.1681/ASN.2020010081Thu, 11 Jun 2020 07:13:31 GMT-07:00A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac HypertrophyCardiac hypertrophy is a common feature in patients with CKD. Recent studies revealed that two phosphate regulators, fibroblast growth factor-23 and α-Klotho, are highly involved in the pathophysiologic process of CKD-induced cardiac hypertrophy. With decreasing renal function, elevated fibroblast growth factor-23 and decreased α-Klotho may contribute to cardiac hypertrophy by targeting the heart directly or by inducing systemic changes, such as vascular injury, hemodynamic disorders, and inflammation. However, several studies have demonstrated that disturbances in the fibroblast growth factor-23/α-Klotho axis do not lead to cardiac hypertrophy. In this review, we describe the cardiac effects of the fibroblast growth factor-23/α-Klotho axis and summarize recent progress in this field. In addition, we present not only the main controversies in this field but also provide possible directions to resolve these disputes.Bao, Jing-FuHu, Pan-PanShe, Qin-YingLi, Aiqing2020-06-11T07:13:31-07:00doi:10.1681/ASN.2020010081hwp:resource-id:jnephrol;31/7/1423American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyfibroblast growth factor-23, α-Klotho, uremic cardiac hypertrophyUp Front MattersReviewsUp Front MattersReviewsresearch-article20202020-07-01July 202010.1681/ASN.20200100811046-66731533-34502020-06-11T07:13:31-07:002020-07Journal of the American Society of NephrologyUp Front Matters31714231434http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040461?cct=218810.1681/ASN.2020040461Mon, 01 Jun 2020 02:02:41 GMT-07:00Hemodialysis with Cohort Isolation to Prevent Secondary Transmission during a COVID-19 Outbreak in KoreaCho, Jang-HeeKang, Seok HuiPark, Hayne ChoKim, Dong KiLee, Sang-HoDo, Jun YoungPark, Jong WonKim, Seong NamKim, Myeong SeongJin, KyubokKang, Gun WooPark, Sun-HeeKim, Yong-LimLee, Young-Ki,2020-06-01T14:02:41-07:00doi:10.1681/ASN.2020040461hwp:resource-id:jnephrol;31/7/1398American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycoronavirus, hemodialysis units, end-stage renal disease, quarantine, cohort isolation, COVID-19Clinical ResearchClinical Researchresearch-article20202020-07-01July 202010.1681/ASN.20200404611046-66731533-34502020-06-01T14:02:41-07:002020-07Journal of the American Society of NephrologyClinical Research31713981408http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040470?cct=218810.1681/ASN.2020040470Thu, 28 May 2020 12:40:01 GMT-07:00Presentation and Outcomes of Patients with ESKD and COVID-19Valeri, Anthony M.Robbins-Juarez, Shelief Y.Stevens, Jacob S.Ahn, WooinRao, Maya K.Radhakrishnan, JaiGharavi, Ali G.Mohan, SumitHusain, S. Ali2020-05-28T12:40:01-07:00doi:10.1681/ASN.2020040470hwp:resource-id:jnephrol;31/7/1409American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycoronavirus, dialysis, Epidemiology and outcomes, ESRD, COVID-19Rapid CommunicationRapid Communicationresearch-article20202020-07-01July 202010.1681/ASN.20200404701046-66731533-34502020-05-28T12:40:01-07:002020-07Journal of the American Society of NephrologyRapid Communication31714091415http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030354?cct=218810.1681/ASN.2020030354Fri, 08 May 2020 01:21:53 GMT-07:00Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, ChinaXiong, FeiTang, HuiLiu, LiTu, CanTian, Jian-BoLei, Chun-TaoLiu, JingDong, Jun-WuChen, Wen-LiWang, Xiao-HuiLuo, DanShi, MingMiao, Xiao-PingZhang, Chun2020-05-08T13:21:53-07:00doi:10.1681/ASN.2020030354hwp:resource-id:jnephrol;31/7/1387American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCOVID-19, Clinical characteristics, Interventions, hemodialysisClinical EpidemiologyClinical Epidemiologyresearch-article20202020-07-01July 202010.1681/ASN.20200303541046-66731533-34502020-05-08T13:21:53-07:002020-07Journal of the American Society of NephrologyClinical Epidemiology31713871397http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040419?cct=218810.1681/ASN.2020040419Mon, 04 May 2020 10:56:16 GMT-07:00Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct PathophysiologyBatlle, DanielSoler, Maria JoseSparks, Matthew A.Hiremath, SwapnilSouth, Andrew M.Welling, Paul A.Swaminathan, Sundararaman,Sparks, Matthew A.Hiremath, SwapnilBatlle, DanielSouth, AndrewWelling, PaulLuther, J. MattCohen, JordanaByrd, James BrianBurrell, Louise M.Tomlinson, LaurieBhalla, VivekJosé Soler, MaríaSwaminathan, SundarRheault, Michelle N.Swaminathan, Sundar2020-05-04T10:56:16-07:00doi:10.1681/ASN.2020040419hwp:resource-id:jnephrol;31/7/1380American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyAcute kidney Injury, COVID-19, ACE2, Macrophage, ThromboticPerspectivePerspectiveresearch-article20202020-07-01July 202010.1681/ASN.20200404191046-66731533-34502020-05-04T10:56:16-07:002020-07Journal of the American Society of NephrologyPerspective31713801383http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050589?cct=218810.1681/ASN.2020050589Mon, 08 Jun 2020 05:30:27 GMT-07:00Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19Adamsick, Meagan L.Gandhi, Ronak G.Bidell, Monique R.Elshaboury, Ramy H.Bhattacharyya, Roby P.Kim, Arthur Y.Nigwekar, SagarRhee, Eugene P.Sise, Meghan E.2020-06-08T05:30:27-07:00doi:10.1681/ASN.2020050589hwp:resource-id:jnephrol;31/7/1384American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyacute renal failure, end-stage renal disease, antiviral, COVID-19PerspectivesPerspectivesresearch-article20202020-07-01July 202010.1681/ASN.20200505891046-66731533-34502020-06-08T05:30:27-07:002020-07Journal of the American Society of NephrologyPerspectives3172213845185191386519520http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040520?cct=218810.1681/ASN.2020040520Thu, 04 Jun 2020 05:58:30 GMT-07:00Disaster Response to the COVID-19 Pandemic for Patients with Kidney Disease in New York CityThe Division of Nephrology, Columbia University Vagelos College of Physicians Working GroupAhmad, Syeda B.Ahn, WooinAkomeah, JaneAl-Awqati, QaisAponte, Maria AlejandraAppel, Gerald B.Barasch, JonathanBaramidze, Irina Y.Beenken, AndrewBomback, Andrew S.Canetta, PietroChang, Jae-HyungClement, NishaCohen, David J.Craig, Bessie N.Daniel, EmilyCrew, Russell J.Douglas, DenzilDube, GeoffreyFernandez, HildaFerrer, RobinGharavi, Ali G.Ghavami, Iman AzamHusain, Syed AliKalloo, SeanKhairallah, PascaleKim, Jung SooKiryluk, KrzysztofLandry, DonaldLewis, JordannLee, MeeranLovisi, BrunoMedina, Allyson R.Marasa, MaddalenaMathew, DaisyPeleg, YonatanMehl, KarlaMorban, Maria M.Moses, AndrewMohan, SumitMorris, HeatherNelson, BradleyNestor, Jordan GabrielaNicasio, Vanna M.Nickolas, TomPaget, KathrynPiva, StaceyRadhakrishnan, JaiRao, Maya K.Sanna-Cherchi, SimoneShah, VaqarSampogna, Rosemary V.Shirazian, ShayanSiddall, EricStarakiewicz, PiotrStevens, Jacob S.Toma, KatherineValeri, AnthonyVerduzco, Hector AlvaradoWilliams, GailZheng, JasonMohan, SumitRao, Maya K.Stevens, Jacob S.Radhakrishnan, JaiGharavi, Ali G.2020-06-04T05:58:30-07:00doi:10.1681/ASN.2020040520hwp:resource-id:jnephrol;31/7/1371American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologypublic health, COVID-19, disaster planning, pandemic, organizational preparednessPerspectivePerspectiveresearch-article20202020-07-01July 202010.1681/ASN.20200405201046-66731533-34502020-06-04T05:58:30-07:002020-07Journal of the American Society of NephrologyPerspective31713711379http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020050661?cct=218810.1681/ASN.2020050661Mon, 01 Jun 2020 02:02:41 GMT-07:00Can Diet Induce Transplantation Tolerance?Alegre, Maria-Luisa2020-06-01T14:02:41-07:00doi:10.1681/ASN.2020050661hwp:resource-id:jnephrol;31/7/1417American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologymicrobiota; short chain fatty acids, acetate, kidney transplantation, rejectionUp Front MattersEditorialUp Front MattersEditorialeditorial20202020-07-01July 202010.1681/ASN.20200506611046-66731533-34502020-06-01T14:02:41-07:002020-07Journal of the American Society of NephrologyUp Front Matters31771417144514181461http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101100?cct=218810.1681/ASN.2019101100Tue, 02 Jun 2020 09:18:12 GMT-07:00Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and DiabetesCheng, YuanWang, DandanWang, FengLiu, JingHuang, BaoruiBaker, Maria AngelesYin, JianyongWu, RuiLiu, XuanchenRegner, Kevin R.Usa, KristieLiu, YongZhang, CongxiaoDong, LijinGeurts, Aron M.Wang, NiansongMiller, Sheldon S.He, YongchengLiang, Mingyu2020-06-02T09:18:12-07:00doi:10.1681/ASN.2019101100hwp:resource-id:jnephrol;31/7/1539American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic renal disease, albuminuria, microRNA, hypertension, diabetesBasic ResearchBasic Researchresearch-article20202020-07-01July 202010.1681/ASN.20191011001046-66731533-34502020-06-02T09:18:12-07:002020-07Journal of the American Society of NephrologyBasic Research31715391554http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121308?cct=218810.1681/ASN.2019121308Tue, 02 Jun 2020 09:18:14 GMT-07:00Health Care Costs by Type of Expenditure across eGFR Stages among Patients with and without Diabetes, Cardiovascular Disease, and Heart FailureNichols, Gregory A.Ustyugova, AnastasiaDéruaz-Luyet, AnoukO’Keeffe-Rosetti, MaureenBrodovicz, Kimberly G.2020-06-02T09:18:14-07:00doi:10.1681/ASN.2019121308hwp:resource-id:jnephrol;31/7/1594American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, Economic Impact, Epidemiology and outcomesClinical EpidemiologyClinical Epidemiologyresearch-article20202020-07-01July 202010.1681/ASN.20191213081046-66731533-34502020-06-02T09:18:14-07:002020-07Journal of the American Society of NephrologyClinical Epidemiology31715941601http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000092020?cct=218810.34067/KID.0000092020Fri, 03 Apr 2020 01:25:57 GMT-07:00Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD InhibitorsBhute, Vijesh J.Harte, JamesHoughton, Jack W.Maxwell, Patrick H.2020-04-03T13:25:57-07:00doi:10.34067/KID.0000092020hwp:resource-id:kidney360;1/6/447American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, collagen prolyl-4-hydroxylase, FG-4592, HEK293 cells, hypoxia inducible factor, mannose binding lectin, PHD inhibitors, protein processing, post-translational, renal anemia, vadadustat; molidustat, Basic ScienceOriginal InvestigationsChronic Kidney DiseaseOriginal InvestigationsChronic Kidney Diseaseresearch-article20202020-06-2510.34067/KID.00000920202641-76502020-04-03T13:25:57-07:002020-06-25Kidney360Original Investigations16447457http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000862019?cct=218810.34067/KID.0000862019Fri, 01 May 2020 09:42:46 GMT-07:00US Trends in Prevalence of Sleep Problems and Associations with Chronic Kidney Disease and MortalityShieu, MonicaMorgenstern, HalBragg-Gresham, JenniferGillespie, Brenda W.Shamim-Uzzaman, Q. AfifaTuot, DelphineSaydah, SharonRolka, DeborahBurrows, Nilka RiosPowe, Neil R.Saran, Rajiv,2020-05-01T09:42:46-07:00doi:10.34067/KID.0000862019hwp:resource-id:kidney360;1/6/458American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360chronic kidney disease, cross-sectional studies, logistic models, mortality, nocturia, prevalence, renal insufficiency, chronic, self report, sleep wake disorders, survival analysisOriginal InvestigationsChronic Kidney DiseaseOriginal InvestigationsChronic Kidney Diseaseresearch-article20202020-06-2510.34067/KID.00008620192641-76502020-05-01T09:42:46-07:002020-06-25Kidney360Original Investigations16458468http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000062020?cct=218810.34067/KID.0000062020Mon, 13 Apr 2020 07:38:45 GMT-07:00Depression and the Effect of Sertraline on Inflammatory Biomarkers in Patients with Nondialysis CKDGregg, L. ParkerCarmody, ThomasLe, DustinBharadwaj, NinaTrivedi, Madhukar H.Hedayati, S. Susan2020-04-13T07:38:45-07:00doi:10.34067/KID.0000062020hwp:resource-id:kidney360;1/6/436American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Chronic Kidney Disease, biomarkers, C-reactive protein, chronic kidney disease, depression, major depressive disorder, fatigue, high-sensitivity C-reactive protein, inflammation, interleukin-6, medically unexplained symptoms, quality of life, SertralineOriginal InvestigationsChronic Kidney DiseaseOriginal InvestigationsChronic Kidney Diseaseresearch-article20202020-06-2510.34067/KID.00000620202641-76502020-04-13T07:38:45-07:002020-06-25Kidney360Original Investigations16436446http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002362020?cct=218810.34067/KID.0002362020Thu, 25 Jun 2020 05:30:20 GMT-07:00Acute Abdominal Pain in a COVID-19 PatientMocerino, RyanKumar, Neelja2020-06-25T05:30:20-07:00doi:10.34067/KID.0002362020hwp:resource-id:kidney360;1/6/584American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, COVID-19, renal artery thrombosis, renal infarction, severe acute respiratory syndrome coronavirus 2, thrombosisClinical Images in Nephrology and DialysisClinical Images in Nephrology and Dialysisresearch-article20202020-06-2510.34067/KID.00023620202641-76502020-06-25T05:30:20-07:002020-06-25Kidney360Clinical Images in Nephrology and Dialysis16584585http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001662020?cct=218810.34067/KID.0001662020Tue, 28 Apr 2020 09:39:51 GMT-07:00Early Use of Telehealth in Home Dialysis during the COVID-19 Pandemic in New York CitySrivatana, VeshLiu, FrankLevine, Daniel M.Kalloo, Sean D.2020-04-28T09:39:51-07:00doi:10.34067/KID.0001662020hwp:resource-id:kidney360;1/6/524American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, COVID-19, Hemodialysis, Home, New York City, Patient Care, Renal Dialysis, Telehealth, TelemedicineBrief CommunicationsBrief Communicationsin-brief20202020-06-2510.34067/KID.00016620202641-76502020-04-28T09:39:51-07:002020-06-25Kidney360Brief Communications16524526http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001272019?cct=218810.34067/KID.0001272019Fri, 01 May 2020 09:42:46 GMT-07:00Automated Image Analyses of Glomerular Hypertrophy in a Mouse Model of Diabetic NephropathyØstergaard, Mette V.Sembach, Frederikke E.Skytte, Jacob L.Roostalu, UrmasSecher, ThomasOvergaard, AgneteFink, Lisbeth N.Vrang, NielsJelsing, JacobHecksher-Sørensen, Jacob2020-05-01T09:42:46-07:00doi:10.34067/KID.0001272019hwp:resource-id:kidney360;1/6/469American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360diabetes and the kidney, 3D, CKD, diabetes mellitus, diabetic nephropathies, glomeruli, hypertrophy, kidney glomerulus, lightsheet, LSFM, microscopy, obesity, plant lectins, uninephrectomy, Basic ScienceOriginal InvestigationsDiabetes and the KidneyOriginal InvestigationsDiabetes and the Kidneyresearch-article20202020-06-2510.34067/KID.00012720192641-76502020-05-01T09:42:46-07:002020-06-25Kidney360Original Investigations16469479http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001672020?cct=218810.34067/KID.0001672020Wed, 29 Apr 2020 09:47:10 GMT-07:00Management of Hemodialysis Patients with Suspected or Confirmed COVID-19 Infection: Perspective of Two Nephrologists in BrazilSesso, RicardoDurão, Marcelino de Souza2020-04-29T09:47:10-07:00doi:10.34067/KID.0001672020hwp:resource-id:kidney360;1/6/541American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Acute Kidney Disease, Brazil, Chronic Kidney Disease, COVID-19, Dialysis, PandemicGlobal PerspectivesGlobal Perspectivesresearch-article20202020-06-2510.34067/KID.00016720202641-76502020-04-29T09:47:10-07:002020-06-25Kidney360Global Perspectives16541543http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002002020?cct=218810.34067/KID.0002002020Wed, 06 May 2020 01:43:10 GMT-07:00Providing Care to Patients with AKI and COVID-19 Infection: Experience of Front Line Nephrologists in New YorkFisher, MollyPrudhvi, KalyanBrogan, MaureenGolestaneh, Ladan2020-05-06T13:43:10-07:00doi:10.34067/KID.0002002020hwp:resource-id:kidney360;1/6/544American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, acute kidney injury, COVID-19, health resources, hospitalization, infections, nephrologists, New York City, pandemics, renal dialysis, severe acute respiratory syndrome coronavirus 2, workforceGlobal PerspectivesGlobal Perspectivesresearch-article20202020-06-2510.34067/KID.00020020202641-76502020-05-06T13:43:10-07:002020-06-25Kidney360Global Perspectives16544548http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000682020?cct=218810.34067/KID.0000682020Tue, 07 Apr 2020 01:33:52 GMT-07:00Dialysis for Undocumented Immigrants: Challenges and SolutionsBerger, Joseph R.Quinones, HenryVazquez, Miguel A.2020-04-07T13:33:52-07:00doi:10.34067/KID.0000682020hwp:resource-id:kidney360;1/6/549American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, catheter infections, delivery of health care, emergency service, hospital, kidney failure, chronic, patient care, quality of life, renal dialysis, resource allocation, safety-net providers, Texas, undocumented immigrantsPerspectivesPerspectivesresearch-article20202020-06-2510.34067/KID.00006820202641-76502020-04-07T13:33:52-07:002020-06-25Kidney360Perspectives16549552http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001122019?cct=218810.34067/KID.0001122019Wed, 22 Apr 2020 01:45:16 GMT-07:00The Role of Telemedicine in Providing Nephrology Care in Rural HospitalsLea, Janice P.Tannenbaum, Jerome2020-04-22T13:45:16-07:00doi:10.34067/KID.0001122019hwp:resource-id:kidney360;1/6/553American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360clinical nephrology, hemodialysis, home, hospitals, rural, renal dialysis, telemedicine, telenephrology, videoconferencingPerspectivesPerspectivesresearch-article20202020-06-2510.34067/KID.00011220192641-76502020-04-22T13:45:16-07:002020-06-25Kidney360Perspectives16553556http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002842020?cct=218810.34067/KID.0002842020Thu, 07 May 2020 01:26:35 GMT-07:00COVID-19 Perspective from a Hemodialysis PatientAllon, Michael2020-05-07T13:26:35-07:00doi:10.34067/KID.0002842020hwp:resource-id:kidney360;1/6/432American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, COVID-19, hemodialysis, patientPatient PerspectivePatient Perspectiveresearch-article20202020-06-2510.34067/KID.00028420202641-76502020-05-07T13:26:35-07:002020-06-25Kidney360Patient Perspective16432432http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000912020?cct=218810.34067/KID.0000912020Mon, 20 Apr 2020 08:06:50 GMT-07:00Global Dialysis Perspective: MexicoVasquez-Jimenez, EnzoMadero, Magdalena2020-04-20T08:06:50-07:00doi:10.34067/KID.0000912020hwp:resource-id:kidney360;1/6/534American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, delayed diagnosis, Diabetes Mellitus, dialysis, hypertension, kidney failure, chronic, Latin America, Mexico, obesity, prevalence, renal insufficiency, Chronic, risk factorsGlobal PerspectivesGlobal Perspectivesresearch-article20202020-06-2510.34067/KID.00009120202641-76502020-04-20T08:06:50-07:002020-06-25Kidney360Global Perspectives16534537http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000882020?cct=218810.34067/KID.0000882020Tue, 21 Apr 2020 01:45:16 GMT-07:00Global Dialysis Perspective: SenegalNiang, AbdouLemrabott, Ahmed Tall2020-04-21T13:45:16-07:00doi:10.34067/KID.0000882020hwp:resource-id:kidney360;1/6/538American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, diabetic nephropathies, hypertension, hypertensive nephropathy, kidney failure, nephritis, renal dialysis, renal replacement therapy, senegal, sub-Saharan AfricaGlobal PerspectivesGlobal Perspectivesresearch-article20202020-06-2510.34067/KID.00008820202641-76502020-04-21T13:45:16-07:002020-06-25Kidney360Global Perspectives16538540http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001172020?cct=218810.34067/KID.0001172020Wed, 22 Apr 2020 01:45:16 GMT-07:00The Advancing American Kidney Health (AAKH) Executive Order: Promise and Caveats for Expanding Access to Kidney TransplantationLentine, Krista L.Mannon, Roslyn B.2020-04-22T13:45:16-07:00doi:10.34067/KID.0001172020hwp:resource-id:kidney360;1/6/557American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, access, advocacy, compensation, donor, organs, transplantPerspectivesPerspectivesresearch-article20202020-06-2510.34067/KID.00011720202641-76502020-04-22T13:45:16-07:002020-06-25Kidney360Perspectives16557560http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000662019?cct=2188Home dialysis modalities remain significantly underused in the United States despite similar overall survival in the modalities, and recent incentives to expand these modalities. Although the absolute number of patients using home modalities has grown, the proportion compared to in-center hemodialysis (ICHD) continues to remain quite low. Well known barriers to home dialysis utilization exist, and an organized and team-based approach is required to overcome these barriers. Herein, we describe our efforts at growing our home dialysis program at a large academic medical center, with the proportion of home dialysis patients growing from 12% to 21% over the past 9 years. We prioritized individualized education for patients and better training for physicians, with the help of existing resources, aimed at better utilization of home modalities; an example includes dedicated dialysis education classes taught twice monthly by an experienced nurse practitioner, as well as the utilization of the dialysis educator from a dialysis provider for inpatient education of patients with CKD. The nephrology fellowship curriculum was restructured with emphasis on home modalities, and participation in annual home dialysis conferences has been encouraged. For timely placement and troubleshooting of access for dialysis, we followed a complementary team approach using surgeons and interventional radiologists and nephrologists, driven by a standardized protocol developed at UAB, and comanaged by our access coordinators. A team-based approach, with emphasis on staff engagement and leadership opportunities for dialysis nurses as well as collaborative efforts from a team of clinical nephrologists and the dialysis provider helped maintain efficiency, kindle growth, and provide consistently high-quality clinical care in the home program. Lastly, efforts at reducing burden of disease such as decreased number of monthly visits as well as using innovative strategies, such as telenephrology and assisted PD and HHD, were instrumental in reducing attrition.10.34067/KID.0000662019Fri, 01 May 2020 01:31:00 GMT-07:00Setting Up and Expanding a Home Dialysis Program: Is There a Recipe for Success?Home dialysis modalities remain significantly underused in the United States despite similar overall survival in the modalities, and recent incentives to expand these modalities. Although the absolute number of patients using home modalities has grown, the proportion compared to in-center hemodialysis (ICHD) continues to remain quite low. Well known barriers to home dialysis utilization exist, and an organized and team-based approach is required to overcome these barriers. Herein, we describe our efforts at growing our home dialysis program at a large academic medical center, with the proportion of home dialysis patients growing from 12% to 21% over the past 9 years. We prioritized individualized education for patients and better training for physicians, with the help of existing resources, aimed at better utilization of home modalities; an example includes dedicated dialysis education classes taught twice monthly by an experienced nurse practitioner, as well as the utilization of the dialysis educator from a dialysis provider for inpatient education of patients with CKD. The nephrology fellowship curriculum was restructured with emphasis on home modalities, and participation in annual home dialysis conferences has been encouraged. For timely placement and troubleshooting of access for dialysis, we followed a complementary team approach using surgeons and interventional radiologists and nephrologists, driven by a standardized protocol developed at UAB, and comanaged by our access coordinators. A team-based approach, with emphasis on staff engagement and leadership opportunities for dialysis nurses as well as collaborative efforts from a team of clinical nephrologists and the dialysis provider helped maintain efficiency, kindle growth, and provide consistently high-quality clinical care in the home program. Lastly, efforts at reducing burden of disease such as decreased number of monthly visits as well as using innovative strategies, such as telenephrology and assisted PD and HHD, were instrumental in reducing attrition.Ahmad, MasoodWallace, Eric L.Jain, Gaurav2020-05-01T13:31:00-07:00doi:10.34067/KID.0000662019hwp:resource-id:kidney360;1/6/569American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, barriers to home dialysis, home dialysis, home dialysis academy, home hemodialysis, modality education, peritoneal dialysis, telenephrology, urgent peritoneal dialysisReview ArticleReview Articlereview-article20202020-06-2510.34067/KID.00006620192641-76502020-05-01T13:31:00-07:002020-06-25Kidney360Review Article16569579http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090982?cct=218810.1681/ASN.2019090982Wed, 18 Mar 2020 10:07:58 GMT-07:00ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular FunctionMatsuda, JunMaier, MirelaAoudjit, LamineBaldwin, CindyTakano, Tomoko2020-03-18T10:07:58-07:00doi:10.1681/ASN.2019090982hwp:resource-id:jnephrol;31/5/996American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyapoptosis, ARHGEF7 (β-PIX), Cdc42, podocyte, small Rho GTPase, yes-associated protein (YAP)Basic ResearchBasic Researchresearch-article20202020-05-01May 202010.1681/ASN.20190909821046-66731533-34502020-03-18T10:07:58-07:002020-05Journal of the American Society of NephrologyBasic Research3159961008http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121340?cct=218810.1681/ASN.2019121340Mon, 06 Apr 2020 08:53:55 GMT-07:00The Value of Intravenous Iron: Beyond the Cave of SpeculationCoyne, Daniel W.Fishbane, Steven2020-04-06T08:53:55-07:00doi:10.1681/ASN.2019121340hwp:resource-id:jnephrol;31/5/896American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyanemia, Hemodialysis hazards, infection, cardiovascular eventsUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-05-01May 202010.1681/ASN.20191213401046-66731533-34502020-04-06T08:53:55-07:002020-05Journal of the American Society of NephrologyUp Front Matters315589611188971127http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030305?cct=218810.1681/ASN.2020030305Mon, 06 Apr 2020 08:53:55 GMT-07:00Tubular MST1/2 Deletion and Renal FibrosisChang-Panesso, Monica2020-04-06T08:53:55-07:00doi:10.1681/ASN.2020030305hwp:resource-id:jnephrol;31/5/893American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyMST1/2, Hippo pathway, renal fibrosis, YAPUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-05-01May 202010.1681/ASN.20200303051046-66731533-34502020-04-06T08:53:55-07:002020-05Journal of the American Society of NephrologyUp Front Matters3155893946894961http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030344?cct=218810.1681/ASN.2020030344Thu, 30 Apr 2020 10:00:29 GMT-07:00This Month's HighlightsAmerican Society of Nephrology2020-04-30T10:00:29-07:00doi:10.1681/ASN.2020030344hwp:resource-id:jnephrol;31/5/iAmerican Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyThis Month’s HighlightsThis Month’s Highlightsin-brief20202020-05-01May 202010.1681/ASN.20200303441046-66731533-34502020-04-30T10:00:29-07:002020-05Journal of the American Society of NephrologyThis Month’s Highlights315iihttp://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070712?cct=218810.1681/ASN.2019070712Fri, 20 Mar 2020 07:40:36 GMT-07:00Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for CystinosisHollywood, Jennifer A.Przepiorski, AnetaD’Souza, Randall F.Sreebhavan, SreevalsanWolvetang, Ernst J.Harrison, Patrick T.Davidson, Alan J.Holm, Teresa M.2020-03-20T07:40:36-07:00doi:10.1681/ASN.2019070712hwp:resource-id:jnephrol;31/5/962American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyinduced pluripotent stem cells, kidney organoids, new treatments, kidney disease, cystinosisBasic ResearchBasic Researchresearch-article20202020-05-01May 202010.1681/ASN.20190707121046-66731533-34502020-03-20T07:40:36-07:002020-05Journal of the American Society of NephrologyBasic Research315962982http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020212?cct=218810.1681/ASN.2020020212Tue, 31 Mar 2020 09:03:01 GMT-07:00Biomarkers of CKD in ChildrenAl-Aly, ZiyadBowe, Benjamin2020-03-31T09:03:01-07:00doi:10.1681/ASN.2020020212hwp:resource-id:jnephrol;31/5/894American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, children, biomarkers, TNF receptor-1, soluble urokinase-type plasminogen activator receptor, kidney injury molecule 1Up Front MattersEditorialsUp Front MattersEditorialseditorial20202020-05-01May 202010.1681/ASN.20200202121046-66731533-34502020-03-31T09:03:01-07:002020-05Journal of the American Society of NephrologyUp Front Matters315589410678961077http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019111168?cct=218810.1681/ASN.2019111168Thu, 30 Apr 2020 10:00:30 GMT-07:00Renal, Cardiovascular, and Safety Outcomes of Canagliflozin by Baseline Kidney Function: A Secondary Analysis of the CREDENCE Randomized TrialJardine, Meg J.Zhou, ZienMahaffey, Kenneth W.Oshima, MegumiAgarwal, RajivBakris, GeorgeBajaj, Harpreet S.Bull, ScottCannon, Christopher P.Charytan, David M.de Zeeuw, DickDi Tanna, Gian LucaGreene, TomHeerspink, Hiddo J.L.Levin, AdeeraNeal, BrucePollock, CarolQiu, RoseSun, TaoWheeler, David C.Zhang, HongZinman, BernardRosenthal, NormanPerkovic, Vlado,Guerrero, Rodolfo Andres AhuadAizenberg, DiegoAlbisu, Juan PabloAlvarisqueta, AndresBartolacci, InesBerli, Mario AlbertoBordonava, AnselmoCalella, PedroCantero, Maria CeciliaCartasegna, Luis RodolfoCercos, EstebanColoma, Gabriela CeciliaColombo, HugoCommendatore, VictorCuadrado, JesusCuneo, Carlos AlbertoCusumano, Ana MariaDouthat, Walter GuillermoDran, Ricardo DarioFarias, EduardoFernandez, Maria FlorenciaFinkelstein, HernanFragale, GuillermoFretes, Jose OsvaldoGarcia, Nestor HoracioGastaldi, AnibalGelersztein, ElizabethGlenny, Jorge ArchibaldoGonzalez, Joaquin PabloColaso, Patricia del Carmen GonzalezGoycoa, ClaudiaGreloni, Gustavo CristianGuinsburg, AdrianHermida, SoniaJuncos, Luis IsaiasValdez, MariaKraft, FlorenciaKrynski, FernandoLanchiotti, Paulina VirginiaLeon de la Fuente, Ricardo AlfonsoMarchetta, NoraMele, PabloNicolai, SilviaNovoa, Pablo AntonioOrio, Silvia InesOtreras, FabianOviedo, AlejandraRaffaele, PabloResk, Jorge HectorRista, LucasPapini, Nelson RodriguezSala, JorgelinaSantos, Juan CarlosSchiavi, Lilia BeatrizSessa, HoracioCasabella, Tomas SmithUlla, Maria RosaVallejos, AugustoVillarino, AdrianaVisco, Virginia EstherWassermann, AlfredoZaidman, Cesar JavierCheung, Ngai WahDroste, CarolynFraser, IanJohnson, DavidMah, Peak MannNicholls, KathyPackham, DavidProietto, JosephRoberts, AnthonyRoger, SimonTsang, VenessaRaduan, Roberto AbrãoAlves da Costa, Fernando AugustoAmodeo, CelsoTuratti, Luiz Alberto AndreottiBregman, RachelCamelo Sanches, Fernanda CristinaCanani, Luis HenriqueChacra, Antônio RobertoCunha Borges, João LindolfoVêncio, Sérgio Alberto Cunhada Silva Franco, Roberto Jorged’Avila, Domingosde Souza Portes, Evandrode Souza, PedroDeboni, Luciane MônicaFilho, Fadlo FraigeNeto, Bruno GelonezeGomes, MarcusKohara, Suely KeikoKeitel, ElizeteSaraiva, Jose Francisco KerrKurtz Lisboa, Hugo Robertode Carvalho Contieri, Fabiana LossMilagres, RosângelaJunior, Renan MontenegroMoreira de Brito, ClaudiaHissa, Miguel NasserSabbag, Ângela Regina NazarioNoronha, IrenePanarotto, DanielFilho, Roberto PecoitsPereira, Márcio AntônioSaporito, WladmirScotton, Antonio ScafutoSchuch, TiagoSimões de Almeida, RobertoRamos, Cássio SlompoFelício, João SoaresThomé, FernandoTibes Hachmann, Jean CarloYamada, SérgioHayashida, Cesar YoitiPetry, Tarissa Beatrice ZanataZanella, Maria TeresaAndreeva, ViktoriaAngelova, AngelinaDimitrov, StefanGenadieva, VeselkaGenova-Hristova, GabrielaHristozov, KirilKamenov, ZdravkoKoundurdjiev, AtanasLozanov, LachezarMargaritov, ViktorNonchev, BoyanRangelov, RangelShinkov, AlexanderTemelkova, MargaritaVelichkova, EkaterinaYakov, AndrianAggarwal, NareshAronson, RonnieBajaj, HarpreetCherney, DavidChouinard, GuyConway, JamesCournoyer, SergeDaRoza, GeraldDe Serres, SachaDubé, FrançoisGoldenberg, RonaldGupta, AnilGupta, MilanHenein, SamKhandwala, HasnainLeiter, LawrenceLevin, AdeeraMadore, FrançoisMcMahon, AlanMuirhead, NormanPichette, VincentRabasa-Lhoret, RemiSteele, AndrewTangri, NavdeepTorshizi, AliWoo, VincentZalunardo, NadiaFernández Montenegro, María AliciaJorquera, Juan Gonzalo GodoyFariña, Marcelo MedinaGajardo, Victor SaavedraVejar, MargaritaChen, NanChen, QinkaiGan, ShenglianKong, YaozhongLi, DetianLi, WengeLi, XuemeiLin, HongliLiu, JianLu, WeipingMao, HongRen, YanSong, WeihongSun, JiaoSun, LinTu, PingWang, GuixiaYang, JinkuiYin, AipingYu, XueqingZhao, MinghuiZheng, HongguangMendoza, Jose Luis AcciniArcos, EdgarAvendano, JorgeRuiz, Jorge Ernesto Andres DiazGarcia Ortiz, Luis HernandoGonzalez, AlexanderTriana, Eric HernandezHiguera, Juan DiegoMalaver, NataliaMolina de Salazar, Dora InésRosero, RicardoTerront Lozano, Monica AlexandraCometa, Luis ValderramaValenzuela, AlexVargas Alonso, Ruben DarioVillegas, IvanYupanqui, HernanBartaskova, DagmarBarton, PetrBelobradkova, JanaDohnalova, LenkaDrasnar, TomasFerkl, RichardHalciakova, KatarinaKlokocnikova, VeraKovar, RichardLastuvka, JiriLukac, MartinPesickova, SatuPeterka, KarelPumprla, JiriRychlik, IvanSaudek, FrantisekTesar, VladimirValis, MartinWeiner, PavelZemek, StanislavAlamartine, EricBorot, SophieCariou, BertrandDussol, BertrandFauvel, Jean-PierreGourdy, PierreKlein, AlexandreLe Meur, YannickPenfornis, AlfredRoussel, RonanSaulnier, Pierre-JeanThervet, EricZaoui, PhilippeBurst, VolkerFaghih, MarkusFaulmann, GritHaller, HermannJerwan-Keim, ReinholdMaxeiner, StephanPaschen, BjörnPlassmann, GeorgRose, LudgerGonzalez Orellana, Ronaldo ArturoHaase, Franklin PaulMoreira Diaz, Juan PabloRamirez Roca, Luis AlbertoSánchez Arenales, Jose AntonioSanchez Polo, José VicenteJuarez, Erick TurciosCsecsei, GyongyiCsiky, BotondDanos, PeterDeak, LaszloDudas, MihalyHarcsa, EleonoraKeltai, KatalinKeresztesi, SandorKiss, KrisztianKonyves, LaszloMajor, LajosMileder, MargitMolnar, MartaMucsi, JanosOroszlan, TamasOry, IvanParagh, GyorgyPeterfai, EvaPetro, GizellaRevesz, KatalinTakacs, RobertVangel, SandorVasas, SzilardZsom, MariannaAbraham, OommanBhushan, Raju SreeDeepak, DewanEdwin, Fernando M.Gopalakrishnan, NatarajanGracious, NobleHansraj, AlvaJain, DineshKeshavamurthy, C. B.Khullar, DineshManisha, SahayPeringat, JayameenaPrasad, NarayanSatyanarayana, Rao K.Sreedhar, ReddySreelatha, MelemadathilSudhakar, BhimavarapuVyasam, Ramesh ChandraBonadonna, RiccardoCastellino, PietroCeriello, AntonioChiovato, LucaDe Cosmo, SalvatoreDe Nicola, LucaDerosa, GiuseppeDi Carlo, AlbertoDi Cianni, GrazianoFrascà, GiovanniFuiano, GiorgioGambaro, GiovanniGaribotto, GiacomoGiorda, CarloMalberti, FabioMandreoli, MarcoraMannucci, EdoardoOrsi, EmanuelaPiatti, PiermarcoSantoro, DomenicoSasso, Ferdinando CarloServiddio, GaetanoStella, AndreaTrevisan, RobertoVeronelli, Anna MariaAkiyama, HitoshiAoki, HiromiAsano, AkimichiIitsuka, TadashiKajiyama, ShizuoKashine, SusumuKawada, ToshioKodera, TakamotoKono, HiroshiKoyama, KazunoriKumeda, YasuroMiyauchi, ShozoMizuyama, KazuyukiNiiya, TetsujiOishi, HirokoOta, SatoshiSakakibara, TerueTakai, MasahikoTomonaga, OsamuTsujimoto, MitsuruWada, TakashiWakasugi, MasakiyoWakida, YasushiWatanabe, TakayukiYamada, MasayoYanagida, KazuhiroYanase, ToshihikoYumita, WataruGaupsiene, EgleKozloviene, DaliaNavickas, AntanasUrbanaviciene, EgleGhani, Rohana AbdulKadir, Khalid AbdulAli, NorsiahYusof, Mohd Daud CheGan, Chye LeeIsmail, MasturaKong, Wei YenLam, Swee WinLee, Li YuanLim, Soo KunLoh, Chek LoongManocha, Anita BhajanNg, Kee SingAhmad, Nik Nur Fatnoon NikRatnasingam, VanassaBin Shudim, Saiful ShahrizalVengadasalam, ParanthamanAbraira Munoz, Luis DavidSalazar, Melchor AlpizarCruz, Juan BaasSoto, Mario BurgosRamos, Jose ChevaileWong, Alfredo ChewCorrea Rotter, Jose RicardoEscalante, Tonatiu DiazEnriquez Sosa, Favio EdmundoLozano, Fernando FloresFlota Cervera, Luis FernandoBaron, Paul FrenkBallesteros, Cecilia GarciaGomez Rangel, Jose DavidHerrera Jimenez, Luis EnriqueSantana, Sergio Saul IrizarFlores, Fernando JimenezMolina, Hugo LaviadaLuna Ceballos, Rosa Iseladel Campo Blanco, Belia MartinFranco, Guadalupe MoralesMoreno Loza, Oscar TarsicioRocha, Cynthia MustielesVera, Gregorio ObradorCastellanos, Ricardo OrozcoCalcaneo, Juan PeraltaReyes Rosano, Miguel AngelPattzi, Hiromi RodriguezGuzman, Juan RosasRucker Joerg, Isabel ErikaSaavedra Sanchez, Sandra BereniceSanchez Mijangos, Jose HectorSanson, Pablo SerranoTamayo y Orozco, Juan AlfredoChavez, Eloisa TellezCepeda, Alejandro ValdesCarrillo, Luis VenegasMesa, Juan VillagordoaEscobedo, Rolando ZamarripaBaker, JohnNoonan, PaulScott, RussellWalker, RobertWatson, EdwardWilliams, MichaelYoung, SimonAbejuela, ZaynabAgra, JeimeenAquitania, GraceCaringal, ClodoaidoComia, Rhea SeverinaSantos, Lalaine DelosGomez, OlivertJimeno, CeciliaSantos, FlorenceTan, GerryTolentino, MarshaYao, ChristyYap, Yvette EthelYgpuara, Ma. Dovie LallaineBijata-Bronisz, RenataHotlos, LucynaJanuszewicz, AndrzejKaczmarek, BarbaraKaminska, AnnaLazuka, LechMadej, AndrzejMazur, StanislawMlodawska-Choluj, DorotaNowicki, MichalOrlowska-Kowalik, GrazynaPopenda, GrazynaRewerska, BarbaraSowinski, DariuszAngelescu, Liliana MonicaAnghel, VeronicaAvram, Rodica-IoanaBusegeanu, Mihaela-MagdalenaCif, AdrianaCosma, DanaCrisan, CarmenDemian, Luiza DespinaFerariu, Ioana EmiliaHalmagyi, IldikoHancu, NicolaeMunteanu, MirceaNegru, DoruOnaca, Adriana GabrielaPetrica, LigiaPopa, Amorin RemusRanetti, Aurelian-EmilSerafinceanu, CristianToarba, CristinaAgafyina, AlinaBarbarash, OlgaBarysheva, OlgaChizhov, DaniilDobronravov, VladimirDreval, AlexanderGlinkina, IrinaGrineva, ElenaKhirmanov, VladimirKolmakova, ElenaKoroleva, TatianaKvitkova, LiudmilaMarasaev, ViacheslavMkrtumyan, AshotMorugova, TatianaNagibovich, GalinaNagibovich, OlegNedogoda, SergeiOsipova, IrinaRaskina, TatianaSamoylova, YuliaSazonova, OlgaShamkhalova, MinaraShutemova, ElenaShwartz, 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2020 by the American Society of NephrologyJournal of the American Society of Nephrologyacute renal failure, chronic kidney disease, Chronic inflammation, kidney tubule, interstitial fibrosis, macrophagesBasic ResearchBasic Researchresearch-article20202020-05-01May 202010.1681/ASN.20191010851046-66731533-34502020-03-24T07:47:57-07:002020-05Journal of the American Society of NephrologyBasic Research315983995http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101052?cct=218810.1681/ASN.2019101052Mon, 06 Apr 2020 08:53:56 GMT-07:00Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP MechanismsXu, ChunhuaWang, LiZhang, YuLi, WenlingLi, JinhongWang, YangMeng, ChenlingQin, JinzhongZheng, Zhi-HuaLan, Hui-YaoMak, Kingston King-LunHuang, YuXia, Yin2020-04-06T08:53:56-07:00doi:10.1681/ASN.2019101052hwp:resource-id:jnephrol;31/5/946American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyHippo, MST1, MST2, YAP, 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Renal Collecting DuctSassi, AliWang, YubaoChassot, AlexandraKomarynets, OlgaRoth, IsabelleOlivier, ValérieCrambert, GillesDizin, EvaBoscardin, EmilieHummler, EdithFeraille, Eric2020-04-03T06:03:27-07:00doi:10.1681/ASN.2019080790hwp:resource-id:jnephrol;31/5/1009American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyprincipal cell, epithelial sodium channel, tight junction, sodium reabsorption, paracellular ion permeabilityBasic ResearchBasic Researchresearch-article20202020-05-01May 202010.1681/ASN.20190807901046-66731533-34502020-04-03T06:03:27-07:002020-05Journal of the American Society of NephrologyBasic Research31510091023http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090877?cct=218810.1681/ASN.2019090877Wed, 18 Mar 2020 10:07:58 GMT-07:00Effect of Low-Sodium versus Conventional Sodium Dialysate on Left Ventricular Mass in Home and Self-Care Satellite Facility Hemodialysis Patients: A Randomized Clinical TrialMarshall, Mark R.Vandal, Alain C.de Zoysa, Janak R.Gabriel, Ruvin S.Haloob, Imad A.Hood, Christopher J.Irvine, John H.Matheson, Philip J.McGregor, David O.R.Rabindranath, Kannaiyan S.Schollum, John B.W.Semple, David J.Xie, ZhengxiuMa, Tian MinSisk, RoseDunlop, Joanna L.2020-03-18T10:07:58-07:00doi:10.1681/ASN.2019090877hwp:resource-id:jnephrol;31/5/1078American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyhemodialysis, clinical trial, hypertension, left ventricular hypertrophy, hypotensionClinical ResearchClinical Researchresearch-article20202020-05-01May 202010.1681/ASN.20190908771046-66731533-34502020-03-18T10:07:58-07:002020-05Journal of the American Society of NephrologyClinical Research31510781091http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13341019?cct=218810.2215/CJN.13341019Tue, 26 May 2020 02:18:37 GMT-07:00Benzodiazepines, Codispensed Opioids, and Mortality among Patients Initiating Long-Term In-Center HemodialysisMuzaale, Abimereki D.Daubresse, MatthewBae, SunjaeChu, Nadia M.Lentine, Krista L.Segev, Dorry L.McAdams-DeMarco, Mara2020-05-26T14:18:37-07:00doi:10.2215/CJN.13341019hwp:resource-id:clinjasn;15/6/794American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyBenzodiazepines, Analgesics, Opioid, Medicare, Proportional Hazards Models, Opioid Epidemic, Follow-Up Studies, renal dialysis, dialysis, Cohort Studies, Prescriptions, RecordsOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-06-08June 08, 202010.2215/CJN.133410191555-90411555-905X2020-05-26T14:18:37-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles1566794743804744http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13711119?cct=218810.2215/CJN.13711119Wed, 13 May 2020 07:48:48 GMT-07:00Donor Age, Cold Ischemia Time, and Delayed Graft FunctionHelanterä, IlkkaIbrahim, Hassan N.Lempinen, MarkoFinne, Patrik2020-05-13T07:48:48-07:00doi:10.2215/CJN.13711119hwp:resource-id:clinjasn;15/6/813American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyEpidemiology and outcomes, transplant outcomes, cadaver organ transplantation, delayed graft function, Cold Ischemia, kidney transplantation, creatinine, Retrospective Studies, Transplant Recipients, risk factors, Cause of Death, Body Mass Index, renal dialysis, Tissue Donors, Kidney Diseases, Registries, diabetes mellitus, hypertension, Cohort StudiesOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-06-08June 08, 202010.2215/CJN.137111191555-90411555-905X2020-05-13T07:48:48-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles1566813750821751http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11130919?cct=218810.2215/CJN.11130919Thu, 07 May 2020 05:34:26 GMT-07:00Plasma Endothelin-1 and Risk of Death and Hospitalization in Patients Undergoing Maintenance HemodialysisLi, PingSchmidt, Insa M.Sabbisetti, VenkataTio, Maria ClarissaOpotowsky, Alexander R.Waikar, Sushrut S.2020-05-07T05:34:26-07:00doi:10.2215/CJN.11130919hwp:resource-id:clinjasn;15/6/784American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyEndothelin-1, hemodialysis, mortality, cardiovascular disease, risk factors, Prospective Studies, Kidney Failure, Chronic, dialysis, Endothelins, Renal Insufficiency, Chronic, Vasoconstrictor Agents, hospitalization, heart failure, hypertension, endothelium, Inflammation, Cohort StudiesOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-06-08June 08, 202010.2215/CJN.111309191555-90411555-905X2020-05-07T05:34:26-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles156784793http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05150420?cct=218810.2215/CJN.05150420Tue, 26 May 2020 02:18:37 GMT-07:00A Patient’s Perspective on Benzodiazepines, Co-Dispensed Opioids, and Mortality among Patients Initiating Long-Term In-Center HemodialysisThomas, Cher2020-05-26T14:18:37-07:00doi:10.2215/CJN.05150420hwp:resource-id:clinjasn;15/6/743American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologybenzodiazepines, opioids, hemodialysis, analgesics, opioid, renal dialysis, drug prescriptionsPatient VoicePatient Voiceresearch-article20202020-06-08June 08, 202010.2215/CJN.051504201555-90411555-905X2020-05-26T14:18:37-07:002020-06-08Clinical Journal of the American Society of NephrologyPatient Voice1566743794744804http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05850420?cct=218810.2215/CJN.05850420Wed, 13 May 2020 07:48:47 GMT-07:00Donor Characteristics and Short-Term Kidney Allograft OutcomesFriedewald, John J.Ho, Bing2020-05-13T07:48:47-07:00doi:10.2215/CJN.05850420hwp:resource-id:clinjasn;15/6/750American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologydelayed graft function, ischemia, transplant outcomes, Tissue Donors, AllograftsEditorialsEditorialseditorial20202020-06-08June 08, 202010.2215/CJN.058504201555-90411555-905X2020-05-13T07:48:47-07:002020-06-08Clinical Journal of the American Society of NephrologyEditorials1566750813751821http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04430420?cct=218810.2215/CJN.04430420Tue, 28 Apr 2020 06:21:15 GMT-07:00Can COMBINED Magnetic Resonance Imaging Measure the Progression of Kidney Disease?Pruijm, Menno2020-04-28T06:21:15-07:00doi:10.2215/CJN.04430420hwp:resource-id:clinjasn;15/6/747American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, outcomes, magnetic resonance imaging, biomarker, Renin, Angiotensins, Sodium-Glucose Transporter 2 Inhibitors, Renal Insufficiency, Chronic, Renal Insufficiency, Disease Progression, Magnetic Resonance ImagingEditorialsEditorialseditorial20202020-06-08June 08, 202010.2215/CJN.044304201555-90411555-905X2020-04-28T06:21:15-07:002020-06-08Clinical Journal of the American Society of NephrologyEditorials1566747776749783http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06810619?cct=218810.2215/CJN.06810619Thu, 07 May 2020 05:34:27 GMT-07:00Intradialytic Hypotension and Cardiac Arrhythmias in Patients Undergoing Maintenance HemodialysisMc Causland, Finnian R.Tumlin, Jim A.Roy-Chaudhury, PrabirKoplan, Bruce A.Costea, Alexandru I.Kher, VijayWilliamson, DonPokhariyal, SaurabhCharytan, David M.,2020-05-07T05:34:27-07:00doi:10.2215/CJN.06810619hwp:resource-id:clinjasn;15/6/805American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhemodialysis, cardiovascular disease, Bradycardia, Incidence, Arrhythmias, , Cardiac Conduction System Disease, hypotension, Tachycardia, VentricularOriginal ArticlesMaintenance DialysisOriginal ArticlesMaintenance Dialysisresearch-article20202020-06-08June 08, 202010.2215/CJN.068106191555-90411555-905X2020-05-07T05:34:27-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles156805812http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14041119?cct=218810.2215/CJN.14041119Thu, 07 May 2020 05:34:27 GMT-07:00Management of Active Surveillance-Eligible Prostate Cancer during Pretransplantation Workup of Patients with Kidney Failure: A Simulation StudyBieri, UweHübel, KerstinSeeger, HaraldKulkarni, Girish S.Sulser, TullioHermanns, ThomasWettstein, Marian S.2020-05-07T05:34:27-07:00doi:10.2215/CJN.14041119hwp:resource-id:clinjasn;15/6/822American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycancer, quality-adjusted life years, life expectancy, quality of life, kidney transplantation, watchful waiting, calibration, expert testimony, renal insufficiency, prostatic neoplasms, cohort studies, dialysis, contraindicationsOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-06-08June 08, 202010.2215/CJN.140411191555-90411555-905X2020-05-07T05:34:27-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles156822829http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05290420?cct=218810.2215/CJN.05290420Fri, 22 May 2020 05:48:44 GMT-07:00Environmental Risks to Kidney HealthKaufman, James S.2020-05-22T05:48:44-07:00doi:10.2215/CJN.05290420hwp:resource-id:clinjasn;15/6/745American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney, risk assessmentEditorialsEditorialseditorial20202020-06-08June 08, 202010.2215/CJN.052904201555-90411555-905X2020-05-22T05:48:44-07:002020-06-08Clinical Journal of the American Society of NephrologyEditorials1566745766746775http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12141019?cct=2188The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 “Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors” was developed to assist medical professionals who evaluate living kidney donor candidates and provide care before, during, and after donation. This guideline Work Group concluded that a comprehensive approach to donor candidate risk assessment should replace eligibility decisions on the basis of assessments of single risk factors in isolation. To address all issues important to living donors in a pragmatic and comprehensive guideline, many of the guideline recommendations were on the basis of expert consensus opinion even when no direct evidence was available. To advance available evidence, original data analyses were also undertaken to produce a “proof-of-concept” risk projection model for kidney failure. This was done to illustrate how the community can advance a new quantitative framework of risk that considers each candidate’s profile of demographic and health characteristics. A public review by stakeholders and subject matter experts as well as industry and professional organizations informed the final formulation of the guideline. This review highlights the guideline framework, key concepts, and recommendations, and uses five patient scenarios and 12 guideline statements to illustrate how the guideline can be applied to support living donor evaluation and care in clinical practice.10.2215/CJN.12141019Fri, 10 Apr 2020 09:20:11 GMT-07:00Application of the 2017 KDIGO Guideline for the Evaluation and Care of Living Kidney Donors to Clinical PracticeThe Kidney Disease: Improving Global Outcomes (KDIGO) 2017 “Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors” was developed to assist medical professionals who evaluate living kidney donor candidates and provide care before, during, and after donation. This guideline Work Group concluded that a comprehensive approach to donor candidate risk assessment should replace eligibility decisions on the basis of assessments of single risk factors in isolation. To address all issues important to living donors in a pragmatic and comprehensive guideline, many of the guideline recommendations were on the basis of expert consensus opinion even when no direct evidence was available. To advance available evidence, original data analyses were also undertaken to produce a “proof-of-concept” risk projection model for kidney failure. This was done to illustrate how the community can advance a new quantitative framework of risk that considers each candidate’s profile of demographic and health characteristics. A public review by stakeholders and subject matter experts as well as industry and professional organizations informed the final formulation of the guideline. This review highlights the guideline framework, key concepts, and recommendations, and uses five patient scenarios and 12 guideline statements to illustrate how the guideline can be applied to support living donor evaluation and care in clinical practice.Garg, Amit X.Levey, Andrew S.Kasiske, Bertram L.Cheung, MichaelLentine, Krista L.,2020-04-10T09:20:11-07:00doi:10.2215/CJN.12141019hwp:resource-id:clinjasn;15/6/896American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyDonor nephrectomy, Living donation, Patient-centered care, Risks, Guideline, risk factors, Living Donors, kidney transplantation, Consensus, Data Analysis, Kidney Diseases, Risk Assessment, Renal Insufficiency, kidney, DemographyFeaturesFeaturesresearch-article20202020-06-08June 08, 202010.2215/CJN.121410191555-90411555-905X2020-04-10T09:20:11-07:002020-06-08Clinical Journal of the American Society of NephrologyFeatures156896905http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01400220?cct=218810.2215/CJN.01400220Wed, 06 May 2020 04:57:17 GMT-07:00The Effects of Intensive Blood Pressure Lowering on Markers of Mineral Metabolism in Persons with CKD in SPRINTGinsberg, CharlesKatz, RonitChonchol, Michel B.Bullen, Alexander L.Raphael, Kalani L.Zhang, William R.Ambrosius, Walter T.Bates, Jeffrey T.Neyra, Javier A.Killeen, Anthony A.Punzi, HenryShlipak, Michael G.Ix, Joachim H.2020-05-06T04:57:17-07:00doi:10.2215/CJN.01400220hwp:resource-id:clinjasn;15/6/852American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, hypertension, mineral metabolism, calcium, blood pressure, Biomarkers, Renal Insufficiency, Chronic, Minerals, Antihypertensive AgentsResearch LetterResearch Letterresearch-article20202020-06-08June 08, 202010.2215/CJN.014002201555-90411555-905X2020-05-06T04:57:17-07:002020-06-08Clinical Journal of the American Society of NephrologyResearch Letter156852854http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06780619?cct=218810.2215/CJN.06780619Fri, 22 May 2020 09:48:27 GMT-07:00Environment-Wide Association Study of CKDLee, JeonghwanOh, SoheeKang, HabyeongKim, SunmiLee, GowoonLi, LilinKim, Clara TammyAn, Jung NamOh, Yun KyuLim, Chun SooKim, Dong KiKim, Yon SuChoi, KyunghoLee, Jung Pyo2020-05-22T09:48:27-07:00doi:10.2215/CJN.06780619hwp:resource-id:clinjasn;15/6/766American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyenvironmental chemicals, chronic kidney disease, glomerular filtration rate, lead, cadmium, volatile organic compounds, perfluorooctanoic acid, albuminuria, phenylglyoxylic acid, Cotinine, Thiocyanates, Volatile Organic Compounds, creatinine, Polycyclic Aromatic Hydrocarbons, risk factors, Caprylates, Fluorocarbons, Renal Insufficiency, ChronicOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-06-08June 08, 202010.2215/CJN.067806191555-90411555-905X2020-05-22T09:48:27-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles1566766745775746http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07060619?cct=218810.2215/CJN.07060619Thu, 28 May 2020 03:00:08 GMT-07:00Low Serum Bicarbonate and CKD Progression in ChildrenBrown, Denver D.Roem, JenniferNg, Derek K.Reidy, Kimberly J.Kumar, JuhiAbramowitz, Matthew K.Mak, Robert H.Furth, Susan L.Schwartz, George J.Warady, Bradley A.Kaskel, Frederick J.Melamed, Michal L.2020-05-28T15:00:08-07:00doi:10.2215/CJN.07060619hwp:resource-id:clinjasn;15/6/755American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, chronic metabolic acidosis, pediatrics, renal progression, bicarbonates, phosphates, alkalis, renal insufficiency, chronic, longitudinal studies, proteinuria, glomerular filtration rate, renal replacement therapy, anemia, acidosis, hypertension, demographyOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-06-08June 08, 202010.2215/CJN.070606191555-90411555-905X2020-05-28T15:00:08-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles156755765http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13201019?cct=218810.2215/CJN.13201019Tue, 28 Apr 2020 06:21:14 GMT-07:00Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKDSrivastava, AnandCai, XuanLee, JungwhaLi, WeiLarive, BrettKendrick, CynthiaGassman, Jennifer J.Middleton, John P.Carr, JamesRaphael, Kalani L.Cheung, Alfred K.Raj, Dominic S.Chonchol, Michel B.Fried, Linda F.Block, Geoffrey A.Sprague, Stuart M.Wolf, MylesIx, Joachim H.Prasad, Pottumarthi V.Isakova, Tamara2020-04-28T06:21:14-07:00doi:10.2215/CJN.13201019hwp:resource-id:clinjasn;15/6/776American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyMRI, hypoxia, fibrosis, chronic kidney disease, ESRD, glomerular filtration rate, lanthanum carbonate, albuminuria, Niacinamide, Follow-Up Studies, Diffusion Magnetic Resonance Imaging, Renal Insufficiency, Chronic, Magnetic Resonance Imaging, Lanthanum, Biomarkers, OxygenOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-06-08June 08, 202010.2215/CJN.132010191555-90411555-905X2020-04-28T06:21:14-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles1566776747783749http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08890719?cct=2188The class of human genetic kidney diseases is extremely broad and heterogeneous. Accordingly, the range of associated disease phenotypes is highly variable. Many children and adults affected by inherited kidney disease will progress to ESKD at some point in life. Extensive research has been performed on various different disease models to investigate the underlying causes of genetic kidney disease and to identify disease mechanisms that are amenable to therapy. We review some of the research highlights that, by modeling inherited kidney disease, contributed to a better understanding of the underlying pathomechanisms, leading to the identification of novel genetic causes, new therapeutic targets, and to the development of new treatments. We also discuss how the implementation of more efficient genome-editing techniques and tissue-culture methods for kidney research is providing us with personalized models for a precision-medicine approach that takes into account the specificities of the patient and the underlying disease. We focus on the most common model systems used in kidney research and discuss how, according to their specific features, they can differentially contribute to biomedical research. Unfortunately, no definitive treatment exists for most inherited kidney disorders, warranting further exploitation of the existing disease models, as well as the implementation of novel, complex, human patient–specific models to deliver research breakthroughs.10.2215/CJN.08890719Thu, 05 Mar 2020 06:30:37 GMT-08:00Disease Modeling To Understand the Pathomechanisms of Human Genetic Kidney DisordersThe class of human genetic kidney diseases is extremely broad and heterogeneous. Accordingly, the range of associated disease phenotypes is highly variable. Many children and adults affected by inherited kidney disease will progress to ESKD at some point in life. Extensive research has been performed on various different disease models to investigate the underlying causes of genetic kidney disease and to identify disease mechanisms that are amenable to therapy. We review some of the research highlights that, by modeling inherited kidney disease, contributed to a better understanding of the underlying pathomechanisms, leading to the identification of novel genetic causes, new therapeutic targets, and to the development of new treatments. We also discuss how the implementation of more efficient genome-editing techniques and tissue-culture methods for kidney research is providing us with personalized models for a precision-medicine approach that takes into account the specificities of the patient and the underlying disease. We focus on the most common model systems used in kidney research and discuss how, according to their specific features, they can differentially contribute to biomedical research. Unfortunately, no definitive treatment exists for most inherited kidney disorders, warranting further exploitation of the existing disease models, as well as the implementation of novel, complex, human patient–specific models to deliver research breakthroughs.Molinari, ElisaSayer, John A.2020-03-05T06:30:37-08:00doi:10.2215/CJN.08890719hwp:resource-id:clinjasn;15/6/855American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologygenetic renal disease, transgenic mouse, zebrafish, molecular geneticsGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-06-08June 08, 202010.2215/CJN.088907191555-90411555-905X2020-03-05T06:30:37-08:002020-06-08Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease156855872http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08540719?cct=218810.2215/CJN.08540719Tue, 04 Feb 2020 09:06:07 GMT-08:00SONARWalsh, Michael2020-02-04T09:06:07-08:00doi:10.2215/CJN.08540719hwp:resource-id:clinjasn;15/6/889American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyatrasentan, randomized controlled trials, diabetic nephropathy, humans, albuminuria, diabetic nephropathies, endothelin A receptor antagonists, type 2 diabetes mellitus, creatinine, nephrology, incidence, confidence intervals, endothelin A receptor, sample size, reproducibility of results, pyrrolidines, chronic renal insufficiency, chronic kidney failure, kidneyPerspectivesPerspectivesresearch-article20202020-06-08June 08, 202010.2215/CJN.085407191555-90411555-905X2020-02-04T09:06:07-08:002020-06-08Clinical Journal of the American Society of NephrologyPerspectives156889891http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05180420?cct=218810.2215/CJN.05180420Tue, 28 Apr 2020 06:21:15 GMT-07:00Impending Shortages of Kidney Replacement Therapy for COVID-19 PatientsGoldfarb, David S.Benstein, Judith A.Zhdanova, OlgaHammer, ElizabethBlock, Clay A.Caplin, Nina J.Thompson, NathanCharytan, David M.2020-04-28T06:21:15-07:00doi:10.2215/CJN.05180420hwp:resource-id:clinjasn;15/6/880American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyacute kidney injury, kidney replacement, hemodialysis, peritoneal dialysis, intensive care medicine, COVID-19, severe acute respiratory syndrome coronavirus 2, Renal Replacement TherapyPerspectivesPerspectivesresearch-article20202020-06-08June 08, 202010.2215/CJN.051804201555-90411555-905X2020-04-28T06:21:15-07:002020-06-08Clinical Journal of the American Society of NephrologyPerspectives156880882http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09000819?cct=218810.2215/CJN.09000819Tue, 04 Feb 2020 09:06:07 GMT-08:00Screening for Cancer in Patients with Glomerular DiseasesPlaisier, EmmanuelleRonco, Pierre2020-02-04T09:06:07-08:00doi:10.2215/CJN.09000819hwp:resource-id:clinjasn;15/6/886American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyCancer, nephrotic syndrome, membranous nephropathy, humans, human PLA2R1 protein, phospholipase A2 receptors, membranoproliferative glomerulonephritis, nephrologists, immunosuppressive agents, risk factors, nephrology, cost-benefit analysis, early detection of cancer, follow-up studies, kidney, recurrence, phospholipases A2, cytosolic phospholipases A2, treatment failure, thrombospondins, neoplasmsPerspectivesPerspectivesresearch-article20202020-06-08June 08, 202010.2215/CJN.090008191555-90411555-905X2020-02-04T09:06:07-08:002020-06-08Clinical Journal of the American Society of NephrologyPerspectives156886888http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04530420?cct=218810.2215/CJN.04530420Fri, 24 Apr 2020 04:43:33 GMT-07:00How COVID-19 Has Changed the Management of Glomerular DiseasesBomback, Andrew S.Canetta, Pietro A.Ahn, WooinAhmad, Syeda B.Radhakrishnan, JaiAppel, Gerald B.2020-04-24T04:43:33-07:00doi:10.2215/CJN.04530420hwp:resource-id:clinjasn;15/6/876American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyglomerular disease, immunosuppression, COVID-19, severe acute respiratory syndrome coronavirus 2, kidney diseasesPerspectivesPerspectivesresearch-article20202020-06-08June 08, 202010.2215/CJN.045304201555-90411555-905X2020-04-24T04:43:33-07:002020-06-08Clinical Journal of the American Society of NephrologyPerspectives156876879http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09390819?cct=218810.2215/CJN.09390819Fri, 21 Feb 2020 07:05:01 GMT-08:00Chronicle of a Death ForetoldRifkin, Dena E.2020-02-21T07:05:01-08:00doi:10.2215/CJN.09390819hwp:resource-id:clinjasn;15/6/883American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologymortality risk, study design, male, humans, conservative treatment, epidemiologists, hospice care, terminal care, kidney, chronic kidney failure, bias, neoplasmsPerspectivesPerspectivesresearch-article20202020-06-08June 08, 202010.2215/CJN.093908191555-90411555-905X2020-02-21T07:05:01-08:002020-06-08Clinical Journal of the American Society of NephrologyPerspectives156883885http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12541019?cct=218810.2215/CJN.12541019Thu, 07 May 2020 05:34:26 GMT-07:00Association of Socioeconomic Status and Comorbidities with Racial Disparities during Kidney Transplant EvaluationMurphy, Karly A.Jackson, John W.Purnell, Tanjala S.Shaffer, Ashton A.Haugen, Christine E.Chu, Nadia M.Crews, Deidra C.Norman, Silas P.Segev, Dorry L.McAdams-DeMarco, Mara A.2020-05-07T05:34:26-07:00doi:10.2215/CJN.12541019hwp:resource-id:clinjasn;15/6/843American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologytransplantation, end stage kidney disease, kidney transplantation, risk factors, Incidence, Prospective Studies, African Americans, Social Class, Continental Population Groups, Renal Insufficiency, Employment, Comorbidity, Cohort StudiesOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-06-08June 08, 202010.2215/CJN.125410191555-90411555-905X2020-05-07T05:34:26-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles156843851http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11460919?cct=218810.2215/CJN.11460919Thu, 28 May 2020 03:00:07 GMT-07:00Inequity in Access to Transplantation in the United KingdomPruthi, RishiRobb, Matthew L.Oniscu, Gabriel C.Tomson, CharlesBradley, AndrewForsythe, John L.Metcalfe, WendyBradley, ClareDudley, ChristopherJohnson, Rachel J.Watson, ChristopherDraper, HeatherFogarty, DamianRavanan, RommelRoderick, Paul J.,2020-05-28T15:00:07-07:00doi:10.2215/CJN.11460919hwp:resource-id:clinjasn;15/6/830American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyclinical epidemiology, Epidemiology and outcomes, ethnicity, kidney transplantation, inequity, socio-economic deprivation, transplant waiting list, renal dialysis, Ethnic Groups, Minority Groups, Universal Health Care, Cohort Studies, Body Mass Index, Prospective Studies, Social Class, Renal Replacement Therapy, African Americans, Diagnosis-Related Groups, Outcome Assessment, Health CareOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-06-08June 08, 202010.2215/CJN.114609191555-90411555-905X2020-05-28T15:00:07-07:002020-06-08Clinical Journal of the American Society of NephrologyOriginal Articles1566830752842754http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00100120?cct=218810.2215/CJN.00100120Fri, 06 Mar 2020 07:58:10 GMT-08:00A Case of Nephrotic Syndrome after Allogeneic Stem Cell TransplantationHogan, Jonathan J.2020-03-06T07:58:10-08:00doi:10.2215/CJN.00100120hwp:resource-id:clinjasn;15/6/873American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyidiopathic nephrotic syndrome, onconephrology, minimal change disease, glomerular disease, nephrotic syndrome, Hematopoietic Stem Cell, TransplantationKidney Case Conference: Nephrology Quiz and QuestionnaireKidney Case Conference: Nephrology Quiz and Questionnaireresearch-article20202020-06-08June 08, 202010.2215/CJN.001001201555-90411555-905X2020-03-06T07:58:10-08:002020-06-08Clinical Journal of the American Society of NephrologyKidney Case Conference: Nephrology Quiz and Questionnaire156873875http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04510420?cct=218810.2215/CJN.04510420Tue, 28 Apr 2020 06:21:15 GMT-07:00Outpatient Management of the Kidney Transplant Recipient during the SARS-CoV-2 Virus PandemicGleeson, Shana E.Formica, Richard N.Marin, Ethan P.2020-04-28T06:21:15-07:00doi:10.2215/CJN.04510420hwp:resource-id:clinjasn;15/6/892American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyimmunosuppression, virology, COVID-19, SARS Virus, Cough, Pandemics, Public Health, Outpatients, Oxygen, kidney transplantation, Physical Exertion, severe acute respiratory syndrome coronavirus 2, Severe Acute Respiratory Syndrome, Fever, Patient Care, Dyspnea, Cytomegalovirus InfectionsFeaturesFeaturesother20202020-06-08June 08, 202010.2215/CJN.045104201555-90411555-905X2020-04-28T06:21:15-07:002020-06-08Clinical Journal of the American Society of NephrologyFeatures156892895http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03000320?cct=218810.2215/CJN.03000320Thu, 28 May 2020 03:00:08 GMT-07:00Will Universal Access to Health Care Mean Equitable Access to Kidney Transplantation?Harhay, Meera N.Mark, Patrick B.2020-05-28T15:00:08-07:00doi:10.2215/CJN.03000320hwp:resource-id:clinjasn;15/6/752American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, healthcare, disparities, Health Services, Accessibility, Healthcare DisparitiesEditorialsEditorialseditorial20202020-06-08June 08, 202010.2215/CJN.030003201555-90411555-905X2020-05-28T15:00:08-07:002020-06-08Clinical Journal of the American Society of NephrologyEditorials1566752830754842http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070756?cct=218810.1681/ASN.2019070756Thu, 07 May 2020 10:08:18 GMT-07:00ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid TreatmentWidmeier, EugenYu, SeyoungNag, AnishChung, Youn WookNakayama, MakikoFernández-del-Río, LucíaHugo, HannahSchapiro, DavidBuerger, FlorianChoi, Won-IlHelmstädter, MartinKim, Jae-wooRyu, Ji-HwanLee, Min GooClarke, Catherine F.Hildebrandt, FriedhelmGee, Heon Yung2020-05-07T10:08:18-07:00doi:10.1681/ASN.2019070756hwp:resource-id:jnephrol;31/6/1191American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyADCK4, steroid-resistant nephrotic syndrome, coenzyme Q10, Q complex, 2,4-dihydroxybenzoic acidBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20190707561046-66731533-34502020-05-07T10:08:18-07:002020-06Journal of the American Society of NephrologyBasic Research31661191116712111169http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101008?cct=218810.1681/ASN.2019101008Thu, 16 Apr 2020 06:18:00 GMT-07:00Incident Chronic Kidney Disease Risk among Hispanics/Latinos in the United States: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)Ricardo, Ana C.Loop, Matthew ShaneGonzalez, FranklynLora, Claudia M.Chen, JinsongFranceschini, NoraKramer, Holly J.Toth-Manikowski, Stephanie M.Talavera, Gregory A.Daviglus, MarthaLash, James P.2020-04-16T06:18:00-07:00doi:10.1681/ASN.2019101008hwp:resource-id:jnephrol;31/6/1315American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCKD, clinical epidemiology, risk factorsClinical EpidemiologyClinical Epidemiologyresearch-article20202020-06-01June 202010.1681/ASN.20191010081046-66731533-34502020-04-16T06:18:00-07:002020-06Journal of the American Society of NephrologyClinical Epidemiology31613151324http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010071?cct=218810.1681/ASN.2020010071Fri, 01 May 2020 07:53:50 GMT-07:00Quantitative Proteomics of All 14 Renal Tubule Segments in RatLimbutara, KaveeChou, Chung-LinKnepper, Mark A.2020-05-01T07:53:50-07:00doi:10.1681/ASN.2020010071hwp:resource-id:jnephrol;31/6/1255American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologykidney tubule, Mass spectrometry, Database, Systems BiologyBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20200100711046-66731533-34502020-05-01T07:53:50-07:002020-06Journal of the American Society of NephrologyBasic Research31612551266http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090904?cct=218810.1681/ASN.2019090904Tue, 05 May 2020 05:45:03 GMT-07:00Hip Fracture Risk among Hemodialysis-Dependent Patients Prescribed Opioids and GabapentinoidsVangala, ChandanNiu, JingboMontez-Rath, Maria E.Yan, JingyinNavaneethan, Sankar D.Naik, Aanand D.Winkelmayer, Wolfgang C.2020-05-05T05:45:03-07:00doi:10.1681/ASN.2019090904hwp:resource-id:jnephrol;31/6/1325American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyUnited States Renal Data System, clinical epidemiology, mineral metabolismClinical EpidemiologyClinical Epidemiologyresearch-article20202020-06-01June 202010.1681/ASN.20190909041046-66731533-34502020-05-05T05:45:03-07:002020-06Journal of the American Society of NephrologyClinical Epidemiology31613251334http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090962?cct=218810.1681/ASN.2019090962Thu, 07 May 2020 10:08:17 GMT-07:00Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult KidneyLaszczyk, Ann M.Higashi, Atsuko Y.Patel, Sanjeevkumar R.Johnson, Craig N.Soofi, AbdulAbraham, SajiDressler, Gregory R.2020-05-07T10:08:17-07:00doi:10.1681/ASN.2019090962hwp:resource-id:jnephrol;31/6/1212American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCell & Transport Physiology, diabetes insipidus, genetics and development, osmolality, renal epithelial cell, water channelsBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20190909621046-66731533-34502020-05-07T10:08:17-07:002020-06Journal of the American Society of NephrologyBasic Research31612121225http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090923?cct=218810.1681/ASN.2019090923Wed, 15 Apr 2020 09:19:02 GMT-07:00Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted TubuleWu, PengSu, Xiao-TongGao, Zhong-XiuziZhang, Dan-DanDuan, Xin-PengXiao, YuStaub, OlivierWang, Wen-HuiLin, Dao-Hong2020-04-15T09:19:02-07:00doi:10.1681/ASN.2019090923hwp:resource-id:jnephrol;31/6/1226American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologypotassium channels, renal tubular epithelial cells, Cell Signaling, Cell and Transport Physiology, hypokalemiaBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20190909231046-66731533-34502020-04-15T09:19:02-07:002020-06Journal of the American Society of NephrologyBasic Research31612261242http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121285?cct=218810.1681/ASN.2019121285Thu, 16 Apr 2020 06:18:00 GMT-07:00Urinary Soluble CD163: a Novel Noninvasive Biomarker of Activity for Lupus NephritisMejia-Vilet, Juan M.Zhang, Xiaolan L.Cruz, CristinoCano-Verduzco, Mayra L.Shapiro, John P.Nagaraja, Haikady N.Morales-Buenrostro, Luis E.Rovin, Brad H.2020-04-16T06:18:00-07:00doi:10.1681/ASN.2019121285hwp:resource-id:jnephrol;31/6/1335American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologysoluble CD163, CD163 receptor, lupus nephritis, biomarkers, systemic lupus erythematosus, macrophagesClinical ResearchClinical Researchresearch-article20202020-06-01June 202010.1681/ASN.20191212851046-66731533-34502020-04-16T06:18:00-07:002020-06Journal of the American Society of NephrologyClinical Research31613351347http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070745?cct=218810.1681/ASN.2019070745Thu, 07 May 2020 10:08:17 GMT-07:00A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized ChildrenSandokji, IbrahimYamamoto, YuBiswas, AdityaArora, TanimaUgwuowo, UgochukwuSimonov, MichaelSaran, IshanMartin, MelissaTestani, Jeffrey M.Mansour, SherryMoledina, Dennis G.Greenberg, Jason H.Wilson, F. Perry2020-05-07T10:08:17-07:00doi:10.1681/ASN.2019070745hwp:resource-id:jnephrol;31/6/1348American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyacute kidney injury, pediatrics, electronic health records, risk, feature selectionClinical ResearchClinical Researchresearch-article20202020-06-01June 202010.1681/ASN.20190707451046-66731533-34502020-05-07T10:08:17-07:002020-06Journal of the American Society of NephrologyClinical Research31613481357http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019111174?cct=218810.1681/ASN.2019111174Fri, 22 May 2020 05:50:33 GMT-07:00A Deregulated Stress Response Underlies Distinct INF2-Associated Disease ProfilesBayraktar, SametNehrig, JulianMenis, EkaterinaKarli, KevserJanning, AnnetteStruk, ThaddäusHalbritter, JanMichgehl, UlfKrahn, Michael P.Schuberth, Christian E.Pavenstädt, HermannWedlich-Söldner, Roland2020-05-22T05:50:33-07:00doi:10.1681/ASN.2019111174hwp:resource-id:jnephrol;31/6/1296American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyactin, INF2, CaAR, focal segmental glomerulosclerosis, imagingBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20191111741046-66731533-34502020-05-22T05:50:33-07:002020-06Journal of the American Society of NephrologyBasic Research31612961313http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040467?cct=218810.1681/ASN.2020040467Thu, 07 May 2020 10:08:19 GMT-07:00Mitochondria Matter: A Critical Role of ADCK4 in Stabilizing the CoQ Complex in Podocytes in Steroid-Resistant Nephrotic SyndromeDaehn, Ilse S.2020-05-07T10:08:19-07:00doi:10.1681/ASN.2020040467hwp:resource-id:jnephrol;31/6/1167American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycoenzyme Q10, mitochondria, nephrotic syndrome, molecular geneticsEditorialEditorialresearch-article20202020-06-01June 202010.1681/ASN.20200404671046-66731533-34502020-05-07T10:08:19-07:002020-06Journal of the American Society of NephrologyEditorial31661167119111691211http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101131?cct=218810.1681/ASN.2019101131Thu, 07 May 2020 10:08:18 GMT-07:00Perturbations of the Gut Microbiome and Metabolome in Children with Calcium Oxalate Kidney Stone DiseaseDenburg, Michelle R.Koepsell, KristenLee, Jung-JinGerber, JeffreyBittinger, KyleTasian, Gregory E.2020-05-07T10:08:18-07:00doi:10.1681/ASN.2019101131hwp:resource-id:jnephrol;31/6/1358American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologykidney stones, metabolism, intestine, pediatric nephrologyClinical ResearchClinical Researchresearch-article20202020-06-01June 202010.1681/ASN.20191011311046-66731533-34502020-05-07T10:08:18-07:002020-06Journal of the American Society of NephrologyClinical Research31613581369http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060619?cct=218810.1681/ASN.2019060619Fri, 22 May 2020 05:50:33 GMT-07:00Experimental Antiglomerular Basement Membrane GN Induced by a Peptide from ActinomycesGu, Qiu-huaHuynh, MeganShi, YueJia, Xiao-yuLuo, Jie-jianJiang, Tai-jiaoCui, ZhaoOoi, Joshua D.Kitching, A. RichardZhao, Ming-hui2020-05-22T05:50:33-07:00doi:10.1681/ASN.2019060619hwp:resource-id:jnephrol;31/6/1282American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyglomerular disease, pathology, renal injuryBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20190606191046-66731533-34502020-05-22T05:50:33-07:002020-06Journal of the American Society of NephrologyBasic Research31612821295http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040494?cct=218810.1681/ASN.2020040494Fri, 29 May 2020 09:59:49 GMT-07:00This Month’s HighlightsAmerican Society of Nephrology2020-05-29T09:59:49-07:00doi:10.1681/ASN.2020040494hwp:resource-id:jnephrol;31/6/iAmerican Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyThis Month’s HighlightsThis Month’s Highlightsin-brief20202020-06-01June 202010.1681/ASN.20200404941046-66731533-34502020-05-29T09:59:49-07:002020-06Journal of the American Society of NephrologyThis Month’s Highlights316iihttp://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090934?cct=218810.1681/ASN.2019090934Thu, 16 Apr 2020 06:17:59 GMT-07:00Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2–Mediated Blood Pressure Reduction Independent of CystogenesisLakshmipathi, JayalakshmiGao, YangHu, ChunyanStuart, DeborahGenzen, JonathanRamkumar, NirupamaKohan, Donald E.2020-04-16T06:17:59-07:00doi:10.1681/ASN.2019090934hwp:resource-id:jnephrol;31/6/1243American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologynephron, polycystic kidney disease, blood pressure, epithelial sodium transportBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20190909341046-66731533-34502020-04-16T06:17:59-07:002020-06Journal of the American Society of NephrologyBasic Research31612431254http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121320?cct=2188The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and cells from the renal interstitium. Through modulating immune responses and via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. In this Review, we provide an overview of the development, structure, and function of lymphatic vessels in the healthy adult kidney. We then highlight the contributions of lymphatic vessels to multiple forms of renal pathology, emphasizing CKD, transplant rejection, and polycystic kidney disease and discuss strategies to target renal lymphatics using genetic and pharmacologic approaches. Overall, we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and treatments modulating these vessels having therapeutic potential across the spectrum of kidney disease.10.1681/ASN.2019121320Wed, 15 Apr 2020 09:19:01 GMT-07:00Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney DiseasesThe kidney contains a network of lymphatic vessels that clear fluid, small molecules, and cells from the renal interstitium. Through modulating immune responses and via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. In this Review, we provide an overview of the development, structure, and function of lymphatic vessels in the healthy adult kidney. We then highlight the contributions of lymphatic vessels to multiple forms of renal pathology, emphasizing CKD, transplant rejection, and polycystic kidney disease and discuss strategies to target renal lymphatics using genetic and pharmacologic approaches. Overall, we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and treatments modulating these vessels having therapeutic potential across the spectrum of kidney disease.Jafree, Daniyal J.Long, David A.2020-04-15T09:19:01-07:00doi:10.1681/ASN.2019121320hwp:resource-id:jnephrol;31/6/1178American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycell signaling, endothelial cells, kidney development, pathophysiology of renal disease and progression, renal cell biology, kidney diseaseReviewReviewreview-article20202020-06-01June 202010.1681/ASN.20191213201046-66731533-34502020-04-15T09:19:01-07:002020-06Journal of the American Society of NephrologyReview31611781190http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101029?cct=218810.1681/ASN.2019101029Fri, 01 May 2020 07:53:51 GMT-07:00Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid–Mediated Activation of G Protein–Coupled Receptors GPR43 and GPR109ALi, Yan JunChen, XiaochenKwan, Tony K.Loh, Yik WenSinger, JulianLiu, YunziMa, JinTan, JianMacia, LaurenceMackay, Charles R.Chadban, Steven J.Wu, Huiling2020-05-01T07:53:51-07:00doi:10.1681/ASN.2019101029hwp:resource-id:jnephrol;31/6/1267American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydiabetic nephropathy, metabolism, chronic inflammationBasic ResearchBasic Researchresearch-article20202020-06-01June 202010.1681/ASN.20191010291046-66731533-34502020-05-01T07:53:51-07:002020-06Journal of the American Society of NephrologyBasic Research31612671281http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040416?cct=218810.1681/ASN.2020040416Tue, 28 Apr 2020 02:53:06 GMT-07:00The Immunocompromised Transplant Recipient and SARS-CoV-2 InfectionFishman, Jay A.2020-04-28T14:53:06-07:00doi:10.1681/ASN.2020040416hwp:resource-id:jnephrol;31/6/1147American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCOVID-19, transplantation, immunosuppressionEditorialEditorialeditorial20202020-06-01June 201910.1681/ASN.20200404161046-66731533-34502020-04-28T14:53:06-07:002020-06Journal of the American Society of NephrologyEditorial31661147115011491156http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030276?cct=218810.1681/ASN.2020030276Tue, 28 Apr 2020 02:53:06 GMT-07:00Renal Involvement and Early Prognosis in Patients with COVID-19 PneumoniaPei, GuangchangZhang, ZhiguoPeng, JingLiu, LiuZhang, ChunxiuYu, ChongMa, ZufuHuang, YiLiu, WeiYao, YingZeng, RuiXu, Gang2020-04-28T14:53:06-07:00doi:10.1681/ASN.2020030276hwp:resource-id:jnephrol;31/6/1157American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyPneumonia, proteinuria, Hematuria, Acute Kidney Failure, COVID-19Rapid CommunicationRapid Communicationresearch-article20202020-06-01June 202010.1681/ASN.20200302761046-66731533-34502020-04-28T14:53:06-07:002020-06Journal of the American Society of NephrologyRapid Communication31611571165http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020040412?cct=218810.1681/ASN.2020040412Thu, 16 Apr 2020 06:17:58 GMT-07:00Counterpoint: Twice-Weekly Hemodialysis Should Be an Approach of Last Resort Even in Times of Dialysis Unit StressMehrotra, Rajnish2020-04-16T06:17:58-07:00doi:10.1681/ASN.2020040412hwp:resource-id:jnephrol;31/6/1143American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyhemodialysis, kidney failure, congestive heart failure, COVID-19EditorialEditorialresearch-article20202020-06-01June 202010.1681/ASN.20200404121046-66731533-34502020-04-16T06:17:58-07:002020-06Journal of the American Society of NephrologyEditorial31661143114111441142http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030375?cct=218810.1681/ASN.2020030375Tue, 21 Apr 2020 04:45:09 GMT-07:00Early Description of Coronavirus 2019 Disease in Kidney Transplant Recipients in New YorkThe Columbia University Kidney Transplant ProgramHusain, S. AliChang, Jae H.Cohen, David J.Crew, R. JohnDube, Geoffrey K.Fernandez, Hilda E.Morris, Heather K.Aaron, Justin G.Miko, Benjamin A.Pereira, Marcus R.Hardy, Mark A.McCune, Kasi R.Ratner, Lloyd E.Sandoval, P. RodrigoWeiner, JoshuaTsapepas, DemetraMohan, Sumit2020-04-21T16:45:09-07:00doi:10.1681/ASN.2020030375hwp:resource-id:jnephrol;31/6/1150American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologytransplant outcomes, kidney transplantation, Epidemiology and outcomes, COVID-19Rapid CommunicationRapid Communicationresearch-article20202020-06-01June 202010.1681/ASN.20200303751046-66731533-34502020-04-21T16:45:09-07:002020-06Journal of the American Society of NephrologyRapid Communication31661150114711561149http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030348?cct=218810.1681/ASN.2020030348Mon, 20 Apr 2020 12:06:55 GMT-07:00COVID-19 and Calcineurin Inhibitors: Should They Get Left Out in the Storm?Willicombe, MichelleThomas, DavidMcAdoo, Stephen2020-04-20T12:06:55-07:00doi:10.1681/ASN.2020030348hwp:resource-id:jnephrol;31/6/1145American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyimmunosuppression, tacrolimus, transplantation, COVID-19PerspectivePerspectiveresearch-article20202020-06-01June 202010.1681/ASN.20200303481046-66731533-34502020-04-20T12:06:55-07:002020-06Journal of the American Society of NephrologyPerspective31611451146http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050510?cct=218810.1681/ASN.2019050510Thu, 16 Apr 2020 06:18:00 GMT-07:00On the Etymology of Nephritis: A Historical Appraisal of its OriginsEknoyan, Garabed2020-04-16T06:18:00-07:00doi:10.1681/ASN.2019050510hwp:resource-id:jnephrol;31/6/1170American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyBright’s disease, glomerulus, GN, nephritis, nephrosis, glomerulosclerosisUp Front MattersPerspectivesUp Front MattersPerspectivesresearch-article20202020-06-01June 202010.1681/ASN.20190505101046-66731533-34502020-04-16T06:18:00-07:002020-06Journal of the American Society of NephrologyUp Front Matters31611701173http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020030361?cct=218810.1681/ASN.2020030361Thu, 16 Apr 2020 06:17:58 GMT-07:00Twice-Weekly Hemodialysis Is an Option for Many Patients in Times of Dialysis Unit StressMeyer, Timothy W.Hostetter, Thomas H.Watnick, Suzanne2020-04-16T06:17:58-07:00doi:10.1681/ASN.2020030361hwp:resource-id:jnephrol;31/6/1141American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCOVID-19, hemodialysis, dialysisPerspectivePerspectiveeditorial20202020-06-01June 202010.1681/ASN.20200303611046-66731533-34502020-04-16T06:17:58-07:002020-06Journal of the American Society of NephrologyPerspective31661141114311421144http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020121?cct=218810.1681/ASN.2020020121Mon, 20 Apr 2020 04:55:27 GMT-07:00The Broader Sharing of Deceased Donor Kidneys Is an Ethical and Legal ImperativeKlarman, Sharon E.Formica, Richard N.2020-04-20T04:55:27-07:00doi:10.1681/ASN.2020020121hwp:resource-id:jnephrol;31/6/1174American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologykidney transplantation, cadaver organ transplantation, clinical nephrologyPerspectivesPerspectivesresearch-article20202020-06-01June 202010.1681/ASN.20200201211046-66731533-34502020-04-20T04:55:27-07:002020-06Journal of the American Society of NephrologyPerspectives31611741176http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000672019?cct=218810.34067/KID.0000672019Fri, 27 Mar 2020 11:05:26 GMT-07:00ESKD Treatment Choices Model: Responsible Home Dialysis Growth Requires Systems ChangesWallace, Eric L.Allon, Michael2020-03-27T11:05:26-07:00doi:10.34067/KID.0000672019hwp:resource-id:kidney360;1/5/424American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Feasibility Studies, Hemodialysis, Home, Patient Preference, Peritoneal Dialysis, Renal Insufficiency, Chronic, Sustainable GrowthPerspectivePerspectiveresearch-article20202020-05-2810.34067/KID.00006720192641-76502020-03-27T11:05:26-07:002020-05-28Kidney360Perspective15424427http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000702020?cct=218810.34067/KID.0000702020Tue, 14 Apr 2020 05:30:10 GMT-07:00Should Buttonhole Cannulation of Arteriovenous Fistulas be Used? PROLabriola, Laura2020-04-14T05:30:10-07:00doi:10.34067/KID.0000702020hwp:resource-id:kidney360;1/5/318American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, arteriovenous fistulas, buttonhole cannulation, catheterization, disinfection, needles, punctures, renal dialysisDebates in NephrologyDebates in Nephrologyresearch-article20202020-05-2810.34067/KID.00007020202641-76502020-04-14T05:30:10-07:002020-05-28Kidney360Debates in Nephrology15318321http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001682020?cct=218810.34067/KID.0001682020Tue, 14 Apr 2020 05:30:10 GMT-07:00Should Buttonhole Cannulation of Arteriovenous Fistulas Be Used? Moderator CommentaryAgarwal, Anil K.2020-04-14T05:30:10-07:00doi:10.34067/KID.0001682020hwp:resource-id:kidney360;1/5/326American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Buttonhole, Cannulation, Hemodialysis vascular access, Home hemodialysis, Infections, Rope LadderModerator CommentaryModerator Commentaryarticle-commentary20202020-05-2810.34067/KID.00016820202641-76502020-04-14T05:30:10-07:002020-05-28Kidney360Moderator Commentary15326329http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000602019?cct=218810.34067/KID.0000602019Tue, 14 Apr 2020 05:30:10 GMT-07:00Should Buttonhole Cannulation of Arteriovenous Fistulas Be Used? CONMacRae, Jennifer M.2020-04-14T05:30:10-07:00doi:10.34067/KID.0000602019hwp:resource-id:kidney360;1/5/322American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, arteriovenous fistula, buttonhole, constant site cannulation, fistula, hemodialysis, rope ladder cannulation, vascular accessDebates in NephrologyDebates in Nephrologyresearch-article20202020-05-2810.34067/KID.00006020192641-76502020-04-14T05:30:10-07:002020-05-28Kidney360Debates in Nephrology15322325http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000162020?cct=218810.34067/KID.0000162020Thu, 16 Apr 2020 06:16:51 GMT-07:00Global Dialysis Perspective: JapanHanafusa, NorioFukagawa, Masafumi2020-04-16T06:16:51-07:00doi:10.34067/KID.0000162020hwp:resource-id:kidney360;1/5/416American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, anemia, hemodiafiltration, hemodialysis, Japan, peritoneal dialysis, PTH, reimbursement, survival, transplantation, vascular accessGlobal PerspectivesGlobal Perspectivesresearch-article20202020-05-2810.34067/KID.00001620202641-76502020-04-16T06:16:51-07:002020-05-28Kidney360Global Perspectives15416419http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0002152020?cct=218810.34067/KID.0002152020Fri, 24 Apr 2020 02:30:46 GMT-07:00Peritoneal Dialysis for Acute Kidney Injury Treatment in the United States: Brought to You by the COVID-19 PandemicSrivatana, VeshAggarwal, VikramFinkelstein, Fredric O.Naljayan, MihranCrabtree, John H.Perl, Jeffrey2020-04-24T14:30:46-07:00doi:10.34067/KID.0002152020hwp:resource-id:kidney360;1/5/410American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, acute kidney injury, acute peritoneal dialysis, automated peritoneal dialysis, continuous ambulatory peritoneal dialysis, COVID-19, peritoneal dialysis, peritoneal dialysis catheterGlobal PerspectivesGlobal Perspectivesresearch-article20202020-05-2810.34067/KID.00021520202641-76502020-04-24T14:30:46-07:002020-05-28Kidney360Global Perspectives15410415http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001782020?cct=218810.34067/KID.0001782020Fri, 17 Apr 2020 10:39:57 GMT-07:00Delivering Safe and Effective Hemodialysis in Patients with Suspected or Confirmed COVID-19 Infection: A Single-Center Perspective from ItalyGallieni, MaurizioSabiu, GianmarcoScorza, Daniele2020-04-17T10:39:57-07:00doi:10.34067/KID.0001782020hwp:resource-id:kidney360;1/5/403American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, coronavirus, COVID-19, hemodialysis, infection, Italy, management, protocolGlobal PerspectivesGlobal Perspectivesresearch-article20202020-05-2810.34067/KID.00017820202641-76502020-04-17T10:39:57-07:002020-05-28Kidney360Global Perspectives15403409http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000782019?cct=218810.34067/KID.0000782019Tue, 24 Mar 2020 02:22:15 GMT-07:00α1-Acid Glycoprotein Attenuates Adriamycin-Induced Nephropathy via CD163 Expressing Macrophage InductionFujimura, RuiWatanabe, HiroshiNishida, KentoFujiwara, YukioKoga, TomoakiBi, JingImafuku, TadashiKobayashi, KazukiKomori, HisakazuMiyahisa, MasakoMaeda, HitoshiTanaka, MotokoMatsushita, KazutakaWada, TakashiFukagawa, MasafumiMaruyama, Toru2020-03-24T14:22:15-07:00doi:10.34067/KID.0000782019hwp:resource-id:kidney360;1/5/343American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360CKD, α1-acid glycoprotein, macrophage polarization, proteinuria, Basic ScienceOriginal InvestigationsAcute Kidney Injury and ICU NephrologyOriginal InvestigationsAcute Kidney Injury and ICU Nephrologyresearch-article20202020-05-2810.34067/KID.00007820192641-76502020-03-24T14:22:15-07:002020-05-28Kidney360Original Investigations15343353http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000222020?cct=218810.34067/KID.0000222020Thu, 19 Mar 2020 09:36:56 GMT-07:00Serum Transaminases at Presentation and Association with Acute Dialysis in Children with Hemolytic Uremic SyndromeTalathi, SaurabhBarnes, MargauxAban, InmaculadaDimmitt, ReedAskenazi, David J.2020-03-19T09:36:56-07:00doi:10.34067/KID.0000222020hwp:resource-id:kidney360;1/5/337American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360acute kidney injury and ICU nephrology, acute kidney injury, dialysis, GI manifestations, hemolytic uremic syndrome, HUS, liver enzymes, renal insufficiency, severity, STECOriginal InvestigationsAcute Kidney Injury and ICU NephrologyOriginal InvestigationsAcute Kidney Injury and ICU Nephrologyresearch-article20202020-05-2810.34067/KID.00002220202641-76502020-03-19T09:36:56-07:002020-05-28Kidney360Original Investigations15337342http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000332020?cct=218810.34067/KID.0000332020Fri, 03 Apr 2020 07:30:50 GMT-07:00The Role of Telemedicine in Kidney Transplantation: Opportunities and ChallengesConcepcion, Beatrice P.Forbes, Rachel C.2020-04-03T07:30:50-07:00doi:10.34067/KID.0000332020hwp:resource-id:kidney360;1/5/420American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360transplantation, access to health care, health services, kidney transplant, mobile health, telehealth, telemedicine, videoconferencingGlobal PerspectivesGlobal Perspectivesresearch-article20202020-05-2810.34067/KID.00003320202641-76502020-04-03T07:30:50-07:002020-05-28Kidney360Global Perspectives15420423http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11220919?cct=218810.2215/CJN.11220919Fri, 21 Feb 2020 07:05:02 GMT-08:00Providing Continuous Renal Replacement Therapy in Patients on Extracorporeal Membrane OxygenationKarakala, NithinJuncos, Luis A.2020-02-21T07:05:02-08:00doi:10.2215/CJN.11220919hwp:resource-id:clinjasn;15/5/704American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyAKI, volume overload, acute renal failure, ischemic renal failure, kidney dysfunction, extracorporeal membrane oxygenation, continuous renal replacement therapyKidney Case Conference: How I TreatKidney Case Conference: How I Treatresearch-article20202020-05-07May 07, 202010.2215/CJN.112209191555-90411555-905X2020-02-21T07:05:02-08:002020-05-07Clinical Journal of the American Society of NephrologyKidney Case Conference: How I Treat155704706http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.15031219?cct=218810.2215/CJN.15031219Tue, 14 Apr 2020 10:16:18 GMT-07:00Kidney Health Initiative Roadmap for Kidney Replacement TherapyGee, Patrick O.2020-04-14T10:16:18-07:00doi:10.2215/CJN.15031219hwp:resource-id:clinjasn;15/5/585American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyRenal Replacement Therapy, Acute Kidney InjuryPatient VoicePatient Voiceresearch-article20202020-05-07May 07, 202010.2215/CJN.150312191555-90411555-905X2020-04-14T10:16:18-07:002020-05-07Clinical Journal of the American Society of NephrologyPatient Voice155585586http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11780919?cct=218810.2215/CJN.11780919Tue, 14 Apr 2020 10:16:18 GMT-07:00Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKDSteubl, DominikSchneider, Markus P.Meiselbach, HeikeNadal, JenniferSchmid, Matthias C.Saritas, TurgayKrane, VeraSommerer, ClaudiaBaid-Agrawal, SeemaVoelkl, JakobKotsis, FruzsinaKöttgen, AnnaEckardt, Kai-UweScherberich, Jürgen E.,2020-04-14T10:16:18-07:00doi:10.2215/CJN.11780919hwp:resource-id:clinjasn;15/5/616American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyuromodulin, Tamm–Horsfall protein, chronic kidney disease, tubular function, end-stage renal disease, coronary artery disease, coronary angiography, glomerular filtration rate, albuminuria, confidence intervals, cardiovascular diseases, risk factors, renal insufficiency, chronic, myocardial infarction, stroke, hypertension, diabetes mellitus, regression analysis, peripheral vascular diseases, epithelial cellsOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-05-07May 07, 202010.2215/CJN.117809191555-90411555-905X2020-04-14T10:16:18-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles1555616589624591http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.15951219?cct=218810.2215/CJN.15951219Tue, 14 Apr 2020 10:16:18 GMT-07:00A Pharmacologic “Stress Test” for Assessing Select Antioxidant Defenses in Patients with CKDZager, Richard A.Johnson, Ali C.M.Guillem, AlvaroKeyser, JeffSingh, Bhupinder2020-04-14T10:16:18-07:00doi:10.2215/CJN.15951219hwp:resource-id:clinjasn;15/5/633American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologymice, creatinine, CST3 protein, human, cystatin C, albuminuria, antioxidants, lipocalin-2, tin, ferritins, tin protoporphyrin IX, protoporphyrins, hexosaminidases, healthy volunteers, exercise test, blood urea nitrogen, HAVCR1 protein, humanOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-05-07May 07, 202010.2215/CJN.159512191555-90411555-905X2020-04-14T10:16:18-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles155633642http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09750819?cct=218810.2215/CJN.09750819Mon, 06 Apr 2020 08:22:57 GMT-07:00Discontinuation of RAAS Inhibition in Children with Advanced CKDvan den Belt, Sophie M.Heerspink, Hiddo J.L.Kirchner, MariettaGracchi, ValentinaThurn-Valsassina, DanielaBayazit, Aysun K.Niemirska, AnnaCanpolat, NurKaplan Bulut, IpekAzukaitis, KarolisDuzova, AliBacchetta, JustineShroff, RukshanaParipovic, DusanÖzçakar, Zeynep BirsinFidan, KibriyaErdogan, HakanGellermann, JuttaWühl, Elkede Zeeuw, DickMelk, AnetteQuerfeld, UweSchaefer, Franz2020-04-06T08:22:57-07:00doi:10.2215/CJN.09750819hwp:resource-id:clinjasn;15/5/625American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyRAAS inhibition, pediatric nephrology, chronic renal disease, Hyperkalemia, albuminuria, Renin-Angiotensin System, creatinine, blood pressure, Potassium, Prospective Studies, Follow-Up Studies, glomerular filtration rate, Renal Insufficiency, Chronic, Cohort Studies, Blood Pressure Determination, hypotension, Comorbidity, AccelerationOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-05-07May 07, 202010.2215/CJN.097508191555-90411555-905X2020-04-06T08:22:57-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles1555625592632593http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12581019?cct=2188Congenital anomalies of the kidneys and urinary tracts (CAKUT) are disorders caused by defects in the development of the kidneys and their outflow tracts. The formation of the kidneys begins at week 3 and nephrogenesis continues until week 36, therefore, the kidneys and outflow tracts are susceptible to environmental risk factors that perturb development throughout gestation. Many genes have been implicated in kidney and outflow tract development, and mutations have been identified in patients with CAKUT. In severe cases of CAKUT, when the kidneys do not form, the fetus will not survive. However, in less severe cases, the baby can survive with combined kidney and outflow tract defects or they may only be identified in adulthood. In this review, we will cover the clinical presentation of CAKUT, its epidemiology, and its long-term outcomes. We will then discuss risk factors for CAKUT, including genetic and environmental contributions. Although severe CAKUT is rare, low nephron number is a much more common disorder with its effect on kidney function increasingly apparent as a person ages. Low nephron number appears to arise by the same mechanisms as CAKUT, but it differs in terms of the magnitude of the insult and the timing of when it occurs during gestation. By understanding the causes of CAKUT and low nephron number, we can begin to identify preventive treatments and establish clinical guidelines for how these patients should be followed.10.2215/CJN.12581019Wed, 18 Mar 2020 08:55:09 GMT-07:00A Primer on Congenital Anomalies of the Kidneys and Urinary Tracts (CAKUT)Congenital anomalies of the kidneys and urinary tracts (CAKUT) are disorders caused by defects in the development of the kidneys and their outflow tracts. The formation of the kidneys begins at week 3 and nephrogenesis continues until week 36, therefore, the kidneys and outflow tracts are susceptible to environmental risk factors that perturb development throughout gestation. Many genes have been implicated in kidney and outflow tract development, and mutations have been identified in patients with CAKUT. In severe cases of CAKUT, when the kidneys do not form, the fetus will not survive. However, in less severe cases, the baby can survive with combined kidney and outflow tract defects or they may only be identified in adulthood. In this review, we will cover the clinical presentation of CAKUT, its epidemiology, and its long-term outcomes. We will then discuss risk factors for CAKUT, including genetic and environmental contributions. Although severe CAKUT is rare, low nephron number is a much more common disorder with its effect on kidney function increasingly apparent as a person ages. Low nephron number appears to arise by the same mechanisms as CAKUT, but it differs in terms of the magnitude of the insult and the timing of when it occurs during gestation. By understanding the causes of CAKUT and low nephron number, we can begin to identify preventive treatments and establish clinical guidelines for how these patients should be followed.Murugapoopathy, VasikarGupta, Indra R.2020-03-18T08:55:09-07:00doi:10.2215/CJN.12581019hwp:resource-id:clinjasn;15/5/723American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycongenital anomalies of the kidney and urinary tract, genetics, development, kidney malformations, environment, epigenetics, pediatric nephrology, infant, CAKUT, risk factors, urogenital abnormalities, vesicoureteral reflux, nephrons, mutation, fetus, longitudinal studiesReviewsReviewsreview-article20202020-05-07May 07, 202010.2215/CJN.125810191555-90411555-905X2020-03-18T08:55:09-07:002020-05-07Clinical Journal of the American Society of NephrologyReviews155723731http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09990819?cct=2188The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis in the human body. The combination of distinct, yet interrelated, molecular functions across different cell types make the delineation of factors associated with loss or decline in kidney function challenging. Consequently, there has been a paucity of new diagnostic markers and treatment options becoming available to clinicians and patients in managing kidney diseases. A systems biology approach to understanding the kidney leverages recent advances in computational technology and methods to integrate diverse sets of data. It has the potential to unravel the interplay of multiple genes, proteins, and molecular mechanisms that drive key functions in kidney health and disease. The emergence of large, detailed, multilevel biologic and clinical data from national databases, cohort studies, and trials now provide the critical pieces needed for meaningful application of systems biology approaches in nephrology. The purpose of this review is to provide an overview of the current state in the evolution of the field. Recent successes of systems biology to identify targeted therapies linked to mechanistic biomarkers in the kidney are described to emphasize the relevance to clinical care and the outlook for improving outcomes for patients with kidney diseases.10.2215/CJN.09990819Tue, 28 Jan 2020 11:10:19 GMT-08:00Systems Biology and Kidney DiseaseThe kidney is a complex organ responsible for maintaining multiple aspects of homeostasis in the human body. The combination of distinct, yet interrelated, molecular functions across different cell types make the delineation of factors associated with loss or decline in kidney function challenging. Consequently, there has been a paucity of new diagnostic markers and treatment options becoming available to clinicians and patients in managing kidney diseases. A systems biology approach to understanding the kidney leverages recent advances in computational technology and methods to integrate diverse sets of data. It has the potential to unravel the interplay of multiple genes, proteins, and molecular mechanisms that drive key functions in kidney health and disease. The emergence of large, detailed, multilevel biologic and clinical data from national databases, cohort studies, and trials now provide the critical pieces needed for meaningful application of systems biology approaches in nephrology. The purpose of this review is to provide an overview of the current state in the evolution of the field. Recent successes of systems biology to identify targeted therapies linked to mechanistic biomarkers in the kidney are described to emphasize the relevance to clinical care and the outlook for improving outcomes for patients with kidney diseases.Schaub, Jennifer A.Hamidi, HabibSubramanian, LalitaKretzler, Matthias2020-01-28T11:10:19-08:00doi:10.2215/CJN.09990819hwp:resource-id:clinjasn;15/5/695American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney disease, transcriptional profiling, gene expression, kidney biopsy, Genomics, systems biology, bioinformatics, proteomics, precision medicine, humans, nephrology, human body, kidney diseases, kidney, urinary tract physiological phenomena, biomarkers, homeostasis, cohort studies, Kidney Genomics SeriesGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-05-07May 07, 202010.2215/CJN.099908191555-90411555-905X2020-01-28T11:10:19-08:002020-05-07Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease155695703http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09310819?cct=2188Metabolic disorders are highly prevalent in kidney transplant candidates and recipients and can adversely affect post-transplant graft outcomes. Management of diabetes, hyperparathyroidism, and obesity presents distinct opportunities to optimize patients both before and after transplant as well as the ability to track objective data over time to assess a patient’s ability to partner effectively with the health care team and adhere to complex treatment regimens. Optimization of these particular disorders can most dramatically decrease the risk of surgical and cardiovascular complications post-transplant. Approximately 60% of nondiabetic patients experience hyperglycemia in the immediate post-transplant phase. Multiple risk factors have been identified related to development of new onset diabetes after transplant, and it is estimated that upward of 7%–30% of patients will develop new onset diabetes within the first year post-transplant. There are a number of medications studied in the kidney transplant population for diabetes management, and recent data and the risks and benefits of each regimen should be optimized. Secondary hyperparathyroidism occurs in most patients with CKD and can persist after kidney transplant in up to 66% of patients, despite an initial decrease in parathyroid hormone levels. Parathyroidectomy and medical management are the options for treatment of secondary hyperparathyroidism, but there is no randomized, controlled trial providing clear recommendations for optimal management, and patient-specific factors should be considered. Obesity is the most common metabolic disorder affecting the transplant population in both the pre- and post-transplant phases of care. Not only does obesity have associations and interactions with comorbid illnesses, such as diabetes, dyslipidemia, and cardiovascular disease, all of which increase morbidity and mortality post-transplant, but it also is intimately inter-related with access to transplantation for patients with kidney failure. We review these metabolic disorders and their management, including data in patients with kidney transplants.10.2215/CJN.09310819Mon, 13 Apr 2020 10:57:30 GMT-07:00Metabolic Disorders with Kidney TransplantMetabolic disorders are highly prevalent in kidney transplant candidates and recipients and can adversely affect post-transplant graft outcomes. Management of diabetes, hyperparathyroidism, and obesity presents distinct opportunities to optimize patients both before and after transplant as well as the ability to track objective data over time to assess a patient’s ability to partner effectively with the health care team and adhere to complex treatment regimens. Optimization of these particular disorders can most dramatically decrease the risk of surgical and cardiovascular complications post-transplant. Approximately 60% of nondiabetic patients experience hyperglycemia in the immediate post-transplant phase. Multiple risk factors have been identified related to development of new onset diabetes after transplant, and it is estimated that upward of 7%–30% of patients will develop new onset diabetes within the first year post-transplant. There are a number of medications studied in the kidney transplant population for diabetes management, and recent data and the risks and benefits of each regimen should be optimized. Secondary hyperparathyroidism occurs in most patients with CKD and can persist after kidney transplant in up to 66% of patients, despite an initial decrease in parathyroid hormone levels. Parathyroidectomy and medical management are the options for treatment of secondary hyperparathyroidism, but there is no randomized, controlled trial providing clear recommendations for optimal management, and patient-specific factors should be considered. Obesity is the most common metabolic disorder affecting the transplant population in both the pre- and post-transplant phases of care. Not only does obesity have associations and interactions with comorbid illnesses, such as diabetes, dyslipidemia, and cardiovascular disease, all of which increase morbidity and mortality post-transplant, but it also is intimately inter-related with access to transplantation for patients with kidney failure. We review these metabolic disorders and their management, including data in patients with kidney transplants.Cohen, ElizabethKorah, MariaCallender, GlendaBelfort de Aguiar, RenataHaakinson, Danielle2020-04-13T10:57:30-07:00doi:10.2215/CJN.09310819hwp:resource-id:clinjasn;15/5/732American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney failure, diabetes, diabetic nephropathy, end stage kidney disease, hyperparathyroidism, kidney transplantation, metabolism, organ transplant, transplantation, cadaver organ transplantation, obesity, pediatric nephrology, phosphate binders, Parathyroidectomy, Cardiovascular Diseases, diabetes mellitus, Hyperglycemia, Renal Insufficiency, Chronic, Dyslipidemias, Hyperparathyroidism, Secondary, parathyroid hormone, Risk AssessmentReviewsReviewsreview-article20202020-05-07May 07, 202010.2215/CJN.093108191555-90411555-905X2020-04-13T10:57:30-07:002020-05-07Clinical Journal of the American Society of NephrologyReviews155732742http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03540320?cct=218810.2215/CJN.03540320Sat, 28 Mar 2020 07:24:34 GMT-07:00On the Frontline of the COVID-19 OutbreakWatnick, SuzanneMcNamara, Elizabeth2020-03-28T07:24:34-07:00doi:10.2215/CJN.03540320hwp:resource-id:clinjasn;15/5/710American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyCOVID-19, chronic dialysis, severe acute respiratory syndrome coronavirus 2, Disease Outbreaks, RecordsPerspectivesPerspectivesresearch-article20202020-05-07May 07, 202010.2215/CJN.035403201555-90411555-905X2020-03-28T07:24:34-07:002020-05-07Clinical Journal of the American Society of NephrologyPerspectives155710713http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03530320?cct=218810.2215/CJN.03530320Fri, 27 Mar 2020 02:03:21 GMT-07:00Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19Sparks, Matthew A.South, AndrewWelling, PaulLuther, J. MattCohen, JordanaByrd, James BrianBurrell, Louise M.Batlle, DanielTomlinson, LaurieBhalla, VivekRheault, Michelle N.Soler, María JoséSwaminathan, SundarHiremath, Swapnil2020-03-27T14:03:21-07:00doi:10.2215/CJN.03530320hwp:resource-id:clinjasn;15/5/714American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyangiotensin, renin angiotensin system, virology, hypertension, ACE inhibitors, COVID-19, severe acute respiratory syndrome coronavirus 2, Renin-Angiotensin System, Angiotensin-Converting Enzyme InhibitorsPerspectivesPerspectivesresearch-article20202020-05-07May 07, 202010.2215/CJN.035303201555-90411555-905X2020-03-27T14:03:21-07:002020-05-07Clinical Journal of the American Society of NephrologyPerspectives155714716http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03420320?cct=218810.2215/CJN.03420320Thu, 02 Apr 2020 01:32:19 GMT-07:00Lessons from the Experience in Wuhan to Reduce Risk of COVID-19 Infection in Patients Undergoing Long-Term HemodialysisLi, JunhuaXu, Gang2020-04-02T13:32:19-07:00doi:10.2215/CJN.03420320hwp:resource-id:clinjasn;15/5/717American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyCOVID-19, severe acute respiratory syndrome coronavirus 2, renal dialysis, Infections, Kidney Failure, Chronic, dialysis, hemodialysisPerspectivesPerspectivesresearch-article20202020-05-07May 07, 202010.2215/CJN.034203201555-90411555-905X2020-04-02T13:32:19-07:002020-05-07Clinical Journal of the American Society of NephrologyPerspectives155717719http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03750320?cct=218810.2215/CJN.03750320Fri, 03 Apr 2020 02:54:11 GMT-07:00COVID-19 and the Inpatient Dialysis UnitBurgner, AnnaIkizler, T. AlpDwyer, Jamie P.2020-04-03T14:54:11-07:00doi:10.2215/CJN.03750320hwp:resource-id:clinjasn;15/5/720American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologydialysis, infection control, COVID-19, severe acute respiratory syndrome coronavirus 2, inpatients, hospital departments, kidney failure, chronicPerspectivesPerspectivesresearch-article20202020-05-07May 07, 202010.2215/CJN.037503201555-90411555-905X2020-04-03T14:54:11-07:002020-05-07Clinical Journal of the American Society of NephrologyPerspectives155720722http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03340320?cct=218810.2215/CJN.03340320Fri, 20 Mar 2020 01:20:05 GMT-07:00Mitigating Risk of COVID-19 in Dialysis FacilitiesKliger, Alan S.Silberzweig, Jeffrey2020-03-20T13:20:05-07:00doi:10.2215/CJN.03340320hwp:resource-id:clinjasn;15/5/707American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyCOVID-19, severe acute respiratory syndrome coronavirus 2, renal dialysis, kidney failure, chronic, ambulatory care facilities, dialysisPerspectivesPerspectivesresearch-article20202020-05-07May 07, 202010.2215/CJN.033403201555-90411555-905X2020-03-20T13:20:05-07:002020-05-07Clinical Journal of the American Society of NephrologyPerspectives155707709http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08900719?cct=218810.2215/CJN.08900719Fri, 03 Apr 2020 06:00:08 GMT-07:00Darbepoetin Alfa in Patients with Advanced CKD without Diabetes: Randomized, Controlled TrialHayashi, TerumasaMaruyama, ShoichiNangaku, MasaomiNarita, IchieiHirakata, HidekiTanabe, KenichiroMorita, SatoshiTsubakihara, YoshiharuImai, EnyuAkizawa, Tadao,2020-04-03T06:00:08-07:00doi:10.2215/CJN.08900719hwp:resource-id:clinjasn;15/5/608American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, hemoglobin, renal outcome, non-diabetic, Darbepoetin alfa, Hematinics, renal dialysis, glomerular filtration rate, kidney transplantation, Proportional Hazards Models, Renal Insufficiency, Chronic, diabetes mellitus, Hemoglobins, Cardiovascular DiseasesOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-05-07May 07, 202010.2215/CJN.089007191555-90411555-905X2020-04-03T06:00:08-07:002020-05-07Clinical Journal of the American Society of NephrologyOriginal Articles155608615http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101015?cct=2188Understanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells reabsorb fructose as a substrate for gluconeogenesis. However, in instances when fructose intake is excessive, fructose metabolism is costly, resulting in energy depletion, uric acid generation, inflammation, and fibrosis in the kidney. A recent scientific advance is the discovery that fructose can be endogenously produced from glucose under pathologic conditions, not only in kidney diseases, but also in diabetes, in cardiac hypertrophy, and with dehydration. Why humans have such a deleterious mechanism to produce fructose is unknown, but it may relate to an evolutionary benefit in the past. In this article, we aim to illuminate the roles of fructose as it relates to gluconeogenesis and fructoneogenesis in the kidney.10.1681/ASN.2019101015Mon, 06 Apr 2020 08:53:56 GMT-07:00Fructose Production and Metabolism in the KidneyUnderstanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells reabsorb fructose as a substrate for gluconeogenesis. However, in instances when fructose intake is excessive, fructose metabolism is costly, resulting in energy depletion, uric acid generation, inflammation, and fibrosis in the kidney. A recent scientific advance is the discovery that fructose can be endogenously produced from glucose under pathologic conditions, not only in kidney diseases, but also in diabetes, in cardiac hypertrophy, and with dehydration. Why humans have such a deleterious mechanism to produce fructose is unknown, but it may relate to an evolutionary benefit in the past. In this article, we aim to illuminate the roles of fructose as it relates to gluconeogenesis and fructoneogenesis in the kidney.Nakagawa, TakahikoJohnson, Richard J.Andres-Hernando, AnaRoncal-Jimenez, CarlosSanchez-Lozada, Laura G.Tolan, Dean R.Lanaspa, Miguel A.2020-04-06T08:53:56-07:00doi:10.1681/ASN.2019101015hwp:resource-id:jnephrol;31/5/898American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyfructose, fructolysis, fructoneogenesis, gluconeogenesis, glycolysisReviewsReviewsreview-article20202020-05-01May 202010.1681/ASN.20191010151046-66731533-34502020-04-06T08:53:56-07:002020-05Journal of the American Society of NephrologyReviews315898906http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010010?cct=2188Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger changes in ion channels and inflammatory pathways that may undermine cellular homeostasis and survival, are critical determinants of injury in the diabetic kidney. Cells are normally able to mitigate these cellular stresses by maintaining high levels of autophagy, an intracellular lysosome-dependent degradative pathway that clears the cytoplasm of dysfunctional organelles. However, the capacity for autophagy in both podocytes and renal tubular cells is markedly impaired in type 2 diabetes, and this deficiency contributes importantly to the intensity of renal injury. The primary drivers of autophagy in states of nutrient and oxygen deprivation—sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia-inducible factors (HIF-1α and HIF-2α)—can exert renoprotective effects by promoting autophagic flux and by exerting direct effects on sodium transport and inflammasome activation. Type 2 diabetes is characterized by marked suppression of SIRT1 and AMPK, leading to a diminution in autophagic flux in glomerular podocytes and renal tubules and markedly increasing their susceptibility to renal injury. Importantly, because insulin acts to depress autophagic flux, these derangements in nutrient deprivation signaling are not ameliorated by antihyperglycemic drugs that enhance insulin secretion or signaling. Metformin is an established AMPK agonist that can promote autophagy, but its effects on the course of CKD have been demonstrated only in the experimental setting. In contrast, the effects of sodium-glucose cotransporter–2 (SGLT2) inhibitors may be related primarily to enhanced SIRT1 and HIF-2α signaling; this can explain the effects of SGLT2 inhibitors to promote ketonemia and erythrocytosis and potentially underlies their actions to increase autophagy and mute inflammation in the diabetic kidney. These distinctions may contribute importantly to the consistent benefit of SGLT2 inhibitors to slow the deterioration in glomerular function and reduce the risk of ESKD in large-scale randomized clinical trials of patients with type 2 diabetes.10.1681/ASN.2020010010Fri, 10 Apr 2020 07:16:41 GMT-07:00Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-InhibitorsGrowing evidence indicates that oxidative and endoplasmic reticular stress, which trigger changes in ion channels and inflammatory pathways that may undermine cellular homeostasis and survival, are critical determinants of injury in the diabetic kidney. Cells are normally able to mitigate these cellular stresses by maintaining high levels of autophagy, an intracellular lysosome-dependent degradative pathway that clears the cytoplasm of dysfunctional organelles. However, the capacity for autophagy in both podocytes and renal tubular cells is markedly impaired in type 2 diabetes, and this deficiency contributes importantly to the intensity of renal injury. The primary drivers of autophagy in states of nutrient and oxygen deprivation—sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia-inducible factors (HIF-1α and HIF-2α)—can exert renoprotective effects by promoting autophagic flux and by exerting direct effects on sodium transport and inflammasome activation. Type 2 diabetes is characterized by marked suppression of SIRT1 and AMPK, leading to a diminution in autophagic flux in glomerular podocytes and renal tubules and markedly increasing their susceptibility to renal injury. Importantly, because insulin acts to depress autophagic flux, these derangements in nutrient deprivation signaling are not ameliorated by antihyperglycemic drugs that enhance insulin secretion or signaling. Metformin is an established AMPK agonist that can promote autophagy, but its effects on the course of CKD have been demonstrated only in the experimental setting. In contrast, the effects of sodium-glucose cotransporter–2 (SGLT2) inhibitors may be related primarily to enhanced SIRT1 and HIF-2α signaling; this can explain the effects of SGLT2 inhibitors to promote ketonemia and erythrocytosis and potentially underlies their actions to increase autophagy and mute inflammation in the diabetic kidney. These distinctions may contribute importantly to the consistent benefit of SGLT2 inhibitors to slow the deterioration in glomerular function and reduce the risk of ESKD in large-scale randomized clinical trials of patients with type 2 diabetes.Packer, Milton2020-04-10T07:16:41-07:00doi:10.1681/ASN.2020010010hwp:resource-id:jnephrol;31/5/907American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydiabetic nephropathy, antihyperglycemic drugs, autophagyReviewsReviewsreview-article20202020-05-01May 202010.1681/ASN.20200100101046-66731533-34502020-04-10T07:16:41-07:002020-05Journal of the American Society of NephrologyReviews315907919http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019101060?cct=218810.1681/ASN.2019101060Tue, 14 Apr 2020 10:16:32 GMT-07:00Protein Kinase C-δ Mediates Kidney Tubular Injury in Cold Storage–Associated Kidney TransplantationZhu, JiefuZhang, GangSong, ZhixiaXiang, XiaohongShu, ShaoqunLiu, ZhiwenYang, DanyiWei, QingqingDong, Zheng2020-04-14T10:16:32-07:00doi:10.1681/ASN.2019101060hwp:resource-id:jnephrol;31/5/1050American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologytransplantation, mitochondria, PKCδ; kidney, ischemia-reperfusionBasic ResearchBasic Researchresearch-article20202020-05-01May 202010.1681/ASN.20191010601046-66731533-34502020-04-14T10:16:32-07:002020-05Journal of the American Society of NephrologyBasic Research31510501065http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060573?cct=218810.1681/ASN.2019060573Thu, 30 Apr 2020 10:00:29 GMT-07:00In Vivo Assessment of Size-Selective Glomerular Sieving in Transplanted Human Induced Pluripotent Stem Cell–Derived Kidney Organoidsvan den Berg, Cathelijne W.Koudijs, AngelaRitsma, LailaRabelink, Ton J.2020-04-30T10:00:29-07:00doi:10.1681/ASN.2019060573hwp:resource-id:jnephrol;31/5/921American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologypluripotent stem cells, kidney organoids, kidney transplantation, intravital microscopy, glomerular filtrationRapid CommunicationRapid Communicationresearch-article20202020-05-01May 202010.1681/ASN.20190605731046-66731533-34502020-04-30T10:00:29-07:002020-05Journal of the American Society of NephrologyRapid Communication315921929http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000032019?cct=218810.34067/KID.0000032019Tue, 31 Mar 2020 06:00:11 GMT-07:00Housing Insecurity and Risk of Adverse Kidney OutcomesNovick, Tessa K.Omenyi, ChiazamHan, DingfenZonderman, Alan B.Evans, Michele K.Crews, Deidra C.2020-03-31T06:00:11-07:00doi:10.34067/KID.0000032019hwp:resource-id:kidney360;1/4/241American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Chronic Kidney Disease, Albuminuria, Chronic Kidney Disease, Housing Insecurity, Social Conditions, Social Determinants of Health, Urban PopulationOriginal InvestigationsChronic Kidney DiseaseOriginal InvestigationsChronic Kidney Diseaseresearch-article20202020-04-3010.34067/KID.00000320192641-76502020-03-31T06:00:11-07:002020-04-30Kidney360Original Investigations14241247http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001252019?cct=2188Diabetic kidney disease (DKD) is the most common cause of ESKD in the United States and worldwide. Current treatment for DKD includes strict glycemic control and normalization of BP with renin-angiotensin-aldosterone system (RAAS) blockade. Although RAAS blockers slow progression of disease, they do not generally prevent ESKD and none of the studies with these agents in DKD included patients who were nonproteinuric, which make up an increasingly large percentage of patients with diabetes now seen in clinical practice. Recent studies with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors have shown beneficial renal effects, and the benefits of SGLT2 inhibitors likely extend to patients who are nonproteinuric. However, there remains a need to develop new therapies for DKD, particularly in those patients with advanced disease. A role of chronic low-grade inflammation in microvascular complications in patients with diabetes has now been widely accepted. Large clinical trials are being carried out with experimental agents such as bardoxolone and selonsertib that target inflammation and oxidative stress. The Food and Drug Administration–approved, nonspecific phosphodiesterase inhibitor pentoxifylline (PTX) has been shown to have anti-inflammatory effects in both animal and human studies by inhibiting the production of proinflammatory cytokines. Small randomized clinical trials and meta-analyses indicate that PTX may have therapeutic benefits in DKD, raising the possibility that a clinically available drug may be able to be repurposed to treat this disease. A large, multicenter, randomized clinical trial to determine whether this agent can decrease time to ESKD or death is currently being conducted, but results will not be available for several years. At this time, the combination of RAAS blockade plus SGLT2 inhibition is considered standard of care for DKD, but it may be reasonable for clinicians to consider addition of PTX in patients whose disease continues to progress despite optimization of current standard-of-care therapies.10.34067/KID.0001252019Fri, 28 Feb 2020 05:30:09 GMT-08:00Targeting Inflammation in Diabetic Kidney Disease: Is There a Role for Pentoxifylline?Diabetic kidney disease (DKD) is the most common cause of ESKD in the United States and worldwide. Current treatment for DKD includes strict glycemic control and normalization of BP with renin-angiotensin-aldosterone system (RAAS) blockade. Although RAAS blockers slow progression of disease, they do not generally prevent ESKD and none of the studies with these agents in DKD included patients who were nonproteinuric, which make up an increasingly large percentage of patients with diabetes now seen in clinical practice. Recent studies with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors have shown beneficial renal effects, and the benefits of SGLT2 inhibitors likely extend to patients who are nonproteinuric. However, there remains a need to develop new therapies for DKD, particularly in those patients with advanced disease. A role of chronic low-grade inflammation in microvascular complications in patients with diabetes has now been widely accepted. Large clinical trials are being carried out with experimental agents such as bardoxolone and selonsertib that target inflammation and oxidative stress. The Food and Drug Administration–approved, nonspecific phosphodiesterase inhibitor pentoxifylline (PTX) has been shown to have anti-inflammatory effects in both animal and human studies by inhibiting the production of proinflammatory cytokines. Small randomized clinical trials and meta-analyses indicate that PTX may have therapeutic benefits in DKD, raising the possibility that a clinically available drug may be able to be repurposed to treat this disease. A large, multicenter, randomized clinical trial to determine whether this agent can decrease time to ESKD or death is currently being conducted, but results will not be available for several years. At this time, the combination of RAAS blockade plus SGLT2 inhibition is considered standard of care for DKD, but it may be reasonable for clinicians to consider addition of PTX in patients whose disease continues to progress despite optimization of current standard-of-care therapies.Leehey, David J.2020-02-28T05:30:09-08:00doi:10.34067/KID.0001252019hwp:resource-id:kidney360;1/4/292American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Diabetes and the Kidney, Anti-Inflammatory Agents, Diabetic Nephropathies, Inflammation, Pentoxifylline, Sodium-Glucose Transporter 2 Inhibitors, Standard of CareReview ArticlesReview Articlesreview-article20202020-04-3010.34067/KID.00012520192641-76502020-02-28T05:30:09-08:002020-04-30Kidney360Review Articles14292299http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000402019?cct=218810.34067/KID.0000402019Wed, 25 Mar 2020 12:39:00 GMT-07:00Fluid Overload and Mortality in Patients with Severe Acute Kidney Injury and Extracorporeal Membrane OxygenationGunning, SamanthaKutuby, FouadRose, RebeccaTrevino, SharonSong, TaeKoyner, Jay L.2020-03-25T12:39:00-07:00doi:10.34067/KID.0000402019hwp:resource-id:kidney360;1/4/232American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acute Kidney Injury and ICU Nephrology, Acute Kidney Injury, Catheterization, Extracorporeal Membrane Oxygenation, Fluid Overload, Mortality, Renal Dialysis, Renal Replacement Therapy, Water-Electrolyte ImbalanceOriginal InvestigationsAcute Kidney Injury and ICU NephrologyOriginal InvestigationsAcute Kidney Injury and ICU Nephrologyresearch-article20202020-04-3010.34067/KID.00004020192641-76502020-03-25T12:39:00-07:002020-04-30Kidney360Original Investigations14232240http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001452020?cct=218810.34067/KID.0001452020Wed, 25 Mar 2020 12:38:59 GMT-07:00Management of Hemodialysis Patients with Suspected or Confirmed COVID-19 Infection: Perspective of Two Nephrologists in the United StatesMokrzycki, Michele H.Coco, Maria2020-03-25T12:38:59-07:00doi:10.34067/KID.0001452020hwp:resource-id:kidney360;1/4/273American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360dialysis, acute kidney injury, continuous renal replacement therapy, coronavirus, COVID-19, hemodialysis, severe acute respiratory syndrome coronavirus 2Global PerspectivesGlobal Perspectivesresearch-article20202020-04-3010.34067/KID.00014520202641-76502020-03-25T12:38:59-07:002020-04-30Kidney360Global Perspectives14273278http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000692020?cct=218810.34067/KID.0000692020Thu, 12 Mar 2020 09:15:10 GMT-07:00Raising the Volume on Alport Syndrome: A Patient PerspectiveDunleavy, Megan E.2020-03-12T09:15:10-07:00doi:10.34067/KID.0000692020hwp:resource-id:kidney360;1/4/227American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Genetics, Communication Barriers, Genes, X-Linked, Genetic Counseling, Genetic Testing, Nephritis, Hereditary, Patient Participation, Persons With Hearing Impairments, X Chromosome InactivationPatient PerspectivePatient Perspectiveresearch-article20202020-04-3010.34067/KID.00006920202641-76502020-03-12T09:15:10-07:002020-04-30Kidney360Patient Perspective14227228http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000312019?cct=2188Growth in knowledge of the genetics of kidney disease has revealed that significant percentages of patients with diverse types of nephropathy have causative mutations. Genetic testing is poised to play an increasing role in the care of patients with kidney disease. The role of genetic testing in kidney transplantation is not well established. This review will explore the ways in which genetic testing may be applied to improve the care of kidney transplant recipients and donors.10.34067/KID.0000312019Wed, 11 Mar 2020 01:47:44 GMT-07:00Clinical Applications of Genetic Discoveries in Kidney Transplantation: a ReviewGrowth in knowledge of the genetics of kidney disease has revealed that significant percentages of patients with diverse types of nephropathy have causative mutations. Genetic testing is poised to play an increasing role in the care of patients with kidney disease. The role of genetic testing in kidney transplantation is not well established. This review will explore the ways in which genetic testing may be applied to improve the care of kidney transplant recipients and donors.Marin, Ethan P.Cohen, ElizabethDahl, Neera2020-03-11T13:47:44-07:00doi:10.34067/KID.0000312019hwp:resource-id:kidney360;1/4/300American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Hypertension, Blood Pressure, renal denervation, Resistant HypertensionReview ArticlesReview Articlesreview-article20202020-04-3010.34067/KID.00003120192641-76502020-03-11T13:47:44-07:002020-04-30Kidney360Review Articles14300305http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000052020?cct=2188The cannulation technique of a hemodialysis vascular access has remained controversial with differing viewpoints. The quality of dialysis, overall patient safety, and individual dialysis experience often dictate the type of cannulation technique used in clinical practice. The three commonly used techniques to access a hemodialysis vascular access are the rope ladder, area, and buttonhole. Although the buttonhole technique has been around since the mid-1970s, the dialysis community remains divided on its suitability for routine use to provide maintenance hemodialysis therapy. The proponents of this technique value the ease of cannulation with less pain and discomfort whereas the opponents highlight the increased risk of infection. The actual clinical evidence from the United States is limited and remains inconclusive. The current review provides an overview of the available experience from the United States, highlighting the correct technique of creating a buttonhole, summarizing the current evidence, and recommending a need for larger randomized controlled studies in both in-center and home hemodialysis populations.10.34067/KID.0000052020Fri, 06 Mar 2020 05:29:38 GMT-08:00Buttonhole Cannulation of Arteriovenous Fistulas in the United StatesThe cannulation technique of a hemodialysis vascular access has remained controversial with differing viewpoints. The quality of dialysis, overall patient safety, and individual dialysis experience often dictate the type of cannulation technique used in clinical practice. The three commonly used techniques to access a hemodialysis vascular access are the rope ladder, area, and buttonhole. Although the buttonhole technique has been around since the mid-1970s, the dialysis community remains divided on its suitability for routine use to provide maintenance hemodialysis therapy. The proponents of this technique value the ease of cannulation with less pain and discomfort whereas the opponents highlight the increased risk of infection. The actual clinical evidence from the United States is limited and remains inconclusive. The current review provides an overview of the available experience from the United States, highlighting the correct technique of creating a buttonhole, summarizing the current evidence, and recommending a need for larger randomized controlled studies in both in-center and home hemodialysis populations.Vachharajani, Tushar J.Wong, LeslieNiyyar, Vandana D.Abreo, Kenneth D.Mokrzycki, Michele H.2020-03-06T05:29:38-08:00doi:10.34067/KID.0000052020hwp:resource-id:kidney360;1/4/306American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, arteriovenous fistula, Buttonhole, cannulation, Dialysis vascular access, hemodialysis, intervention, pain, patient satisfaction, rope-ladderReview ArticlesReview Articlesreview-article20202020-04-3010.34067/KID.00000520202641-76502020-03-06T05:29:38-08:002020-04-30Kidney360Review Articles14306313http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001022020?cct=218810.34067/KID.0001022020Thu, 05 Mar 2020 10:06:45 GMT-08:00Buttonhole Cannulation of Arteriovenous Fistulas: a Dialysis Nurse’s PerspectiveBushey, Margaret2020-03-05T10:06:45-08:00doi:10.34067/KID.0001022020hwp:resource-id:kidney360;1/4/279American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, arteriovenous fistulas, Buttonhole cannulation, Catheterization, Hemodialysis, Home, Kidney Failure, Chronic, Needles, Renal DialysisPerspectivePerspectiveproduct-review20202020-04-3010.34067/KID.00010220202641-76502020-03-05T10:06:45-08:002020-04-30Kidney360Perspective14279280http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000332019?cct=218810.34067/KID.0000332019Mon, 23 Mar 2020 01:15:34 GMT-07:00Sucroferric Oxyhydroxide as Part of Combination Phosphate Binder Therapy among Hemodialysis PatientsMolony, Donald A.Parameswaran, VidhyaFicociello, Linda H.Mullon, ClaudyKossmann, Robert J.2020-03-23T13:15:34-07:00doi:10.34067/KID.0000332019hwp:resource-id:kidney360;1/4/263American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Mineral Metabolism, combination therapy, Hemodialysis, phosphate binder, phosphorus, Renal Dialysis, Retrospective Studies, sucroferric oxyhydroxideOriginal InvestigationsMineral MetabolismOriginal InvestigationsMineral Metabolismresearch-article20202020-04-3010.34067/KID.00003320192641-76502020-03-23T13:15:34-07:002020-04-30Kidney360Original Investigations14263272http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09480819?cct=218810.2215/CJN.09480819Wed, 04 Mar 2020 07:23:06 GMT-08:00The Changing Landscape of Fabry DiseaseSvarstad, EinarMarti, Hans Peter2020-03-04T07:23:06-08:00doi:10.2215/CJN.09480819hwp:resource-id:clinjasn;15/4/569American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologygenetic renal disease, podocyte, kidney biopsy, renal function decline, vascular disease, progression of renal failure, cardiovascular disease, Fabry’s disease, male, female, humans, adult, agalsidase α, agalsidase β, Fabry disease, enzyme replacement therapy, kidney transplantation, angiokeratoma, cardiac myocytes, longevity, vascular endothelium, cause of death, follow-up studies, renal dialysis, alphagalactosidaseFeatureFeatureresearch-article20202020-04-07April 07, 202010.2215/CJN.094808191555-90411555-905X2020-03-04T07:23:06-08:002020-04-07Clinical Journal of the American Society of NephrologyFeature154569576http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10760919?cct=218810.2215/CJN.10760919Tue, 03 Dec 2019 05:22:08 GMT-08:00Intravascular Volume Assessment in the Critically Ill PatientVincent, Jean-Louis2019-12-03T05:22:08-08:00doi:10.2215/CJN.10760919hwp:resource-id:clinjasn;15/4/557American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyHemodynamics and Vascular Regulation, humans, central venous pressure, norepinephrine, blood pressure, critical illness, diuretics, central venous catheters, hypotension, vasoconstrictor agents, hemodynamics, edema, peritonitisKidney Case Conference: How I TreatKidney Case Conference: How I Treatresearch-article20202020-04-07April 07, 202010.2215/CJN.107609191555-90411555-905X2019-12-03T05:22:08-08:002020-04-07Clinical Journal of the American Society of NephrologyKidney Case Conference: How I Treat154557559http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10570919?cct=218810.2215/CJN.10570919Thu, 26 Mar 2020 05:59:15 GMT-07:00Association of 24-Hour Ambulatory Blood Pressure Patterns with Cognitive Function and Physical Functioning in CKDGhazi, LamaYaffe, KristineTamura, Manjula K.Rahman, MahboobHsu, Chi-yuanAnderson, Amanda H.Cohen, Jordana B.Fischer, Michael J.Miller, Edgar R.Navaneethan, Sankar D.He, JiangWeir, Matthew R.Townsend, Raymond R.Cohen, Debbie L.Feldman, Harold I.Drawz, Paul E.,2020-03-26T05:59:15-07:00doi:10.2215/CJN.10570919hwp:resource-id:clinjasn;15/4/455American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologycognitive function, ambulatory blood pressure, chronic kidney disease, male, humans, preschool child, cross-sectional studies, frailty, masked hypertension, walking speed, muscle weakness, linear models, weight loss, frail elderly, follow-up studies, ambulatory blood pressure monitoring, cohort studies, cognitive dysfunction, chronic renal insufficiency, prevalence, cognition, mental status and dementia tests, exercise, physical functional performanceOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-04-07April 07, 202010.2215/CJN.105709191555-90411555-905X2020-03-26T05:59:15-07:002020-04-07Clinical Journal of the American Society of NephrologyOriginal Articles15444455441501464443510http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11881019?cct=218810.2215/CJN.11881019Wed, 04 Mar 2020 07:23:06 GMT-08:00Safety of Liraglutide in Type 2 Diabetes and Chronic Kidney DiseaseMann, Johannes F.E.Fonseca, Vivian A.Poulter, Neil R.Raz, ItamarIdorn, ThomasRasmussen, Sørenvon Scholten, Bernt JohanMosenzon, Ofri,2020-03-04T07:23:06-08:00doi:10.2215/CJN.11881019hwp:resource-id:clinjasn;15/4/465American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, microalbuminuria, humans, liraglutide, type 2 diabetes mellitus, GFR, glucagon-like peptide-1 receptor, creatinine, confidence intervals, standard of care, hypoglycemia, chronic renal insufficiency, kidney, albuminsOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-04-07April 07, 202010.2215/CJN.118810191555-90411555-905X2020-03-04T07:23:06-08:002020-04-07Clinical Journal of the American Society of NephrologyOriginal Articles1544465444473446http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01260120?cct=218810.2215/CJN.01260120Wed, 04 Mar 2020 07:23:05 GMT-08:00Liraglutide for the Treatment of Type 2 Diabetes and Safety in Diabetic Kidney DiseaseCherney, David Z.Tuttle, Katherine R.2020-03-04T07:23:05-08:00doi:10.2215/CJN.01260120hwp:resource-id:clinjasn;15/4/444American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyalbuminuria, chronic kidney disease, diabetes mellitus, diabetic nephropathy, glomerular filtration rate, Liraglutide, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Glucagon-Like Peptide 1EditorialsEditorialseditorial20202020-04-07April 07, 202010.2215/CJN.012601201555-90411555-905X2020-03-04T07:23:05-08:002020-04-07Clinical Journal of the American Society of NephrologyEditorials1544444465446473http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07470619?cct=2188Methods to differentiate human pluripotent stem cells into kidney organoids were first introduced about 5 years ago, and since that time, the field has grown substantially. Protocols are producing increasingly complex three-dimensional structures, have been used to model human kidney disease, and have been adapted for high-throughput screening. Over this same time frame, technologies for massively parallel, single-cell RNA sequencing (scRNA-seq) have matured. Now, both of these powerful approaches are being combined to better understand how kidney organoids can be applied to the understanding of kidney development and disease. There are several reasons why this is a synergistic combination. Kidney organoids are complicated and contain many different cell types of variable maturity. scRNA-seq is an unbiased technology that can comprehensively categorize cell types, making it ideally suited to catalog all cell types present in organoids. These same characteristics also make scRNA-seq a powerful approach for quantitative comparisons between protocols, batches, and pluripotent cell lines as it becomes clear that reproducibility and quality can vary across all three variables. Lineage trajectories can be reconstructed using scRNA-seq data, enabling the rational adjustment of differentiation strategies to promote maturation of desired kidney cell types or inhibit differentiation of undesired off-target cell types. Here, we review the ways that scRNA-seq has been successfully applied in the organoid field and predict future applications for this powerful technique. We also review other developing single-cell technologies and discuss how they may be combined, using “multiomic” approaches, to improve our understanding of kidney organoid differentiation and usefulness in modeling development, disease, and toxicity testing.10.2215/CJN.07470619Tue, 28 Jan 2020 11:10:20 GMT-08:00Single Cell Sequencing and Kidney Organoids Generated from Pluripotent Stem CellsMethods to differentiate human pluripotent stem cells into kidney organoids were first introduced about 5 years ago, and since that time, the field has grown substantially. Protocols are producing increasingly complex three-dimensional structures, have been used to model human kidney disease, and have been adapted for high-throughput screening. Over this same time frame, technologies for massively parallel, single-cell RNA sequencing (scRNA-seq) have matured. Now, both of these powerful approaches are being combined to better understand how kidney organoids can be applied to the understanding of kidney development and disease. There are several reasons why this is a synergistic combination. Kidney organoids are complicated and contain many different cell types of variable maturity. scRNA-seq is an unbiased technology that can comprehensively categorize cell types, making it ideally suited to catalog all cell types present in organoids. These same characteristics also make scRNA-seq a powerful approach for quantitative comparisons between protocols, batches, and pluripotent cell lines as it becomes clear that reproducibility and quality can vary across all three variables. Lineage trajectories can be reconstructed using scRNA-seq data, enabling the rational adjustment of differentiation strategies to promote maturation of desired kidney cell types or inhibit differentiation of undesired off-target cell types. Here, we review the ways that scRNA-seq has been successfully applied in the organoid field and predict future applications for this powerful technique. We also review other developing single-cell technologies and discuss how they may be combined, using “multiomic” approaches, to improve our understanding of kidney organoid differentiation and usefulness in modeling development, disease, and toxicity testing.Wu, HaojiaHumphreys, Benjamin D.2020-01-28T11:10:20-08:00doi:10.2215/CJN.07470619hwp:resource-id:clinjasn;15/4/550American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologystem cell, transcriptomics, organoid, humans, organoids, RNA sequence analysis, small cytoplasmic RNA, reproducibility of results, kidney diseases, pluripotent stem cells, kidney, cell line, cell differentiation, Kidney Genomics SeriesGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-04-07April 07, 202010.2215/CJN.074706191555-90411555-905X2020-01-28T11:10:20-08:002020-04-07Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease154550556http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09510819?cct=218810.2215/CJN.09510819Tue, 04 Feb 2020 09:06:06 GMT-08:00Consenting for Dialysis or Its AlternativeLi, Kelly ChenleiBrown, Mark A.2020-02-04T09:06:06-08:00doi:10.2215/CJN.09510819hwp:resource-id:clinjasn;15/4/560American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic dialysis, dialysis, Kidney Failure, ChronicPerspectivesPerspectivesresearch-article20202020-04-07April 07, 202010.2215/CJN.095108191555-90411555-905X2020-02-04T09:06:06-08:002020-04-07Clinical Journal of the American Society of NephrologyPerspectives154560562http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11800919?cct=218810.2215/CJN.11800919Wed, 18 Dec 2019 08:16:50 GMT-08:00Making Assisted Peritoneal Dialysis a Reality in the United StatesOliver, Matthew J.Salenger, Page2019-12-18T08:16:50-08:00doi:10.2215/CJN.11800919hwp:resource-id:clinjasn;15/4/566American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyperitoneal dialysis, home care services, aged, end stage kidney disease, humans, United States, depression, caregivers, self care, renal dialysis, low vision, frailty, pilot projects, Canada, home hemodialysis, dementia, learning disorders, schizophrenia, cognitionPerspectivesPerspectivesresearch-article20202020-04-07April 07, 202010.2215/CJN.118009191555-90411555-905X2019-12-18T08:16:50-08:002020-04-07Clinical Journal of the American Society of NephrologyPerspectives154566568http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09770819?cct=218810.2215/CJN.09770819Mon, 18 Nov 2019 08:35:30 GMT-08:00Contraception and CKDBurgner, AnnaHladunewich, Michelle A.2019-11-18T08:35:30-08:00doi:10.2215/CJN.09770819hwp:resource-id:clinjasn;15/4/563American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, pregnancy, humans, female, United States, nephrologists, Canada, contraceptive agents, contraception, proteinuria, contraceptive devices, chronic renal insufficiency, hypertension, surveys and questionnaires, counselingPerspectivesPerspectivesresearch-article20202020-04-07April 07, 202010.2215/CJN.097708191555-90411555-905X2019-11-18T08:35:30-08:002020-04-07Clinical Journal of the American Society of NephrologyPerspectives154563565http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.02080220?cct=218810.2215/CJN.02080220Tue, 24 Mar 2020 07:47:32 GMT-07:00The Long Road to Kidney TransplantationPurnell, Tanjala S.McAdams-DeMarco, Mara2020-03-24T07:47:32-07:00doi:10.2215/CJN.02080220hwp:resource-id:clinjasn;15/4/453American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, Referral and Consultation, Kidney Failure, Chronic, Waiting ListsEditorialsEditorialseditorial20202020-04-07April 07, 202010.2215/CJN.020802201555-90411555-905X2020-03-24T07:47:32-07:002020-04-07Clinical Journal of the American Society of NephrologyEditorials15444453439539454440549http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.02130220?cct=218810.2215/CJN.02130220Tue, 24 Mar 2020 07:47:33 GMT-07:00Distance from a Transplant Center and Getting Listed for a TransplantGarner, Lisa2020-03-24T07:47:33-07:00doi:10.2215/CJN.02130220hwp:resource-id:clinjasn;15/4/439American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyTransplants, Waiting Lists, GeographyPatient VoicePatient Voiceeditorial20202020-04-07April 07, 202010.2215/CJN.021302201555-90411555-905X2020-03-24T07:47:33-07:002020-04-07Clinical Journal of the American Society of NephrologyPatient Voice15444439453539440454549http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08530719?cct=218810.2215/CJN.08530719Tue, 24 Mar 2020 07:47:33 GMT-07:00Distance to Kidney Transplant Center and Access to Early Steps in the Kidney Transplantation Process in the Southeastern United StatesMcPherson, Laura J.Barry, VaughnYackley, JaneGander, Jennifer C.Pastan, Stephen O.Plantinga, Laura C.Paul, SudeshnaPatzer, Rachel E.,2020-03-24T07:47:33-07:00doi:10.2215/CJN.08530719hwp:resource-id:clinjasn;15/4/539American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney, ESRD, transplantation, distance, referral, transplant evaluation, adult, United States, humans, renal dialysis, kidney transplantation, Georgia, North Carolina, South Carolina, logistic models, data systems, chronic kidney failure, transplants, referral and consultationOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-04-07April 07, 202010.2215/CJN.085307191555-90411555-905X2020-03-24T07:47:33-07:002020-04-07Clinical Journal of the American Society of NephrologyOriginal Articles15444539439453549440454http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020213?cct=218810.1681/ASN.2020020213Tue, 31 Mar 2020 10:00:23 GMT-07:00This Month's HighlightsAmerican Society of Nephrology2020-03-31T10:00:23-07:00doi:10.1681/ASN.2020020213hwp:resource-id:jnephrol;31/4/iAmerican Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyThis Month’s HighlightsThis Month’s Highlightsin-brief20202020-04-01April 202010.1681/ASN.20200202131046-66731533-34502020-03-31T10:00:23-07:002020-04Journal of the American Society of NephrologyThis Month’s Highlights314iihttp://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020173?cct=218810.1681/ASN.2020020173Wed, 04 Mar 2020 07:26:28 GMT-08:00MoCA: Turn Your Mind to ItJassal, Sarbjit V.Farragher, Janine F.2020-03-04T07:26:28-08:00doi:10.1681/ASN.2020020173hwp:resource-id:jnephrol;31/4/672American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydialysis, MoCA, cognitionEditorialsEditorialseditorial20202020-04-01April 202010.1681/ASN.20200201731046-66731533-34502020-03-04T07:26:28-08:002020-04Journal of the American Society of NephrologyEditorials3144672855673864http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010083?cct=218810.1681/ASN.2020010083Tue, 31 Mar 2020 10:00:23 GMT-07:00ErratumAmerican Society of Nephrology2020-03-31T10:00:23-07:00doi:10.1681/ASN.2020010083hwp:resource-id:jnephrol;31/4/892American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyErratum, correction, genetic renal disease, human genetics, family historyErratumErratumcorrection20202020-04-01April 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A Fine BalanceSalama, Alan D.Little, Mark A.2020-03-04T07:26:27-08:00doi:10.1681/ASN.2020020146hwp:resource-id:jnephrol;31/4/668American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyrenal ischemia, MDSC, Neutrophils, acute renal failureEditorialsEditorialseditorial20202020-04-01April 202010.1681/ASN.20200201461046-66731533-34502020-03-04T07:26:27-08:002020-04Journal of the American Society of NephrologyEditorials3144668731670746http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020020139?cct=218810.1681/ASN.2020020139Mon, 02 Mar 2020 08:36:54 GMT-08:00Pulling the Hood off Genetic Susceptibility to Hypertensive Renal DiseaseDhande, Isha S.Doris, Peter A.2020-03-02T08:36:54-08:00doi:10.1681/ASN.2020020139hwp:resource-id:jnephrol;31/4/667American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyblood pressure, hypertensive renal disease, genetic markersEditorialsEditorialseditorial20202020-04-01April 202010.1681/ASN.20200201391046-66731533-34502020-03-02T08:36:54-08:002020-04Journal of the American Society of NephrologyEditorials3144667687668700http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050497?cct=218810.1681/ASN.2019050497Tue, 03 Mar 2020 08:49:07 GMT-08:00Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte LossNajafian, BehzadTøndel, CamillaSvarstad, EinarGubler, Marie-ClaireOliveira, João-PauloMauer, Michael2020-03-03T08:49:07-08:00doi:10.1681/ASN.2019050497hwp:resource-id:jnephrol;31/4/865American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyFabry disease, podocyte, chronic kidney disease, pathologyClinical ResearchClinical Researchresearch-article20202020-04-01April 202010.1681/ASN.20190504971046-66731533-34502020-03-03T08:49:07-08:002020-04Journal of the American 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Research314841854http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080804?cct=218810.1681/ASN.2019080804Fri, 07 Feb 2020 09:57:49 GMT-08:00Two Mineralocorticoid Receptor–Mediated Mechanisms of Pendrin Activation in Distal NephronsAyuzawa, NobuhiroNishimoto, MitsuhiroUeda, KoheiHirohama, DaigoroKawarazaki, WakakoShimosawa, TatsuoMarumo, TakeshiFujita, Toshiro2020-02-07T09:57:49-08:00doi:10.1681/ASN.2019080804hwp:resource-id:jnephrol;31/4/748American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologymineralocorticoid receptor, aldosterone, angiotensin II, pendrin, sodium chloride cotransporter, blood pressureBasic ResearchBasic Researchresearch-article20202020-04-01April 202010.1681/ASN.20190808041046-66731533-34502020-02-07T09:57:49-08:002020-04Journal of the American Society of NephrologyBasic Research314748764http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080811?cct=218810.1681/ASN.2019080811Mon, 23 Mar 2020 05:30:19 GMT-07:00Kidney Clearance of Secretory Solutes Is Associated with Progression of CKD: The CRIC StudyChen, YanZelnick, Leila R.Wang, KeHoofnagle, Andrew N.Becker, Jessica O.Hsu, Chi-yuanFeldman, Harold I.Mehta, Rupal C.Lash, James P.Waikar, Sushrut S.Shafi, TariqSeliger, Stephen L.Shlipak, Michael G.Rahman, MahboobKestenbaum, Bryan R.,Appel, Lawrence J.Feldman, Harold I.Go, Alan S.He, JiangLash, James P.Rao, Panduranga S.Rahman, MahboobTownsend, Raymond R.2020-03-23T05:30:19-07:00doi:10.1681/ASN.2019080811hwp:resource-id:jnephrol;31/4/817American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyproximal tubular secretion, secretory solutes clearances, CKD progression, mortalityClinical EpidemiologyClinical Epidemiologyresearch-article20202020-04-01April 202010.1681/ASN.20190808111046-66731533-34502020-03-23T05:30:19-07:002020-04Journal of the American Society of NephrologyClinical 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MichaelaCippà, Pietro E.McMahon, JillOberbauer, RainerMcMahon, Andrew P.2020-02-07T09:57:49-08:00doi:10.1681/ASN.2019090876hwp:resource-id:jnephrol;31/4/701American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyGDF15, ischemia-reperfusion, kidney transplantation, acute kidney injury, acute allograft rejectionBasic ResearchBasic Researchresearch-article20202020-04-01April 202010.1681/ASN.20190908761046-66731533-34502020-02-07T09:57:49-08:002020-04Journal of the American Society of NephrologyBasic Research314701715http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060601?cct=218810.1681/ASN.2019060601Wed, 04 Mar 2020 07:26:27 GMT-08:00Granulocyte Colony-Stimulating Factor Attenuates Renal Ischemia-Reperfusion Injury by Inducing Myeloid-Derived Suppressor CellsYan, Ji-JingRyu, Jung-HwaPiao, HonglinHwang, Ju HeeHan, DongkyuLee, Sun-KyungJang, Joon YoungLee, JoongyubKoo, Tai YeonYang, 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NephrologyJournal of the American Society of Nephrologyburnout, graduate medical education, well-being, depression, fellowship, surveySpecial ArticleSpecial Articleresearch-article20202020-04-01April 202010.1681/ASN.20190707151046-66731533-34502020-03-02T08:36:54-08:002020-04Journal of the American Society of NephrologySpecial Article314675685http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080847?cct=218810.1681/ASN.2019080847Thu, 12 Mar 2020 07:59:16 GMT-07:00Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft FailureJacquemont, LolaTilly, GaëlleYap, MichelleDoan-Ngoc, Tra-MyDanger, RichardGuérif, PierrickDelbos, FlorentMartinet, BernardGiral, MagaliFoucher, YohannBrouard, SophieDegauque, Nicolas2020-03-12T07:59:16-07:00doi:10.1681/ASN.2019080847hwp:resource-id:jnephrol;31/4/876American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologylymphocytes, chronic allograft rejection, clinical immunology, immunology and pathology, kidney transplantationClinical ResearchClinical Researchresearch-article20202020-04-01April 202010.1681/ASN.20190808471046-66731533-34502020-03-12T07:59:16-07:002020-04Journal of the American Society of NephrologyClinical Research314876891http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000102019?cct=218810.34067/KID.0000102019Wed, 12 Feb 2020 01:34:15 GMT-08:00Racial and Ethnic Disparities in Pregnancy-Related Acute Kidney InjuryBeers, KellyWen, Huei HsunSaha, AparnaChauhan, KinsukDave, MihirCoca, StevenNadkarni, GirishChan, Lili2020-02-12T13:34:15-08:00doi:10.34067/KID.0000102019hwp:resource-id:kidney360;1/3/169American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Acute Kidney Injury and ICU Nephrology, Abortion, Spontaneous, Acute Kidney Injury, African Americans, Hispanic Americans, Hospitalization, Pregnancy, Racial Disparities, 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Underappreciated EpidemicFreeman, Natasha S.Canetta, Pietro A.Bomback, Andrew S.2020-02-06T10:35:00-08:00doi:10.34067/KID.0000792019hwp:resource-id:kidney360;1/3/220American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Diabetes and the Kidney, Glomerular and Tubulointerstitial Diseases, Diabetes, Diabetic Nephropathy, Glomerular disease, Non-diabetic Kidney DiseasePerspectivePerspectiveresearch-article20202020-03-2610.34067/KID.00007920192641-76502020-02-06T10:35:00-08:002020-03-26Kidney360Perspective13220222http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000642019?cct=218810.34067/KID.0000642019Tue, 04 Feb 2020 01:26:18 GMT-08:00Global Dialysis Perspective: BrazilSesso, RicardoLugon, Jocemir R.2020-02-04T13:26:18-08:00doi:10.34067/KID.0000642019hwp:resource-id:kidney360;1/3/216American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Chronic Kidney Disease, Dialysis, Brazil, chronic kidney disease, dialysis, epidemiology, Health Services Accessibility, Kidney Failure, Chronic, Public Health, Socioeconomic FactorsGlobal PerspectiveGlobal Perspectiveresearch-article20202020-03-2610.34067/KID.00006420192641-76502020-02-04T13:26:18-08:002020-03-26Kidney360Global Perspective13216219http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00180120?cct=218810.2215/CJN.00180120Thu, 20 Feb 2020 07:32:16 GMT-08:00The Impact of Household Income on Kidney CareWeed, Stephen2020-02-20T07:32:16-08:00doi:10.2215/CJN.00180120hwp:resource-id:clinjasn;15/3/299American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyANCA, lupus nephritis, membranous nephropathy, focal segmental glomerulosclerosis, kidney disease, renal progression, humans, membranous glomerulonephritis, IGA glomerulonephritis, cytoplasmic antineutrophil antibodies, life change events, reading, breakfast, prevalence, friends, British Columbia, psychological distress, economic status, glomerulonephritis, social class, inflammation, prognosis, diet, hygiene, renal dialysisPatient VoicePatient Voiceeditorial20202020-03-06March 06, 202010.2215/CJN.001801201555-90411555-905X2020-02-20T07:32:16-08:002020-03-06Clinical Journal of the American Society of NephrologyPatient Voice15333299306367300307374http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08060719?cct=218810.2215/CJN.08060719Thu, 20 Feb 2020 07:32:16 GMT-08:00Socioeconomic Position and Incidence of Glomerular DiseasesCanney, MarkInduruwage, DilshaniSahota, AnahatMcCrory, CathalHladunewich, Michelle A.Gill, JagbirBarbour, Sean J.2020-02-20T07:32:16-08:00doi:10.2215/CJN.08060719hwp:resource-id:clinjasn;15/3/367American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyclinical epidemiology, glomerular disease, kidney biopsy, lupus nephritis, ANCA, male, female, humans, focal segmental glomerulosclerosis, membranous glomerulonephritis, IGA glomerulonephritis, antineutrophil cytoplasmic antibodies, incidence, risk factors, censuses, British Columbia, confidence intervals, retrospective studies, glomerulonephritis, kidney, biopsy, chronic renal insufficiency, socioeconomic factorsOriginal ArticlesGlomerular and Tubulointerstitial DiseasesOriginal ArticlesGlomerular and Tubulointerstitial Diseasesresearch-article20202020-03-06March 06, 202010.2215/CJN.080607191555-90411555-905X2020-02-20T07:32:16-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles15333367299306374300307http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11921019?cct=218810.2215/CJN.11921019Thu, 20 Feb 2020 07:32:16 GMT-08:00Association of APOL1 Risk Genotype and Air Pollution for Kidney DiseaseParanjpe, IshanChaudhary, KumardeepParanjpe, ManishO’Hagan, RossManna, SayanJaladanki, SurajKapoor, ArjunHorowitz, CarolDeFelice, NicholasCooper, RichardGlicksberg, BenjaminBottinger, Erwin P.Just, Allan C.Nadkarni, Girish N.2020-02-20T07:32:16-08:00doi:10.2215/CJN.11921019hwp:resource-id:clinjasn;15/3/401American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyESRD, genetic renal disease, female, humans, United States, middle aged, human APOL1 protein, apolipoprotein L1, risk factors, particulate matter, diabetes mellitus type 2, urban population, meteorology, New Jersey, follow-up studies, New York City, data systems, biological specimen banks, penetrance, chronic renal insufficiency, kidney, renal insufficiency, hypertension, air pollution, genotypeResearch LetterResearch Letterresearch-article20202020-03-06March 06, 202010.2215/CJN.119210191555-90411555-905X2020-02-20T07:32:16-08:002020-03-06Clinical Journal of the American Society of NephrologyResearch Letter153401403http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.16031219?cct=218810.2215/CJN.16031219Thu, 27 Feb 2020 12:17:32 GMT-08:00Air Pollution and Kidney DiseaseAl-Aly, ZiyadBowe, Benjamin2020-02-27T12:17:32-08:00doi:10.2215/CJN.16031219hwp:resource-id:clinjasn;15/3/301American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, risk factors, pollution, air pollution, burden of disease, particulate matter, environment, CKD, disparity, injustice, environmental injustice, race, socioeconomic, inequity, humans, nitrogen dioxide, vehicle emissions, carbon monoxide, nanomedicine, developing countries, sclerosis, metal nanoparticles, kidney, environmental exposure, epidemiological studiesEditorialsEditorialseditorial20202020-03-06March 06, 202010.2215/CJN.160312191555-90411555-905X2020-02-27T12:17:32-08:002020-03-06Clinical Journal of the American Society of NephrologyEditorials1533301311303319http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.15051219?cct=218810.2215/CJN.15051219Thu, 20 Feb 2020 07:32:16 GMT-08:00Social Determinants of Glomerular DiseaseO'Shaughnessy, Michelle M.2020-02-20T07:32:16-08:00doi:10.2215/CJN.15051219hwp:resource-id:clinjasn;15/3/306American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyglomerular disease, clinical epidemiology, humans, lupus nephritis, membranous glomerulonephritis, cytoplasmic antineutrophil antibodies, incidence, ethnic groups, vulnerable populations, genetic predisposition to disease, minority groups, glomerulonephritis, poverty, health behavior, chronic renal insufficiency, smoking, employment, social support, mutation, air pollution, epidemiological studies, North America, ScotlandEditorialsEditorialseditorial20202020-03-06March 06, 202010.2215/CJN.150512191555-90411555-905X2020-02-20T07:32:16-08:002020-03-06Clinical Journal of the American Society of NephrologyEditorials15333306299367307300374http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11991019?cct=2188Advances in immunosuppressive therapy have drastically improved acute rejection rates in kidney transplant recipients over the past five decades. Nevertheless, it should remain high on any differential diagnosis of unexplained graft dysfunction because of the potential negative effect on graft longevity. Understanding the pre- and post-transplant risk factors for acute rejection can help estimate the probability of immunologic graft damage, and accurate identification of the type and severity of acute rejection will guide appropriate treatment. Tissue biopsy remains the gold standard for evaluating immunologic graft damage, and the histologic definition of acute rejection has evolved in recent years. Intravenous steroids and T cell depletion remain the standard therapy for T cell–mediated rejection and are effective in reversing most cases. Plasma exchange and intravenous Ig, with or without rituximab, are most commonly used for the treatment of antibody-mediated rejection and several newer agents have recently been investigated for severe cases. This review aims to provide the general nephrologist caring for transplant recipients with an approach to immunologic risk assessment and a summary of recent advances in the diagnosis and treatment of acute graft rejection.10.2215/CJN.11991019Mon, 17 Feb 2020 05:12:58 GMT-08:00Evaluation and Treatment of Acute Rejection in Kidney AllograftsAdvances in immunosuppressive therapy have drastically improved acute rejection rates in kidney transplant recipients over the past five decades. Nevertheless, it should remain high on any differential diagnosis of unexplained graft dysfunction because of the potential negative effect on graft longevity. Understanding the pre- and post-transplant risk factors for acute rejection can help estimate the probability of immunologic graft damage, and accurate identification of the type and severity of acute rejection will guide appropriate treatment. Tissue biopsy remains the gold standard for evaluating immunologic graft damage, and the histologic definition of acute rejection has evolved in recent years. Intravenous steroids and T cell depletion remain the standard therapy for T cell–mediated rejection and are effective in reversing most cases. Plasma exchange and intravenous Ig, with or without rituximab, are most commonly used for the treatment of antibody-mediated rejection and several newer agents have recently been investigated for severe cases. This review aims to provide the general nephrologist caring for transplant recipients with an approach to immunologic risk assessment and a summary of recent advances in the diagnosis and treatment of acute graft rejection.Cooper, James E.2020-02-17T05:12:58-08:00doi:10.2215/CJN.11991019hwp:resource-id:clinjasn;15/3/430American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyacute allograft rejection, renal transplantation, immunosuppression, Immunology and pathology, intravenous immunoglobulins, graft rejection, rituximab, plasma exchange, transplant recipients, kidney transplantation, nephrologists, risk factors, differential diagnosis, longevity, t-lymphocytes, plasmapheresis, antibodies, biopsy, risk assessment, allografts, humansReviewsReviewsresearch-article20202020-03-06March 06, 202010.2215/CJN.119910191555-90411555-905X2020-02-17T05:12:58-08:002020-03-06Clinical Journal of the American Society of NephrologyReviews153430438http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10410919?cct=2188The long-term sequelae of AKI have received increasing attention so that its associations with a number of adverse outcomes, including higher mortality and development of CKD, are now widely appreciated. These associations take on particular importance when considering the high incidence of AKI, with a lack of proven interventions and uncertainties around optimal care provision meaning that the long-term sequelae of AKI present a major unmet clinical need. In this review, we examine the published data that inform our current understanding of long-term outcomes following AKI and discuss potential knowledge gaps, covering long-term mortality, CKD, progression to ESKD, proteinuria, cardiovascular events, recurrent AKI, and hospital readmission.10.2215/CJN.10410919Wed, 19 Feb 2020 08:33:16 GMT-08:00Long-Term Outcomes in Patients with Acute Kidney InjuryThe long-term sequelae of AKI have received increasing attention so that its associations with a number of adverse outcomes, including higher mortality and development of CKD, are now widely appreciated. These associations take on particular importance when considering the high incidence of AKI, with a lack of proven interventions and uncertainties around optimal care provision meaning that the long-term sequelae of AKI present a major unmet clinical need. In this review, we examine the published data that inform our current understanding of long-term outcomes following AKI and discuss potential knowledge gaps, covering long-term mortality, CKD, progression to ESKD, proteinuria, cardiovascular events, recurrent AKI, and hospital readmission.Noble, Rebecca A.Lucas, Bethany J.Selby, Nicholas M.2020-02-19T08:33:16-08:00doi:10.2215/CJN.10410919hwp:resource-id:clinjasn;15/3/423American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyclinical nephrology, outcomes, progression of renal failure, renal injury, humans, incidence, patient readmission, chronic renal insufficiency, acute kidney injury, chronic kidney failure, disease progression, proteinuria, attention, cardiovascular diseasesReviewsReviewsreview-article20202020-03-06March 06, 202010.2215/CJN.104109191555-90411555-905X2020-02-19T08:33:16-08:002020-03-06Clinical Journal of the American Society of NephrologyReviews153423429http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08430719?cct=218810.2215/CJN.08430719Wed, 19 Feb 2020 08:33:17 GMT-08:00Life Course Socioeconomic Status, Allostatic Load, and Kidney Health in Black AmericansLunyera, JosephStanifer, John W.Davenport, Clemontina A.Mohottige, DinushikaBhavsar, Nrupen A.Scialla, Julia J.Pendergast, JaneBoulware, L. EbonyDiamantidis, Clarissa Jonas2020-02-19T08:33:17-08:00doi:10.2215/CJN.08430719hwp:resource-id:clinjasn;15/3/341American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyfemale, humans, child, United States, incidence, allostasis, prevalence, self report, follow-up studies, social class, income, glomerular filtration rate, kidney, biomarkers, chronic renal insufficiency, longitudinal studies, socioeconomic status, life course, allostatic load, kidney diseases, kidney disease, African-AmericansOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-03-06March 06, 202010.2215/CJN.084307191555-90411555-905X2020-02-19T08:33:17-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles153341348http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08350719?cct=218810.2215/CJN.08350719Thu, 27 Feb 2020 12:17:32 GMT-08:00Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKDBlum, Matthew F.Surapaneni, AdityaStewart, James D.Liao, DuanpingYanosky, Jeff D.Whitsel, Eric A.Power, Melinda C.Grams, Morgan E.2020-02-27T12:17:32-08:00doi:10.2215/CJN.08350719hwp:resource-id:clinjasn;15/3/311American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, albuminuria, glomerular filtration rate, epidemiology and outcomes, ARIC, particulate matter, air pollution, humans, cross-sectional studies, creatinine, linear models, geographic information systems, International Classification of Diseases, follow-up studies, confidence intervals, chronic renal insufficiency, chronic kidney failure, kidney function tests, cohort studies, atherosclerosis, demography, hospitalization, social class, albuminOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-03-06March 06, 202010.2215/CJN.083507191555-90411555-905X2020-02-27T12:17:32-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles1533311301319303http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12341019?cct=218810.2215/CJN.12341019Fri, 28 Feb 2020 06:27:30 GMT-08:00A Coaching Program to Improve Dietary Intake of Patients with CKDKelly, Jaimon T.Conley, MargueriteHoffmann, TammyCraig, Jonathan C.Tong, AllisonReidlinger, Dianne P.Reeves, Marina M.Howard, KirstenKrishnasamy, RathikaKurtkoti, JagadeeshPalmer, Suetonia C.Johnson, David W.Campbell, Katrina L.2020-02-28T06:27:30-08:00doi:10.2215/CJN.12341019hwp:resource-id:clinjasn;15/3/330American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, diet, dietary pattern, mobile health, self-efficacy, smartphone, telehealth, telemedicine, text messaging, trial, weight loss, male, humans, vegetables, healthy diet, self-management, blood pressure, mentoring, nutritionists, control groups, confidence intervals, pilot projects, body weight, telephone, chronic renal insufficiencyOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-03-06March 06, 202010.2215/CJN.123410191555-90411555-905X2020-02-28T06:27:30-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles153330340http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.02780319?cct=218810.2215/CJN.02780319Fri, 28 Feb 2020 06:27:29 GMT-08:00Urine Markers of Kidney Tubule Cell Injury and Kidney Function Decline in SPRINT Trial Participants with CKDMalhotra, RakeshKatz, RonitJotwani, VasanthaAmbrosius, Walter T.Raphael, Kalani L.Haley, WilliamRastogi, AnjayCheung, Alfred K.Freedman, Barry I.Punzi, HenryRocco, Michael V.Ix, Joachim H.Shlipak, Michael G.2020-02-28T06:27:29-08:00doi:10.2215/CJN.02780319hwp:resource-id:clinjasn;15/3/349American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, kidney function decline, tubule injury biomarkers, male, humans, human LCN2 protein, lipocalin-2, glomerular filtration rate, interleukin-18, albuminuria, human CCL2 protein, chemokine CCL2, human CHI3L1 protein, chitinase-3-like protein 1, kidney transplantation, proportional hazards models, blood pressure, follow-up studies, confidence intervals, human HAVCR1 protein, hepatitis A virus cellular receptor 1, acute kidney injury, chronic renal insufficiency, kidney tubules, inflammationOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-03-06March 06, 202010.2215/CJN.027803191555-90411555-905X2020-02-28T06:27:29-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles1533349304358305http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08420719?cct=218810.2215/CJN.08420719Fri, 28 Feb 2020 06:27:29 GMT-08:00Sex and Glomerular Filtration Rate Trajectories in ChildrenBonnéric, StéphanieKaradkhele, GeetaCouchoud, CécilePatzer, Rachel E.Greenbaum, Larry A.Hogan, Julien2020-02-28T06:27:29-08:00doi:10.2215/CJN.08420719hwp:resource-id:clinjasn;15/3/320American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, progression of chronic renal failure, children, child, female, humans, male, glomerular filtration rate, kidney transplantation, renal dialysis, chronic kidney failure, chronic renal insufficiency, proteinuria, kidney, immune system diseases, glomerulonephritisOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-03-06March 06, 202010.2215/CJN.084207191555-90411555-905X2020-02-28T06:27:29-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles153320329http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07960719?cct=218810.2215/CJN.07960719Fri, 28 Feb 2020 06:27:30 GMT-08:00Conversion from Intravenous Vitamin D Analogs to Oral Calcitriol in Patients Receiving Maintenance HemodialysisThadhani, Ravi I.Rosen, SophiaOfsthun, Norma J.Usvyat, Len A.Dalrymple, Lorien S.Maddux, Franklin W.Hymes, Jeffrey L.2020-02-28T06:27:30-08:00doi:10.2215/CJN.07960719hwp:resource-id:clinjasn;15/3/384American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyMineral Bone Disorder, calcium, phosphate, parathyroid hormone, adult, humans, United States, paricalcitol, 1 alpha-hydroxyergocalciferol, calcitriol, cinacalcet, phosphates, length of stay, survival rate, retrospective studies, follow-up studies, intention to treat analysis, ergocalciferols, dihydroxy-vitamin D3, Vitamin D, secondary hyperparathyroidism, renal dialysis, minerals, calcium phosphatesOriginal ArticlesMineral MetabolismOriginal ArticlesMineral Metabolismresearch-article20202020-03-06March 06, 202010.2215/CJN.079607191555-90411555-905X2020-02-28T06:27:30-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles153384391http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07420619?cct=2188In this review of the application of proteomics and metabolomics to kidney disease research, we review key concepts, highlight illustrative examples, and outline future directions. The proteome and metabolome reflect the influence of environmental exposures in addition to genetic coding. Circulating levels of proteins and metabolites are dynamic and modifiable, and thus amenable to therapeutic targeting. Design and analytic considerations in proteomics and metabolomics studies should be tailored to the investigator’s goals. For the identification of clinical biomarkers, adjustment for all potential confounding variables, particularly GFR, and strict significance thresholds are warranted. However, this approach has the potential to obscure biologic signals and can be overly conservative given the high degree of intercorrelation within the proteome and metabolome. Mass spectrometry, often coupled to up-front chromatographic separation techniques, is a major workhorse in both proteomics and metabolomics. High-throughput antibody- and aptamer-based proteomic platforms have emerged as additional, powerful approaches to assay the proteome. As the breadth of coverage for these methodologies continues to expand, machine learning tools and pathway analyses can help select the molecules of greatest interest and categorize them in distinct biologic themes. Studies to date have already made a substantial effect, for example elucidating target antigens in membranous nephropathy, identifying a signature of urinary peptides that adds prognostic information to urinary albumin in CKD, implicating circulating inflammatory proteins as potential mediators of diabetic nephropathy, demonstrating the key role of the microbiome in the uremic milieu, and highlighting kidney bioenergetics as a modifiable factor in AKI. Additional studies are required to replicate and expand on these findings in independent cohorts. Further, more work is needed to understand the longitudinal trajectory of select protein and metabolite markers, perform transomics analyses within merged datasets, and incorporate more kidney tissue–based investigation.10.2215/CJN.07420619Mon, 21 Oct 2019 07:55:53 GMT-07:00Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and PreventionIn this review of the application of proteomics and metabolomics to kidney disease research, we review key concepts, highlight illustrative examples, and outline future directions. The proteome and metabolome reflect the influence of environmental exposures in addition to genetic coding. Circulating levels of proteins and metabolites are dynamic and modifiable, and thus amenable to therapeutic targeting. Design and analytic considerations in proteomics and metabolomics studies should be tailored to the investigator’s goals. For the identification of clinical biomarkers, adjustment for all potential confounding variables, particularly GFR, and strict significance thresholds are warranted. However, this approach has the potential to obscure biologic signals and can be overly conservative given the high degree of intercorrelation within the proteome and metabolome. Mass spectrometry, often coupled to up-front chromatographic separation techniques, is a major workhorse in both proteomics and metabolomics. High-throughput antibody- and aptamer-based proteomic platforms have emerged as additional, powerful approaches to assay the proteome. As the breadth of coverage for these methodologies continues to expand, machine learning tools and pathway analyses can help select the molecules of greatest interest and categorize them in distinct biologic themes. Studies to date have already made a substantial effect, for example elucidating target antigens in membranous nephropathy, identifying a signature of urinary peptides that adds prognostic information to urinary albumin in CKD, implicating circulating inflammatory proteins as potential mediators of diabetic nephropathy, demonstrating the key role of the microbiome in the uremic milieu, and highlighting kidney bioenergetics as a modifiable factor in AKI. Additional studies are required to replicate and expand on these findings in independent cohorts. Further, more work is needed to understand the longitudinal trajectory of select protein and metabolite markers, perform transomics analyses within merged datasets, and incorporate more kidney tissue–based investigation.Dubin, Ruth F.Rhee, Eugene P.2019-10-21T07:55:53-07:00doi:10.2215/CJN.07420619hwp:resource-id:clinjasn;15/3/404American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyMetabolomics, proteomics, proteome, diabetic nephropathy, diabetic nephropathies, metabolome, membranous glomerulonephritis, research personnel, confounding factors (epidemiology), prognosis, goals, kidney, mass spectrometry, biomarkers, microbiota, peptides, machine learning, environmental exposure, energy metabolism, chronic renal insufficiency, biological products, albumins, Kidney Genomics SeriesGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-03-06March 06, 202010.2215/CJN.074206191555-90411555-905X2019-10-21T07:55:53-07:002020-03-06Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease153404411http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11710919?cct=218810.2215/CJN.11710919Wed, 19 Feb 2020 08:33:16 GMT-08:00Carbamylated Lipoproteins and Progression of Diabetic Kidney DiseaseTan, Kathryn C.B.Cheung, Ching-LungLee, Alan C.H.Lam, Joanne K.Y.Wong, YingShiu, Sammy W.M.2020-02-19T08:33:16-08:00doi:10.2215/CJN.11710919hwp:resource-id:clinjasn;15/3/359American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologydiabetic nephropathy, progression of renal failure, humans, diabetic nephropathies, glomerular filtration rate, creatinine, case-control studies, HDL2 lipoproteins, HDL cholesterol, type 2 diabetes mellitus, urea, protein carbamylation, follow-up studies, LDL lipoproteins, chronic renal insufficiency, kidney, atherosclerosis, uremia, renal replacement therapy, regression analysis, enzyme-linked immunosorbent assay, cohort studiesOriginal ArticlesDiabetes and the KidneyOriginal ArticlesDiabetes and the Kidneyresearch-article20202020-03-06March 06, 202010.2215/CJN.117109191555-90411555-905X2020-02-19T08:33:16-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles153359366http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09180819?cct=218810.2215/CJN.09180819Tue, 17 Dec 2019 08:31:59 GMT-08:00Personalizing Donor Kidney SelectionFoley, David P.Sawinski, Deirdre2019-12-17T08:31:59-08:00doi:10.2215/CJN.09180819hwp:resource-id:clinjasn;15/3/418American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, donor recipient matching, living donor kidney transplantation, deceased donor transplantation, humans, graft survival, living donors, renal dialysis, chronic kidney failure, donor selection, kidneyPerspectivesPerspectivesresearch-article20202020-03-06March 06, 202010.2215/CJN.091808191555-90411555-905X2019-12-17T08:31:59-08:002020-03-06Clinical Journal of the American Society of NephrologyPerspectives153418420http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10240819?cct=218810.2215/CJN.10240819Mon, 18 Nov 2019 08:35:30 GMT-08:00Management of Membranous Nephropathy after MENTORTrivin-Avillach, ClaireBeck, Laurence H.2019-11-18T08:35:30-08:00doi:10.2215/CJN.10240819hwp:resource-id:clinjasn;15/3/415American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhumans, human PLA2R1 protein, phospholipase A2 receptors, membranous glomerulonephritis, rituximab, calcineurin inhibitors, nephrotic syndrome, cyclosporine, autoantibodies, epitopes, serum albumin, alkylating agents, follow-up studies, MENTOR, immunosuppressive agents, proteinuria, B-lymphocytes, renal insufficiency, adrenal cortex hormonesPerspectivesPerspectivesresearch-article20202020-03-06March 06, 202010.2215/CJN.102408191555-90411555-905X2019-11-18T08:35:30-08:002020-03-06Clinical Journal of the American Society of NephrologyPerspectives153415417http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11060919?cct=218810.2215/CJN.11060919Fri, 06 Dec 2019 07:58:57 GMT-08:00How the Kidney Health Initiative Catalyzes Innovation in a Dynamic EnvironmentHarris, Raymond C.Cahill, Zachary2019-12-06T07:58:57-08:00doi:10.2215/CJN.11060919hwp:resource-id:clinjasn;15/3/421American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyHumans, United States, nephrology, public-private sector partnerships, United States Food and Drug Administration, public health, goals, kidney diseases, kidney, United States Dept. of Health and Human Services, government, attentionPerspectivesPerspectivesresearch-article20202020-03-06March 06, 202010.2215/CJN.110609191555-90411555-905X2019-12-06T07:58:57-08:002020-03-06Clinical Journal of the American Society of NephrologyPerspectives153421422http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07070619?cct=218810.2215/CJN.07070619Wed, 19 Feb 2020 08:33:17 GMT-08:00Survival after Kidney Transplantation during Childhood and AdolescenceFrancis, AnnaJohnson, David W.Melk, AnetteFoster, Bethany J.Blazek, KatrinaCraig, Jonathan C.Wong, Germaine2020-02-19T08:33:17-08:00doi:10.2215/CJN.07070619hwp:resource-id:clinjasn;15/3/392American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychildren, transplantation, transplant outcomes, survival, child, adolescent, male, humans, kidney transplantation, survival rate, living donors, renal dialysis, New Zealand, retrospective studies, registries, risk, neoplasms, proportional hazards modelsOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-03-06March 06, 202010.2215/CJN.070706191555-90411555-905X2020-02-19T08:33:17-08:002020-03-06Clinical Journal of the American Society of NephrologyOriginal Articles1533392308400310http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00370120?cct=218810.2215/CJN.00370120Wed, 19 Feb 2020 08:33:17 GMT-08:00Secular Trends in Survival Outcomes of Kidney Transplantation for ChildrenAmaral, Sandra2020-02-19T08:33:17-08:00doi:10.2215/CJN.00370120hwp:resource-id:clinjasn;15/3/308American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologypediatric, kidney transplant, outcomesEditorialsEditorialseditorial20202020-03-06March 06, 202010.2215/CJN.003701201555-90411555-905X2020-02-19T08:33:17-08:002020-03-06Clinical Journal of the American Society of NephrologyEditorials1533308392310400http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09470819?cct=218810.2215/CJN.09470819Mon, 17 Feb 2020 05:12:59 GMT-08:00Electrolyte Disorders in Kidney TransplantationMiles, Clifford D.Westphal, Scott Gregory2020-02-17T05:12:59-08:00doi:10.2215/CJN.09470819hwp:resource-id:clinjasn;15/3/412American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, electrolytes, hyperparathyroidism, hyperkalemia, hypomagnesemia, immunosuppression, acid-base imbalance, water-electrolyte balanceKidney Case Conference: How I TreatKidney Case Conference: How I Treatresearch-article20202020-03-06March 06, 202010.2215/CJN.094708191555-90411555-905X2020-02-17T05:12:59-08:002020-03-06Clinical Journal of the American Society of NephrologyKidney Case Conference: How I Treat153412414http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090905?cct=218810.1681/ASN.2019090905Wed, 29 Jan 2020 07:29:00 GMT-08:00A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney DiseaseBovée, Dominique M.Visser, Wesley J.Middel, IgorDe Mik–van Egmond, AnnekeGreupink, RickMasereeuw, RosalindeRussel, Frans G. M.Danser, A. H. JanZietse, RobertHoorn, Ewout J.2020-01-29T07:29:00-08:00doi:10.1681/ASN.2019090905hwp:resource-id:jnephrol;31/3/650American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologychronic kidney disease, clinical hypertension, clinical trial, diuretics, pharmacokinetics, water-electrolyte balanceClinical ResearchClinical Researchresearch-article20202020-03-01March 202010.1681/ASN.20190909051046-66731533-34502020-01-29T07:29:00-08:002020-03Journal of the American Society of NephrologyClinical Research313650662http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010103?cct=218810.1681/ASN.2020010103Fri, 28 Feb 2020 10:00:27 GMT-08:00This Month's HighlightsAmerican Society of Nephrology2020-02-28T10:00:27-08:00doi:10.1681/ASN.2020010103hwp:resource-id:jnephrol;31/3/iAmerican Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyThis Month's HighlightsThis Month's Highlightsin-brief20202020-03-01March 202010.1681/ASN.20200101031046-66731533-34502020-02-28T10:00:27-08:002020-03Journal of the American Society of NephrologyThis Month's Highlights313iihttp://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090869?cct=218810.1681/ASN.2019090869Thu, 13 Feb 2020 11:00:13 GMT-08:00Measuring Quality in Kidney Care: An Evaluation of Existing Quality Metrics and Approach to Facilitating Improvements in Care DeliveryMendu, Mallika L.Tummalapalli, Sri LekhaLentine, Krista L.Erickson, Kevin F.Lew, Susie Q.Liu, FrankGould, EdwardSomers, MichaelGarimella, Pranav S.O’Neil, TerrenceWhite, David L.Meyer, RachelBieber, Scott D.Weiner, Daniel E.2020-02-13T11:00:13-08:00doi:10.1681/ASN.2019090869hwp:resource-id:jnephrol;31/3/602American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyQuality Metrics, Quality Improvement, chronic kidney disease, end-stage renal diseaseClinical ResearchClinical Researchresearch-article20202020-03-01March202010.1681/ASN.20190908691046-66731533-34502020-02-13T11:00:13-08:002020-03Journal of the American Society of NephrologyClinical Research3133602454614455http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090944?cct=218810.1681/ASN.2019090944Tue, 04 Feb 2020 09:07:32 GMT-08:00A Randomized Trial of Empagliflozin to Increase Plasma Sodium Levels in Patients with the Syndrome of Inappropriate AntidiuresisRefardt, JulieImber, CorneliaSailer, Clara O.Jeanloz, NicaPotasso, LauraKutz, AlexanderWidmer, AndreaUrwyler, Sandrine A.Ebrahimi, FahimVogt, Deborah R.Winzeler, BettinaChrist-Crain, Mirjam2020-02-04T09:07:32-08:00doi:10.1681/ASN.2019090944hwp:resource-id:jnephrol;31/3/615American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologySGLT2-inhibitors, hyponatremia, SIAD, treatmentClinical ResearchClinical Researchresearch-article20202020-03-01March 202010.1681/ASN.20190909441046-66731533-34502020-02-04T09:07:32-08:002020-03Journal of the American Society of NephrologyClinical Research313615624http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019030274?cct=218810.1681/ASN.2019030274Wed, 15 Jan 2020 06:42:02 GMT-08:00Racial and Sex Disparities in Catheter Use and Dialysis Access in the United States Medicare PopulationArya, ShipraMelanson, Taylor A.George, Elizabeth L.Rothenberg, Kara A.Kurella Tamura, ManjulaPatzer, Rachel E.Hockenberry, Jason M.2020-01-15T06:42:02-08:00doi:10.1681/ASN.2019030274hwp:resource-id:jnephrol;31/3/625American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyarteriovenous shunt, renal dialysis, healthcare disparitiesClinical ResearchClinical Researchresearch-article20202020-03-01March 202010.1681/ASN.20190302741046-66731533-34502020-01-15T06:42:02-08:002020-03Journal of the American Society of NephrologyClinical Research313625636http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050543?cct=218810.1681/ASN.2019050543Thu, 20 Feb 2020 07:33:36 GMT-08:00Racial/Ethnic Disparities in Atrial Fibrillation Treatment and Outcomes among Dialysis Patients in the United StatesWaddy, Salina P.Solomon, Allen J.Becerra, Adan Z.Ward, Julia B.Chan, Kevin E.Fwu, Chyng-WenNorton, Jenna M.Eggers, Paul W.Abbott, Kevin C.Kimmel, Paul L.2020-02-20T07:33:36-08:00doi:10.1681/ASN.2019050543hwp:resource-id:jnephrol;31/3/637American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydialysis, hemodialysis, cardiovascular diseaseClinical ResearchClinical Researchresearch-article20202020-03-01March 202010.1681/ASN.20190505431046-66731533-34502020-02-20T07:33:36-08:002020-03Journal of the American Society of NephrologyClinical Research313637649http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050551?cct=218810.1681/ASN.2019050551Thu, 13 Feb 2020 11:00:12 GMT-08:00Aldosterone Regulates Pendrin and Epithelial Sodium Channel Activity through Intercalated Cell Mineralocorticoid Receptor–Dependent and –Independent Mechanisms over a Wide Range in Serum PotassiumPham, Truyen D.Verlander, Jill W.Wang, YanhuaRomero, Cesar A.Yue, QiangChen, ChaoThumova, MonikaEaton, Douglas C.Lazo-Fernandez, YoskalyWall, Susan M.2020-02-13T11:00:12-08:00doi:10.1681/ASN.2019050551hwp:resource-id:jnephrol;31/3/483American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyCell & Transport Physiology, ENaC, ion transport, hypertensionBasic ResearchBasic Researchresearch-article20202020-03-01March 202010.1681/ASN.20190505511046-66731533-34502020-02-13T11:00:12-08:002020-03Journal of the American Society of NephrologyBasic Research3133483451499452http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050523?cct=218810.1681/ASN.2019050523Wed, 29 Jan 2020 07:29:00 GMT-08:00Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1Rajendran, GaneshkumarSchonfeld, Michael P.Tiwari, RatnakarHuang, ShengpingTorosyan, RafaelFields, TimothyPark, JihwanSusztak, KatalinKapitsinou, Pinelopi P.2020-01-29T07:29:00-08:00doi:10.1681/ASN.2019050523hwp:resource-id:jnephrol;31/3/501American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyischemia-reperfusion, HIF, PHD2, endotheliumBasic ResearchBasic Researchresearch-article20202020-03-01March 202010.1681/ASN.20190505231046-66731533-34502020-01-29T07:29:00-08:002020-03Journal of the American Society of NephrologyBasic Research313501516http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019020109?cct=218810.1681/ASN.2019020109Fri, 10 Jan 2020 07:34:23 GMT-08:00Injured Podocytes Are Sensitized to Angiotensin II–Induced Calcium SignalingBinz-Lotter, JuliaJüngst, ChristianRinschen, Markus M.Koehler, SybilleZentis, PeterSchauss, AstridSchermer, BernhardBenzing, ThomasHackl, Matthias J.2020-01-10T07:34:23-08:00doi:10.1681/ASN.2019020109hwp:resource-id:jnephrol;31/3/532American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyAASK (African American Study of Kidney Disease and Hypertension), calcium, podocyte, angiotensin, glomerular disease, nephrinBasic ResearchBasic Researchresearch-article20202020-03-01March 202010.1681/ASN.20190201091046-66731533-34502020-01-10T07:34:23-08:002020-03Journal of the American Society of NephrologyBasic Research313532542http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060575?cct=218810.1681/ASN.2019060575Tue, 04 Feb 2020 09:07:33 GMT-08:00Bundled Payment Reform and Dialysis Facility Closures in ESKDNorouzi, SaynaZhao, BoAwan, AhmedWinkelmayer, Wolfgang C.Ho, VivianErickson, Kevin F.2020-02-04T09:07:33-08:00doi:10.1681/ASN.2019060575hwp:resource-id:jnephrol;31/3/579American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyChronic dialysis, Economic impact, Epidemiology and outcomes, United States Renal Data System, Ethnic minorityClinical EpidemiologyClinical Epidemiologyresearch-article20202020-03-01March 202010.1681/ASN.20190605751046-66731533-34502020-02-04T09:07:33-08:002020-03Journal of the American Society of NephrologyClinical Epidemiology313579590http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060605?cct=218810.1681/ASN.2019060605Wed, 05 Feb 2020 07:27:32 GMT-08:00Estimating Urine Albumin-to-Creatinine Ratio from Protein-to-Creatinine Ratio: Development of Equations using Same-Day MeasurementsWeaver, Robert G.James, Matthew T.Ravani, PietroWeaver, Colin G.W.Lamb, Edmund J.Tonelli, MarcelloManns, Braden J.Quinn, Robert R.Jun, MinHemmelgarn, Brenda R.2020-02-05T07:27:32-08:00doi:10.1681/ASN.2019060605hwp:resource-id:jnephrol;31/3/591American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyalbuminuria, proteinuria, gender difference, chronic kidney diseaseClinical ResearchClinical Researchresearch-article20202020-03-01March 202010.1681/ASN.20190606051046-66731533-34502020-02-05T07:27:32-08:002020-03Journal of the American Society of NephrologyClinical Research313133559145211406014531140http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010077?cct=218810.1681/ASN.2020010077Thu, 13 Feb 2020 11:00:11 GMT-08:00How Does Aldosterone Work in the β-Intercalated Cell?Leipziger, JensPraetorius, Helle2020-02-13T11:00:11-08:00doi:10.1681/ASN.2020010077hwp:resource-id:jnephrol;31/3/451American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycollecting ducts, epithelial sodium transport, ion transportUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-03-01March 202010.1681/ASN.20200100771046-66731533-34502020-02-13T11:00:11-08:002020-03Journal of the American Society of NephrologyUp Front Matters3133451483452499http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010049?cct=218810.1681/ASN.2020010049Wed, 05 Feb 2020 07:27:32 GMT-08:00Aligning Albuminuria and Proteinuria MeasurementsCoresh, Josef2020-02-05T07:27:32-08:00doi:10.1681/ASN.2020010049hwp:resource-id:jnephrol;31/3/452American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyalbuminuria, proteinuria, Laboratory methodsUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-03-01March 202010.1681/ASN.20200100491046-66731533-34502020-02-05T07:27:32-08:002020-03Journal of the American Society of NephrologyUp Front Matters3133452591453601http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019111234?cct=218810.1681/ASN.2019111234Thu, 13 Feb 2020 11:00:12 GMT-08:00Measuring UpPalevsky, Paul M.2020-02-13T11:00:12-08:00doi:10.1681/ASN.2019111234hwp:resource-id:jnephrol;31/3/454American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyQuality, Performance measurement, kidney disease, Quality improvementUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-03-01March 202010.1681/ASN.20191112341046-66731533-34502020-02-13T11:00:12-08:002020-03Journal of the American Society of NephrologyUp Front Matters3133454602455614http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010067?cct=218810.1681/ASN.2020010067Fri, 28 Feb 2020 10:00:27 GMT-08:00ErratumAmerican Society of Nephrology2020-02-28T10:00:27-08:00doi:10.1681/ASN.2020010067hwp:resource-id:jnephrol;31/3/665American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyDialysis access, vascular, arteriovenous fistulaErratumErratumcorrection20202020-03-01March 202010.1681/ASN.20200100671046-66731533-34502020-02-28T10:00:27-08:002020-03Journal of the American Society of NephrologyErratum312931166527356652744http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070677?cct=2188Retrospective analyses and single-center prospective studies identify chronic metabolic acidosis as an independent and modifiable risk factor for progression of CKD. In patients with CKD, untreated chronic metabolic acidosis often leads to an accelerated reduction in GFR. Mechanisms responsible for this reduction include adaptive responses that increase acid excretion but lead to a decline in kidney function. Metabolic acidosis in CKD stimulates production of intrakidney paracrine hormones including angiotensin II, aldosterone, and endothelin-1 (ET-1) that mediate the immediate benefit of increased kidney acid excretion, but their chronic upregulation promotes inflammation and fibrosis. Chronic metabolic acidosis also stimulates ammoniagenesis that increases acid excretion but also leads to ammonia-induced complement activation and deposition of C3 and C5b-9 that can cause tubule-interstitial damage, further worsening disease progression. These effects, along with acid accumulation in kidney tissue, combine to accelerate progression of kidney disease. Treatment of chronic metabolic acidosis attenuates these adaptive responses; reduces levels of angiotensin II, aldosterone, and ET-1; reduces ammoniagenesis; and diminishes inflammation and fibrosis that may lead to slowing of CKD progression.10.1681/ASN.2019070677Mon, 27 Jan 2020 06:13:17 GMT-08:00Mechanisms of Metabolic Acidosis–Induced Kidney Injury in Chronic Kidney DiseaseRetrospective analyses and single-center prospective studies identify chronic metabolic acidosis as an independent and modifiable risk factor for progression of CKD. In patients with CKD, untreated chronic metabolic acidosis often leads to an accelerated reduction in GFR. Mechanisms responsible for this reduction include adaptive responses that increase acid excretion but lead to a decline in kidney function. Metabolic acidosis in CKD stimulates production of intrakidney paracrine hormones including angiotensin II, aldosterone, and endothelin-1 (ET-1) that mediate the immediate benefit of increased kidney acid excretion, but their chronic upregulation promotes inflammation and fibrosis. Chronic metabolic acidosis also stimulates ammoniagenesis that increases acid excretion but also leads to ammonia-induced complement activation and deposition of C3 and C5b-9 that can cause tubule-interstitial damage, further worsening disease progression. These effects, along with acid accumulation in kidney tissue, combine to accelerate progression of kidney disease. Treatment of chronic metabolic acidosis attenuates these adaptive responses; reduces levels of angiotensin II, aldosterone, and ET-1; reduces ammoniagenesis; and diminishes inflammation and fibrosis that may lead to slowing of CKD progression.Wesson, Donald E.Buysse, Jerry M.Bushinsky, David A.2020-01-27T06:13:17-08:00doi:10.1681/ASN.2019070677hwp:resource-id:jnephrol;31/3/469American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyaldosterone, angiotensin, chronic kidney disease, chronic metabolic acidosis, progression of chronic renal failure, endothelinUp Front MattersSpecial ArticleUp Front MattersSpecial Articleresearch-article20202020-03-01March 202010.1681/ASN.20190706771046-66731533-34502020-01-27T06:13:17-08:002020-03Journal of the American Society of NephrologyUp Front Matters313469482http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019030312?cct=218810.1681/ASN.2019030312Tue, 11 Feb 2020 01:15:14 GMT-08:00Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular SclerosisKoehler, SybilleKuczkowski, AlexanderKuehne, LucasJüngst, ChristianHoehne, MartinGrahammer, FlorianEddy, SeanKretzler, MatthiasBeck, Bodo B.Höhfeld, JörgSchermer, BernhardBenzing, ThomasBrinkkoetter, Paul T.Rinschen, Markus M.2020-02-11T13:15:14-08:00doi:10.1681/ASN.2019030312hwp:resource-id:jnephrol;31/3/544American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologypodocyte, glomerular disease, renal injuryBasic ResearchBasic Researchresearch-article20202020-03-01March 202010.1681/ASN.20190303121046-66731533-34502020-02-11T13:15:14-08:002020-03Journal of the American Society of NephrologyBasic Research313544559http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019020213?cct=2188Anemia is a complication that affects a majority of individuals with advanced CKD. Although relative deficiency of erythropoietin production is the major driver of anemia in CKD, iron deficiency stands out among the mechanisms contributing to the impaired erythropoiesis in the setting of reduced kidney function. Iron deficiency plays a significant role in anemia in CKD. This may be due to a true paucity of iron stores (absolute iron deficiency) or a relative (functional) deficiency which prevents the use of available iron stores. Several risk factors contribute to absolute and functional iron deficiency in CKD, including blood losses, impaired iron absorption, and chronic inflammation. The traditional biomarkers used for the diagnosis of iron-deficiency anemia (IDA) in patients with CKD have limitations, leading to persistent challenges in the detection and monitoring of IDA in these patients. Here, we review the pathophysiology and available diagnostic tests for IDA in CKD, we discuss the literature that has informed the current practice guidelines for the treatment of IDA in CKD, and we summarize the available oral and intravenous (IV) iron formulations for the treatment of IDA in CKD. Two important issues are addressed, including the potential risks of a more liberal approach to iron supplementation as well as the potential risks and benefits of IV versus oral iron supplementation in patients with CKD.10.1681/ASN.2019020213Mon, 10 Feb 2020 08:18:57 GMT-08:00Iron Deficiency in Chronic Kidney Disease: Updates on Pathophysiology, Diagnosis, and TreatmentAnemia is a complication that affects a majority of individuals with advanced CKD. Although relative deficiency of erythropoietin production is the major driver of anemia in CKD, iron deficiency stands out among the mechanisms contributing to the impaired erythropoiesis in the setting of reduced kidney function. Iron deficiency plays a significant role in anemia in CKD. This may be due to a true paucity of iron stores (absolute iron deficiency) or a relative (functional) deficiency which prevents the use of available iron stores. Several risk factors contribute to absolute and functional iron deficiency in CKD, including blood losses, impaired iron absorption, and chronic inflammation. The traditional biomarkers used for the diagnosis of iron-deficiency anemia (IDA) in patients with CKD have limitations, leading to persistent challenges in the detection and monitoring of IDA in these patients. Here, we review the pathophysiology and available diagnostic tests for IDA in CKD, we discuss the literature that has informed the current practice guidelines for the treatment of IDA in CKD, and we summarize the available oral and intravenous (IV) iron formulations for the treatment of IDA in CKD. Two important issues are addressed, including the potential risks of a more liberal approach to iron supplementation as well as the potential risks and benefits of IV versus oral iron supplementation in patients with CKD.Batchelor, Elizabeth KatherineKapitsinou, PinelopiPergola, Pablo E.Kovesdy, Csaba P.Jalal, Diana I.2020-02-10T08:18:57-08:00doi:10.1681/ASN.2019020213hwp:resource-id:jnephrol;31/3/456American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyanemia, chronic kidney disease, ironReviewReviewreview-article20202020-03-01March 202010.1681/ASN.20190202131046-66731533-34502020-02-10T08:18:57-08:002020-03Journal of the American Society of NephrologyReview313456468http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019090966?cct=218810.1681/ASN.2019090966Mon, 27 Jan 2020 06:13:17 GMT-08:00Hypothesis as to How a Common Missense Mutation in COL4A3 May Confer Protection against Diabetic Kidney DiseasePieri, Myrtani2020-01-27T06:13:17-08:00doi:10.1681/ASN.2019090966hwp:resource-id:jnephrol;31/3/663American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologydiabetic glomerulopathy, podocyte, collagen IV, unfolded protein responseLetter to the EditorLetter to the Editorletter20202020-03-01March 202010.1681/ASN.20190909661046-66731533-34502020-01-27T06:13:17-08:002020-03Journal of the American Society of NephrologyLetter to the Editor313663664http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060582?cct=218810.1681/ASN.2019060582Wed, 29 Jan 2020 07:28:59 GMT-08:00Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic MiceSugahara, MaiTanaka, ShinjiTanaka, TetsuhiroSaito, HisakoIshimoto, YuWakashima, TakeshiUeda, MasatoshiFukui, KenjiShimizu, AkiraInagi, ReikoYamauchi, ToshimasaKadowaki, TakashiNangaku, Masaomi2020-01-29T07:28:59-08:00doi:10.1681/ASN.2019060582hwp:resource-id:jnephrol;31/3/560American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyprolyl hydroxylase domain inhibitors, diabetic kidney disease, monocyte chemoattractant protein-1, adiponectinBasic ResearchBasic Researchresearch-article20202020-03-01March 202010.1681/ASN.20190605821046-66731533-34502020-01-29T07:28:59-08:002020-03Journal of the American Society of NephrologyBasic Research313560577http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019080778?cct=218810.1681/ASN.2019080778Mon, 27 Jan 2020 06:13:17 GMT-08:00Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c+F4/80+ Macrophages through IL-1R8 RegulationAiello, SistianaPodestà, Manuel AlfredoRodriguez-Ordonez, Pamela Y.Pezzuto, FrancescaAzzollini, NadiaSolini, SamanthaCarrara, CamilloTodeschini, MartaCasiraghi, FedericaNoris, MarinaRemuzzi, GiuseppeBenigni, Ariela2020-01-27T06:13:17-08:00doi:10.1681/ASN.2019080778hwp:resource-id:jnephrol;31/3/517American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologytransplantation, ischemia/reperfusion injury, macrophagesBasic ResearchBasic Researchresearch-article20202020-03-01March 202010.1681/ASN.20190807781046-66731533-34502020-01-27T06:13:17-08:002020-03Journal of the American Society of NephrologyBasic Research313517531http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000462019?cct=218810.34067/KID.0000462019Thu, 16 Jan 2020 05:30:10 GMT-08:00Global Dialysis Perspective: CanadaBlake, Peter G.2020-01-16T05:30:10-08:00doi:10.34067/KID.0000462019hwp:resource-id:kidney360;1/2/115American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Canada, Delivery of Health Care, Dialysis, Funding, Hemodialysis, Home dialysis, Peritoneal dialysisGlobal PerspectivesGlobal Perspectivesresearch-article20202020-02-2710.34067/KID.00004620192641-76502020-01-16T05:30:10-08:002020-02-27Kidney360Global Perspectives12115118http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0001012019?cct=218810.34067/KID.0001012019Wed, 15 Jan 2020 05:30:09 GMT-08:00Should My Patient Accept a Kidney from a Hepatitis C Virus–Infected Donor?Pagan, JavierLadino, MarcoRoth, David2020-01-15T05:30:09-08:00doi:10.34067/KID.0001012019hwp:resource-id:kidney360;1/2/127American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Transplantation, Antiviral Agents, Hepatitis C virus, kidney transplantation, Tissue DonorsPerspectivesPerspectivesresearch-article20202020-02-2710.34067/KID.00010120192641-76502020-01-15T05:30:09-08:002020-02-27Kidney360Perspectives12127129http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000052019?cct=218810.34067/KID.0000052019Mon, 20 Jan 2020 07:20:02 GMT-08:00Global Dialysis Perspective: IsraelHaviv, Yosef S.Golan, Eliezer2020-01-20T07:20:02-08:00doi:10.34067/KID.0000052019hwp:resource-id:kidney360;1/2/119American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Dialysis, Acute Kidney Injury, Ambulatory Care Facilities, Arteriovenous Fistula, Israel, Kidney Failure, Chronic, Kidney Transplantation, Renal Dialysis, Resource AllocationGlobal PerspectivesGlobal Perspectivesresearch-article20202020-02-2710.34067/KID.00000520192641-76502020-01-20T07:20:02-08:002020-02-27Kidney360Global Perspectives12119122http://kidney360.asnjournals.org/lookup/doi/10.34067/KID.0000502019?cct=218810.34067/KID.0000502019Thu, 27 Feb 2020 08:33:17 GMT-08:00Safety of Gadolinium-Based Contrast Agents in Patients with Stage 4 and 5 Chronic Kidney Disease: a Radiologist’s PerspectiveSoloff, Erik V.Wang, Carolyn L.2020-02-27T08:33:17-08:00doi:10.34067/KID.0000502019hwp:resource-id:kidney360;1/2/123American Society of NephrologyCopyright © 2020 by the American Society of NephrologyKidney360Chronic Kidney Disease, chronic kidney disease, Gadolinium, gadolinium deposition, gadolinium-based contrast agent, nephrogenic systemic fibrosis, radiologyPerspectivesPerspectivesresearch-article20202020-02-2710.34067/KID.00005020192641-76502020-02-27T08:33:17-08:002020-02-27Kidney360Perspectives12123126http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08140719?cct=218810.2215/CJN.08140719Thu, 23 Jan 2020 07:59:44 GMT-08:00Trends in the Proportions of Women Program Chairs, Moderators, and Speakers at American Society of Nephrology Kidney Week 2011–2019Malieckal, Deepa A.Ng, Jia H.Shah, Hitesh H.Hong, SusanaJhaveri, Kenar D.2020-01-23T07:59:44-08:00doi:10.2215/CJN.08140719hwp:resource-id:clinjasn;15/2/265American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyeducation, women in nephrology, conferences, Gender, humans, female, United States, nephrology, cross-sectional studies, linear models, records, societies, publications, awards and prizes, faculty, Internet, softwareResearch LetterResearch Letterresearch-article20202020-02-07February 07, 202010.2215/CJN.081407191555-90411555-905X2020-01-23T07:59:44-08:002020-02-07Clinical Journal of the American Society of NephrologyResearch Letter152265266http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06660619?cct=218810.2215/CJN.06660619Tue, 28 Jan 2020 11:10:19 GMT-08:00Patient and Kidney Allograft Survival with National Kidney Paired DonationLeeser, David B.Thomas, Alvin G.Shaffer, Ashton A.Veale, Jeffrey L.Massie, Allan B.Cooper, MatthewKapur, SandipTurgeon, NicoleSegev, Dorry L.Waterman, Amy D.Flechner, Stuart M.2020-01-28T11:10:19-08:00doi:10.2215/CJN.06660619hwp:resource-id:clinjasn;15/2/228American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantation, donor exchange, kidney donation, humans, female, United States, transplant recipients, risk factors, incidence, living donors, renal dialysis, follow-up studies, allografts, body mass index, semantic web, age factors, sex factors, hepatitis C, registries, diabetes mellitus, Hispanic AmericansOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-02-07February 07, 202010.2215/CJN.066606191555-90411555-905X2020-01-28T11:10:19-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles1522228168237170http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14941219?cct=218810.2215/CJN.14941219Thu, 30 Jan 2020 01:02:25 GMT-08:00Socioeconomic Determinants of Quality of Life in Patients with Kidney DiseasesJhamb, ManishaRoumelioti, Maria-Eleni2020-01-30T13:02:25-08:00doi:10.2215/CJN.14941219hwp:resource-id:clinjasn;15/2/162American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of NephrologyHumans, female, nephrology, quality of life, risk factors, patient reported outcome measures, renal dialysis, developed countries, prospective studies, frailty, chronic renal insufficiency, glomerular filtration rate, kidney, life style, biomarkers, hospitalization, vascular diseases, heart failure, diabetes mellitus, obesity, India, North AmericaEditorialsEditorialseditorial20202020-02-07February 07, 202010.2215/CJN.149412191555-90411555-905X2020-01-30T13:02:25-08:002020-02-07Clinical Journal of the American Society of NephrologyEditorials15222162161191164161199http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14101119?cct=218810.2215/CJN.14101119Thu, 30 Jan 2020 01:02:25 GMT-08:00Patient Perspective on CKD in IndiaUppaluri, Rama Krishna Rao2020-01-30T13:02:25-08:00doi:10.2215/CJN.14101119hwp:resource-id:clinjasn;15/2/161American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologymale, humans, female, quality of life, self-assessment, glomerular filtration rate, body mass index, blood pressure, language, poverty, social workers, surveys and questionnaires, translations, chronic renal insufficiency, blood pressure determination, IndiaPatient VoicePatient Voiceeditorial20202020-02-07February 07, 202010.2215/CJN.141011191555-90411555-905X2020-01-30T13:02:25-08:002020-02-07Clinical Journal of the American Society of NephrologyPatient Voice15222161162191161164199http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06510619?cct=218810.2215/CJN.06510619Thu, 30 Jan 2020 01:02:26 GMT-08:00Nonmedical Factors and Health-Related Quality of Life in CKD in IndiaModi, Gopesh K.Yadav, Ashok K.Ghosh, ArpitaKamboj, KajalKaur, PrabhjotKumar, VivekBhansali, ShobhitPrasad, NarayanSahay, ManishaParameswaran, SreejithVarughese, SantoshGang, SishirSingh, ShivendraSircar, DipankarGopalakrishnan, NatarajanJaryal, AjayVikrant, SanjayAgarwal, Seema BaidJha, Vivekanand2020-01-30T13:02:26-08:00doi:10.2215/CJN.06510619hwp:resource-id:clinjasn;15/2/191American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, quality of life, KDQOL, humans, female, albuminuria, patient reported outcome measures, clinical decision making, factor V, prospective studies, noncommunicable diseases, chronic renal insufficiency, socioeconomic factors, glomerular filtration rate, diabetes mellitus, hypertension, occupations, IndiaOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-02-07February 07, 202010.2215/CJN.065106191555-90411555-905X2020-01-30T13:02:26-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles15222191161162199161164http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07880719?cct=218810.2215/CJN.07880719Wed, 22 Jan 2020 07:48:33 GMT-08:00Association of Sleep Apnea with Mortality in Patients with Advanced Kidney DiseaseJhamb, ManishaRan, XinhuiAbdalla, HossamRoumelioti, Maria-EleniHou, SuruiDavis, HerbertPatel, Sanjay R.Yabes, JonathanUnruh, Mark2020-01-22T07:48:33-08:00doi:10.2215/CJN.07880719hwp:resource-id:clinjasn;15/2/182American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologysleep duration mortality ckd, sleep duration mortality, mortality risk, nocturnal hypoxemia, sleep apnea, female, polysomnography, proportional hazards models, body mass index, oxygen, follow-up studies, prospective studies, kidney transplantation, sleep apnea syndromes, survival analysis, kidney, chronic renal insufficiency, hypoxia, diabetes mellitusOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-02-07February 07, 202010.2215/CJN.078807191555-90411555-905X2020-01-22T07:48:33-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles152182190http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05050419?cct=218810.2215/CJN.05050419Fri, 07 Feb 2020 10:00:21 GMT-08:00Screening for CKD To Improve Processes of Care among Nondiabetic Veterans with HypertensionPeralta, Carmen A.Frigaard, MartinRolon, LeticiaSeal, KarenTuot, DelphineSenyak, JoshLo, LowellPowe, NeilScherzer, RebeccaChao, ShirleyChiao, PhillipLui, KimberlyShlipak, Michael G.Rubinsky, Anna D.2020-02-07T10:00:21-08:00doi:10.2215/CJN.05050419hwp:resource-id:clinjasn;15/2/174American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, screening, hypertension, pragmatic trial, humans, aged, cystatin C, blood pressure, creatinine, renin-angiotensin system, diuretics, pharmacists, veterans, intention to treat analysis, process assessment (health care), blood pressure determination, electronic health records, primary health care, chronic renal insufficiency, albuminsOriginal ArticlesChronic Kidney DiseaseOriginal ArticlesChronic Kidney Diseaseresearch-article20202020-02-07February 07, 202010.2215/CJN.050504191555-90411555-905X2020-02-07T10:00:21-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles152174181http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08570719?cct=218810.2215/CJN.08570719Tue, 28 Jan 2020 11:10:18 GMT-08:00Introduction to Genomics of Kidney DiseaseSampson, Matthew G.Fox, Caroline S.2020-01-28T11:10:18-08:00doi:10.2215/CJN.08570719hwp:resource-id:clinjasn;15/2/267American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologygenomics, genetics, kidney diseases, kidney disease, translations, humans, metabolics, systems biology, proteomics, genome-wide association study, research, genetic testing, patient care, Kidney Genomics SeriesGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-02-07February 07, 202010.2215/CJN.085707191555-90411555-905X2020-01-28T11:10:18-08:002020-02-07Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease152267267http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09340819?cct=2188The kidney is subject to a wide range of abnormalities, many of which have a significant hereditable component. Next generation sequencing is increasingly bringing the genetic drivers of Mendelian disease into focus at the base pair level, whereas inexpensive genotyping arrays have surveyed hundreds of thousands of individuals to identify common variants that predispose to kidney dysfunction. In this first article in a CJASN series on kidney genomics, we review how both rare and common variants contribute to kidney disease, explore how evolution may influence the genetic variants that affect kidney function, consider how genetic information is and will be used in the clinic, and identify some of the most important future directions for kidney disease research. Forthcoming articles in the series will elaborate on many of these themes.10.2215/CJN.09340819Tue, 28 Jan 2020 11:10:19 GMT-08:00The Genetic Architecture of Kidney DiseaseThe kidney is subject to a wide range of abnormalities, many of which have a significant hereditable component. Next generation sequencing is increasingly bringing the genetic drivers of Mendelian disease into focus at the base pair level, whereas inexpensive genotyping arrays have surveyed hundreds of thousands of individuals to identify common variants that predispose to kidney dysfunction. In this first article in a CJASN series on kidney genomics, we review how both rare and common variants contribute to kidney disease, explore how evolution may influence the genetic variants that affect kidney function, consider how genetic information is and will be used in the clinic, and identify some of the most important future directions for kidney disease research. Forthcoming articles in the series will elaborate on many of these themes.Pollak, Martin R.Friedman, David J.2020-01-28T11:10:19-08:00doi:10.2215/CJN.09340819hwp:resource-id:clinjasn;15/2/268American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhumans, high-throughput nucleotide sequencing, genotype, base pairing, genomics, kidney diseases, kidney, urinary tract physiological phenomena, architecture, Kidney Genomics Series, renal insufficiencyGenomics of Kidney DiseaseGenomics of Kidney Diseaseresearch-article20202020-02-07February 07, 202010.2215/CJN.093408191555-90411555-905X2020-01-28T11:10:19-08:002020-02-07Clinical Journal of the American Society of NephrologyGenomics of Kidney Disease152268275http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06600619?cct=218810.2215/CJN.06600619Thu, 23 Jan 2020 07:59:43 GMT-08:00Sodium Bicarbonate Supplementation and Urinary TGF-β1 in Nonacidotic Diabetic Kidney DiseaseRaphael, Kalani L.Greene, TomWei, GuoBullshoe, TristinTuttle, KunaniCheung, Alfred K.Beddhu, Srinivasan2020-01-23T07:59:43-08:00doi:10.2215/CJN.06600619hwp:resource-id:clinjasn;15/2/200American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologydiabetes mellitus, chronic kidney disease, TGF-beta, acidosis, humans, human LCN2 protein, lipocalin, creatinine, sodium bicarbonate, diabetic nephropathies, carbon dioxide, human FN1 protein, fibronectins, veterans, ammonium compounds, human HAVCR1 protein, hepatitis A virus cellular receptor 1, kidney function tests, bicarbonate, transforming growth factors, chronic renal insufficiency, albuminsOriginal ArticlesDiabetes and the KidneyOriginal ArticlesDiabetes and the Kidneyresearch-article20202020-02-07February 07, 202010.2215/CJN.066006191555-90411555-905X2020-01-23T07:59:43-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles152200208http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04880419?cct=218810.2215/CJN.04880419Thu, 10 Oct 2019 04:05:04 GMT-07:00Therapeutic Relowering of Plasma Sodium after Overly Rapid Correction of HyponatremiaRondon-Berrios, Helbert2019-10-10T04:05:04-07:00doi:10.2215/CJN.04880419hwp:resource-id:clinjasn;15/2/282American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyhyponatremia, osmotic demyelination syndrome, desmopressin, sodiumPerspectivesPerspectivesresearch-article20202020-02-07February 07, 202010.2215/CJN.048804191555-90411555-905X2019-10-10T04:05:04-07:002020-02-07Clinical Journal of the American Society of NephrologyPerspectives152282284http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.07730719?cct=218810.2215/CJN.07730719Mon, 18 Nov 2019 08:35:30 GMT-08:00Sodium Glucose Cotransporter 2 Inhibition Heralds a Call-to-Action for Diabetic Kidney DiseaseTuttle, Katherine R.Cherney, David Z.,2019-11-18T08:35:30-08:00doi:10.2215/CJN.07730719hwp:resource-id:clinjasn;15/2/285American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologychronic kidney disease, SGLT2 inhibitor, diabetes, diabetic nephropathy, anti-hyperglycemic therapies, sodium-glucose transporter 2, hypoglycemic agents, kidney diseasePerspectivesPerspectivesresearch-article20202020-02-07February 07, 202010.2215/CJN.077307191555-90411555-905X2019-11-18T08:35:30-08:002020-02-07Clinical Journal of the American Society of NephrologyPerspectives152285288http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10300819?cct=218810.2215/CJN.10300819Mon, 18 Nov 2019 08:35:30 GMT-08:00Peritoneal Dialysis in the Obese PatientKennedy, ClaireBargman, Joanne2019-11-18T08:35:30-08:00doi:10.2215/CJN.10300819hwp:resource-id:clinjasn;15/2/276American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyperitoneal dialysis, humans, body mass index, renal dialysis, chronic kidney failure, dialysis solutions, obesity, contraindicationsKidney Case Conference: How I TreatKidney Case Conference: How I Treatresearch-article20202020-02-07February 07, 202010.2215/CJN.103008191555-90411555-905X2019-11-18T08:35:30-08:002020-02-07Clinical Journal of the American Society of NephrologyKidney Case Conference: How I Treat152276278http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.06710619?cct=218810.2215/CJN.06710619Thu, 02 Jan 2020 05:50:18 GMT-08:00Mediterranean Style Diet and Kidney Function Loss in Kidney Transplant RecipientsGomes-Neto, António W.Osté, Maryse C.J.Sotomayor, Camilo G.van den Berg, ElseGeleijnse, Johanna MariannaBerger, Stefan P.Gans, Reinold O.B.Bakker, Stephan J.L.Navis, Gerjan J.2020-01-02T05:50:18-08:00doi:10.2215/CJN.06710619hwp:resource-id:clinjasn;15/2/238American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologynutrition, transplant, chronic graft deterioration, renal transplantation, proteinuria, adult, graft survival, kidney transplantation, creatinine, Mediterranean diet, follow-up studies, renal insufficiency, kidney, death, transplants, regression analysis, surveys and questionnaires, humansOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-02-07February 07, 202010.2215/CJN.067106191555-90411555-905X2020-01-02T05:50:18-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles152238246http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08580719?cct=2188Hematopoietic stem cell transplantation is a life-saving therapy for many patients with cancer, as well as patients with some nonmalignant hematologic disorders, such as aplastic anemia, sickle cell disease, and certain congenital immune deficiencies. Kidney injury directly associated with stem cell transplantation includes a wide range of structural and functional abnormalities, which may be vascular (hypertension, thrombotic microangiopathy), glomerular (albuminuria, nephrotic glomerulopathies), and/or tubulointerstitial. AKI occurs commonly after stem cell transplant, affecting 10%–73% of patients. The cause is often multifactorial and can include sepsis, nephrotoxic medications, marrow infusion syndrome, hepatic sinusoidal obstruction syndrome, thrombotic microangiopathy, infections, and graft versus host disease. The risk of post-transplant kidney injury varies depending on patient characteristics, type of transplant (allogeneic versus autologous), and choice of chemotherapeutic conditioning regimen (myeloablative versus nonmyeloablative). Importantly, AKI is associated with substantial morbidity, including the need for KRT in approximately 5% of patients and the development of CKD in up to 60% of transplant recipients. AKI has been associated universally with higher all-cause and nonrelapse mortality regardless of transplant type, and studies have consistently shown extremely high (>80%) mortality rates in those patients requiring acute dialysis. Accordingly, prevention, early recognition, and prompt treatment of kidney injury are essential to improving kidney and patient outcomes after hematopoietic stem cell transplantation, and for realizing the full potential of this therapy.10.2215/CJN.08580719Fri, 13 Dec 2019 07:20:38 GMT-08:00Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell TransplantationHematopoietic stem cell transplantation is a life-saving therapy for many patients with cancer, as well as patients with some nonmalignant hematologic disorders, such as aplastic anemia, sickle cell disease, and certain congenital immune deficiencies. Kidney injury directly associated with stem cell transplantation includes a wide range of structural and functional abnormalities, which may be vascular (hypertension, thrombotic microangiopathy), glomerular (albuminuria, nephrotic glomerulopathies), and/or tubulointerstitial. AKI occurs commonly after stem cell transplant, affecting 10%–73% of patients. The cause is often multifactorial and can include sepsis, nephrotoxic medications, marrow infusion syndrome, hepatic sinusoidal obstruction syndrome, thrombotic microangiopathy, infections, and graft versus host disease. The risk of post-transplant kidney injury varies depending on patient characteristics, type of transplant (allogeneic versus autologous), and choice of chemotherapeutic conditioning regimen (myeloablative versus nonmyeloablative). Importantly, AKI is associated with substantial morbidity, including the need for KRT in approximately 5% of patients and the development of CKD in up to 60% of transplant recipients. AKI has been associated universally with higher all-cause and nonrelapse mortality regardless of transplant type, and studies have consistently shown extremely high (>80%) mortality rates in those patients requiring acute dialysis. Accordingly, prevention, early recognition, and prompt treatment of kidney injury are essential to improving kidney and patient outcomes after hematopoietic stem cell transplantation, and for realizing the full potential of this therapy.Renaghan, Amanda DeMauroJaimes, Edgar A.Malyszko, JolantaPerazella, Mark A.Sprangers, BenRosner, Mitchell Howard2019-12-13T07:20:38-08:00doi:10.2215/CJN.08580719hwp:resource-id:clinjasn;15/2/289American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyacute renal failure, chronic kidney disease, stem cell, oncology, humans, graft versus host disease, albuminuria, hepatic veno-occlusive disease, transplant recipients, bone marrow, renal dialysis, transplantation conditioning, acute kidney injury, hematopoietic stem cell transplantation, kidney, chronic renal insufficiency, thrombotic microangiopathies, aplastic anemia, sepsis, sickle cell anemia, hypertension, neoplasmsReviewReviewresearch-article20202020-02-07February 07, 202010.2215/CJN.085807191555-90411555-905X2019-12-13T07:20:38-08:002020-02-07Clinical Journal of the American Society of NephrologyReview152289297http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.14841219?cct=218810.2215/CJN.14841219Thu, 23 Jan 2020 07:59:43 GMT-08:00Facing the Vexing Problem of Recurrent FSGS after Kidney TransplantationLafayette, Richard A.2020-01-23T07:59:43-08:00doi:10.2215/CJN.14841219hwp:resource-id:clinjasn;15/2/171American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyfsgs, kidney transplantation, humans, United States, nephrotic syndrome, cicatrix, risk factors, half-life, renal dialysis, focal segmental glomerulosclerosis, proteinuria, kidney diseases, renal insufficiency, biopsy, obesity, mutationEditorialsEditorialseditorial20202020-02-07February 07, 202010.2215/CJN.148412191555-90411555-905X2020-01-23T07:59:43-08:002020-02-07Clinical Journal of the American Society of NephrologyEditorials1522171247173256http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08970719?cct=218810.2215/CJN.08970719Thu, 23 Jan 2020 07:59:44 GMT-08:00Recurrence of FSGS after Kidney Transplantation in AdultsUffing, AudreyPérez-Sáez, Maria JoséMazzali, MarildaManfro, Roberto C.Bauer, Andrea Carlade Sottomaior Drumond, FredericoO’Shaughnessy, Michelle M.Cheng, Xingxing S.Chin, Kuo-KaiVentura, Carlucci G.Agena, FabianaDavid-Neto, EliasMansur, Juliana B.Kirsztajn, Gianna MastroianniTedesco-Silva, HelioNeto, Gilberto M.V.Arias-Cabrales, CarlosBuxeda, AnnaBugnazet, MathildeJouve, ThomasMalvezzi, PaoloAkalin, EnverAlani, OmarAgrawal, NikhilLa Manna, GaetanoComai, GiorgiaBini, ClaudiaMuhsin, Saif A.Riella, Miguel CarlosHokazono, Silvia R.Farouk, Samira S.Haverly, MeredithMothi, Suraj SarvodeBerger, Stefan P.Cravedi, PaoloRiella, Leonardo V.2020-01-23T07:59:44-08:00doi:10.2215/CJN.08970719hwp:resource-id:clinjasn;15/2/247American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologyfocal segmental glomerulosclerosis, transplant outcomes, recurrence, renal transplantation, risk factors, humans, adult, kidney transplantation, graft survival, rituximab, incidence, cohort studies, plasmapheresis, sample size, body mass index, transplant recipients, kidney diseases, kidney, Nephrectomy, treatment outcome, registriesOriginal ArticlesTransplantationOriginal ArticlesTransplantationresearch-article20202020-02-07February 07, 202010.2215/CJN.089707191555-90411555-905X2020-01-23T07:59:44-08:002020-02-07Clinical Journal of the American Society of NephrologyOriginal Articles1522247171256173http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04090419?cct=218810.2215/CJN.04090419Tue, 01 Oct 2019 10:02:18 GMT-07:00Personalizing the Kidney Transplant DecisionSawinski, DeirdreFoley, David P.2019-10-01T10:02:18-07:00doi:10.2215/CJN.04090419hwp:resource-id:clinjasn;15/2/279American Society of NephrologyCopyright © 2020 by the American Society of NephrologyClinical Journal of the American Society of Nephrologykidney transplantationPerspectivesPerspectivesresearch-article20202020-02-07February 07, 202010.2215/CJN.040904191555-90411555-905X2019-10-01T10:02:18-07:002020-02-07Clinical Journal of the American Society of NephrologyPerspectives152279281http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050502?cct=218810.1681/ASN.2019050502Fri, 06 Dec 2019 08:00:11 GMT-08:00Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort StudyOlaniran, Kabir O.Allegretti, Andrew S.Zhao, Sophia H.Achebe, Maureen M.Eneanya, Nwamaka D.Thadhani, Ravi I.Nigwekar, Sagar U.Kalim, Sahir2019-12-06T08:00:11-08:00doi:10.1681/ASN.2019050502hwp:resource-id:jnephrol;31/2/393American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologySickle cell trait, Sickle cell disease, chronic kidney disease, African American, kidney function decline, estimated glomerular filtration ratClinical EpidemiologyClinical Epidemiologyresearch-article20202020-02-01February 202010.1681/ASN.20190505021046-66731533-34502019-12-06T08:00:11-08:002020-02Journal of the American Society of NephrologyClinical Epidemiology3122393236404238http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019050443?cct=218810.1681/ASN.2019050443Fri, 10 Jan 2020 07:34:23 GMT-08:00FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in PodocytesSubramanian, BalajikarthickChun, JustinPerez-Gill, ChandraYan, PaulStillman, Isaac E.Higgs, Henry N.Alper, Seth L.Schlöndorff, Johannes S.Pollak, Martin R.2020-01-10T07:34:23-08:00doi:10.1681/ASN.2019050443hwp:resource-id:jnephrol;31/2/374American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyFSGS, INF2, podocyte, Actin, Cathepsins, cytoskeletonBasic ResearchBasic Researchresearch-article20202020-02-01February 202010.1681/ASN.20190504431046-66731533-34502020-01-10T07:34:23-08:002020-02Journal of the American Society of NephrologyBasic Research3122374235391236http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060570?cct=218810.1681/ASN.2019060570Mon, 25 Nov 2019 06:07:27 GMT-08:00Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical ScavengersMishima, EikanSato, EmikoIto, JunyaYamada, Ken-ichiSuzuki, ChitoseOikawa, YoshitsuguMatsuhashi, TetsuroKikuchi, KoichiToyohara, TakafumiSuzuki, TakehiroIto, SadayoshiNakagawa, KiyotakaAbe, Takaaki2019-11-25T06:07:27-08:00doi:10.1681/ASN.2019060570hwp:resource-id:jnephrol;31/2/280American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyFerroptosis, lipid peroxidation, acute kidney injury, Promethazine, Rifampicin, Regulated cell deathBasic ResearchBasic Researchresearch-article20202020-02-01February 202010.1681/ASN.20190605701046-66731533-34502019-11-25T06:07:27-08:002020-02Journal of the American Society of NephrologyBasic Research312280296http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019121295?cct=218810.1681/ASN.2019121295Mon, 13 Jan 2020 08:46:56 GMT-08:00Unraveling the Complexity of the Renal Mononuclear Phagocyte System by Genetic Cell Lineage TracingBöhner, Alexander M.C.Viehmann, Susanne F.Kurts, Christian2020-01-13T08:46:56-08:00doi:10.1681/ASN.2019121295hwp:resource-id:jnephrol;31/2/233American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyimmunology, embryology, macrophagesUp Front MattersEditorialsUp Front MattersEditorialseditorial20202020-02-01February 202010.1681/ASN.20191212951046-66731533-34502020-01-13T08:46:56-08:002020-02Journal of the American Society of NephrologyUp Front Matters3122233257235278http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019040419?cct=218810.1681/ASN.2019040419Mon, 13 Jan 2020 08:46:56 GMT-08:00The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory PropertiesSalei, NatalliaRambichler, StephanSalvermoser, JohannaPapaioannou, Nikos E.Schuchert, RonjaPakalniškytė, DaliaLi, NaMarschner, Julian A.Lichtnekert, JuliaStremmel, ChristopherCernilogar, Filippo M.Salvermoser, MelanieWalzog, BarbaraStraub, TobiasSchotta, GunnarAnders, Hans-JoachimSchulz, ChristianSchraml, Barbara U.2020-01-13T08:46:56-08:00doi:10.1681/ASN.2019040419hwp:resource-id:jnephrol;31/2/257American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologymacrophages, kidney development, immunology, dendritic cell, hematopoiesis, acute kidney injuryBasic ResearchBasic Researchresearch-article20202020-02-01February 202010.1681/ASN.20190404191046-66731533-34502020-01-13T08:46:56-08:002020-02Journal of the American Society of NephrologyBasic Research3122257233278235http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019040433?cct=218810.1681/ASN.2019040433Thu, 09 Jan 2020 10:35:16 GMT-08:00Large-Scale Whole-Genome Sequencing Reveals the Genetic Architecture of Primary Membranoproliferative GN and C3 GlomerulopathyLevine, Adam P.Chan, Melanie M.Y.Sadeghi-Alavijeh, OmidWong, Edwin K.S.Cook, H. TerenceAshford, SofieCarss, KerenChristian, Martin T.Hall, MatthewHarris, Claire LouiseMcAlinden, PaulMarchbank, Kevin J.Marks, Stephen D.Maxwell, HeatherMegy, KarynPenkett, Christopher J.Mozere, MonikaStirrups, Kathleen E.Tuna, SalihWessels, JulieWhitehorn, Deborah,,Johnson, Sally A.Gale, Daniel P.2020-01-09T10:35:16-08:00doi:10.1681/ASN.2019040433hwp:resource-id:jnephrol;31/2/365American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of NephrologyC3 glomerulopathy, Human leukocyte antigen, membranoproliferative glomerulonephritis (MPGN), Genome-wide association study, complementBasic ResearchBasic Researchresearch-article20202020-02-01February 202010.1681/ASN.20190404331046-66731533-34502020-01-09T10:35:16-08:002020-02Journal of the American Society of NephrologyBasic Research312365373http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019070718?cct=218810.1681/ASN.2019070718Mon, 02 Dec 2019 08:42:19 GMT-08:00BP Fluctuations and the Real-Time Dynamics of Renal Blood Flow Responses in Conscious RatsBidani, Anil K.Polichnowski, Aaron J.Licea-Vargas, HectorLong, JianruiKliethermes, StephanieWilliamson, Geoffrey A.Griffin, Karen A.2019-12-02T08:42:19-08:00doi:10.1681/ASN.2019070718hwp:resource-id:jnephrol;31/2/324American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologyhypertension, renal hemodynamics, nephrosclerosis, glomerulosclerosisBasic ResearchBasic Researchresearch-article20202020-02-01February 202010.1681/ASN.20190707181046-66731533-34502019-12-02T08:42:19-08:002020-02Journal of the American Society of NephrologyBasic Research312324336http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060574?cct=218810.1681/ASN.2019060574Thu, 09 Jan 2020 10:35:15 GMT-08:00Incident Hospitalization with Major Cardiovascular Diseases and Subsequent Risk of ESKD: Implications for Cardiorenal SyndromeIshigami, JunichiCowan, Logan T.Demmer, Ryan T.Grams, Morgan E.Lutsey, Pamela L.Carrero, Juan-JesusCoresh, JosefMatsushita, Kunihiro2020-01-09T10:35:15-08:00doi:10.1681/ASN.2019060574hwp:resource-id:jnephrol;31/2/405American Society of NephrologyCopyright © 2020 by the American Society of NephrologyJournal of the American Society of Nephrologycardiovascular disease, chronic kidney disease, end-stage renal disease, end stage kidney diseaseClinical EpidemiologyClinical Epidemiologyresearch-article20202020-02-01February 202010.1681/ASN.20190605741046-66731533-34502020-01-09T10:35:15-08:002020-02Journal of the American Society of NephrologyClinical Epidemiology312405414http://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2019060618?cct=218810.1681/ASN.2019060618Thu, 26 Dec 2019 09:27:02 GMT-08:00Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GNAntonelou, MarilinaMichaëlsson, ErikEvans, Rhys D.R.Wang, Chun JingHenderson, Scott R.Walker, Lucy S.K.Unwin,